REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.25[1] 0.16[2] 0.07[3] 0.35[4] -0.33[5] -0.49[6]
2 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform -0.28[7] -0.10[8] -0.75[9] -0.11[10] -0.01[11] -0.74[12]
3 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform -0.94[13] -1.20[14] -1.13[15] -1.31[16] -1.42[17] -1.62[18]
4 TFDP1 Transcription factor Dp-1 [19] 0.12[20] -0.47[21] -0.42[22] -0.25[23] 0.32[24] -1.78[25]
5 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform -0.10[26] -0.54[27] -0.14[28] -0.58[29] -0.81[30] 2.30[31]
6 RB1 Retinoblastoma-associated protein [32] 0.67[33] 1.25[34] 1.80[35] 1.42[36] 1.74[37] 0.84[38]
7 E2F1 Transcription factor E2F1 [39] 1.40[40] 1.33[41] 1.45[42] 1.01[43] 1.44[44] -4.25[45]
8 POLA2 DNA polymerase alpha subunit B [46] 0.09[47] -0.19[48] 0.36[49] 0.66[50] 0.96[51] -1.47[52]
9 PRIM1 DNA primase small subunit [53] 0.12[54] 1.53[55] 1.85[56] 0.30[57] 0.89[58] -1.54[59]
10 PRIM2 DNA primase large subunit [60] 0.73[61] 0.61[62] 0.22[63] 0.32[64] 0.57[65] -2.22[66]
11 TFDP2 Transcription factor Dp-2 [67] 1.36[68] 2.13[69] 2.13[70] 1.53[71] 1.75[72] 1.72[73]
12 PPP2R3B Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [74] [75] [76] [77] [78] [79]
13 POLA1 DNA polymerase alpha catalytic subunit [80] 1.46[81] 1.65[82] 2.20[83] 2.13[84] 2.09[85] 1.04[86]
[1]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[2]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[3]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[4]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[5]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[6]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[7]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[8]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[9]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[10]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[11]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[12]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[13]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[14]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[15]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[16]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[17]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[18]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[19]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[20]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[21]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[22]
ref_hepatocyte TFDP1
Mean 14.3
Standard deviation 8.3
Values 23 24 5.8 10 9.4
[23]
HepG2 TFDP1
Mean 50.2
Standard deviation 7.6
Values 45 56
[24]
HepG2.C3A TFDP1
Mean 28.1
Standard deviation 13
Values 19 38
[25]
HuH.7 TFDP1
Mean 28.3
Standard deviation 13
Values 35 13 37
[26]
SNU475 TFDP1
Mean 40
Standard deviation 3.2
Values 42 38
[27]
THLE TFDP1
Mean 67
Standard deviation 13
Values 58 76
[28]
liver TFDP1
Mean 9.23
Standard deviation 0.4
Values 9.3 9.6 8.7 9.3
[29]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[30]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[31]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[32]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[33]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[34]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[35]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[36]
ref_hepatocyte RB1
Mean 3.07
Standard deviation 1.4
Values 5 3.8 3 1.4 2.2
[37]
HepG2 RB1
Mean 15.8
Standard deviation 7.9
Values 10 21
[38]
HepG2.C3A RB1
Mean 19.9
Standard deviation 6.1
Values 16 24
[39]
HuH.7 RB1
Mean 28.2
Standard deviation 3.3
Values 32 25 28
[40]
SNU475 RB1
Mean 27.3
Standard deviation 0.91
Values 28 27
[41]
THLE RB1
Mean 38.3
Standard deviation 1.7
Values 37 40
[42]
liver RB1
Mean 12.1
Standard deviation 2.2
Values 12 14 13 9
[43]
ref_hepatocyte E2F1
Mean 2.5
Standard deviation 3.1
Values 7.9 2.2 0.64 1.2 0.54
[44]
HepG2 E2F1
Mean 21.3
Standard deviation 1.8
Values 20 23
[45]
HepG2.C3A E2F1
Mean 17.2
Standard deviation 4.9
Values 14 21
[46]
HuH.7 E2F1
Mean 18
Standard deviation 12
Values 21 5.1 28
[47]
SNU475 E2F1
Mean 16.7
Standard deviation 4.8
Values 13 20
[48]
THLE E2F1
Mean 25.4
Standard deviation 2.4
Values 24 27
[49]
liver E2F1
Mean 0.29
Standard deviation 0.19
Values 0.12 0.49 0.41 0.15
[50]
ref_hepatocyte POLA2
Mean 2.46
Standard deviation 0.96
Values 1.8 2.8 3.9 2.3 1.5
[51]
HepG2 POLA2
Mean 8.49
Standard deviation 2.2
Values 6.9 10
[52]
HepG2.C3A POLA2
Mean 5.87
Standard deviation 3.6
Values 3.3 8.4
[53]
HuH.7 POLA2
Mean 8.32
Standard deviation 5.1
Values 11 2.5 11
[54]
SNU475 POLA2
Mean 12.9
Standard deviation 3.1
Values 11 15
[55]
THLE POLA2
Mean 17.9
Standard deviation 4
Values 15 21
[56]
liver POLA2
Mean 1.96
Standard deviation 0.6
Values 1.2 1.9 2.6 2.2
[57]
ref_hepatocyte PRIM1
Mean 2.43
Standard deviation 1.4
Values 4.4 2.6 0.57 2.6 1.9
[58]
HepG2 PRIM1
Mean 8.54
Standard deviation 0.87
Values 7.9 9.2
[59]
HepG2.C3A PRIM1
Mean 19.1
Standard deviation 8.1
Values 13 25
[60]
HuH.7 PRIM1
Mean 23.1
Standard deviation 6.2
Values 27 16 26
[61]
SNU475 PRIM1
Mean 9.98
Standard deviation 3.1
Values 7.8 12
[62]
THLE PRIM1
Mean 16.8
Standard deviation 2.1
Values 15 18
[63]
liver PRIM1
Mean 1.84
Standard deviation 0.34
Values 2.1 1.6 2.1 1.5
[64]
ref_hepatocyte PRIM2
Mean 2.32
Standard deviation 2.3
Values 6.1 2.9 0.46 1.4 0.78
[65]
HepG2 PRIM2
Mean 12.4
Standard deviation 3.6
Values 9.9 15
[66]
HepG2.C3A PRIM2
Mean 9.66
Standard deviation 4.4
Values 6.5 13
[67]
HuH.7 PRIM2
Mean 7.1
Standard deviation 1.5
Values 7.8 5.4 8.1
[68]
SNU475 PRIM2
Mean 9.65
Standard deviation 1.6
Values 8.5 11
[69]
THLE PRIM2
Mean 12.8
Standard deviation 1.5
Values 12 14
[70]
liver PRIM2
Mean 1.1
Standard deviation 0.41
Values 0.68 1.5 0.82 1.4
[71]
ref_hepatocyte TFDP2
Mean 1.97
Standard deviation 0.83
Values 3.4 2.1 1.3 1.4 1.7
[72]
HepG2 TFDP2
Mean 16.3
Standard deviation 2.5
Values 15 18
[73]
HepG2.C3A TFDP2
Mean 23.5
Standard deviation 2.1
Values 22 25
[74]
HuH.7 TFDP2
Mean 22.8
Standard deviation 3.1
Values 26 20 22
[75]
SNU475 TFDP2
Mean 18.9
Standard deviation 4.1
Values 22 16
[76]
THLE TFDP2
Mean 24.9
Standard deviation 1.2
Values 24 26
[77]
liver TFDP2
Mean 14.3
Standard deviation 3.4
Values 17 14 9.6 16
[78]
ref_hepatocyte PPP2R3B
Mean 1.4
Standard deviation 0.74
Values 2.3 0.82 2.1 0.99 0.8
[79]
HepG2 PPP2R3B
Missing
[80]
HepG2.C3A PPP2R3B
Missing
[81]
HuH.7 PPP2R3B
Missing
[82]
SNU475 PPP2R3B
Missing
[83]
THLE PPP2R3B
Missing
[84]
liver PPP2R3B
Missing
[85]
ref_hepatocyte POLA1
Mean 0.985
Standard deviation 0.81
Values 1.8 2 0.27 0.52 0.41
[86]
HepG2 POLA1
Mean 8.75
Standard deviation 4.7
Values 5.4 12
[87]
HepG2.C3A POLA1
Mean 8.42
Standard deviation 3.5
Values 5.9 11
[88]
HuH.7 POLA1
Mean 11.9
Standard deviation 5.3
Values 17 6.3 13
[89]
SNU475 POLA1
Mean 14.3
Standard deviation 5.6
Values 10 18
[90]
THLE POLA1
Mean 15.7
Standard deviation 1.1
Values 15 17
[91]
liver POLA1
Mean 4.45
Standard deviation 2.4
Values 1.9 7.6 3.5 4.8