REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ANAPC11 Anaphase-promoting complex subunit 11 [1] -1.85[2] -1.92[3] -2.34[4] -2.36[5] -2.48[6] -0.84[7]
2 CDC26 Anaphase-promoting complex subunit CDC26 [8] -2.79[9] -2.83[10] -2.86[11] -3.07[12] -2.68[13] -1.65[14]
3 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 [15] -0.97[16] -1.24[17] -0.53[18] -0.52[19] -0.76[20] -2.25[21]
4 BUB3 Mitotic checkpoint protein BUB3 [22] 0.30[23] 0.67[24] 0.06[25] -0.35[26] 0.60[27] -0.03[28]
5 ANAPC16 Anaphase-promoting complex subunit 16 [29] 0.17[30] 0.37[31] -0.79[32] -0.47[33] -0.74[34] 1.10[35]
6 ANAPC5 Anaphase-promoting complex subunit 5 [36] 0.86[37] 1.01[38] 1.18[39] 0.29[40] 0.25[41] 1.27[42]
7 CDC27 Cell division cycle protein 27 homolog [43] 0.20[44] 0.53[45] -0.12[46] 1.14[47] 0.18[48] 0.71[49]
8 CDC16 Cell division cycle protein 16 homolog [50] -0.51[51] -0.79[52] -1.44[53] -0.46[54] -0.52[55] 0.43[56]
9 UBE2C Ubiquitin-conjugating enzyme E2 C [57] -0.25[58] -0.38[59] 0.39[60] 0.09[61] 0.48[62] -3.24[63]
10 UBE2S Ubiquitin-conjugating enzyme E2 S [64] 0.43[65] -0.51[66] 1.68[67] 0.92[68] 1.78[69] -2.03[70]
11 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A [71] 0.58[72] 1.19[73] 0.53[74] 0.01[75] 0.62[76] -2.31[77]
12 CDC23 Cell division cycle protein 23 homolog [78] 0.36[79] 0.05[80] 0.31[81] 0.99[82] 0.20[83] 0.76[84]
13 ANAPC7 Anaphase-promoting complex subunit 7 [85] 0.99[86] 0.88[87] 0.35[88] 0.86[89] 0.61[90] 0.75[91]
14 ANAPC2 Anaphase-promoting complex subunit 2 [92] 0.59[93] -0.48[94] 0.13[95] 0.00[96] -0.54[97] 0.61[98]
15 CDC20 Cell division cycle protein 20 homolog [99] 2.34[100] 1.85[101] 2.22[102] 2.46[103] 2.61[104] -1.75[105]
16 ANAPC1 Anaphase-promoting complex subunit 1 [106] 2.40[107] 2.07[108] 1.95[109] 1.88[110] 1.40[111] 2.01[112]
17 ANAPC4 Anaphase-promoting complex subunit 4 [113] 0.18[114] 0.59[115] 0.92[116] 1.15[117] 0.12[118] 1.54[119]
18 UBE2D1 Ubiquitin-conjugating enzyme E2 D1 [120] 0.78[121] 1.14[122] 1.48[123] 1.48[124] 0.74[125] 1.06[126]
19 ANAPC10 Anaphase-promoting complex subunit 10 [127] -0.25[128] 0.13[129] -0.49[130] -0.27[131] 0.01[132] 0.68[133]
20 BUB1B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [134] 2.13[135] 2.32[136] 2.24[137] 3.02[138] 2.81[139] -1.04[140]
21 ANAPC15 Anaphase-promoting complex subunit 15 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte ANAPC11
Mean 54.5
Standard deviation 27
Values 63 82 10 54 64
[2]
HepG2 ANAPC11
Mean 33.8
Standard deviation 7.4
Values 39 29
[3]
HepG2.C3A ANAPC11
Mean 40.9
Standard deviation 8.3
Values 35 47
[4]
HuH.7 ANAPC11
Mean 29.3
Standard deviation 14
Values 30 15 43
[5]
SNU475 ANAPC11
Mean 20.1
Standard deviation 5.4
Values 24 16
[6]
THLE ANAPC11
Mean 29.3
Standard deviation 0.86
Values 30 29
[7]
liver ANAPC11
Mean 29.4
Standard deviation 28
Values 60 5.9 47 5.7
[8]
ref_hepatocyte CDC26
Mean 30
Standard deviation 5.8
Values 24 31 34 37 24
[9]
HepG2 CDC26
Mean 9.65
Standard deviation 1.5
Values 8.6 11
[10]
HepG2.C3A CDC26
Mean 12
Standard deviation 3.9
Values 9.2 15
[11]
HuH.7 CDC26
Mean 11.2
Standard deviation 1.9
Values 10 10 13
[12]
SNU475 CDC26
Mean 6.75
Standard deviation 0.98
Values 7.4 6.1
[13]
THLE CDC26
Mean 14
Standard deviation 0.81
Values 13 15
[14]
liver CDC26
Mean 9.23
Standard deviation 6.7
Values 14 4.5 15 2.6
[15]
ref_hepatocyte UBE2E1
Mean 24.2
Standard deviation 20
Values 24 60 11 13 14
[16]
HepG2 UBE2E1
Mean 27.5
Standard deviation 0.51
Values 28 27
[17]
HepG2.C3A UBE2E1
Mean 29
Standard deviation 6
Values 25 33
[18]
HuH.7 UBE2E1
Mean 45.6
Standard deviation 10
Values 42 37 57
[19]
SNU475 UBE2E1
Mean 31.8
Standard deviation 1
Values 31 33
[20]
THLE UBE2E1
Mean 42.8
Standard deviation 1.4
Values 42 44
[21]
liver UBE2E1
Mean 4.91
Standard deviation 1.6
Values 3.9 6.7 3.3 5.7
[22]
ref_hepatocyte BUB3
Mean 22.2
Standard deviation 9
Values 24 30 31 15 11
[23]
HepG2 BUB3
Mean 61
Standard deviation 9.9
Values 54 68
[24]
HepG2.C3A BUB3
Mean 100
Standard deviation 26
Values 82 1.2e+02
[25]
HuH.7 BUB3
Mean 62.7
Standard deviation 13
Values 65 48 74
[26]
SNU475 BUB3
Mean 33
Standard deviation 3.9
Values 30 36
[27]
THLE BUB3
Mean 101
Standard deviation 8.5
Values 95 1.1e+02
[28]
liver BUB3
Mean 20.9
Standard deviation 8.3
Values 25 17 30 11
[29]
ref_hepatocyte ANAPC16
Mean 18.3
Standard deviation 8.8
Values 23 15 4.6 22 27
[30]
HepG2 ANAPC16
Mean 45.9
Standard deviation 1.7
Values 47 45
[31]
HepG2.C3A ANAPC16
Mean 66.9
Standard deviation 9.3
Values 60 74
[32]
HuH.7 ANAPC16
Mean 28.7
Standard deviation 4.9
Values 27 25 34
[33]
SNU475 ANAPC16
Mean 25
Standard deviation 5
Values 29 21
[34]
THLE ANAPC16
Mean 32.9
Standard deviation 0.68
Values 32 33
[35]
liver ANAPC16
Mean 37.9
Standard deviation 22
Values 61 20 52 18
[36]
ref_hepatocyte ANAPC5
Mean 17.3
Standard deviation 3.4
Values 12 20 18 20 17
[37]
HepG2 ANAPC5
Mean 70
Standard deviation 5.4
Values 66 74
[38]
HepG2.C3A ANAPC5
Mean 99.1
Standard deviation 8.6
Values 93 1.1e+02
[39]
HuH.7 ANAPC5
Mean 106
Standard deviation 32
Values 1.2e+02 70 1.3e+02
[40]
SNU475 ANAPC5
Mean 40.1
Standard deviation 6.5
Values 45 36
[41]
THLE ANAPC5
Mean 61.8
Standard deviation 4.4
Values 59 65
[42]
liver ANAPC5
Mean 40.2
Standard deviation 5.8
Values 42 37 47 34
[43]
ref_hepatocyte CDC27
Mean 13.6
Standard deviation 15
Values 38 16 8.3 2.9 3.1
[44]
HepG2 CDC27
Mean 35
Standard deviation 19
Values 22 48
[45]
HepG2.C3A CDC27
Mean 55.7
Standard deviation 20
Values 42 70
[46]
HuH.7 CDC27
Mean 34.1
Standard deviation 3.9
Values 39 32 31
[47]
SNU475 CDC27
Mean 56.9
Standard deviation 0.87
Values 56 58
[48]
THLE CDC27
Mean 46.4
Standard deviation 3.2
Values 44 49
[49]
liver CDC27
Mean 21.5
Standard deviation 3.1
Values 20 26 20 21
[50]
ref_hepatocyte CDC16
Mean 12.3
Standard deviation 3.1
Values 8.9 13 15 15 9.1
[51]
HepG2 CDC16
Mean 19.3
Standard deviation 0.027
Values 19 19
[52]
HepG2.C3A CDC16
Mean 20.2
Standard deviation 2.9
Values 22 18
[53]
HuH.7 CDC16
Mean 12.3
Standard deviation 2
Values 11 12 15
[54]
SNU475 CDC16
Mean 16.9
Standard deviation 3.3
Values 19 15
[55]
THLE CDC16
Mean 25.8
Standard deviation 4.3
Values 23 29
[56]
liver CDC16
Mean 16
Standard deviation 5.4
Values 17 16 22 9
[57]
ref_hepatocyte UBE2C
Mean 11
Standard deviation 13
Values 28 21 2.1 1.8 1.8
[58]
HepG2 UBE2C
Mean 20.7
Standard deviation 2
Values 22 19
[59]
HepG2.C3A UBE2C
Mean 24
Standard deviation 9.1
Values 18 30
[60]
HuH.7 UBE2C
Mean 39
Standard deviation 20
Values 45 17 55
[61]
SNU475 UBE2C
Mean 22.1
Standard deviation 5.8
Values 18 26
[62]
THLE UBE2C
Mean 46
Standard deviation 12
Values 38 54
[63]
liver UBE2C
Mean 1.12
Standard deviation 1.5
Values 0.89 0.3 3.3 0.013
[64]
ref_hepatocyte UBE2S
Mean 9.88
Standard deviation 5.6
Values 4.4 13 17 11 4.4
[65]
HepG2 UBE2S
Mean 29.7
Standard deviation 11
Values 38 22
[66]
HepG2.C3A UBE2S
Mean 19.7
Standard deviation 0.91
Values 19 20
[67]
HuH.7 UBE2S
Mean 86.1
Standard deviation 32
Values 86 54 1.2e+02
[68]
SNU475 UBE2S
Mean 35.4
Standard deviation 5.6
Values 31 39
[69]
THLE UBE2S
Mean 102
Standard deviation 13
Values 92 1.1e+02
[70]
liver UBE2S
Mean 2.33
Standard deviation 0.97
Values 3.1 1.7 3.2 1.3
[71]
ref_hepatocyte MAD2L1
Mean 8.26
Standard deviation 10
Values 24 15 0.81 1.2 0.97
[72]
HepG2 MAD2L1
Mean 27.6
Standard deviation 8.8
Values 21 34
[73]
HepG2.C3A MAD2L1
Mean 53.6
Standard deviation 40
Values 25 82
[74]
HuH.7 MAD2L1
Mean 32.3
Standard deviation 14
Values 38 16 43
[75]
SNU475 MAD2L1
Mean 15.7
Standard deviation 0.83
Values 16 15
[76]
THLE MAD2L1
Mean 38.1
Standard deviation 7.7
Values 33 44
[77]
liver MAD2L1
Mean 1.6
Standard deviation 1.4
Values 1.4 1.2 3.6 0.25
[78]
ref_hepatocyte CDC23
Mean 7.24
Standard deviation 2.5
Values 8.6 11 6.9 4.9 4.9
[79]
HepG2 CDC23
Mean 20.7
Standard deviation 3.9
Values 18 24
[80]
HepG2.C3A CDC23
Mean 21.2
Standard deviation 4.4
Values 18 24
[81]
HuH.7 CDC23
Mean 24.3
Standard deviation 6
Values 26 18 29
[82]
SNU475 CDC23
Mean 27.2
Standard deviation 0.72
Values 27 28
[83]
THLE CDC23
Mean 24.9
Standard deviation 1.5
Values 24 26
[84]
liver CDC23
Mean 11.8
Standard deviation 3.1
Values 13 11 15 8
[85]
ref_hepatocyte ANAPC7
Mean 5.77
Standard deviation 1.7
Values 4.5 7.7 7.4 5.2 4
[86]
HepG2 ANAPC7
Mean 25.5
Standard deviation 4
Values 23 28
[87]
HepG2.C3A ANAPC7
Mean 30
Standard deviation 1.6
Values 29 31
[88]
HuH.7 ANAPC7
Mean 20
Standard deviation 6.2
Values 23 13 24
[89]
SNU475 ANAPC7
Mean 19.8
Standard deviation 0.8
Values 19 20
[90]
THLE ANAPC7
Mean 26.5
Standard deviation 2.3
Values 25 28
[91]
liver ANAPC7
Mean 9.34
Standard deviation 1.7
Values 9 10 11 7.1
[92]
ref_hepatocyte ANAPC2
Mean 5.57
Standard deviation 3.1
Values 1.7 3.8 5.3 7.8 9.3
[93]
HepG2 ANAPC2
Mean 18.7
Standard deviation 2.4
Values 17 20
[94]
HepG2.C3A ANAPC2
Mean 11.3
Standard deviation 0.75
Values 11 12
[95]
HuH.7 ANAPC2
Mean 16.6
Standard deviation 4.5
Values 18 12 20
[96]
SNU475 ANAPC2
Mean 10.5
Standard deviation 0.9
Values 11 9.9
[97]
THLE ANAPC2
Mean 11.5
Standard deviation 2.7
Values 9.6 13
[98]
liver ANAPC2
Mean 8.17
Standard deviation 1.9
Values 7.8 8.5 5.9 10
[99]
ref_hepatocyte CDC20
Mean 3.72
Standard deviation 3.7
Values 3.7 10 2 1.1 1.7
[100]
HepG2 CDC20
Mean 42
Standard deviation 5.7
Values 38 46
[101]
HepG2.C3A CDC20
Mean 37.9
Standard deviation 18
Values 25 51
[102]
HuH.7 CDC20
Mean 47
Standard deviation 20
Values 58 24 59
[103]
SNU475 CDC20
Mean 38.7
Standard deviation 5.5
Values 35 43
[104]
THLE CDC20
Mean 68.2
Standard deviation 16
Values 57 79
[105]
liver CDC20
Mean 1.07
Standard deviation 0.91
Values 0.99 0.83 2.3 0.15
[106]
ref_hepatocyte ANAPC1
Mean 3.66
Standard deviation 1.4
Values 5.4 4.5 3.9 2.3 2.2
[107]
HepG2 ANAPC1
Mean 42.9
Standard deviation 9.5
Values 36 50
[108]
HepG2.C3A ANAPC1
Mean 43.4
Standard deviation 8.5
Values 37 49
[109]
HuH.7 ANAPC1
Mean 38.4
Standard deviation 12
Values 51 27 38
[110]
SNU475 ANAPC1
Mean 25.5
Standard deviation 0.94
Values 26 25
[111]
THLE ANAPC1
Mean 28.9
Standard deviation 5.8
Values 25 33
[112]
liver ANAPC1
Mean 14.2
Standard deviation 7.2
Values 7.4 22 8.8 19
[113]
ref_hepatocyte ANAPC4
Mean 2.72
Standard deviation 1
Values 2.7 4.2 3 2 1.7
[114]
HepG2 ANAPC4
Mean 6.87
Standard deviation 3
Values 4.8 9
[115]
HepG2.C3A ANAPC4
Mean 11.6
Standard deviation 1.5
Values 11 13
[116]
HuH.7 ANAPC4
Mean 14
Standard deviation 1.6
Values 14 12 16
[117]
SNU475 ANAPC4
Mean 11.4
Standard deviation 1.7
Values 13 10
[118]
THLE ANAPC4
Mean 8.86
Standard deviation 1.3
Values 7.9 9.8
[119]
liver ANAPC4
Mean 7.61
Standard deviation 3
Values 11 5.6 9 4.7
[120]
ref_hepatocyte UBE2D1
Mean 2.43
Standard deviation 1.1
Values 2.2 1.2 4.1 1.7 2.8
[121]
HepG2 UBE2D1
Mean 9.29
Standard deviation 2.7
Values 7.4 11
[122]
HepG2.C3A UBE2D1
Mean 15.1
Standard deviation 2.9
Values 13 17
[123]
HuH.7 UBE2D1
Mean 18.4
Standard deviation 3.8
Values 21 14 20
[124]
SNU475 UBE2D1
Mean 12.8
Standard deviation 0.14
Values 13 13
[125]
THLE UBE2D1
Mean 12.2
Standard deviation 0.065
Values 12 12
[126]
liver UBE2D1
Mean 4.88
Standard deviation 2.6
Values 6.8 2.9 7.4 2.4
[127]
ref_hepatocyte ANAPC10
Mean 2.16
Standard deviation 0.77
Values 1.8 2 1.3 2.2 3.4
[128]
HepG2 ANAPC10
Mean 4.04
Standard deviation 0.5
Values 3.7 4.4
[129]
HepG2.C3A ANAPC10
Mean 6.67
Standard deviation 1.5
Values 5.6 7.7
[130]
HuH.7 ANAPC10
Mean 4.18
Standard deviation 0.77
Values 3.7 3.8 5.1
[131]
SNU475 ANAPC10
Mean 3.39
Standard deviation 0.1
Values 3.5 3.3
[132]
THLE ANAPC10
Mean 6.54
Standard deviation 0.14
Values 6.4 6.6
[133]
liver ANAPC10
Mean 3.33
Standard deviation 2.2
Values 5.8 1.8 4.5 1.1
[134]
ref_hepatocyte BUB1B
Mean 1.91
Standard deviation 2.1
Values 4.6 3.6 0.72 0.18 0.37
[135]
HepG2 BUB1B
Mean 18.6
Standard deviation 7.6
Values 13 24
[136]
HepG2.C3A BUB1B
Mean 27
Standard deviation 16
Values 16 38
[137]
HuH.7 BUB1B
Mean 24.4
Standard deviation 12
Values 32 11 31
[138]
SNU475 BUB1B
Mean 29.3
Standard deviation 0.28
Values 30 29
[139]
THLE BUB1B
Mean 40.1
Standard deviation 7.3
Values 35 45
[140]
liver BUB1B
Mean 0.895
Standard deviation 0.73
Values 0.56 1.4 1.6 0.026
[141]
ref_hepatocyte ANAPC15
Missing
[142]
HepG2 ANAPC15
Mean 3.23
Standard deviation 0.75
Values 2.7 3.8
[143]
HepG2.C3A ANAPC15
Mean 2.36
Standard deviation 0.71
Values 1.9 2.9
[144]
HuH.7 ANAPC15
Mean 2.08
Standard deviation 0.91
Values 2.1 1.2 3
[145]
SNU475 ANAPC15
Mean 3.3
Standard deviation 1.3
Values 4.2 2.4
[146]
THLE ANAPC15
Mean 2.63
Standard deviation 1.1
Values 1.9 3.4
[147]
liver ANAPC15
Mean 1.17
Standard deviation 0.99
Values 2.1 0.37 1.9 0.25