REACTOME_INTERLEUKIN_12_FAMILY_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SOD2 | Superoxide dismutase [Mn], mitochondrial | [1] | -3.52[2] | -2.86[3] | -3.65[4] | -4.74[5] | -2.48[6] | -1.84[7] |
2 | RPLP0 | 60S acidic ribosomal protein P0 | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | SOD1 | Superoxide dismutase [Cu-Zn] | [15] | -1.99[16] | -2.01[17] | -2.97[18] | -2.44[19] | -2.45[20] | -0.53[21] |
4 | P4HB | Protein disulfide-isomerase | [22] | 1.45[23] | 1.26[24] | 0.62[25] | -0.31[26] | -0.05[27] | 1.53[28] |
5 | ANXA2 | Annexin A2 | [29] | -1.73[30] | -1.69[31] | -0.40[32] | 1.32[33] | 0.80[34] | -2.53[35] |
6 | MIF | Macrophage migration inhibitory factor | [36] | [37] | [38] | [39] | [40] | [41] | [42] |
7 | PPIA | Peptidyl-prolyl cis-trans isomerase A | [43] | 1.31[44] | 1.44[45] | 1.80[46] | 1.02[47] | 1.28[48] | 0.61[49] |
8 | CFL1 | Cofilin-1 | [50] | 1.15[51] | 0.12[52] | 0.13[53] | 0.78[54] | 1.00[55] | 0.05[56] |
9 | GSTA2 | Glutathione S-transferase A2 | [57] | -5.33[58] | -7.84[59] | -3.41[60] | -8.19[61] | -11.59[62] | -2.44[63] |
10 | HNRNPA2 | Heterogeneous nuclear ribonucleoproteins A2/B1 | [64] | 0.90[65] | 1.49[66] | 1.65[67] | 1.25[68] | 1.41[69] | -0.06[70] |
11 | ARF1 | ADP-ribosylation factor 1 | [71] | 0.22[72] | 0.41[73] | 0.84[74] | 0.65[75] | 0.47[76] | 0.30[77] |
12 | GSTO1 | Glutathione S-transferase omega-1 | [78] | -0.52[79] | 0.17[80] | -0.32[81] | -2.92[82] | -0.59[83] | -0.22[84] |
13 | CANX | Calnexin | [85] | 1.66[86] | 2.11[87] | 2.47[88] | 1.88[89] | 1.92[90] | 2.38[91] |
14 | TALDO1 | Transaldolase | [92] | 0.08[93] | -0.59[94] | 0.06[95] | 0.68[96] | -1.38[97] | -0.84[98] |
15 | PSME2 | Proteasome activator complex subunit 2 | [99] | 0.07[100] | -1.46[101] | -1.51[102] | -1.18[103] | -1.31[104] | -1.01[105] |
16 | CDC42 | Cell division control protein 42 homolog | [106] | 0.59[107] | 1.29[108] | 0.32[109] | 0.72[110] | 0.14[111] | -1.09[112] |
17 | HSPA9 | Stress-70 protein, mitochondrial | [113] | 1.29[114] | 1.18[115] | 1.21[116] | 0.27[117] | 0.89[118] | 1.41[119] |
18 | RAP1B | Ras-related protein Rap-1b | [120] | -0.89[121] | -0.29[122] | -0.48[123] | 0.73[124] | 0.63[125] | -0.90[126] |
19 | MSN | Moesin | [127] | -6.67[128] | -8.99[129] | -7.65[130] | 2.25[131] | 1.40[132] | -0.29[133] |
20 | HNRNPF | Heterogeneous nuclear ribonucleoprotein F | [134] | 1.44[135] | 1.80[136] | 1.57[137] | 0.87[138] | 0.91[139] | 0.62[140] |
21 | TCP1 | T-complex protein 1 subunit alpha | [141] | 1.88[142] | 2.00[143] | 2.00[144] | 1.01[145] | 1.79[146] | 0.05[147] |
22 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | [148] | -0.88[149] | -0.54[150] | 0.46[151] | -1.16[152] | -0.83[153] | -2.07[154] |
23 | CAPZA1 | F-actin-capping protein subunit alpha-1 | [155] | 0.91[156] | 1.43[157] | 1.78[158] | 1.88[159] | 1.88[160] | 0.93[161] |
24 | STAT3 | Signal transducer and activator of transcription 3 | [162] | 1.96[163] | 0.45[164] | 1.22[165] | 1.49[166] | 0.91[167] | 3.40[168] |
25 | PDCD4 | Programmed cell death protein 4 | [169] | -0.72[170] | 0.70[171] | 1.29[172] | -0.56[173] | -0.38[174] | -0.14[175] |
26 | RALA | Ras-related protein Ral-A | [176] | 0.22[177] | 0.95[178] | 1.16[179] | 0.68[180] | 1.11[181] | -0.74[182] |
27 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [183] | 1.34[184] | 0.41[185] | 1.55[186] | 3.78[187] | 1.66[188] | 1.94[189] |
28 | CNN2 | Calponin-2 | [190] | 2.52[191] | 1.51[192] | 2.12[193] | 2.39[194] | 1.91[195] | -0.16[196] |
29 | AIP | AH receptor-interacting protein | [197] | 0.89[198] | 0.95[199] | 2.17[200] | 1.86[201] | 0.58[202] | -0.71[203] |
30 | BOLA2 | BolA-like protein 2 | [204] | [205] | [206] | [207] | [208] | [209] | [210] |
31 | BOLA2B | [211] | [212] | [213] | [214] | [215] | [216] | [217] | |
32 | IL6ST | Interleukin-6 receptor subunit beta | [218] | 1.67[219] | 2.91[220] | 2.46[221] | 2.98[222] | 4.29[223] | 4.77[224] |
33 | JAK1 | Tyrosine-protein kinase JAK1 | [225] | 1.93[226] | 1.40[227] | 1.61[228] | 1.88[229] | 2.67[230] | 2.52[231] |
34 | LCP1 | Plastin-2 | [232] | -2.92[233] | -2.69[234] | -0.25[235] | -2.66[236] | -0.33[237] | 1.45[238] |
35 | PAK2 | Serine/threonine-protein kinase PAK 2 | [239] | 2.86[240] | 2.59[241] | 2.92[242] | 2.01[243] | 2.70[244] | 2.35[245] |
36 | VAMP7 | Vesicle-associated membrane protein 7 | [246] | [247] | [248] | [249] | [250] | [251] | [252] |
37 | LMNB1 | Lamin-B1 | [253] | 2.39[254] | 2.42[255] | 2.50[256] | 2.56[257] | 2.36[258] | -1.21[259] |
38 | PITPNA | Phosphatidylinositol transfer protein alpha isoform | [260] | 2.18[261] | 1.86[262] | 2.45[263] | 2.41[264] | 2.69[265] | 1.03[266] |
39 | MTAP | S-methyl-5'-thioadenosine phosphorylase | [267] | 2.18[268] | 1.84[269] | 2.07[270] | 1.90[271] | 2.39[272] | 1.54[273] |
40 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [274] | 2.55[275] | 2.90[276] | 3.06[277] | 2.00[278] | 3.07[279] | 2.98[280] |
41 | IL27 | Interleukin-27 subunit alpha | [281] | -4.43[282] | -2.80[283] | 0.12[284] | [285] | -9.02[286] | -0.70[287] |
42 | EBI3 | Interleukin-27 subunit beta | [288] | 0.58[289] | 1.28[290] | -1.51[291] | 0.93[292] | -2.99[293] | -0.06[294] |
43 | IL23A | Interleukin-23 subunit alpha | [295] | -0.73[296] | -0.63[297] | -2.35[298] | -3.68[299] | -2.47[300] | -2.80[301] |
44 | CRLF1 | Cytokine receptor-like factor 1 | [302] | 8.18[303] | 7.40[304] | 1.01[305] | -1.73[306] | -1.53[307] | -2.93[308] |
45 | SERPINB2 | Plasminogen activator inhibitor 2 | [309] | -1.65[310] | -5.35[311] | -4.79[312] | 1.02[313] | 5.80[314] | -7.58[315] |
46 | STAT4 | Signal transducer and activator of transcription 4 | [316] | -3.43[317] | -2.37[318] | -1.81[319] | 2.89[320] | 1.84[321] | 2.02[322] |
47 | JAK2 | Tyrosine-protein kinase JAK2 | [323] | 1.64[324] | 1.62[325] | 1.21[326] | 2.02[327] | 2.76[328] | 3.70[329] |
48 | IL12RB1 | Interleukin-12 receptor subunit beta-1 | [330] | -0.71[331] | -0.54[332] | -1.03[333] | -1.35[334] | -2.09[335] | 0.15[336] |
49 | IL27RA | Interleukin-27 receptor subunit alpha | [337] | 3.27[338] | 3.70[339] | 4.00[340] | 0.93[341] | 2.58[342] | 1.43[343] |
50 | CA1 | Carbonic anhydrase 1 | [344] | -7.34[345] | -4.74[346] | [347] | -7.41[348] | [349] | -0.43[350] |
51 | IL10 | Interleukin-10 | [351] | -0.46[352] | -0.72[353] | -0.51[354] | -0.73[355] | -1.05[356] | -0.60[357] |
52 | IFNG | Interferon gamma | [358] | [359] | [360] | [361] | 0.56[362] | [363] | -1.31[364] |
53 | IL12A | Interleukin-12 subunit alpha | [365] | 0.01[366] | [367] | 1.52[368] | -0.29[369] | 1.65[370] | -2.18[371] |
54 | IL23R | Interleukin-23 receptor | [372] | -0.65[373] | 0.52[374] | 2.44[375] | -1.68[376] | -1.78[377] | -0.53[378] |
55 | IL12RB2 | Interleukin-12 receptor subunit beta-2 | [379] | 4.28[380] | 4.87[381] | 6.93[382] | 6.65[383] | 4.86[384] | 8.95[385] |
56 | HNRNPDL | Heterogeneous nuclear ribonucleoprotein D-like | [386] | [387] | [388] | [389] | [390] | [391] | [392] |
57 | IL12B | Interleukin-12 subunit beta | [393] | [394] | [395] | [396] | [397] | [398] | [399] |