REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | IFITM3 | Interferon-induced transmembrane protein 3 | [1] | -3.12[2] | -3.91[3] | -3.76[4] | -3.31[5] | -4.56[6] | -0.93[7] |
2 | IFITM2 | Interferon-induced transmembrane protein 2 | [8] | -2.97[9] | -2.47[10] | -6.19[11] | -4.46[12] | -4.38[13] | -0.39[14] |
3 | HLA-A | HLA class I histocompatibility antigen, A-68 alpha chain | [15] | 0.85[16] | 1.22[17] | -4.40[18] | 0.67[19] | 0.29[20] | -1.27[21] |
4 | HLA-C | HLA class I histocompatibility antigen, Cw-17 alpha chain | [22] | 0.00[23] | -0.55[24] | -4.05[25] | -0.11[26] | 0.58[27] | -0.88[28] |
5 | HLA-B | HLA class I histocompatibility antigen, B-73 alpha chain | [29] | -0.97[30] | -2.18[31] | -6.16[32] | 1.33[33] | 0.96[34] | -0.53[35] |
6 | HLA-E | HLA class I histocompatibility antigen, alpha chain E | [36] | 0.20[37] | 0.17[38] | 0.10[39] | 0.82[40] | 0.09[41] | 0.99[42] |
7 | BST2 | Bone marrow stromal antigen 2 | [43] | -0.07[44] | -0.33[45] | -6.57[46] | -3.19[47] | -1.16[48] | -0.77[49] |
8 | PSMB8 | Proteasome subunit beta type-8 | [50] | -0.60[51] | -1.17[52] | -8.00[53] | 0.23[54] | -0.41[55] | -1.28[56] |
9 | IFI6 | Interferon alpha-inducible protein 6 | [57] | -0.46[58] | -4.15[59] | -2.62[60] | -1.22[61] | -1.66[62] | 1.03[63] |
10 | ISG15 | Ubiquitin-like protein ISG15 | [64] | -0.13[65] | 0.24[66] | -0.51[67] | -2.38[68] | -2.87[69] | -1.59[70] |
11 | IFITM1 | Interferon-induced transmembrane protein 1 | [71] | -3.55[72] | -1.23[73] | -5.75[74] | -4.45[75] | -2.66[76] | -0.26[77] |
12 | ISG20 | Interferon-stimulated gene 20 kDa protein | [78] | -1.63[79] | -0.49[80] | -2.64[81] | -6.08[82] | -4.18[83] | -2.67[84] |
13 | GBP2 | Guanylate-binding protein 2 | [85] | -1.44[86] | -2.92[87] | -1.68[88] | 0.05[89] | -1.71[90] | -0.81[91] |
14 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [92] | 2.47[93] | 3.02[94] | 3.34[95] | 1.81[96] | 3.09[97] | 2.07[98] |
15 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [99] | 1.95[100] | 1.16[101] | 2.62[102] | 3.45[103] | 1.83[104] | 1.76[105] |
16 | ABCE1 | ATP-binding cassette sub-family E member 1 | [106] | 1.81[107] | 2.81[108] | 2.98[109] | 0.79[110] | 2.58[111] | 0.64[112] |
17 | JAK1 | Tyrosine-protein kinase JAK1 | [113] | 2.54[114] | 2.15[115] | 2.69[116] | 1.55[117] | 2.84[118] | 2.34[119] |
18 | IFI35 | Interferon-induced 35 kDa protein | [120] | 0.50[121] | 0.85[122] | 0.80[123] | -0.04[124] | -0.27[125] | -0.33[126] |
19 | ADAR | Double-stranded RNA-specific adenosine deaminase | [127] | 3.78[128] | 3.46[129] | 5.32[130] | 3.70[131] | 3.65[132] | 3.08[133] |
20 | IRF9 | Interferon regulatory factor 9 | [134] | 1.21[135] | -0.49[136] | 0.14[137] | 0.55[138] | 0.16[139] | 0.71[140] |
21 | IFNAR2 | Interferon alpha/beta receptor 2 | [141] | 0.82[142] | 0.59[143] | 1.64[144] | -0.47[145] | 0.17[146] | 0.03[147] |
22 | EGR1 | Early growth response protein 1 | [148] | 0.22[149] | 0.83[150] | -0.93[151] | -1.41[152] | 0.89[153] | 1.95[154] |
23 | MX1 | Interferon-induced GTP-binding protein Mx1 | [155] | -0.51[156] | -3.14[157] | -4.82[158] | -2.06[159] | -0.81[160] | 0.63[161] |
24 | IRF7 | Interferon regulatory factor 7 | [162] | -7.21[163] | -6.09[164] | -4.62[165] | -2.23[166] | -1.84[167] | 0.74[168] |
25 | OAS1 | 2'-5'-oligoadenylate synthase 1 | [169] | 1.40[170] | -1.36[171] | -6.81[172] | -1.83[173] | -2.64[174] | 0.38[175] |
26 | SOCS3 | Suppressor of cytokine signaling 3 | [176] | -2.11[177] | -2.40[178] | -0.32[179] | 0.12[180] | -0.31[181] | 0.94[182] |
27 | IP6K2 | Inositol hexakisphosphate kinase 2 | [183] | 2.47[184] | 3.11[185] | 3.93[186] | 0.50[187] | 1.84[188] | 0.65[189] |
28 | IRF3 | Interferon regulatory factor 3 | [190] | 2.32[191] | 2.62[192] | 3.70[193] | 1.28[194] | 1.51[195] | -0.37[196] |
29 | IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 | [197] | -1.84[198] | -3.88[199] | -1.01[200] | -0.22[201] | 0.26[202] | 0.31[203] |
30 | IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | [204] | -1.39[205] | -3.15[206] | 0.42[207] | -0.97[208] | -1.09[209] | 0.18[210] |
31 | IRF2 | Interferon regulatory factor 2 | [211] | 0.93[212] | 1.45[213] | 0.64[214] | -0.17[215] | 0.53[216] | 0.47[217] |
32 | PTPN1 | Tyrosine-protein phosphatase non-receptor type 1 | [218] | 3.14[219] | 2.93[220] | 2.82[221] | 2.75[222] | 2.69[223] | 0.50[224] |
33 | IFNAR1 | Interferon alpha/beta receptor 1 | [225] | 2.09[226] | 2.68[227] | 2.75[228] | 1.91[229] | 2.54[230] | 3.24[231] |
34 | IFI27 | Interferon alpha-inducible protein 27, mitochondrial | [232] | 0.36[233] | -2.71[234] | -4.01[235] | 0.02[236] | -4.98[237] | 1.21[238] |
35 | HLA-F | HLA class I histocompatibility antigen, alpha chain F | [239] | -0.42[240] | -1.76[241] | -5.53[242] | 2.21[243] | 0.97[244] | 0.83[245] |
36 | IRF1 | Interferon regulatory factor 1 | [246] | 1.52[247] | 1.17[248] | 1.67[249] | 2.18[250] | 1.82[251] | 1.64[252] |
37 | STAT2 | Signal transducer and activator of transcription 2 | [253] | 2.05[254] | 3.54[255] | 3.06[256] | 2.45[257] | 2.55[258] | 3.83[259] |
38 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [260] | 1.56[261] | 1.88[262] | 2.81[263] | -6.22[264] | -0.56[265] | 0.63[266] |
39 | XAF1 | XIAP-associated factor 1 | [267] | -1.84[268] | -1.45[269] | -4.39[270] | -0.70[271] | -0.39[272] | 2.63[273] |
40 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [274] | 3.16[275] | 3.64[276] | 4.14[277] | 1.67[278] | 3.24[279] | 2.80[280] |
41 | IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 | [281] | -3.48[282] | -4.21[283] | 0.08[284] | -0.52[285] | -0.10[286] | 1.07[287] |
42 | IRF6 | Interferon regulatory factor 6 | [288] | -4.00[289] | -4.24[290] | -4.80[291] | -2.52[292] | -1.73[293] | 2.53[294] |
43 | HLA-G | HLA class I histocompatibility antigen, alpha chain G | [295] | -0.99[296] | -1.88[297] | -6.21[298] | -0.40[299] | -5.88[300] | -2.99[301] |
44 | USP18 | Ubl carboxyl-terminal hydrolase 18 | [302] | 1.96[303] | 2.55[304] | 2.55[305] | 0.43[306] | -1.38[307] | 0.83[308] |
45 | OASL | 2'-5'-oligoadenylate synthase-like protein | [309] | -2.21[310] | -3.46[311] | -4.95[312] | -4.04[313] | -1.13[314] | 0.26[315] |
46 | SAMHD1 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | [316] | 3.51[317] | 2.95[318] | 2.08[319] | 2.53[320] | 2.71[321] | 2.69[322] |
47 | IRF8 | Interferon regulatory factor 8 | [323] | -4.80[324] | -3.60[325] | 5.39[326] | -3.51[327] | 0.21[328] | 1.49[329] |
48 | IFIT5 | Interferon-induced protein with tetratricopeptide repeats 5 | [330] | 1.30[331] | -0.75[332] | 1.37[333] | 0.74[334] | 2.14[335] | 2.58[336] |
49 | OAS3 | 2'-5'-oligoadenylate synthase 3 | [337] | 4.29[338] | 1.93[339] | -3.98[340] | 2.05[341] | 3.44[342] | 2.13[343] |
50 | OAS2 | 2'-5'-oligoadenylate synthase 2 | [344] | -0.12[345] | -4.12[346] | -8.00[347] | -0.19[348] | 0.04[349] | 1.99[350] |
51 | SOCS1 | Suppressor of cytokine signaling 1 | [351] | 0.58[352] | 1.57[353] | 2.20[354] | -0.87[355] | -1.61[356] | -0.66[357] |
52 | MX2 | Interferon-induced GTP-binding protein Mx2 | [358] | 4.80[359] | 4.84[360] | 6.20[361] | 1.22[362] | 0.59[363] | 0.32[364] |
53 | IRF5 | Interferon regulatory factor 5 | [365] | 2.32[366] | 2.23[367] | 1.42[368] | 1.28[369] | -0.35[370] | 1.79[371] |
54 | RSAD2 | Radical S-adenosyl methionine domain-containing protein 2 | [372] | -0.83[373] | -2.29[374] | -1.80[375] | -3.63[376] | -1.94[377] | 2.00[378] |
55 | RNASEL | 2-5A-dependent ribonuclease | [379] | -0.63[380] | -2.63[381] | -6.61[382] | 3.16[383] | 3.42[384] | 2.44[385] |
56 | IRF4 | Interferon regulatory factor 4 | [386] | -2.80[387] | -2.34[388] | -2.61[389] | -3.38[390] | -3.85[391] | 1.42[392] |
57 | IFNA16 | Interferon alpha-16 | [393] | [394] | [395] | [396] | [397] | [398] | [399] |
58 | IFNB1 | Interferon beta | [400] | [401] | [402] | [403] | [404] | [405] | [406] |
59 | IFNA4 | Interferon alpha-4 | [407] | [408] | [409] | [410] | [411] | [412] | [413] |
60 | IFNA21 | Interferon alpha-21 | [414] | [415] | [416] | [417] | [418] | [419] | [420] |
61 | IFNA17 | Interferon alpha-17 | [421] | [422] | [423] | [424] | [425] | [426] | [427] |
62 | IFNA13 | [428] | [429] | [430] | [431] | [432] | [433] | [434] | |
63 | IFNA5 | Interferon alpha-5 | [435] | [436] | [437] | [438] | [439] | [440] | [441] |
64 | IFNA14 | Interferon alpha-14 | [442] | [443] | [444] | [445] | [446] | [447] | [448] |
65 | IFNA8 | Interferon alpha-8 | [449] | [450] | [451] | [452] | [453] | [454] | [455] |
66 | IFNA7 | Interferon alpha-7 | [456] | [457] | [458] | [459] | [460] | [461] | [462] |
67 | IFNA2 | Interferon alpha-2 | [463] | [464] | [465] | [466] | [467] | [468] | [469] |
68 | IFNA10 | Interferon alpha-10 | [470] | [471] | [472] | [473] | [474] | [475] | [476] |
69 | IFNA6 | Interferon alpha-6 | [477] | [478] | [479] | [480] | [481] | [482] | [483] |
70 | HLA-H | Putative HLA class I histocompatibility antigen, alpha chain H | [484] | [485] | [486] | [487] | [488] | [489] | [490] |
71 | IFNA1 | Interferon alpha-1/13 | [491] | [492] | [493] | [494] | [495] | [496] | [497] |