REACTOME_INTERLEUKIN_12_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SOD2 | Superoxide dismutase [Mn], mitochondrial | [1] | -3.31[2] | -2.66[3] | -3.45[4] | -4.53[5] | -2.28[6] | -1.45[7] |
2 | RPLP0 | 60S acidic ribosomal protein P0 | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | SOD1 | Superoxide dismutase [Cu-Zn] | [15] | -1.79[16] | -1.81[17] | -2.77[18] | -2.23[19] | -2.25[20] | -0.14[21] |
4 | P4HB | Protein disulfide-isomerase | [22] | 1.65[23] | 1.46[24] | 0.82[25] | -0.10[26] | 0.16[27] | 1.92[28] |
5 | ANXA2 | Annexin A2 | [29] | -1.53[30] | -1.49[31] | -0.20[32] | 1.53[33] | 1.00[34] | -2.15[35] |
6 | MIF | Macrophage migration inhibitory factor | [36] | [37] | [38] | [39] | [40] | [41] | [42] |
7 | PPIA | Peptidyl-prolyl cis-trans isomerase A | [43] | 1.51[44] | 1.64[45] | 2.00[46] | 1.23[47] | 1.48[48] | 0.99[49] |
8 | CFL1 | Cofilin-1 | [50] | 1.35[51] | 0.32[52] | 0.34[53] | 1.00[54] | 1.20[55] | 0.43[56] |
9 | GSTA2 | Glutathione S-transferase A2 | [57] | -5.13[58] | -7.64[59] | -3.21[60] | -7.98[61] | -11.39[62] | -2.06[63] |
10 | HNRNPA2 | Heterogeneous nuclear ribonucleoproteins A2/B1 | [64] | 1.10[65] | 1.69[66] | 1.86[67] | 1.46[68] | 1.61[69] | 0.32[70] |
11 | ARF1 | ADP-ribosylation factor 1 | [71] | 0.42[72] | 0.61[73] | 1.04[74] | 0.86[75] | 0.67[76] | 0.68[77] |
12 | GSTO1 | Glutathione S-transferase omega-1 | [78] | -0.32[79] | 0.38[80] | -0.11[81] | -2.71[82] | -0.39[83] | 0.16[84] |
13 | TALDO1 | Transaldolase | [85] | 0.28[86] | -0.39[87] | 0.26[88] | 0.89[89] | -1.18[90] | -0.46[91] |
14 | PSME2 | Proteasome activator complex subunit 2 | [92] | 0.27[93] | -1.26[94] | -1.31[95] | -0.97[96] | -1.10[97] | -0.63[98] |
15 | CDC42 | Cell division control protein 42 homolog | [99] | 0.79[100] | 1.49[101] | 0.52[102] | 0.93[103] | 0.34[104] | -0.71[105] |
16 | HSPA9 | Stress-70 protein, mitochondrial | [106] | 1.49[107] | 1.38[108] | 1.41[109] | 0.48[110] | 1.09[111] | 1.79[112] |
17 | RAP1B | Ras-related protein Rap-1b | [113] | -0.69[114] | -0.08[115] | -0.27[116] | 0.94[117] | 0.83[118] | -0.52[119] |
18 | MSN | Moesin | [120] | -6.47[121] | -8.78[122] | -7.45[123] | 2.47[124] | 1.60[125] | 0.10[126] |
19 | HNRNPF | Heterogeneous nuclear ribonucleoprotein F | [127] | 1.64[128] | 2.00[129] | 1.77[130] | 1.09[131] | 1.11[132] | 1.00[133] |
20 | TCP1 | T-complex protein 1 subunit alpha | [134] | 2.09[135] | 2.20[136] | 2.21[137] | 1.22[138] | 1.99[139] | 0.43[140] |
21 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | [141] | -0.67[142] | -0.34[143] | 0.67[144] | -0.95[145] | -0.63[146] | -1.69[147] |
22 | CAPZA1 | F-actin-capping protein subunit alpha-1 | [148] | 1.11[149] | 1.63[150] | 1.99[151] | 2.09[152] | 2.08[153] | 1.31[154] |
23 | PDCD4 | Programmed cell death protein 4 | [155] | -0.52[156] | 0.90[157] | 1.50[158] | -0.35[159] | -0.18[160] | 0.25[161] |
24 | RALA | Ras-related protein Ral-A | [162] | 0.42[163] | 1.16[164] | 1.37[165] | 0.89[166] | 1.31[167] | -0.36[168] |
25 | CNN2 | Calponin-2 | [169] | 2.72[170] | 1.71[171] | 2.32[172] | 2.60[173] | 2.11[174] | 0.23[175] |
26 | AIP | AH receptor-interacting protein | [176] | 1.10[177] | 1.15[178] | 2.37[179] | 2.08[180] | 0.78[181] | -0.33[182] |
27 | BOLA2B | [183] | [184] | [185] | [186] | [187] | [188] | [189] | |
28 | BOLA2 | BolA-like protein 2 | [190] | [191] | [192] | [193] | [194] | [195] | [196] |
29 | JAK1 | Tyrosine-protein kinase JAK1 | [197] | 2.13[198] | 1.60[199] | 1.82[200] | 2.09[201] | 2.87[202] | 2.90[203] |
30 | LCP1 | Plastin-2 | [204] | -2.71[205] | -2.49[206] | -0.05[207] | -2.45[208] | -0.13[209] | 1.83[210] |
31 | PAK2 | Serine/threonine-protein kinase PAK 2 | [211] | 3.06[212] | 2.80[213] | 3.13[214] | 2.22[215] | 2.90[216] | 2.74[217] |
32 | VAMP7 | Vesicle-associated membrane protein 7 | [218] | [219] | [220] | [221] | [222] | [223] | [224] |
33 | LMNB1 | Lamin-B1 | [225] | 2.60[226] | 2.62[227] | 2.71[228] | 2.77[229] | 2.56[230] | -0.83[231] |
34 | PITPNA | Phosphatidylinositol transfer protein alpha isoform | [232] | 2.38[233] | 2.06[234] | 2.65[235] | 2.62[236] | 2.89[237] | 1.41[238] |
35 | MTAP | S-methyl-5'-thioadenosine phosphorylase | [239] | 2.38[240] | 2.04[241] | 2.27[242] | 2.11[243] | 2.59[244] | 1.92[245] |
36 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [246] | 2.75[247] | 3.10[248] | 3.26[249] | 2.21[250] | 3.27[251] | 3.36[252] |
37 | SERPINB2 | Plasminogen activator inhibitor 2 | [253] | -1.45[254] | -5.15[255] | -4.59[256] | 1.24[257] | 6.00[258] | -7.19[259] |
38 | STAT4 | Signal transducer and activator of transcription 4 | [260] | -3.22[261] | -2.17[262] | -1.61[263] | 3.10[264] | 2.04[265] | 2.40[266] |
39 | JAK2 | Tyrosine-protein kinase JAK2 | [267] | 1.84[268] | 1.82[269] | 1.42[270] | 2.23[271] | 2.96[272] | 4.08[273] |
40 | IL12RB1 | Interleukin-12 receptor subunit beta-1 | [274] | -0.51[275] | -0.34[276] | -0.83[277] | -1.13[278] | -1.89[279] | 0.54[280] |
41 | CA1 | Carbonic anhydrase 1 | [281] | -7.14[282] | -4.54[283] | [284] | -7.20[285] | [286] | -0.05[287] |
42 | IL10 | Interleukin-10 | [288] | -0.25[289] | -0.52[290] | -0.31[291] | -0.52[292] | -0.85[293] | -0.22[294] |
43 | IFNG | Interferon gamma | [295] | [296] | [297] | [298] | 0.77[299] | [300] | -0.92[301] |
44 | IL12A | Interleukin-12 subunit alpha | [302] | 0.21[303] | [304] | 1.72[305] | -0.08[306] | 1.85[307] | -1.80[308] |
45 | IL12RB2 | Interleukin-12 receptor subunit beta-2 | [309] | 4.48[310] | 5.07[311] | 7.13[312] | 6.86[313] | 5.06[314] | 9.34[315] |
46 | IL12B | Interleukin-12 subunit beta | [316] | [317] | [318] | [319] | [320] | [321] | [322] |
47 | HNRNPDL | Heterogeneous nuclear ribonucleoprotein D-like | [323] | [324] | [325] | [326] | [327] | [328] | [329] |