REACTOME_INTERLEUKIN_17_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.03[2] | -1.33[3] | -1.15[4] | -1.45[5] | -1.06[6] | -0.74[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.59[16] | -0.58[17] | -0.79[18] | -0.60[19] | -0.68[20] | -0.29[21] |
4 | SKP1 | S-phase kinase-associated protein 1 | [22] | 0.19[23] | 0.48[24] | -0.36[25] | 0.82[26] | 0.97[27] | 0.44[28] |
5 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [29] | 1.85[30] | 1.65[31] | 2.72[32] | 0.80[33] | 1.54[34] | 0.48[35] |
6 | JUN | Transcription factor AP-1 | [36] | 0.68[37] | -0.97[38] | -0.67[39] | -0.37[40] | 0.12[41] | -0.67[42] |
7 | FOS | Proto-oncogene c-Fos | [43] | -4.84[44] | -3.68[45] | -4.32[46] | -4.84[47] | -3.84[48] | -0.17[49] |
8 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [50] | -0.05[51] | 0.15[52] | -0.93[53] | -0.50[54] | -0.70[55] | -0.30[56] |
9 | UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1 | [57] | -2.71[58] | -3.00[59] | -2.83[60] | -2.56[61] | -3.28[62] | -3.87[63] |
10 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [64] | 0.24[65] | -0.19[66] | 0.42[67] | 0.79[68] | 1.22[69] | -0.06[70] |
11 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 1.97[71] | 1.69[72] | 1.65[73] | 2.54[74] | 1.79[75] | 1.28[76] | |
12 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 1.44[77] | 1.43[78] | 0.83[79] | 2.07[80] | 2.11[81] | 1.03[82] | |
13 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 0.77[83] | 0.33[84] | 0.44[85] | 0.87[86] | 0.70[87] | 0.15[88] | |
14 | DUSP3 | Dual specificity protein phosphatase 3 | [89] | 1.94[90] | 1.24[91] | 1.81[92] | 0.65[93] | 0.59[94] | 2.54[95] |
15 | IKBKG | NF-kappa-B essential modulator | [96] | 0.28[97] | 0.33[98] | -1.89[99] | 0.48[100] | -0.80[101] | 0.53[102] |
16 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [103] | 2.58[104] | 1.88[105] | 0.89[106] | 2.13[107] | 2.42[108] | 0.45[109] |
17 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [110] | 1.86[111] | 2.23[112] | 1.08[113] | 1.65[114] | 1.47[115] | 0.42[116] |
18 | TNIP2 | TNFAIP3-interacting protein 2 | [117] | 0.48[118] | 0.45[119] | 0.19[120] | 0.67[121] | -0.04[122] | -0.32[123] |
19 | DUSP6 | Dual specificity protein phosphatase 6 | [124] | 0.68[125] | 2.66[126] | 1.97[127] | -2.58[128] | 1.14[129] | 1.39[130] |
20 | CUL1 | Cullin-1 | [131] | 0.78[132] | 1.36[133] | 0.94[134] | 1.91[135] | 1.49[136] | 1.88[137] |
21 | IL17RC | Interleukin-17 receptor C | [138] | -0.68[139] | -0.17[140] | -0.10[141] | 0.36[142] | -0.99[143] | 1.09[144] |
22 | MAPKAPK | MAP kinase-activated protein kinase 2 | [145] | 1.63[146] | 0.56[147] | 1.00[148] | 2.73[149] | 1.86[150] | 0.19[151] |
23 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | 1.62[152] | 0.99[153] | 1.44[154] | 1.60[155] | 1.31[156] | 4.07[157] | |
24 | IL17RB | Interleukin-17 receptor B | [158] | 1.34[159] | 2.61[160] | 0.35[161] | -3.93[162] | -3.54[163] | 1.05[164] |
25 | MAPK1 | Mitogen-activated protein kinase 1 | [165] | 2.88[166] | 2.91[167] | 2.77[168] | 3.18[169] | 2.76[170] | 2.91[171] |
26 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | [172] | [173] | [174] | [175] | [176] | [177] | [178] |
27 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [179] | 1.53[180] | 1.60[181] | 1.89[182] | 3.03[183] | 2.42[184] | 1.38[185] |
28 | VRK3 | Inactive serine/threonine-protein kinase VRK3 | [186] | 0.41[187] | 0.48[188] | 0.78[189] | 0.18[190] | -0.28[191] | 0.65[192] |
29 | MAPK14 | Mitogen-activated protein kinase 14 | [193] | 2.64[194] | 2.61[195] | 2.22[196] | 3.01[197] | 2.42[198] | 2.42[199] |
30 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [200] | 1.07[201] | 2.04[202] | 1.94[203] | 1.82[204] | 1.93[205] | 1.38[206] |
31 | IRAK2 | Interleukin-1 receptor-associated kinase-like 2 | [207] | 1.09[208] | 1.09[209] | 0.90[210] | -1.10[211] | 0.38[212] | 0.11[213] |
32 | MAPKAPK | MAP kinase-activated protein kinase 3 | [214] | 2.18[215] | 2.02[216] | 1.15[217] | -0.15[218] | 1.50[219] | 0.90[220] |
33 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 2.42[221] | 2.08[222] | 1.67[223] | 2.62[224] | 2.43[225] | 0.87[226] | |
34 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [227] | 1.81[228] | 2.75[229] | 3.01[230] | 2.11[231] | 1.81[232] | 2.16[233] |
35 | MAPK8 | Mitogen-activated protein kinase 8 | [234] | -0.28[235] | 1.03[236] | -0.07[237] | 0.43[238] | 0.21[239] | 0.62[240] |
36 | ELK1 | ETS domain-containing protein Elk-1 | [241] | 0.85[242] | -1.38[243] | 1.07[244] | 1.60[245] | 2.12[246] | 0.97[247] |
37 | TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | [248] | 1.22[249] | 3.07[250] | 3.19[251] | 1.68[252] | 2.81[253] | 1.96[254] |
38 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [255] | 1.84[256] | 1.41[257] | 1.23[258] | 1.08[259] | 1.92[260] | 1.59[261] |
39 | FBXW11 | F-box/WD repeat-containing protein 11 | [262] | 2.54[263] | 2.35[264] | 3.14[265] | 2.85[266] | 2.69[267] | 2.08[268] |
40 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [269] | 1.87[270] | 2.40[271] | 1.63[272] | 2.54[273] | 1.86[274] | 2.20[275] |
41 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [276] | [277] | [278] | [279] | [280] | [281] | [282] |
42 | ATF1 | Cyclic AMP-dependent transcription factor ATF-1 | [283] | 0.54[284] | 1.70[285] | 1.45[286] | 1.48[287] | 1.29[288] | 0.66[289] |
43 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | [290] | 0.59[291] | 1.09[292] | 1.13[293] | 1.13[294] | 1.03[295] | 0.00[296] |
44 | MAPK9 | Mitogen-activated protein kinase 9 | [297] | 2.39[298] | 2.52[299] | 2.61[300] | 3.04[301] | 2.43[302] | 1.65[303] |
45 | MAPK3 | Mitogen-activated protein kinase 3 | [304] | 3.02[305] | 2.96[306] | 3.03[307] | 1.75[308] | 1.70[309] | 0.10[310] |
46 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [311] | 2.07[312] | 3.19[313] | 3.18[314] | 1.98[315] | 2.72[316] | 2.65[317] |
47 | MEF2A | Myocyte-specific enhancer factor 2A | [318] | 1.14[319] | 1.82[320] | 2.53[321] | 2.50[322] | 2.51[323] | 3.29[324] |
48 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [325] | 2.13[326] | 2.18[327] | 2.78[328] | 1.61[329] | 2.09[330] | 0.38[331] |
49 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [332] | 1.81[333] | 2.36[334] | 2.47[335] | 1.34[336] | 1.61[337] | 1.36[338] |
50 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [339] | 1.69[340] | 1.65[341] | 1.78[342] | 1.59[343] | 1.61[344] | 2.32[345] |
51 | BTRC | F-box/WD repeat-containing protein 1A | [346] | 2.58[347] | 3.27[348] | 2.91[349] | 2.09[350] | 2.55[351] | 2.48[352] |
52 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [353] | 2.89[354] | 3.95[355] | 4.46[356] | 3.87[357] | 3.74[358] | 3.48[359] |
53 | IL17RE | Interleukin-17 receptor E | [360] | 2.12[361] | 3.24[362] | 0.40[363] | -1.20[364] | -4.72[365] | -1.74[366] |
54 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [367] | 2.91[368] | 2.82[369] | 2.03[370] | 1.43[371] | 2.68[372] | 1.62[373] |
55 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [374] | 1.46[375] | -1.86[376] | 3.03[377] | 2.34[378] | -1.77[379] | -0.48[380] |
56 | IL17RA | Interleukin-17 receptor A | [381] | 3.03[382] | 1.73[383] | 3.50[384] | 3.55[385] | 3.69[386] | 3.47[387] |
57 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | [388] | [389] | [390] | [391] | [392] | [393] | [394] |
58 | DUSP7 | Dual specificity protein phosphatase 7 | [395] | 2.72[396] | 1.71[397] | 2.98[398] | 0.90[399] | 3.22[400] | 1.16[401] |
59 | MAPK7 | Mitogen-activated protein kinase 7 | [402] | 2.60[403] | 1.80[404] | 1.83[405] | 3.13[406] | 3.16[407] | 1.47[408] |
60 | TRAF6 | TNF receptor-associated factor 6 | [409] | 2.26[410] | 2.04[411] | 2.64[412] | 2.99[413] | 2.37[414] | 4.04[415] |
61 | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2 | [416] | -0.74[417] | -2.81[418] | [419] | -2.28[420] | 1.20[421] | 0.61[422] |
62 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1 | [423] | 2.19[424] | 1.76[425] | 2.60[426] | 3.57[427] | 3.12[428] | 3.22[429] |
63 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | [430] | [431] | [432] | [433] | [434] | [435] | [436] |
64 | MAPK11 | Mitogen-activated protein kinase 11 | [437] | 1.00[438] | 0.79[439] | -0.07[440] | 1.69[441] | 3.61[442] | 1.30[443] |
65 | MEF2C | Myocyte-specific enhancer factor 2C | [444] | -1.94[445] | -0.91[446] | 4.08[447] | 6.94[448] | 2.85[449] | 6.42[450] |
66 | DUSP4 | Dual specificity protein phosphatase 4 | [451] | 6.67[452] | 3.56[453] | 9.49[454] | 9.06[455] | 6.93[456] | 4.97[457] |
67 | IL17A | Interleukin-17A | [458] | [459] | [460] | [461] | [462] | [463] | [464] |
68 | MAPK10 | Mitogen-activated protein kinase 10 | [465] | -0.32[466] | [467] | [468] | 10.24[469] | 5.90[470] | 8.38[471] |
69 | IL17C | Interleukin-17C | [472] | [473] | [474] | [475] | [476] | [477] | [478] |
70 | IL17F | Interleukin-17F | [479] | [480] | [481] | [482] | [483] | [484] | [485] |
71 | IL25 | Interleukin-25 | [486] | [487] | [488] | [489] | [490] | [491] | [492] |