REACTOME_INTEGRATION_OF_ENERGY_METABOLISM |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
TALDO1 |
Transaldolase |
[1] |
-1.80[2] |
-2.51[3] |
-1.97[4] |
-1.04[5] |
-2.97[6] |
-2.22[7] |
2 |
GNAS |
Guanine nucleotide-binding protein
G(s) subunit alpha isoforms XLas |
-0.04[8] |
-0.05[9] |
-0.48[10] |
0.38[11] |
-0.11[12] |
-1.72[13] |
3 |
TKT |
Transketolase |
[14] |
-0.42[15] |
-0.20[16] |
-0.45[17] |
0.46[18] |
-0.58[19] |
-2.53[20] |
4 |
GNG5 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-5 |
-1.67[21] |
-1.55[22] |
-2.49[23] |
-2.28[24] |
-2.26[25] |
-1.97[26] |
5 |
PRKAR1A |
cAMP-dependent protein kinase type I-alpha regulatory subunit |
[27] |
-0.39[28] |
-0.32[29] |
-0.25[30] |
-0.56[31] |
-0.39[32] |
0.21[33] |
6 |
SLC2A2 |
Solute carrier family 2, facilitated glucose transporter member 2 |
[34] |
-3.67[35] |
-2.95[36] |
-2.37[37] |
-7.25[38] |
-11.33[39] |
1.46[40] |
7 |
GNB1 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
[41] |
0.54[42] |
0.51[43] |
-0.05[44] |
0.81[45] |
0.89[46] |
-1.62[47] |
8 |
GNB2 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 |
[48] |
-1.07[49] |
-1.37[50] |
-1.11[51] |
-0.84[52] |
-0.50[53] |
-1.99[54] |
9 |
GNG10 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-10 |
-5.17[55] |
-4.93[56] |
-5.31[57] |
-4.28[58] |
-3.18[59] |
-4.73[60] |
10 |
GNAI2 |
Guanine nucleotide-binding protein G(i) subunit alpha-2 |
[61] |
-0.40[62] |
-1.51[63] |
-1.43[64] |
-0.64[65] |
0.71[66] |
-0.58[67] |
11 |
ACLY |
ATP-citrate synthase |
[68] |
0.71[69] |
0.32[70] |
1.17[71] |
0.59[72] |
0.63[73] |
-0.74[74] |
12 |
ADIPOR1 |
Adiponectin receptor protein 1 |
[75] |
-0.84[76] |
-0.90[77] |
-0.54[78] |
-0.29[79] |
-0.11[80] |
-0.13[81] |
13 |
PPP2R1A |
Serine/threonine-protein phosphatase
2A 65 kDa regulatory subunit A alpha isoform |
0.33[82] |
0.10[83] |
-0.04[84] |
0.74[85] |
0.34[86] |
-0.24[87] |
14 |
PPP2CA |
Serine/threonine-protein phosphatase
2A catalytic subunit alpha isoform |
-0.20[88] |
-0.15[89] |
-0.86[90] |
0.27[91] |
0.66[92] |
-0.49[93] |
15 |
PPP2CB |
Serine/threonine-protein phosphatase
2A catalytic subunit beta isoform |
-0.86[94] |
-1.25[95] |
-1.25[96] |
-0.93[97] |
-0.75[98] |
-1.37[99] |
16 |
MLXIPL |
Carbohydrate-responsive element-binding protein |
[100] |
-2.33[101] |
0.01[102] |
-2.03[103] |
-8.43[104] |
-6.41[105] |
1.15[106] |
17 |
AHCYL1 |
S-adenosylhomocysteine hydrolase-like protein 1 |
[107] |
-0.23[108] |
-0.19[109] |
0.31[110] |
0.54[111] |
0.69[112] |
-0.08[113] |
18 |
MARCKS |
Myristoylated alanine-rich C-kinase substrate |
[114] |
-0.09[115] |
0.65[116] |
1.02[117] |
1.27[118] |
0.26[119] |
-1.84[120] |
19 |
ACSL3 |
Long-chain-fatty-acid--CoA ligase 3 |
[121] |
-0.37[122] |
1.72[123] |
0.83[124] |
-0.26[125] |
-0.49[126] |
0.34[127] |
20 |
ADIPOR2 |
Adiponectin receptor protein 2 |
[128] |
-0.01[129] |
0.27[130] |
0.48[131] |
-0.87[132] |
-0.11[133] |
0.17[134] |
21 |
RAP1A |
Ras-related protein Rap-1A |
[135] |
-1.52[136] |
-1.63[137] |
-0.87[138] |
-0.69[139] |
-0.64[140] |
-1.67[141] |
22 |
FASN |
Fatty acid synthase |
[142] |
1.93[143] |
2.52[144] |
3.01[145] |
0.26[146] |
0.57[147] |
2.12[148] |
23 |
MLX |
Max-like protein X |
[149] |
-0.81[150] |
-0.05[151] |
-0.67[152] |
-1.26[153] |
-1.39[154] |
-0.91[155] |
24 |
GNG12 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-12 |
-5.22[156] |
-8.20[157] |
-0.33[158] |
1.41[159] |
1.79[160] |
0.10[161] |
25 |
PRKACA |
cAMP-dependent protein kinase catalytic subunit alpha |
[162] |
-0.63[163] |
-0.86[164] |
-0.94[165] |
-0.94[166] |
-0.07[167] |
-1.16[168] |
26 |
AGPAT1 |
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha |
[169] |
0.39[170] |
0.40[171] |
-0.33[172] |
0.09[173] |
0.24[174] |
-1.09[175] |
27 |
PRKAG2 |
5'-AMP-activated protein kinase subunit gamma-2 |
[176] |
-4.53[177] |
-9.68[178] |
-3.32[179] |
-2.21[180] |
-1.79[181] |
-0.86[182] |
28 |
STK11 |
Serine/threonine-protein kinase STK11 |
[183] |
-0.56[184] |
-0.66[185] |
-0.49[186] |
-1.18[187] |
-0.55[188] |
-1.25[189] |
29 |
PPP2R1B |
Serine/threonine-protein phosphatase
2A 65 kDa regulatory subunit A beta isoform |
-0.02[190] |
-0.59[191] |
-0.25[192] |
-0.20[193] |
-0.14[194] |
2.55[195] |
30 |
GNA11 |
Guanine nucleotide-binding protein subunit alpha-11 |
[196] |
-1.14[197] |
-1.27[198] |
-1.39[199] |
-1.66[200] |
-0.58[201] |
-1.64[202] |
31 |
ACSL4 |
Long-chain-fatty-acid--CoA ligase 4 |
[203] |
2.25[204] |
3.93[205] |
4.15[206] |
1.08[207] |
2.19[208] |
0.58[209] |
32 |
PRKAB2 |
5'-AMP-activated protein kinase subunit beta-2 |
[210] |
0.42[211] |
1.55[212] |
1.59[213] |
0.56[214] |
-0.19[215] |
1.02[216] |
33 |
PPP2R5D |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit delta isoform |
0.78[217] |
0.49[218] |
-0.03[219] |
0.82[220] |
0.98[221] |
-0.65[222] |
34 |
PKLR |
Pyruvate kinase PKLR |
[223] |
-2.34[224] |
-0.51[225] |
-2.31[226] |
-10.65[227] |
-10.27[228] |
0.57[229] |
35 |
VAMP2 |
Vesicle-associated membrane protein 2 |
[230] |
-1.82[231] |
-1.50[232] |
-1.23[233] |
-0.94[234] |
-0.85[235] |
-0.58[236] |
36 |
PRKAR2A |
cAMP-dependent protein kinase type II-alpha regulatory subunit |
[237] |
-0.42[238] |
-0.78[239] |
0.25[240] |
-0.76[241] |
-0.62[242] |
-0.24[243] |
37 |
GNAI1 |
Guanine nucleotide-binding protein G(i) subunit alpha-1 |
[244] |
-2.12[245] |
-3.11[246] |
-1.05[247] |
0.74[248] |
0.40[249] |
0.45[250] |
38 |
PRKAR1B |
cAMP-dependent protein kinase type I-beta regulatory subunit |
[251] |
0.51[252] |
-0.09[253] |
-1.96[254] |
-4.57[255] |
-1.49[256] |
-0.56[257] |
39 |
ITPR2 |
Inositol 1,4,5-trisphosphate receptor type 2 |
[258] |
0.44[259] |
1.85[260] |
0.23[261] |
-0.47[262] |
-0.05[263] |
3.49[264] |
40 |
ACACB |
Acetyl-CoA carboxylase 2 |
[265] |
-1.34[266] |
-0.42[267] |
-0.37[268] |
-2.24[269] |
-1.67[270] |
3.80[271] |
41 |
GNB5 |
Guanine nucleotide-binding protein subunit beta-5 |
[272] |
-0.37[273] |
-0.38[274] |
0.56[275] |
0.32[276] |
0.72[277] |
0.50[278] |
42 |
IQGAP1 |
Ras GTPase-activating-like protein IQGAP1 |
[279] |
1.39[280] |
0.88[281] |
1.22[282] |
3.50[283] |
3.62[284] |
1.64[285] |
43 |
PFKFB1 |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 |
[286] |
-3.26[287] |
-2.56[288] |
-7.75[289] |
-7.74[290] |
-8.05[291] |
-0.01[292] |
44 |
ACACA |
Acetyl-CoA carboxylase 1 |
[293] |
1.98[294] |
2.27[295] |
3.11[296] |
2.11[297] |
1.58[298] |
2.97[299] |
45 |
PRKACB |
cAMP-dependent protein kinase catalytic subunit beta |
[300] |
-1.30[301] |
-0.58[302] |
0.63[303] |
1.76[304] |
0.90[305] |
1.33[306] |
46 |
ADCY9 |
Adenylate cyclase type 9 |
[307] |
2.15[308] |
1.29[309] |
1.64[310] |
0.49[311] |
0.31[312] |
2.03[313] |
47 |
PRKCA |
Protein kinase C alpha type |
[314] |
2.37[315] |
2.36[316] |
2.64[317] |
1.68[318] |
2.32[319] |
1.53[320] |
48 |
SLC2A1 |
Solute carrier family 2, facilitated glucose transporter member 1 |
[321] |
6.18[322] |
3.14[323] |
2.13[324] |
2.98[325] |
2.39[326] |
-1.73[327] |
49 |
ITPR3 |
Inositol 1,4,5-trisphosphate receptor type 3 |
[328] |
4.82[329] |
3.62[330] |
2.03[331] |
1.88[332] |
4.33[333] |
-0.16[334] |
50 |
GNAQ |
Guanine nucleotide-binding protein G(q) subunit alpha |
[335] |
-0.40[336] |
0.33[337] |
0.77[338] |
1.12[339] |
1.62[340] |
1.05[341] |
51 |
ADCY6 |
Adenylate cyclase type 6 |
[342] |
1.58[343] |
1.99[344] |
1.88[345] |
2.03[346] |
2.99[347] |
2.25[348] |
52 |
CD36 |
Platelet glycoprotein 4 |
[349] |
0.87[350] |
0.14[351] |
-5.02[352] |
2.71[353] |
-6.01[354] |
2.70[355] |
53 |
PLCB3 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
[356] |
1.54[357] |
0.97[358] |
1.36[359] |
2.24[360] |
2.16[361] |
0.34[362] |
54 |
GNG11 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-11 |
-8.65[363] |
-8.70[364] |
-8.09[365] |
1.79[366] |
3.39[367] |
1.85[368] |
55 |
RAPGEF4 |
Rap guanine nucleotide exchange factor 4 |
[369] |
-4.49[370] |
-2.74[371] |
-1.90[372] |
-2.14[373] |
0.55[374] |
2.51[375] |
56 |
PLCB1 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
[376] |
2.32[377] |
3.90[378] |
3.25[379] |
0.31[380] |
1.08[381] |
2.11[382] |
57 |
GNG7 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-7 |
1.09[383] |
0.69[384] |
1.41[385] |
-2.71[386] |
-1.80[387] |
-0.36[388] |
58 |
CHRM3 |
Muscarinic acetylcholine receptor M3 |
[389] |
-3.98[390] |
-2.85[391] |
0.00[392] |
-0.87[393] |
-3.36[394] |
2.37[395] |
59 |
ADRA2C |
Alpha-2C adrenergic receptor |
[396] |
3.55[397] |
-2.91[398] |
-1.34[399] |
-3.71[400] |
-5.15[401] |
-3.61[402] |
60 |
PRKAA2 |
5'-AMP-activated protein kinase catalytic subunit alpha-2 |
[403] |
2.56[404] |
2.96[405] |
2.91[406] |
2.57[407] |
0.89[408] |
1.47[409] |
61 |
ADCY1 |
Adenylate cyclase type 1 |
[410] |
-1.30[411] |
-3.22[412] |
-3.50[413] |
-2.58[414] |
-2.32[415] |
4.61[416] |
62 |
KCNS3 |
Potassium voltage-gated channel subfamily S member 3 |
[417] |
-4.96[418] |
[419] |
-6.47[420] |
-2.82[421] |
-1.41[422] |
0.17[423] |
63 |
STX1A |
Syntaxin-1A |
[424] |
0.47[425] |
0.39[426] |
-1.18[427] |
2.12[428] |
1.41[429] |
-1.55[430] |
64 |
GNG4 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-4 |
3.00[431] |
0.71[432] |
4.44[433] |
0.79[434] |
-1.05[435] |
-2.93[436] |
65 |
STXBP1 |
Syntaxin-binding protein 1 |
[437] |
1.26[438] |
1.62[439] |
1.97[440] |
3.72[441] |
3.86[442] |
0.45[443] |
66 |
ADCY7 |
Adenylate cyclase type 7 |
[444] |
3.04[445] |
2.61[446] |
1.49[447] |
2.84[448] |
2.59[449] |
2.54[450] |
67 |
PLCB2 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
[451] |
-2.09[452] |
-6.92[453] |
-8.84[454] |
-2.41[455] |
-2.84[456] |
1.85[457] |
68 |
KCNJ11 |
ATP-sensitive inward rectifier potassium channel 11 |
[458] |
-0.17[459] |
-0.72[460] |
-1.36[461] |
-1.68[462] |
-2.13[463] |
-0.83[464] |
69 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[465] |
2.67[466] |
2.50[467] |
3.58[468] |
2.38[469] |
3.53[470] |
4.27[471] |
70 |
GNB4 |
Guanine nucleotide-binding protein subunit beta-4 |
[472] |
-0.84[473] |
-0.40[474] |
0.53[475] |
2.21[476] |
5.23[477] |
3.71[478] |
71 |
GNG2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-2 |
-6.75[479] |
-7.68[480] |
[481] |
2.65[482] |
2.40[483] |
2.40[484] |
72 |
GNA15 |
Guanine nucleotide-binding protein subunit alpha-15 |
[485] |
-3.85[486] |
-5.61[487] |
[488] |
-6.50[489] |
-2.66[490] |
-0.29[491] |
73 |
GNA14 |
Guanine nucleotide-binding protein subunit alpha-14 |
[492] |
-6.53[493] |
-6.97[494] |
-5.90[495] |
-6.76[496] |
-3.39[497] |
2.85[498] |
74 |
AKAP5 |
A-kinase anchor protein 5 |
[499] |
0.61[500] |
1.01[501] |
1.21[502] |
3.65[503] |
2.29[504] |
1.81[505] |
75 |
CACNB3 |
Voltage-dependent L-type calcium channel subunit beta-3 |
[506] |
1.84[507] |
-1.31[508] |
3.32[509] |
4.63[510] |
4.07[511] |
0.08[512] |
76 |
CACNA1D |
Voltage-dependent L-type calcium channel subunit alpha-1D |
[513] |
-4.19[514] |
-1.23[515] |
1.00[516] |
-1.94[517] |
-4.30[518] |
4.12[519] |
77 |
GNGT2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-T2 |
[520] |
[521] |
[522] |
-2.54[523] |
-6.93[524] |
-0.28[525] |
78 |
SNAP25 |
Synaptosomal-associated protein 25 |
[526] |
-3.97[527] |
-3.82[528] |
1.78[529] |
1.98[530] |
4.31[531] |
0.66[532] |
79 |
GNG3 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-3 |
-1.32[533] |
0.46[534] |
-1.85[535] |
-1.17[536] |
-1.21[537] |
-0.47[538] |
80 |
PRKAR2B |
cAMP-dependent protein kinase type II-beta regulatory subunit |
[539] |
-2.81[540] |
-1.03[541] |
3.17[542] |
4.61[543] |
3.41[544] |
2.93[545] |
81 |
ADCY3 |
Adenylate cyclase type 3 |
[546] |
0.99[547] |
-0.30[548] |
2.95[549] |
4.27[550] |
6.08[551] |
3.13[552] |
82 |
CACNB2 |
Voltage-dependent L-type calcium channel subunit beta-2 |
[553] |
-0.46[554] |
1.45[555] |
1.39[556] |
3.10[557] |
1.79[558] |
4.65[559] |
83 |
RAPGEF3 |
Rap guanine nucleotide exchange factor 3 |
[560] |
1.35[561] |
0.98[562] |
0.34[563] |
1.41[564] |
0.34[565] |
3.43[566] |
84 |
ADCY2 |
Adenylate cyclase type 2 |
[567] |
-5.85[568] |
-3.97[569] |
-5.30[570] |
-3.20[571] |
-4.04[572] |
-4.50[573] |
85 |
ADIPOQ |
Adiponectin |
[574] |
-1.99[575] |
-1.83[576] |
-2.14[577] |
-1.34[578] |
-2.06[579] |
-1.14[580] |
86 |
GNB3 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 |
[581] |
1.12[582] |
3.32[583] |
2.55[584] |
0.54[585] |
3.53[586] |
-2.06[587] |
87 |
KCNB1 |
Potassium voltage-gated channel subfamily B member 1 |
[588] |
[589] |
[590] |
-1.34[591] |
-3.68[592] |
-1.35[593] |
5.83[594] |
88 |
ADCY5 |
Adenylate cyclase type 5 |
[595] |
-0.32[596] |
0.63[597] |
1.58[598] |
0.18[599] |
1.58[600] |
5.99[601] |
89 |
CACNA2D2 |
Voltage-dependent calcium channel subunit alpha-2/delta-2 |
[602] |
-1.78[603] |
0.37[604] |
0.87[605] |
-0.23[606] |
1.81[607] |
1.45[608] |
90 |
SYT5 |
Synaptotagmin-5 |
[609] |
3.32[610] |
2.43[611] |
[612] |
1.28[613] |
0.61[614] |
-2.12[615] |
91 |
ABCC8 |
ATP-binding cassette sub-family C member 8 |
[616] |
-1.36[617] |
[618] |
-2.42[619] |
[620] |
[621] |
1.10[622] |
92 |
ADRA2A |
Alpha-2A adrenergic receptor |
[623] |
-3.62[624] |
-2.18[625] |
[626] |
0.87[627] |
3.85[628] |
3.61[629] |
93 |
CACNA1A |
Voltage-dependent P/Q-type calcium channel subunit alpha-1A |
[630] |
-2.57[631] |
-1.27[632] |
1.54[633] |
4.46[634] |
2.81[635] |
3.90[636] |
94 |
CYSLTR2 |
Cysteinyl leukotriene receptor 2 |
[637] |
[638] |
-1.92[639] |
[640] |
-2.71[641] |
-1.37[642] |
2.06[643] |
95 |
ADCY4 |
Adenylate cyclase type 4 |
[644] |
-0.38[645] |
-1.50[646] |
1.06[647] |
[648] |
[649] |
7.98[650] |
96 |
CACNA1C |
Voltage-dependent L-type calcium channel subunit alpha-1C |
[651] |
4.25[652] |
1.70[653] |
4.48[654] |
5.25[655] |
7.76[656] |
7.92[657] |
97 |
GNG8 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-8 |
[658] |
[659] |
[660] |
[661] |
[662] |
[663] |
98 |
KCNC2 |
Potassium voltage-gated channel subfamily C member 2 |
[664] |
[665] |
[666] |
[667] |
[668] |
[669] |
[670] |
99 |
GLP1R |
Glucagon-like peptide 1 receptor |
[671] |
[672] |
[673] |
[674] |
[675] |
[676] |
[677] |
100 |
GNG13 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-13 |
[678] |
[679] |
[680] |
[681] |
[682] |
[683] |
101 |
INS |
Insulin |
[684] |
[685] |
[686] |
[687] |
[688] |
[689] |
[690] |
102 |
ADCY8 |
Adenylate cyclase type 8 |
[691] |
[692] |
[693] |
[694] |
[695] |
[696] |
[697] |
103 |
GNGT1 |
Guanine nucleotide-binding protein G(T) subunit gamma-T1 |
[698] |
[699] |
[700] |
[701] |
[702] |
[703] |
[704] |
104 |
CACNA1E |
Voltage-dependent R-type calcium channel subunit alpha-1E |
[705] |
[706] |
[707] |
[708] |
[709] |
[710] |
[711] |
105 |
PRKACG |
cAMP-dependent protein kinase catalytic subunit gamma |
[712] |
[713] |
[714] |
[715] |
[716] |
[717] |
[718] |
106 |
FFAR1 |
Free fatty acid receptor 1 |
[719] |
[720] |
[721] |
[722] |
[723] |
[724] |
[725] |
107 |
KCNG2 |
Potassium voltage-gated channel subfamily G member 2 |
[726] |
[727] |
[728] |
[729] |
[730] |
[731] |
[732] |
108 |
GCG |
Glucagon |
[733] |
[734] |
[735] |
[736] |
[737] |
[738] |
[739] |
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