REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | TRIB3 | Tribbles homolog 3 | [1] | -0.22[2] | -0.12[3] | -1.50[4] | -2.91[5] | -2.37[6] | -1.70[7] |
2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [8] | -0.68[9] | -0.44[10] | -0.76[11] | 0.00[12] | 0.66[13] | -0.02[14] |
3 | GRB2 | Growth factor receptor-bound protein 2 | [15] | 0.07[16] | -0.29[17] | -0.44[18] | -0.34[19] | -0.39[20] | -0.98[21] |
4 | SHC1 | SHC-transforming protein 1 | [22] | 0.04[23] | 0.06[24] | -0.13[25] | 1.76[26] | 1.28[27] | -0.50[28] |
5 | FGFR4 | Fibroblast growth factor receptor 4 | [29] | 0.83[30] | 0.98[31] | 1.29[32] | -5.13[33] | -5.22[34] | -0.78[35] |
6 | NRAS | GTPase NRas | [36] | -0.50[37] | -0.26[38] | -0.12[39] | 0.11[40] | -0.29[41] | -1.53[42] |
7 | HRAS | GTPase HRas | [43] | -2.14[44] | -3.03[45] | -4.10[46] | -1.84[47] | -2.02[48] | -3.94[49] |
8 | MAPK1 | Mitogen-activated protein kinase 1 | [50] | 0.58[51] | 0.53[52] | 0.09[53] | 0.96[54] | 0.64[55] | 0.49[56] |
9 | AKT2 | RAC-beta serine/threonine-protein kinase | [57] | -0.17[58] | -0.08[59] | -0.23[60] | -0.03[61] | -0.21[62] | -0.15[63] |
10 | KLB | Beta-klotho | [64] | -0.53[65] | -0.89[66] | 0.29[67] | -6.86[68] | -7.46[69] | 0.27[70] |
11 | KRAS | GTPase KRas | [71] | -1.64[72] | -1.85[73] | -0.53[74] | -0.09[75] | -0.40[76] | -0.61[77] |
12 | FGFR3 | Fibroblast growth factor receptor 3 | [78] | 1.60[79] | 1.32[80] | 1.38[81] | -4.19[82] | -2.81[83] | -0.83[84] |
13 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [85] | -1.60[86] | -1.67[87] | -0.85[88] | 1.17[89] | 0.71[90] | 1.72[91] |
14 | SOS1 | Son of sevenless homolog 1 | [92] | -1.23[93] | 0.11[94] | -0.65[95] | -0.05[96] | -0.78[97] | -0.74[98] |
15 | INSR | Insulin receptor | [99] | -0.67[100] | -0.21[101] | 0.95[102] | -3.97[103] | -1.34[104] | 2.72[105] |
16 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [106] | 0.75[107] | 0.78[108] | 1.12[109] | -0.18[110] | 0.41[111] | -1.57[112] |
17 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | [113] | -0.74[114] | -0.31[115] | -1.49[116] | -0.09[117] | 0.15[118] | -0.65[119] |
18 | MAPK3 | Mitogen-activated protein kinase 3 | [120] | 0.72[121] | 0.58[122] | 0.35[123] | -0.47[124] | -0.42[125] | -2.32[126] |
19 | FGF2 | Fibroblast growth factor 2 | [127] | -7.81[128] | -7.75[129] | -3.87[130] | 0.04[131] | 1.65[132] | -2.95[133] |
20 | GRB10 | Growth factor receptor-bound protein 10 | [134] | 1.38[135] | -1.89[136] | 0.21[137] | -0.21[138] | 0.69[139] | 0.66[140] |
21 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [141] | 1.20[142] | 2.21[143] | 0.64[144] | 0.55[145] | 0.97[146] | 1.22[147] |
22 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | [148] | -0.68[149] | 0.09[150] | 0.07[151] | -2.27[152] | -2.68[153] | 1.59[154] |
23 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.08[155] | 0.40[156] | 0.29[157] | 0.16[158] | 0.35[159] | -0.13[160] | |
24 | IRS1 | Insulin receptor substrate 1 | [161] | 0.96[162] | 0.22[163] | 1.37[164] | 0.81[165] | 0.43[166] | 0.83[167] |
25 | IRS2 | Insulin receptor substrate 2 | [168] | -6.78[169] | [170] | -4.39[171] | -1.56[172] | 2.30[173] | 1.10[174] |
26 | PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4 | [175] | 0.03[176] | -0.10[177] | 0.60[178] | 0.77[179] | 1.28[180] | 1.59[181] |
27 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.51[182] | -0.06[183] | -0.14[184] | 0.24[185] | 0.47[186] | 0.63[187] | |
28 | THEM4 | Acyl-coenzyme A thioesterase THEM4 | [188] | -0.48[189] | -0.23[190] | 0.05[191] | 1.11[192] | 0.56[193] | -0.20[194] |
29 | FLT3LG | Fms-related tyrosine kinase 3 ligand | [195] | -3.39[196] | -3.48[197] | -3.29[198] | -3.23[199] | -2.11[200] | -3.44[201] |
30 | GAB2 | GRB2-associated-binding protein 2 | [202] | 0.44[203] | 0.03[204] | 0.01[205] | 0.03[206] | 0.15[207] | -0.74[208] |
31 | FGFR2 | Fibroblast growth factor receptor 2 | [209] | -3.64[210] | -2.62[211] | 1.05[212] | 0.56[213] | -4.25[214] | 2.14[215] |
32 | FRS2 | Fibroblast growth factor receptor substrate 2 | [216] | 0.16[217] | 1.06[218] | 1.29[219] | 2.01[220] | 1.67[221] | 2.06[222] |
33 | FGFR1 | Fibroblast growth factor receptor 1 | [223] | 3.45[224] | 1.57[225] | 2.95[226] | 4.17[227] | 3.46[228] | 0.38[229] |
34 | GAB1 | GRB2-associated-binding protein 1 | [230] | 0.17[231] | 1.07[232] | 0.92[233] | 1.04[234] | 0.93[235] | 1.59[236] |
35 | FGF7 | Fibroblast growth factor 7 | [237] | -10.42[238] | -6.91[239] | [240] | -6.27[241] | -1.97[242] | -2.73[243] |
36 | KL | Klotho | [244] | -7.18[245] | [246] | [247] | -2.28[248] | -7.50[249] | -1.03[250] |
37 | FGF5 | Fibroblast growth factor 5 | [251] | -2.12[252] | -0.99[253] | -1.33[254] | 0.59[255] | 0.31[256] | 1.85[257] |
38 | FGF1 | Fibroblast growth factor 1 | [258] | -3.89[259] | -3.29[260] | -8.03[261] | -0.31[262] | 1.31[263] | -1.24[264] |
39 | FGF19 | Fibroblast growth factor 19 | [265] | -3.19[266] | -2.23[267] | 4.24[268] | -0.06[269] | -3.50[270] | [271] |
40 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | [272] | [273] | [274] | -5.09[275] | -3.68[276] | [277] | 1.64[278] |
41 | FGF8 | Fibroblast growth factor 8 | [279] | -4.46[280] | -4.30[281] | -0.08[282] | -2.81[283] | [284] | 1.41[285] |
42 | FGF18 | Fibroblast growth factor 18 | [286] | 0.65[287] | -3.66[288] | -1.76[289] | -0.28[290] | 0.35[291] | -0.70[292] |
43 | FGF9 | Fibroblast growth factor 9 | [293] | 1.13[294] | -2.71[295] | [296] | 1.89[297] | -3.19[298] | -1.18[299] |
44 | FGF4 | Fibroblast growth factor 4 | [300] | [301] | [302] | [303] | [304] | [305] | [306] |
45 | TLR9 | Toll-like receptor 9 | [307] | [308] | [309] | [310] | [311] | [312] | [313] |
46 | FGF16 | Fibroblast growth factor 16 | [314] | [315] | [316] | [317] | [318] | [319] | [320] |
47 | FGF3 | Fibroblast growth factor 3 | [321] | [322] | [323] | [324] | [325] | [326] | [327] |
48 | FGF20 | Fibroblast growth factor 20 | [328] | [329] | [330] | [331] | [332] | [333] | [334] |
49 | FGF23 | Fibroblast growth factor 23 | [335] | [336] | [337] | [338] | [339] | [340] | [341] |
50 | FGF10 | Fibroblast growth factor 10 | [342] | [343] | [344] | [345] | [346] | [347] | [348] |
51 | FGF22 | Fibroblast growth factor 22 | [349] | [350] | [351] | [352] | [353] | [354] | [355] |
52 | FGF17 | Fibroblast growth factor 17 | [356] | [357] | [358] | [359] | [360] | [361] | [362] |
53 | INS | Insulin | [363] | [364] | [365] | [366] | [367] | [368] | [369] |
54 | FGF6 | Fibroblast growth factor 6 | [370] | [371] | [372] | [373] | [374] | [375] | [376] |