REACTOME_INSULIN_PROCESSING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CPE Carboxypeptidase E [1] 0.99[2] 1.42[3] -3.63[4] -2.17[5] 0.37[6] -4.48[7]
2 KIF5B Kinesin-1 heavy chain [8] -0.69[9] 0.01[10] 1.10[11] 1.42[12] 0.63[13] 0.30[14]
3 EXOC7 Exocyst complex component 7 [15] 0.69[16] -0.10[17] 0.18[18] -0.20[19] -0.57[20] 0.16[21]
4 RAB27A Ras-related protein Rab-27A [22] -2.58[23] -3.26[24] -1.94[25] -1.90[26] -0.60[27] -0.39[28]
5 SLC30A5 Zinc transporter 5 [29] -0.89[30] -1.55[31] 0.00[32] -0.42[33] -0.62[34] -0.02[35]
6 VAMP2 Vesicle-associated membrane protein 2 [36] -2.45[37] -3.37[38] -1.68[39] -1.90[40] -1.97[41] -1.23[42]
7 EXOC3 Exocyst complex component 3 [43] -0.91[44] -2.73[45] -0.80[46] -1.08[47] -1.31[48] -0.88[49]
8 EXOC5 Exocyst complex component 5 [50] -0.08[51] -0.42[52] 0.79[53] 0.98[54] 0.68[55] 1.08[56]
9 EXOC6 Exocyst complex component 6 [57] -1.85[58] -1.04[59] 0.76[60] -1.91[61] -2.08[62] -0.30[63]
10 EXOC4 Exocyst complex component 4 [64] 0.27[65] -1.16[66] 1.48[67] 0.31[68] 0.22[69] 0.81[70]
11 SLC30A6 Zinc transporter 6 [71] 0.24[72] -0.32[73] 0.45[74] 0.45[75] 0.11[76] 0.37[77]
12 EXOC2 Exocyst complex component 2 [78] 0.52[79] -0.75[80] 0.17[81] 0.98[82] -0.21[83] 0.64[84]
13 SLC30A7 Zinc transporter 7 [85] -0.35[86] -0.66[87] 0.65[88] -0.20[89] 0.01[90] 2.30[91]
14 EXOC1 Exocyst complex component 1 [92] -0.48[93] -1.44[94] -0.01[95] 0.07[96] 0.41[97] 0.14[98]
15 MYRIP Rab effector MyRIP [99] -6.39[100] -11.88[101] -5.96[102] -8.66[103] -8.00[104] 1.15[105]
16 EXOC8 Exocyst complex component 8 [106] -0.52[107] -1.65[108] 1.36[109] 0.36[110] 0.13[111] 0.95[112]
17 STX1A Syntaxin-1A [113] -0.16[114] -1.48[115] -1.63[116] 1.16[117] 0.29[118] -2.20[119]
18 MYO5A Unconventional myosin-Va [120] 1.34[121] 0.29[122] 0.75[123] 3.29[124] 2.86[125] 2.05[126]
19 KIF5C Kinesin heavy chain isoform 5C [127] 2.15[128] -5.53[129] 4.43[130] 0.95[131] 2.85[132] 0.32[133]
20 KIF5A Kinesin heavy chain isoform 5A [134] 2.63[135] 4.04[136] -1.02[137] 4.33[138] 3.57[139] -3.56[140]
21 PCSK1 Neuroendocrine convertase 1 [141] -4.47[142] -2.13[143] -0.59[144] 2.88[145] 4.80[146] 4.17[147]
22 SLC30A8 Zinc transporter 8 [148] -0.53[149] -0.74[150] -0.10[151] 7.56[152] 0.59[153] -0.93[154]
23 PCSK2 Neuroendocrine convertase 2 [155] [156] [157] -3.21[158] 1.21[159] [160] 2.56[161]
24 ERO1A ERO1-like protein alpha [162] [163] [164] [165] [166] [167] [168]
25 CLTRN [169] [170] [171] [172] [173] [174] [175]
26 INS Insulin [176] [177] [178] [179] [180] [181] [182]
27 ERO1B ERO1-like protein beta [183] [184] [185] [186] [187] [188] [189]
[1]
ref_hepatocyte CPE
Mean 23.3
Standard deviation 46
Values 1.1e+02 2.7 0.41 2.7 4.9
[2]
HepG2 CPE
Mean 218
Standard deviation 11
Values 2.3e+02 2.1e+02
[3]
HepG2.C3A CPE
Mean 637
Standard deviation 1.7e+02
Values 7.5e+02 5.2e+02
[4]
HuH.7 CPE
Mean 7.33
Standard deviation 1.8
Values 6.1 9.4 6.5
[5]
SNU475 CPE
Mean 25.7
Standard deviation 11
Values 34 18
[6]
THLE CPE
Mean 153
Standard deviation 12
Values 1.6e+02 1.5e+02
[7]
liver CPE
Mean 3.04
Standard deviation 0.4
Values 3.4 3 3.2 2.5
[8]
ref_hepatocyte KIF5B
Mean 13.8
Standard deviation 9.5
Values 24 23 13 3.8 5.2
[9]
HepG2 KIF5B
Mean 40.4
Standard deviation 19
Values 27 54
[10]
HepG2.C3A KIF5B
Mean 142
Standard deviation 30
Values 1.2e+02 1.6e+02
[11]
HuH.7 KIF5B
Mean 115
Standard deviation 18
Values 1.3e+02 1.3e+02 94
[12]
SNU475 KIF5B
Mean 183
Standard deviation 2.9
Values 1.8e+02 1.8e+02
[13]
THLE KIF5B
Mean 108
Standard deviation 25
Values 1.3e+02 91
[14]
liver KIF5B
Mean 49.2
Standard deviation 8.6
Values 51 57 37 51
[15]
ref_hepatocyte EXOC7
Mean 8.63
Standard deviation 1.7
Values 11 8 8.2 8.6 7
[16]
HepG2 EXOC7
Mean 65.8
Standard deviation 9.8
Values 59 73
[17]
HepG2.C3A EXOC7
Mean 82.5
Standard deviation 0.59
Values 82 83
[18]
HuH.7 EXOC7
Mean 37.9
Standard deviation 6.3
Values 44 31 38
[19]
SNU475 EXOC7
Mean 37.2
Standard deviation 8.9
Values 43 31
[20]
THLE EXOC7
Mean 29.5
Standard deviation 2.1
Values 28 31
[21]
liver EXOC7
Mean 28.1
Standard deviation 3.9
Values 27 32 31 23
[22]
ref_hepatocyte RAB27A
Mean 8.42
Standard deviation 6.1
Values 1.8 12 2.7 16 9.9
[23]
HepG2 RAB27A
Mean 6.65
Standard deviation 1.3
Values 5.7 7.6
[24]
HepG2.C3A RAB27A
Mean 9.02
Standard deviation 0.83
Values 8.4 9.6
[25]
HuH.7 RAB27A
Mean 8.52
Standard deviation 0.55
Values 9 7.9 8.7
[26]
SNU475 RAB27A
Mean 11.2
Standard deviation 3
Values 9.1 13
[27]
THLE RAB27A
Mean 28.3
Standard deviation 1.5
Values 29 27
[28]
liver RAB27A
Mean 18.7
Standard deviation 5.5
Values 24 17 22 12
[29]
ref_hepatocyte SLC30A5
Mean 7.81
Standard deviation 4.1
Values 7.1 15 5.3 4.8 7
[30]
HepG2 SLC30A5
Mean 19.9
Standard deviation 4
Values 17 23
[31]
HepG2.C3A SLC30A5
Mean 27.4
Standard deviation 3
Values 30 25
[32]
HuH.7 SLC30A5
Mean 30.4
Standard deviation 2.6
Values 31 33 28
[33]
SNU475 SLC30A5
Mean 29
Standard deviation 8.5
Values 35 23
[34]
THLE SLC30A5
Mean 25.9
Standard deviation 5.2
Values 22 30
[35]
liver SLC30A5
Mean 22.4
Standard deviation 3.1
Values 18 23 23 25
[36]
ref_hepatocyte VAMP2
Mean 7.38
Standard deviation 2
Values 9.9 5.1 8 8.2 5.7
[37]
HepG2 VAMP2
Mean 6.41
Standard deviation 1.5
Values 7.4 5.4
[38]
HepG2.C3A VAMP2
Mean 7.34
Standard deviation 3
Values 9.5 5.2
[39]
HuH.7 VAMP2
Mean 8.97
Standard deviation 0.78
Values 8.3 8.8 9.8
[40]
SNU475 VAMP2
Mean 9.81
Standard deviation 1.6
Values 11 8.7
[41]
THLE VAMP2
Mean 9.61
Standard deviation 0.14
Values 9.5 9.7
[42]
liver VAMP2
Mean 9.18
Standard deviation 10
Values 22 1 11 1.9
[43]
ref_hepatocyte EXOC3
Mean 7.02
Standard deviation 1
Values 6.8 8.7 5.9 7 6.7
[44]
HepG2 EXOC3
Mean 17.6
Standard deviation 1.3
Values 19 17
[45]
HepG2.C3A EXOC3
Mean 10.9
Standard deviation 2.2
Values 12 9.3
[46]
HuH.7 EXOC3
Mean 15.6
Standard deviation 1.2
Values 17 14 16
[47]
SNU475 EXOC3
Mean 16.4
Standard deviation 3.1
Values 19 14
[48]
THLE EXOC3
Mean 14.4
Standard deviation 0.056
Values 14 14
[49]
liver EXOC3
Mean 11.1
Standard deviation 2.2
Values 14 9.3 11 9.8
[50]
ref_hepatocyte EXOC5
Mean 4.17
Standard deviation 3.3
Values 4.7 9.6 2.7 1.2 2.6
[51]
HepG2 EXOC5
Mean 18.7
Standard deviation 10
Values 12 26
[52]
HepG2.C3A EXOC5
Mean 31.9
Standard deviation 12
Values 23 41
[53]
HuH.7 EXOC5
Mean 27.9
Standard deviation 4.9
Values 32 29 23
[54]
SNU475 EXOC5
Mean 40.7
Standard deviation 5.6
Values 45 37
[55]
THLE EXOC5
Mean 34
Standard deviation 3.1
Values 36 32
[56]
liver EXOC5
Mean 25.5
Standard deviation 5.5
Values 21 33 22 27
[57]
ref_hepatocyte EXOC6
Mean 4.15
Standard deviation 2.4
Values 7.8 5.3 2 2.6 3.1
[58]
HepG2 EXOC6
Mean 5.44
Standard deviation 2.5
Values 3.7 7.2
[59]
HepG2.C3A EXOC6
Mean 20.7
Standard deviation 0.32
Values 21 21
[60]
HuH.7 EXOC6
Mean 27.2
Standard deviation 2
Values 26 30 26
[61]
SNU475 EXOC6
Mean 5.46
Standard deviation 0.73
Values 6 4.9
[62]
THLE EXOC6
Mean 4.98
Standard deviation 0.49
Values 4.6 5.3
[63]
liver EXOC6
Mean 9.78
Standard deviation 2.1
Values 10 12 11 6.8
[64]
ref_hepatocyte EXOC4
Mean 3.98
Standard deviation 1.2
Values 3.4 5.8 2.6 3.8 4.2
[65]
HepG2 EXOC4
Mean 22.6
Standard deviation 0.52
Values 22 23
[66]
HepG2.C3A EXOC4
Mean 18.3
Standard deviation 1.8
Values 20 17
[67]
HuH.7 EXOC4
Mean 43
Standard deviation 6.1
Values 48 45 36
[68]
SNU475 EXOC4
Mean 24.3
Standard deviation 7.2
Values 29 19
[69]
THLE EXOC4
Mean 23.6
Standard deviation 3.4
Values 21 26
[70]
liver EXOC4
Mean 20.2
Standard deviation 8.9
Values 13 30 12 25
[71]
ref_hepatocyte SLC30A6
Mean 3.65
Standard deviation 2.7
Values 8.3 3.5 1.5 2.9 2.1
[72]
HepG2 SLC30A6
Mean 20.4
Standard deviation 6.2
Values 16 25
[73]
HepG2.C3A SLC30A6
Mean 29.9
Standard deviation 6.9
Values 25 35
[74]
HuH.7 SLC30A6
Mean 19.4
Standard deviation 2.9
Values 22 20 16
[75]
SNU475 SLC30A6
Mean 24.7
Standard deviation 0.49
Values 25 24
[76]
THLE SLC30A6
Mean 20
Standard deviation 1.6
Values 19 21
[77]
liver SLC30A6
Mean 13.7
Standard deviation 5.7
Values 7.8 21 10 16
[78]
ref_hepatocyte EXOC2
Mean 3.24
Standard deviation 0.9
Values 4.1 4.3 3 2.5 2.3
[79]
HepG2 EXOC2
Mean 21.9
Standard deviation 4.1
Values 19 25
[80]
HepG2.C3A EXOC2
Mean 19.7
Standard deviation 1.6
Values 21 19
[81]
HuH.7 EXOC2
Mean 14.1
Standard deviation 1.5
Values 16 14 13
[82]
SNU475 EXOC2
Mean 31.6
Standard deviation 4.6
Values 35 28
[83]
THLE EXOC2
Mean 14.2
Standard deviation 1.8
Values 13 15
[84]
liver EXOC2
Mean 14.7
Standard deviation 2
Values 15 17 14 13
[85]
ref_hepatocyte SLC30A7
Mean 3.15
Standard deviation 0.43
Values 3.7 3.4 3 2.9 2.6
[86]
HepG2 SLC30A7
Mean 11.7
Standard deviation 4
Values 8.8 15
[87]
HepG2.C3A SLC30A7
Mean 20.5
Standard deviation 5.6
Values 24 17
[88]
HuH.7 SLC30A7
Mean 19.2
Standard deviation 0.9
Values 20 18 19
[89]
SNU475 SLC30A7
Mean 13.5
Standard deviation 1.3
Values 14 13
[90]
THLE SLC30A7
Mean 16.1
Standard deviation 1.1
Values 17 15
[91]
liver SLC30A7
Mean 45.2
Standard deviation 9.3
Values 34 57 46 44
[92]
ref_hepatocyte EXOC1
Mean 2.43
Standard deviation 0.65
Values 2.4 3.5 1.7 2.2 2.4
[93]
HepG2 EXOC1
Mean 8.27
Standard deviation 1.4
Values 7.2 9.3
[94]
HepG2.C3A EXOC1
Mean 9.17
Standard deviation 1.4
Values 8.2 10
[95]
HuH.7 EXOC1
Mean 9.39
Standard deviation 0.54
Values 9.1 9.1 10
[96]
SNU475 EXOC1
Mean 12.6
Standard deviation 1.9
Values 14 11
[97]
THLE EXOC1
Mean 16.4
Standard deviation 1
Values 17 16
[98]
liver EXOC1
Mean 7.79
Standard deviation 1.7
Values 8.8 9.5 7.3 5.6
[99]
ref_hepatocyte MYRIP
Mean 1.97
Standard deviation 2
Values 0.19 0.81 0.67 3.3 4.9
[100]
HepG2 MYRIP
Mean 0.111
Standard deviation 0.068
Values 0.063 0.16
[101]
HepG2.C3A MYRIP
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[102]
HuH.7 MYRIP
Mean 0.123
Standard deviation 0.15
Values 0.0082 0.3 0.066
[103]
SNU475 MYRIP
Mean 0.0241
Standard deviation 0.0053
Values 0.028 0.02
[104]
THLE MYRIP
Mean 0.039
Standard deviation 0.005
Values 0.035 0.043
[105]
liver MYRIP
Mean 12.7
Standard deviation 2.9
Values 11 17 11 12
[106]
ref_hepatocyte EXOC8
Mean 1.53
Standard deviation 0.48
Values 2 1.7 1.9 0.93 1.1
[107]
HepG2 EXOC8
Mean 5.04
Standard deviation 1.3
Values 4.1 6
[108]
HepG2.C3A EXOC8
Mean 5.01
Standard deviation 0.51
Values 4.6 5.4
[109]
HuH.7 EXOC8
Mean 15.3
Standard deviation 0.92
Values 16 15 14
[110]
SNU475 EXOC8
Mean 9.73
Standard deviation 0.91
Values 10 9.1
[111]
THLE EXOC8
Mean 8.52
Standard deviation 0.43
Values 8.8 8.2
[112]
liver EXOC8
Mean 8.6
Standard deviation 6
Values 4 14 2.9 13
[113]
ref_hepatocyte STX1A
Mean 0.672
Standard deviation 0.98
Values 0.23 0.39 2.4 0.095 0.24
[114]
HepG2 STX1A
Mean 2.85
Standard deviation 0.85
Values 3.4 2.2
[115]
HepG2.C3A STX1A
Mean 2.48
Standard deviation 0.71
Values 3 2
[116]
HuH.7 STX1A
Mean 0.845
Standard deviation 0.25
Values 0.57 0.91 1.1
[117]
SNU475 STX1A
Mean 7.45
Standard deviation 3.6
Values 4.9 10
[118]
THLE STX1A
Mean 4.19
Standard deviation 1.3
Values 5.1 3.3
[119]
liver STX1A
Mean 0.426
Standard deviation 0.18
Values 0.35 0.31 0.69 0.34
[120]
ref_hepatocyte MYO5A
Mean 0.5
Standard deviation 0.32
Values 0.47 1 0.49 0.21 0.3
[121]
HepG2 MYO5A
Mean 6
Standard deviation 1.8
Values 4.7 7.3
[122]
HepG2.C3A MYO5A
Mean 6.28
Standard deviation 1.6
Values 5.2 7.4
[123]
HuH.7 MYO5A
Mean 3.28
Standard deviation 0.74
Values 3.5 3.9 2.4
[124]
SNU475 MYO5A
Mean 24.2
Standard deviation 4.1
Values 27 21
[125]
THLE MYO5A
Mean 18.5
Standard deviation 1.2
Values 19 18
[126]
liver MYO5A
Mean 6.02
Standard deviation 3.6
Values 3.1 10 2.9 8.1
[127]
ref_hepatocyte KIF5C
Mean 0.092
Standard deviation 0.045
Values 0.08 0.067 0.17 0.06 0.081
[128]
HepG2 KIF5C
Mean 1.93
Standard deviation 1.3
Values 2.8 1
[129]
HepG2.C3A KIF5C
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[130]
HuH.7 KIF5C
Mean 7.73
Standard deviation 3.5
Values 6.3 12 5.2
[131]
SNU475 KIF5C
Mean 0.882
Standard deviation 0.39
Values 0.61 1.2
[132]
THLE KIF5C
Mean 3.38
Standard deviation 0.9
Values 4 2.7
[133]
liver KIF5C
Mean 0.333
Standard deviation 0.17
Values 0.4 0.51 0.1 0.32
[134]
ref_hepatocyte KIF5A
Mean 0.0406
Standard deviation 0.078
Values 0.18 0 0 0 0.024
[135]
HepG2 KIF5A
Mean 1.19
Standard deviation 0.0056
Values 1.2 1.2
[136]
HepG2.C3A KIF5A
Mean 6.85
Standard deviation 0.38
Values 6.6 7.1
[137]
HuH.7 KIF5A
Mean 0.0778
Standard deviation 0.011
Values 0.066 0.083 0.084
[138]
SNU475 KIF5A
Mean 4.05
Standard deviation 1.4
Values 5 3.1
[139]
THLE KIF5A
Mean 2.46
Standard deviation 0.12
Values 2.5 2.4
[140]
liver KIF5A
Mean 0.00999
Standard deviation 0.012
Values 0 0.014 0.026 0
[141]
ref_hepatocyte PCSK1
Mean 0.0201
Standard deviation 0.045
Values 0 0 0.1 0 0
[142]
HepG2 PCSK1
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[143]
HepG2.C3A PCSK1
Mean 0.0473
Standard deviation 0.039
Values 0.019 0.075
[144]
HuH.7 PCSK1
Mean 0.0518
Standard deviation 0.022
Values 0.041 0.077 0.037
[145]
SNU475 PCSK1
Mean 0.734
Standard deviation 0.56
Values 0.34 1.1
[146]
THLE PCSK1
Mean 2.86
Standard deviation 0.33
Values 3.1 2.6
[147]
liver PCSK1
Mean 1.05
Standard deviation 1
Values 0.24 2.2 0.1 1.7
[148]
ref_hepatocyte SLC30A8
Mean 0.0133
Standard deviation 0.019
Values 0.042 0 0 0 0.024
[149]
HepG2 SLC30A8
Mean 0.0437
Standard deviation 0.019
Values 0.057 0.03
[150]
HepG2.C3A SLC30A8
Mean 0.0823
Standard deviation 0.02
Values 0.068 0.097
[151]
HuH.7 SLC30A8
Mean 0.0485
Standard deviation 0.0085
Values 0.041 0.058 0.047
[152]
SNU475 SLC30A8
Mean 12.4
Standard deviation 1.9
Values 14 11
[153]
THLE SLC30A8
Mean 0.102
Standard deviation 0.036
Values 0.077 0.13
[154]
liver SLC30A8
Mean 0.0204
Standard deviation 0.018
Values 0 0.043 0.026 0.013
[155]
ref_hepatocyte PCSK2
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[156]
HepG2 PCSK2
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A PCSK2
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 PCSK2
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[159]
SNU475 PCSK2
Mean 0.0743
Standard deviation 0.026
Values 0.093 0.056
[160]
THLE PCSK2
Mean 0
Standard deviation 0
Values 0 0
[161]
liver PCSK2
Mean 0.111
Standard deviation 0.082
Values 0 0.16 0.1 0.19
[162]
ref_hepatocyte ERO1A
Missing
[163]
HepG2 ERO1A
Missing
[164]
HepG2.C3A ERO1A
Missing
[165]
HuH.7 ERO1A
Missing
[166]
SNU475 ERO1A
Missing
[167]
THLE ERO1A
Missing
[168]
liver ERO1A
Missing
[169]
ref_hepatocyte CLTRN
Missing
[170]
HepG2 CLTRN
Missing
[171]
HepG2.C3A CLTRN
Missing
[172]
HuH.7 CLTRN
Missing
[173]
SNU475 CLTRN
Missing
[174]
THLE CLTRN
Missing
[175]
liver CLTRN
Missing
[176]
ref_hepatocyte INS
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 INS
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[178]
HepG2.C3A INS
Mean 0
Standard deviation 0
Values 0 0
[179]
HuH.7 INS
Mean 0
Standard deviation 0
Values 0 0 0
[180]
SNU475 INS
Mean 0
Standard deviation 0
Values 0 0
[181]
THLE INS
Mean 0
Standard deviation 0
Values 0 0
[182]
liver INS
Mean 0.0838
Standard deviation 0.13
Values 0 0.057 0 0.28
[183]
ref_hepatocyte ERO1B
Missing
[184]
HepG2 ERO1B
Missing
[185]
HepG2.C3A ERO1B
Missing
[186]
HuH.7 ERO1B
Missing
[187]
SNU475 ERO1B
Missing
[188]
THLE ERO1B
Missing
[189]
liver ERO1B
Missing