REACTOME_INTERLEUKIN_1_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SAA1 | Serum amyloid A-1 protein | [1] | -15.63[2] | -15.55[3] | -10.78[4] | -13.87[5] | -5.20[6] | -0.44[7] |
2 | UBB | Polyubiquitin-B | [8] | 1.32[9] | 1.24[10] | 1.40[11] | 0.90[12] | 1.20[13] | 0.52[14] |
3 | SQSTM1 | Sequestosome-1 | [15] | 1.76[16] | 0.83[17] | 1.39[18] | 2.51[19] | 2.26[20] | 0.61[21] |
4 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [22] | [23] | [24] | [25] | [26] | [27] | [28] |
5 | UBC | Polyubiquitin-C | [29] | 1.76[30] | 1.99[31] | 1.77[32] | 1.76[33] | 1.58[34] | 0.98[35] |
6 | PSME1 | Proteasome activator complex subunit 1 | [36] | 1.99[37] | 0.40[38] | 0.80[39] | 1.04[40] | 0.36[41] | 0.02[42] |
7 | PSME2 | Proteasome activator complex subunit 2 | [43] | 2.17[44] | 0.78[45] | 0.71[46] | 1.25[47] | 0.82[48] | 0.40[49] |
8 | PSMA7 | Proteasome subunit alpha type-7 | [50] | 3.13[51] | 3.25[52] | 1.95[53] | 2.88[54] | 2.30[55] | 1.42[56] |
9 | PSMB1 | Proteasome subunit beta type-1 | [57] | 2.68[58] | 2.80[59] | 1.76[60] | 1.63[61] | 2.26[62] | 1.26[63] |
10 | PSMB3 | Proteasome subunit beta type-3 | [64] | 2.19[65] | 1.42[66] | 2.48[67] | 1.61[68] | 1.35[69] | 0.96[70] |
11 | PSMB4 | Proteasome subunit beta type-4 | [71] | 2.44[72] | 2.62[73] | 2.78[74] | 3.04[75] | 2.89[76] | 0.64[77] |
12 | PSMB7 | Proteasome subunit beta type-7 | [78] | 1.49[79] | 1.51[80] | 1.68[81] | 1.27[82] | 1.57[83] | 0.20[84] |
13 | HMGB1 | High mobility group protein B1 | [85] | 3.22[86] | 4.08[87] | 3.83[88] | 4.14[89] | 3.46[90] | 1.85[91] |
14 | PSMB5 | Proteasome subunit beta type-5 | [92] | 3.89[93] | 2.48[94] | 2.44[95] | 1.99[96] | 2.13[97] | 0.67[98] |
15 | PSMA6 | Proteasome subunit alpha type-6 | [99] | 4.02[100] | 2.75[101] | 2.72[102] | 2.52[103] | 2.39[104] | 0.75[105] |
16 | NFKBIA | NF-kappa-B inhibitor alpha | [106] | 2.46[107] | 0.79[108] | 0.42[109] | 0.16[110] | 1.89[111] | 1.26[112] |
17 | PSMA4 | Proteasome subunit alpha type-4 | [113] | 2.09[114] | 2.77[115] | 2.60[116] | 2.82[117] | 2.51[118] | 0.67[119] |
18 | SKP1 | S-phase kinase-associated protein 1 | [120] | 2.54[121] | 3.05[122] | 2.19[123] | 3.18[124] | 3.24[125] | 1.71[126] |
19 | PSMC3 | 26S proteasome regulatory subunit 6A | [127] | 2.06[128] | 2.01[129] | 2.66[130] | 1.62[131] | 1.68[132] | 1.15[133] |
20 | PSMA3 | Proteasome subunit alpha type-3 | [134] | 1.47[135] | 2.49[136] | 1.85[137] | 2.37[138] | 1.78[139] | 0.92[140] |
21 | PSMB6 | Proteasome subunit beta type-6 | [141] | 2.02[142] | 2.19[143] | 2.37[144] | 1.82[145] | 1.42[146] | 1.08[147] |
22 | PSMA2 | Proteasome subunit alpha type-2 | [148] | 1.93[149] | 2.91[150] | 3.28[151] | 2.32[152] | 2.55[153] | 1.30[154] |
23 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [155] | 2.45[156] | 2.48[157] | 2.72[158] | 3.02[159] | 2.35[160] | 0.98[161] |
24 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [162] | 2.37[163] | 2.76[164] | 2.66[165] | 1.94[166] | 2.27[167] | 0.80[168] |
25 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [169] | 2.54[170] | 2.80[171] | 2.97[172] | 2.21[173] | 2.83[174] | 0.83[175] |
26 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [176] | 4.07[177] | 3.27[178] | 3.37[179] | 3.32[180] | 4.48[181] | 1.87[182] |
27 | PSMC1 | 26S proteasome regulatory subunit 4 | [183] | 2.39[184] | 2.47[185] | 1.86[186] | 3.50[187] | 2.89[188] | 1.03[189] |
28 | APP | Amyloid-beta A4 protein | [190] | 3.90[191] | 3.46[192] | 4.14[193] | 4.46[194] | 4.71[195] | 2.54[196] |
29 | PSMA1 | Proteasome subunit alpha type-1 | [197] | 2.57[198] | 2.98[199] | 3.08[200] | 3.08[201] | 2.45[202] | 1.51[203] |
30 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [204] | 4.20[205] | 4.22[206] | 5.28[207] | 3.15[208] | 3.81[209] | 1.75[210] |
31 | PSMC5 | 26S proteasome regulatory subunit 8 | [211] | 2.89[212] | 2.81[213] | 2.92[214] | 2.49[215] | 2.77[216] | 1.28[217] |
32 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [218] | 1.46[219] | 2.01[220] | 1.91[221] | 0.98[222] | 1.24[223] | 0.30[224] |
33 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [225] | 3.29[226] | 2.80[227] | 3.43[228] | 3.02[229] | 3.11[230] | 1.00[231] |
34 | PSMB8 | Proteasome subunit beta type-8 | [232] | 0.89[233] | 0.32[234] | -6.86[235] | 2.99[236] | 1.55[237] | 0.31[238] |
35 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [239] | 2.47[240] | 3.09[241] | 3.38[242] | 2.88[243] | 2.78[244] | 0.85[245] |
36 | PSMC4 | 26S proteasome regulatory subunit 6B | [246] | 2.89[247] | 2.94[248] | 2.91[249] | 2.51[250] | 2.49[251] | 1.33[252] |
37 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [253] | 1.74[254] | 2.24[255] | 1.19[256] | 1.89[257] | 2.56[258] | 0.74[259] |
38 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [260] | 2.94[261] | 3.07[262] | 3.60[263] | 2.94[264] | 2.32[265] | 0.93[266] |
39 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [267] | 2.12[268] | 2.21[269] | 1.94[270] | 2.56[271] | 2.50[272] | 0.85[273] |
40 | PSMC6 | 26S proteasome regulatory subunit 10B | [274] | 2.41[275] | 4.01[276] | 2.86[277] | 2.92[278] | 2.72[279] | 1.50[280] |
41 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [281] | 3.29[282] | 2.93[283] | 3.55[284] | 3.33[285] | 3.35[286] | 2.33[287] |
42 | UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1 | [288] | -0.36[289] | -0.43[290] | -0.27[291] | -0.20[292] | -1.01[293] | -2.61[294] |
43 | PSMC2 | 26S proteasome regulatory subunit 7 | [295] | 3.05[296] | 3.47[297] | 3.28[298] | 3.72[299] | 3.42[300] | 2.38[301] |
44 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [302] | 2.59[303] | 2.38[304] | 2.97[305] | 3.14[306] | 3.49[307] | 1.21[308] |
45 | PSME3 | Proteasome activator complex subunit 3 | [309] | 4.28[310] | 4.01[311] | 3.73[312] | 3.75[313] | 3.88[314] | 1.95[315] |
46 | IL1RN | Interleukin-1 receptor antagonist protein | [316] | -0.13[317] | 2.73[318] | -5.44[319] | [320] | -5.21[321] | 1.81[322] |
47 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [323] | 4.04[324] | 4.38[325] | 4.29[326] | 4.56[327] | 4.43[328] | 3.13[329] |
48 | IKBKG | NF-kappa-B essential modulator | [330] | 2.63[331] | 2.89[332] | 0.66[333] | 2.83[334] | 1.46[335] | 1.80[336] |
49 | PSMB10 | Proteasome subunit beta type-10 | [337] | 1.31[338] | 1.93[339] | 0.08[340] | 2.34[341] | 1.05[342] | 0.99[343] |
50 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [344] | 4.93[345] | 4.44[346] | 3.44[347] | 4.48[348] | 4.69[349] | 1.71[350] |
51 | PSMA5 | Proteasome subunit alpha type-5 | [351] | 4.37[352] | 4.81[353] | 4.41[354] | 4.61[355] | 4.03[356] | 2.97[357] |
52 | PSMF1 | Proteasome inhibitor PI31 subunit | [358] | 4.74[359] | 4.81[360] | 3.65[361] | 3.62[362] | 3.24[363] | 2.92[364] |
53 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [365] | 4.21[366] | 4.80[367] | 3.64[368] | 4.00[369] | 3.73[370] | 1.68[371] |
54 | TOLLIP | Toll-interacting protein | [372] | 3.25[373] | 3.25[374] | 3.27[375] | 2.65[376] | 1.65[377] | 3.55[378] |
55 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [379] | 2.75[380] | 3.17[381] | 3.63[382] | 2.30[383] | 2.99[384] | -0.62[385] |
56 | PSMB2 | Proteasome subunit beta type-2 | [386] | 4.52[387] | 4.28[388] | 4.70[389] | 4.91[390] | 4.76[391] | 3.46[392] |
57 | IL1R1 | Interleukin-1 receptor type 1 | [393] | 2.95[394] | 2.70[395] | 2.07[396] | 2.86[397] | 5.37[398] | 3.17[399] |
58 | RELA | Transcription factor p65 | [400] | 3.65[401] | 3.26[402] | 3.42[403] | 3.63[404] | 3.37[405] | 1.52[406] |
59 | TNIP2 | TNFAIP3-interacting protein 2 | [407] | 2.83[408] | 3.02[409] | 2.75[410] | 3.02[411] | 2.22[412] | 0.95[413] |
60 | PSMB9 | Proteasome subunit beta type-9 | [414] | 0.52[415] | -2.08[416] | -4.36[417] | 4.16[418] | 1.76[419] | 0.57[420] |
61 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [421] | 2.90[422] | 3.41[423] | 2.46[424] | 2.79[425] | 3.09[426] | 1.79[427] |
62 | CUL1 | Cullin-1 | [428] | 3.13[429] | 3.93[430] | 3.50[431] | 4.27[432] | 3.76[433] | 3.15[434] |
63 | NFKBIB | NF-kappa-B inhibitor beta | [435] | 2.35[436] | 2.30[437] | 2.64[438] | 1.87[439] | 2.05[440] | 0.67[441] |
64 | MYD88 | Myeloid differentiation primary response protein MyD88 | [442] | 3.33[443] | 3.51[444] | 2.95[445] | 2.65[446] | 2.78[447] | 3.20[448] |
65 | IL1RAP | Interleukin-1 receptor accessory protein | [449] | 2.02[450] | 4.36[451] | 4.02[452] | 2.22[453] | 3.15[454] | 4.59[455] |
66 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [456] | 3.46[457] | 3.80[458] | 3.86[459] | 4.46[460] | 3.64[461] | 1.77[462] |
67 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [463] | 3.88[464] | 4.17[465] | 4.45[466] | 5.38[467] | 4.68[468] | 2.64[469] |
68 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [470] | 3.42[471] | 4.61[472] | 4.49[473] | 4.17[474] | 4.19[475] | 2.65[476] |
69 | IRAK2 | Interleukin-1 receptor-associated kinase-like 2 | [477] | 3.44[478] | 3.66[479] | 3.46[480] | 1.25[481] | 2.64[482] | 1.38[483] |
70 | PSME4 | Proteasome activator complex subunit 4 | [484] | 4.98[485] | 5.92[486] | 5.95[487] | 5.02[488] | 4.84[489] | 4.04[490] |
71 | NKIRAS2 | NF-kappa-B inhibitor-interacting Ras-like protein 2 | [491] | 4.27[492] | 3.14[493] | 4.22[494] | 4.26[495] | 3.90[496] | 2.60[497] |
72 | TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | [498] | 3.57[499] | 5.64[500] | 5.75[501] | 4.03[502] | 5.07[503] | 3.23[504] |
73 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [505] | 4.19[506] | 3.98[507] | 3.79[508] | 3.44[509] | 4.19[510] | 2.85[511] |
74 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [512] | 3.88[513] | 3.45[514] | 5.04[515] | 4.85[516] | 4.79[517] | 3.22[518] |
75 | FBXW11 | F-box/WD repeat-containing protein 11 | [519] | 4.89[520] | 4.92[521] | 5.69[522] | 5.21[523] | 4.96[524] | 3.35[525] |
76 | NKIRAS1 | NF-kappa-B inhibitor-interacting Ras-like protein 1 | [526] | 2.15[527] | 2.06[528] | 3.29[529] | 3.14[530] | 3.26[531] | 2.18[532] |
77 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [533] | 4.22[534] | 4.97[535] | 4.19[536] | 4.89[537] | 4.13[538] | 3.47[539] |
78 | IL1R2 | Interleukin-1 receptor type 2 | [540] | 1.09[541] | 1.16[542] | -2.79[543] | -1.91[544] | 0.04[545] | 1.56[546] |
79 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | [547] | 2.94[548] | 3.66[549] | 3.69[550] | 3.48[551] | 3.29[552] | 1.27[553] |
80 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [554] | 4.42[555] | 5.76[556] | 5.73[557] | 4.33[558] | 4.99[559] | 3.92[560] |
81 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [561] | 4.16[562] | 4.93[563] | 5.02[564] | 3.69[565] | 3.87[566] | 2.62[567] |
82 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [568] | 4.04[569] | 4.22[570] | 4.34[571] | 3.94[572] | 3.87[573] | 3.58[574] |
83 | IL1B | Interleukin-1 beta | [575] | -5.18[576] | -4.93[577] | -0.59[578] | 0.09[579] | 5.52[580] | -2.80[581] |
84 | PELI1 | E3 ubiquitin-protein ligase pellino homolog 1 | [582] | 3.66[583] | 4.70[584] | 5.23[585] | 3.43[586] | 3.36[587] | 3.80[588] |
85 | BTRC | F-box/WD repeat-containing protein 1A | [589] | 4.93[590] | 5.84[591] | 5.47[592] | 4.44[593] | 4.82[594] | 3.75[595] |
86 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [596] | 5.26[597] | 5.39[598] | 4.59[599] | 3.79[600] | 4.95[601] | 2.89[602] |
87 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [603] | 3.81[604] | 0.71[605] | 5.58[606] | 4.69[607] | 0.50[608] | 0.78[609] |
88 | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | [610] | 5.14[611] | 5.74[612] | 5.04[613] | 5.77[614] | 5.86[615] | 4.54[616] |
89 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [617] | 3.77[618] | 5.26[619] | 5.55[620] | 5.10[621] | 4.70[622] | 4.18[623] |
90 | TRAF6 | TNF receptor-associated factor 6 | [624] | 4.61[625] | 4.61[626] | 5.20[627] | 5.35[628] | 4.64[629] | 5.31[630] |
91 | PELI3 | E3 ubiquitin-protein ligase pellino homolog 3 | [631] | 4.89[632] | 4.06[633] | 5.61[634] | 6.17[635] | 5.71[636] | 3.37[637] |
92 | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2 | [638] | 1.61[639] | -0.24[640] | [641] | 0.07[642] | 3.46[643] | 1.87[644] |
93 | S100A12 | Protein S100-A12 | [645] | [646] | [647] | [648] | [649] | [650] | 2.68[651] |
94 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1 | [652] | 4.54[653] | 4.33[654] | 5.15[655] | 5.92[656] | 5.39[657] | 4.49[658] |
95 | AGER | Advanced glycosylation end product-specific receptor | [659] | 2.47[660] | 5.76[661] | 4.71[662] | 4.32[663] | 3.93[664] | 2.29[665] |
96 | PELI2 | E3 ubiquitin-protein ligase pellino homolog 2 | [666] | 0.67[667] | -0.11[668] | -0.64[669] | 7.66[670] | 6.23[671] | 5.88[672] |
97 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | [673] | 2.07[674] | 3.18[675] | 5.06[676] | 9.72[677] | 11.81[678] | 8.29[679] |
98 | S100B | Protein S100-B | [680] | -0.34[681] | -1.20[682] | [683] | 1.93[684] | -2.25[685] | 3.55[686] |
99 | IL1A | Interleukin-1 alpha | [687] | 3.09[688] | 2.81[689] | 1.65[690] | 3.04[691] | 9.63[692] | 0.82[693] |
100 | SEM1 | Putative protein SEM1, isoform 2 | [694] | [695] | [696] | [697] | [698] | [699] | [700] |
101 | PSMA8 | Proteasome subunit alpha type-7-like | [701] | [702] | [703] | [704] | [705] | [706] | [707] |
102 | PSMB11 | Proteasome subunit beta type-11 | [708] | [709] | [710] | [711] | [712] | [713] | [714] |