REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] 0.27[2] -1.22[3] -0.42[4] -0.86[5] -1.12[6] 0.73[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] 0.17[9] 0.61[10] 0.62[11] -0.21[12] 0.88[13] -0.42[14]
3 STAT1 Signal transducer and activator of transcription 1-alpha/beta [15] -0.35[16] -1.26[17] -0.10[18] 1.43[19] -0.37[20] -0.73[21]
4 JAK1 Tyrosine-protein kinase JAK1 [22] 0.24[23] -0.27[24] -0.03[25] -0.47[26] 0.63[27] -0.15[28]
5 SOCS3 Suppressor of cytokine signaling 3 [29] -4.42[30] -4.82[31] -3.04[32] -1.90[33] -2.51[34] -1.54[35]
6 IL10RB Interleukin-10 receptor subunit beta [36] -0.82[37] -0.99[38] -1.95[39] -1.31[40] -0.73[41] -1.65[42]
7 STAT2 Signal transducer and activator of transcription 2 [43] -0.25[44] 1.13[45] 0.34[46] 0.43[47] 0.35[48] 1.35[49]
8 TYK2 Non-receptor tyrosine-protein kinase TYK2 [50] 0.86[51] 1.23[52] 1.41[53] -0.35[54] 1.03[55] 0.31[56]
9 STAT5B Signal transducer and activator of transcription 5B [57] 1.08[58] 0.72[59] 1.47[60] 0.45[61] 0.05[62] -0.06[63]
10 STAT5A Signal transducer and activator of transcription 5A [64] -2.23[65] -1.04[66] -1.92[67] -1.94[68] -0.73[69] -1.44[70]
11 IL22RA1 Interleukin-22 receptor subunit alpha-1 [71] 0.58[72] 3.09[73] -1.71[74] -2.25[75] -2.10[76] -1.24[77]
12 IL24 Interleukin-24 [78] [79] [80] -10.12[81] -3.10[82] -0.78[83] -8.25[84]
13 STAT4 Signal transducer and activator of transcription 4 [85] -5.12[86] -4.04[87] -3.46[88] 0.54[89] -0.20[90] -0.65[91]
14 JAK2 Tyrosine-protein kinase JAK2 [92] -0.05[93] -0.05[94] -0.43[95] -0.33[96] 0.72[97] 1.03[98]
15 IL20RB Interleukin-20 receptor subunit beta [99] -2.45[100] -3.57[101] -0.69[102] -2.07[103] 1.78[104] -3.02[105]
16 IL19 Interleukin-19 [106] [107] [108] -7.89[109] -7.84[110] [111] -5.48[112]
17 JAK3 Tyrosine-protein kinase JAK3 [113] 1.97[114] 4.25[115] -1.70[116] -1.73[117] -0.54[118] 1.42[119]
18 IL20 Interleukin-20 [120] [121] [122] [123] [124] -3.19[125] -5.60[126]
19 IL26 Interleukin-26 [127] [128] [129] [130] -2.44[131] [132] -4.48[133]
20 IFNLR1 Interferon lambda receptor 1 [134] [135] [136] [137] [138] [139] [140]
21 IFNL3 Interferon lambda-3 [141] [142] [143] [144] [145] [146] [147]
22 IL22 Interleukin-22 [148] [149] [150] [151] [152] [153] [154]
23 IFNL2 Interferon lambda-2 [155] [156] [157] [158] [159] [160] [161]
24 IL22RA2 Interleukin-22 receptor subunit alpha-2 [162] [163] [164] [165] [166] [167] [168]
25 IL20RA Interleukin-20 receptor subunit alpha [169] [170] [171] [172] [173] [174] [175]
26 IFNL1 Interferon lambda-1 [176] [177] [178] [179] [180] [181] [182]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[16]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[17]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[18]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[19]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[20]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[21]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[22]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10
[23]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56
[24]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29
[25]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29
[26]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39
[27]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[28]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62
[29]
ref_hepatocyte SOCS3
Mean 11.2
Standard deviation 10
Values 1 1.5 19 24 10
[30]
HepG2 SOCS3
Mean 1.4
Standard deviation 0.4
Values 1.7 1.1
[31]
HepG2.C3A SOCS3
Mean 0.939
Standard deviation 0.87
Values 1.6 0.32
[32]
HuH.7 SOCS3
Mean 2.97
Standard deviation 2.7
Values 1.4 6.1 1.4
[33]
SNU475 SOCS3
Mean 11.8
Standard deviation 0.67
Values 12 11
[34]
THLE SOCS3
Mean 6.29
Standard deviation 1.1
Values 7.1 5.5
[35]
liver SOCS3
Mean 17.4
Standard deviation 5.5
Values 15 14 15 26
[36]
ref_hepatocyte IL10RB
Mean 8.5
Standard deviation 2.9
Values 6.8 6.7 5.7 12 11
[37]
HepG2 IL10RB
Mean 12.9
Standard deviation 0.15
Values 13 13
[38]
HepG2.C3A IL10RB
Mean 10.1
Standard deviation 0.73
Values 11 9.6
[39]
HuH.7 IL10RB
Mean 4.8
Standard deviation 0.49
Values 4.4 5.3 4.7
[40]
SNU475 IL10RB
Mean 13.5
Standard deviation 3.7
Values 16 11
[41]
THLE IL10RB
Mean 16.4
Standard deviation 0.029
Values 16 16
[42]
liver IL10RB
Mean 12.3
Standard deviation 5.1
Values 16 9.1 17 6.9
[43]
ref_hepatocyte STAT2
Mean 5.97
Standard deviation 4.9
Values 2.5 2.7 2.3 9.4 13
[44]
HepG2 STAT2
Mean 13.4
Standard deviation 4
Values 11 16
[45]
HepG2.C3A STAT2
Mean 30.9
Standard deviation 3.5
Values 33 28
[46]
HuH.7 STAT2
Mean 16.5
Standard deviation 0.99
Values 16 16 17
[47]
SNU475 STAT2
Mean 31.7
Standard deviation 16
Values 43 20
[48]
THLE STAT2
Mean 24.3
Standard deviation 2
Values 26 23
[49]
liver STAT2
Mean 69
Standard deviation 4.2
Values 70 74 64 68
[50]
ref_hepatocyte TYK2
Mean 4.82
Standard deviation 1.6
Values 2.6 4 5.2 6.8 5.6
[51]
HepG2 TYK2
Mean 23.5
Standard deviation 0.9
Values 23 24
[52]
HepG2.C3A TYK2
Mean 26.8
Standard deviation 2.6
Values 29 25
[53]
HuH.7 TYK2
Mean 28.1
Standard deviation 8.5
Values 35 19 31
[54]
SNU475 TYK2
Mean 14.9
Standard deviation 0.21
Values 15 15
[55]
THLE TYK2
Mean 31.6
Standard deviation 1.6
Values 33 31
[56]
liver TYK2
Mean 27.2
Standard deviation 3.5
Values 31 24 24 30
[57]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[58]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[59]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[60]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[61]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[62]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[63]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[64]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[65]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[66]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[67]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[68]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[69]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[70]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[71]
ref_hepatocyte IL22RA1
Mean 1.37
Standard deviation 1.2
Values 1.2 0.16 3.4 1.2 0.92
[72]
HepG2 IL22RA1
Mean 5.48
Standard deviation 0.33
Values 5.7 5.2
[73]
HepG2.C3A IL22RA1
Mean 27.6
Standard deviation 11
Values 35 20
[74]
HuH.7 IL22RA1
Mean 0.915
Standard deviation 0.43
Values 1.1 0.43 1.3
[75]
SNU475 IL22RA1
Mean 1.13
Standard deviation 0.088
Values 1.1 1.2
[76]
THLE IL22RA1
Mean 1.03
Standard deviation 0.089
Values 1.1 0.96
[77]
liver IL22RA1
Mean 2.64
Standard deviation 1.6
Values 4.5 1.2 3.4 1.5
[78]
ref_hepatocyte IL24
Mean 1.09
Standard deviation 1.6
Values 0 0 3.4 2 0
[79]
HepG2 IL24
Mean 0
Standard deviation 0
Values 0 0
[80]
HepG2.C3A IL24
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 IL24
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[82]
SNU475 IL24
Mean 0.5
Standard deviation 0.56
Values 0.1 0.9
[83]
THLE IL24
Mean 2.04
Standard deviation 0.25
Values 1.9 2.2
[84]
liver IL24
Mean 0.0163
Standard deviation 0.013
Values 0.024 0.029 0 0.013
[85]
ref_hepatocyte STAT4
Mean 0.825
Standard deviation 0.62
Values 0 1.4 0.35 1 1.3
[86]
HepG2 STAT4
Mean 0.0637
Standard deviation 0.025
Values 0.046 0.082
[87]
HepG2.C3A STAT4
Mean 0.119
Standard deviation 0.044
Values 0.087 0.15
[88]
HuH.7 STAT4
Mean 0.164
Standard deviation 0.023
Values 0.16 0.14 0.19
[89]
SNU475 STAT4
Mean 4.7
Standard deviation 1.3
Values 5.6 3.8
[90]
THLE STAT4
Mean 2.3
Standard deviation 1.2
Values 3.1 1.5
[91]
liver STAT4
Mean 2.39
Standard deviation 1.1
Values 3 1.5 1.4 3.7
[92]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[93]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[94]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[95]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[96]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[97]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[98]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[99]
ref_hepatocyte IL20RB
Mean 0.456
Standard deviation 0.48
Values 0 0.4 1.1 0.69 0.041
[100]
HepG2 IL20RB
Mean 0.223
Standard deviation 0.22
Values 0.38 0.069
[101]
HepG2.C3A IL20RB
Mean 0.091
Standard deviation 0.023
Values 0.11 0.075
[102]
HuH.7 IL20RB
Mean 0.618
Standard deviation 0.21
Values 0.43 0.58 0.84
[103]
SNU475 IL20RB
Mean 0.426
Standard deviation 0.16
Values 0.32 0.54
[104]
THLE IL20RB
Mean 5
Standard deviation 3.7
Values 7.6 2.4
[105]
liver IL20RB
Mean 0.256
Standard deviation 0.19
Values 0.35 0.14 0.051 0.48
[106]
ref_hepatocyte IL19
Mean 0.296
Standard deviation 0.64
Values 0 0 1.4 0 0.041
[107]
HepG2 IL19
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A IL19
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 IL19
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[110]
SNU475 IL19
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[111]
THLE IL19
Mean 0
Standard deviation 0
Values 0 0
[112]
liver IL19
Mean 0.0301
Standard deviation 0.027
Values 0 0.029 0.026 0.066
[113]
ref_hepatocyte JAK3
Mean 0.235
Standard deviation 0.23
Values 0.61 0.026 0.15 0.078 0.31
[114]
HepG2 JAK3
Mean 2.46
Standard deviation 0.35
Values 2.7 2.2
[115]
HepG2.C3A JAK3
Mean 10.6
Standard deviation 4.3
Values 14 7.6
[116]
HuH.7 JAK3
Mean 0.158
Standard deviation 0.069
Values 0.11 0.24 0.12
[117]
SNU475 JAK3
Mean 0.279
Standard deviation 0.0072
Values 0.27 0.28
[118]
THLE JAK3
Mean 0.519
Standard deviation 0.094
Values 0.59 0.45
[119]
liver JAK3
Mean 2.86
Standard deviation 0.73
Values 2.8 2.2 2.5 3.9
[120]
ref_hepatocyte IL20
Mean 0.0707
Standard deviation 0.16
Values 0 0 0 0.35 0
[121]
HepG2 IL20
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A IL20
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 IL20
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 IL20
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE IL20
Mean 0.0248
Standard deviation 0.01
Values 0.018 0.032
[126]
liver IL20
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[127]
ref_hepatocyte IL26
Mean 0.0163
Standard deviation 0.036
Values 0 0 0 0 0.081
[128]
HepG2 IL26
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A IL26
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 IL26
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 IL26
Mean 0.0118
Standard deviation 0.0095
Values 0.019 0.0051
[132]
THLE IL26
Mean 0
Standard deviation 0
Values 0 0
[133]
liver IL26
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013
[134]
ref_hepatocyte IFNLR1
Missing
[135]
HepG2 IFNLR1
Mean 7.18
Standard deviation 0.62
Values 7.6 6.7
[136]
HepG2.C3A IFNLR1
Mean 19.6
Standard deviation 3.7
Values 22 17
[137]
HuH.7 IFNLR1
Mean 4.35
Standard deviation 0.97
Values 4.3 5.3 3.4
[138]
SNU475 IFNLR1
Mean 5.11
Standard deviation 0.16
Values 5.2 5
[139]
THLE IFNLR1
Mean 3.42
Standard deviation 0.35
Values 3.7 3.2
[140]
liver IFNLR1
Mean 6.63
Standard deviation 1.8
Values 4.8 9.1 5.9 6.7
[141]
ref_hepatocyte IFNL3
Missing
[142]
HepG2 IFNL3
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[143]
HepG2.C3A IFNL3
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 IFNL3
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 IFNL3
Mean 0
Standard deviation 0
Values 0 0
[146]
THLE IFNL3
Mean 0
Standard deviation 0
Values 0 0
[147]
liver IFNL3
Mean 0
Standard deviation 0
Values 0 0 0 0
[148]
ref_hepatocyte IL22
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 IL22
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A IL22
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 IL22
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 IL22
Mean 0.0177
Standard deviation 0.025
Values 0 0.035
[153]
THLE IL22
Mean 0
Standard deviation 0
Values 0 0
[154]
liver IL22
Mean 0
Standard deviation 0
Values 0 0 0 0
[155]
ref_hepatocyte IFNL2
Missing
[156]
HepG2 IFNL2
Missing
[157]
HepG2.C3A IFNL2
Missing
[158]
HuH.7 IFNL2
Missing
[159]
SNU475 IFNL2
Missing
[160]
THLE IFNL2
Missing
[161]
liver IFNL2
Missing
[162]
ref_hepatocyte IL22RA2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 IL22RA2
Mean 0
Standard deviation 0
Values 0 0
[164]
HepG2.C3A IL22RA2
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 IL22RA2
Mean 0
Standard deviation 0
Values 0 0 0
[166]
SNU475 IL22RA2
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[167]
THLE IL22RA2
Mean 0
Standard deviation 0
Values 0 0
[168]
liver IL22RA2
Mean 0
Standard deviation 0
Values 0 0 0 0
[169]
ref_hepatocyte IL20RA
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 IL20RA
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[171]
HepG2.C3A IL20RA
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 IL20RA
Mean 0.642
Standard deviation 0.32
Values 0.57 0.36 0.99
[173]
SNU475 IL20RA
Mean 0.311
Standard deviation 0.059
Values 0.35 0.27
[174]
THLE IL20RA
Mean 0.0414
Standard deviation 0.017
Values 0.03 0.053
[175]
liver IL20RA
Mean 0.25
Standard deviation 0.15
Values 0.47 0.11 0.21 0.21
[176]
ref_hepatocyte IFNL1
Missing
[177]
HepG2 IFNL1
Mean 0.0172
Standard deviation 0.024
Values 0.034 0
[178]
HepG2.C3A IFNL1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[179]
HuH.7 IFNL1
Mean 0
Standard deviation 0
Values 0 0 0
[180]
SNU475 IFNL1
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[181]
THLE IFNL1
Mean 0
Standard deviation 0
Values 0 0
[182]
liver IFNL1
Mean 0.0128
Standard deviation 0.026
Values 0 0 0.051 0