REACTOME_INFLAMMASOMES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TXN Thioredoxin [1] -2.52[2] -2.41[3] -2.62[4] -1.57[5] -1.82[6] -1.51[7]
2 HSP90AB1 Heat shock protein HSP 90-beta [8] 0.63[9] 0.77[10] 0.23[11] 0.35[12] -0.07[13] -0.35[14]
3 APP Amyloid-beta A4 protein [15] 0.78[16] 0.28[17] 1.20[18] 1.68[19] 2.28[20] 1.89[21]
4 HMOX1 Heme oxygenase 1 [22] -0.08[23] -0.96[24] -1.81[25] -0.70[26] -0.74[27] -0.33[28]
5 BCL2L1 Bcl-2-like protein 1 [29] 2.54[30] 1.97[31] 3.20[32] 0.28[33] 0.87[34] 0.93[35]
6 SUGT1 Protein SGT1 homolog [36] -1.21[37] -0.68[38] -0.27[39] -0.51[40] -0.39[41] -0.19[42]
7 NFKB2 Nuclear factor NF-kappa-B p100 subunit [43] -0.37[44] -0.02[45] 0.69[46] -0.48[47] 0.57[48] -1.27[49]
8 RELA Transcription factor p65 [50] 0.53[51] 0.08[52] 0.48[53] 0.84[54] 0.95[55] 0.87[56]
9 TXNIP Thioredoxin-interacting protein [57] 1.26[58] 2.02[59] 2.90[60] 3.24[61] 3.45[62] 4.29[63]
10 PANX1 Pannexin-1 [64] 0.02[65] -0.78[66] -1.37[67] 0.27[68] 0.85[69] 1.26[70]
11 NFKB1 Nuclear factor NF-kappa-B p105 subunit [71] 1.07[72] 0.79[73] 0.85[74] 0.65[75] 1.76[76] 2.20[77]
12 CASP1 Caspase-1 [78] -2.63[79] -5.99[80] -4.19[81] 0.98[82] 1.33[83] 1.02[84]
13 PYCARD Apoptosis-associated speck-like protein containing a CARD [85] 0.46[86] 0.69[87] -8.10[88] -7.34[89] 1.43[90] 0.92[91]
14 P2RX7 P2X purinoceptor 7 [92] -4.48[93] -1.15[94] -5.47[95] -4.46[96] 0.92[97] 2.86[98]
15 MEFV Pyrin [99] -0.55[100] 0.33[101] 0.05[102] 0.27[103] 0.42[104] 3.00[105]
16 NLRP1 NACHT, LRR and PYD domains-containing protein 1 [106] 0.48[107] -2.72[108] 6.12[109] 0.27[110] 5.19[111] 5.10[112]
17 PSTPIP1 Proline-serine-threonine phosphatase-interacting protein 1 [113] 0.63[114] 2.41[115] [116] -3.39[117] 1.46[118] 2.43[119]
18 NLRC4 NLR family CARD domain-containing protein 4 [120] -0.46[121] 2.41[122] 2.01[123] 1.84[124] 1.00[125] 4.79[126]
19 NLRP3 NACHT, LRR and PYD domains-containing protein 3 [127] -3.23[128] -0.95[129] -2.48[130] -0.49[131] 2.19[132] 3.34[133]
20 BCL2 Apoptosis regulator Bcl-2 [134] -2.46[135] 3.00[136] -4.14[137] 2.67[138] 2.58[139] 4.98[140]
21 AIM2 Interferon-inducible protein AIM2 [141] [142] [143] [144] 3.09[145] 1.69[146] 3.73[147]
[1]
ref_hepatocyte TXN
Mean 524
Standard deviation 4.3e+02
Values 6.9e+02 1.2e+03 2.7e+02 2.4e+02 2e+02
[2]
HepG2 TXN
Mean 153
Standard deviation 27
Values 1.7e+02 1.3e+02
[3]
HepG2.C3A TXN
Mean 142
Standard deviation 55
Values 1e+02 1.8e+02
[4]
HuH.7 TXN
Mean 98.2
Standard deviation 36
Values 91 67 1.4e+02
[5]
SNU475 TXN
Mean 174
Standard deviation 25
Values 1.9e+02 1.6e+02
[6]
THLE TXN
Mean 143
Standard deviation 0.49
Values 1.4e+02 1.4e+02
[7]
liver TXN
Mean 77.5
Standard deviation 77
Values 1.5e+02 16 1.3e+02 7.5
[8]
ref_hepatocyte HSP90AB1
Mean 469
Standard deviation 3.2e+02
Values 8.1e+02 7.8e+02 4e+02 2.1e+02 1.4e+02
[9]
HepG2 HSP90AB1
Mean 1.22e+03
Standard deviation 89
Values 1.2e+03 1.3e+03
[10]
HepG2.C3A HSP90AB1
Mean 1.16e+03
Standard deviation 1.2e+02
Values 1.2e+03 1.1e+03
[11]
HuH.7 HSP90AB1
Mean 634
Standard deviation 9.5
Values 6.3e+02 6.2e+02 6.4e+02
[12]
SNU475 HSP90AB1
Mean 591
Standard deviation 65
Values 5.4e+02 6.4e+02
[13]
THLE HSP90AB1
Mean 431
Standard deviation 80
Values 3.7e+02 4.9e+02
[14]
liver HSP90AB1
Mean 156
Standard deviation 26
Values 1.5e+02 1.4e+02 1.9e+02 1.3e+02
[15]
ref_hepatocyte APP
Mean 58.3
Standard deviation 28
Values 31 1e+02 46 51 59
[16]
HepG2 APP
Mean 167
Standard deviation 49
Values 2e+02 1.3e+02
[17]
HepG2.C3A APP
Mean 102
Standard deviation 27
Values 1.2e+02 83
[18]
HuH.7 APP
Mean 154
Standard deviation 13
Values 1.6e+02 1.7e+02 1.4e+02
[19]
SNU475 APP
Mean 184
Standard deviation 28
Values 2e+02 1.6e+02
[20]
THLE APP
Mean 273
Standard deviation 68
Values 2.3e+02 3.2e+02
[21]
liver APP
Mean 91
Standard deviation 73
Values 32 1.7e+02 28 1.3e+02
[22]
ref_hepatocyte HMOX1
Mean 45.4
Standard deviation 44
Values 19 4.5 1.2e+02 47 37
[23]
HepG2 HMOX1
Mean 71.8
Standard deviation 29
Values 92 52
[24]
HepG2.C3A HMOX1
Mean 33.6
Standard deviation 4.7
Values 30 37
[25]
HuH.7 HMOX1
Mean 14.9
Standard deviation 6.3
Values 10 22 12
[26]
SNU475 HMOX1
Mean 27.6
Standard deviation 4.6
Values 24 31
[27]
THLE HMOX1
Mean 26.2
Standard deviation 9.7
Values 19 33
[28]
liver HMOX1
Mean 15.2
Standard deviation 2.1
Values 16 13 18 15
[29]
ref_hepatocyte BCL2L1
Mean 26.8
Standard deviation 12
Values 16 44 34 23 16
[30]
HepG2 BCL2L1
Mean 260
Standard deviation 56
Values 3e+02 2.2e+02
[31]
HepG2.C3A BCL2L1
Mean 152
Standard deviation 4.3
Values 1.5e+02 1.5e+02
[32]
HuH.7 BCL2L1
Mean 283
Standard deviation 60
Values 3.1e+02 2.1e+02 3.2e+02
[33]
SNU475 BCL2L1
Mean 32.1
Standard deviation 4.1
Values 29 35
[34]
THLE BCL2L1
Mean 47
Standard deviation 4.7
Values 44 50
[35]
liver BCL2L1
Mean 21.6
Standard deviation 11
Values 31 9.8 31 14
[36]
ref_hepatocyte SUGT1
Mean 24.1
Standard deviation 16
Values 25 52 17 15 12
[37]
HepG2 SUGT1
Mean 17.5
Standard deviation 5.9
Values 13 22
[38]
HepG2.C3A SUGT1
Mean 21.7
Standard deviation 4.7
Values 18 25
[39]
HuH.7 SUGT1
Mean 23
Standard deviation 0.71
Values 22 23 24
[40]
SNU475 SUGT1
Mean 16.7
Standard deviation 0.19
Values 17 17
[41]
THLE SUGT1
Mean 17.8
Standard deviation 1.7
Values 17 19
[42]
liver SUGT1
Mean 8.95
Standard deviation 4
Values 13 6.1 12 5
[43]
ref_hepatocyte NFKB2
Mean 16.8
Standard deviation 20
Values 3.6 24 49 4.1 3
[44]
HepG2 NFKB2
Mean 21.8
Standard deviation 8.1
Values 28 16
[45]
HepG2.C3A NFKB2
Mean 23.9
Standard deviation 12
Values 32 16
[46]
HuH.7 NFKB2
Mean 31.3
Standard deviation 3.8
Values 29 36 29
[47]
SNU475 NFKB2
Mean 11.9
Standard deviation 3
Values 9.7 14
[48]
THLE NFKB2
Mean 24
Standard deviation 2.2
Values 22 26
[49]
liver NFKB2
Mean 2.95
Standard deviation 1.2
Values 2.1 3.3 1.8 4.5
[50]
ref_hepatocyte RELA
Mean 16
Standard deviation 11
Values 9.8 12 35 15 8.1
[51]
HepG2 RELA
Mean 38.7
Standard deviation 4.7
Values 42 35
[52]
HepG2.C3A RELA
Mean 24.3
Standard deviation 6.4
Values 29 20
[53]
HuH.7 RELA
Mean 25.6
Standard deviation 2.6
Values 29 25 23
[54]
SNU475 RELA
Mean 28.2
Standard deviation 0.33
Values 28 28
[55]
THLE RELA
Mean 29.7
Standard deviation 4
Values 27 32
[56]
liver RELA
Mean 12.3
Standard deviation 8.7
Values 19 4.1 20 5.7
[57]
ref_hepatocyte TXNIP
Mean 11
Standard deviation 11
Values 6.2 1.1 4.9 29 13
[58]
HepG2 TXNIP
Mean 44
Standard deviation 36
Values 69 19
[59]
HepG2.C3A TXNIP
Mean 64.3
Standard deviation 30
Values 85 43
[60]
HuH.7 TXNIP
Mean 94.3
Standard deviation 8.4
Values 86 1e+02 94
[61]
SNU475 TXNIP
Mean 102
Standard deviation 25
Values 84 1.2e+02
[62]
THLE TXNIP
Mean 115
Standard deviation 45
Values 1.5e+02 83
[63]
liver TXNIP
Mean 90.5
Standard deviation 29
Values 1.2e+02 66 65 1.1e+02
[64]
ref_hepatocyte PANX1
Mean 7.99
Standard deviation 5.8
Values 5.7 12 16 3.7 2.6
[65]
HepG2 PANX1
Mean 13.6
Standard deviation 2.4
Values 12 15
[66]
HepG2.C3A PANX1
Mean 6.72
Standard deviation 2.2
Values 5.2 8.3
[67]
HuH.7 PANX1
Mean 3.55
Standard deviation 0.36
Values 3.8 3.7 3.1
[68]
SNU475 PANX1
Mean 9.5
Standard deviation 0.8
Values 8.9 10
[69]
THLE PANX1
Mean 13.8
Standard deviation 3.4
Values 11 16
[70]
liver PANX1
Mean 8.07
Standard deviation 2.2
Values 8.2 11 5.6 7.5
[71]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 3 6.7 12 5.3 4.7
[72]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 18 26
[73]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 15 17
[74]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 14 12 13
[75]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 9.6 10
[76]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[77]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 9.7 15 7.2 17
[78]
ref_hepatocyte CASP1
Mean 3.66
Standard deviation 3.7
Values 0.5 9.1 0.076 3.7 4.9
[79]
HepG2 CASP1
Mean 0.987
Standard deviation 0.74
Values 0.46 1.5
[80]
HepG2.C3A CASP1
Mean 0.0833
Standard deviation 0.049
Values 0.049 0.12
[81]
HuH.7 CASP1
Mean 0.231
Standard deviation 0.041
Values 0.19 0.27 0.23
[82]
SNU475 CASP1
Mean 7.12
Standard deviation 0.23
Values 7.3 6.9
[83]
THLE CASP1
Mean 8.87
Standard deviation 1.2
Values 9.7 8
[84]
liver CASP1
Mean 3.13
Standard deviation 0.99
Values 3.7 2.6 4.2 2
[85]
ref_hepatocyte PYCARD
Mean 2.47
Standard deviation 1.8
Values 0.17 2 2.3 2.7 5.2
[86]
HepG2 PYCARD
Mean 5.68
Standard deviation 3.5
Values 8.1 3.2
[87]
HepG2.C3A PYCARD
Mean 5.76
Standard deviation 0.0033
Values 5.8 5.8
[88]
HuH.7 PYCARD
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[89]
SNU475 PYCARD
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[90]
THLE PYCARD
Mean 6.42
Standard deviation 0.22
Values 6.3 6.6
[91]
liver PYCARD
Mean 1.97
Standard deviation 1.2
Values 3.3 0.9 2.7 0.99
[92]
ref_hepatocyte P2RX7
Mean 0.791
Standard deviation 1
Values 0.038 0.61 2.6 0.16 0.55
[93]
HepG2 P2RX7
Mean 0.0594
Standard deviation 0.029
Values 0.08 0.039
[94]
HepG2.C3A P2RX7
Mean 0.516
Standard deviation 0.27
Values 0.71 0.32
[95]
HuH.7 P2RX7
Mean 0.0205
Standard deviation 0.023
Values 0.0082 0.0064 0.047
[96]
SNU475 P2RX7
Mean 0.0353
Standard deviation 0.043
Values 0.0046 0.066
[97]
THLE P2RX7
Mean 1.45
Standard deviation 0.57
Values 1.9 1
[98]
liver P2RX7
Mean 2.43
Standard deviation 0.35
Values 2.6 2.6 2.6 1.9
[99]
ref_hepatocyte MEFV
Mean 0.361
Standard deviation 0.42
Values 1.1 0 0.4 0.1 0.25
[100]
HepG2 MEFV
Mean 0.414
Standard deviation 0.039
Values 0.44 0.39
[101]
HepG2.C3A MEFV
Mean 0.653
Standard deviation 0.17
Values 0.53 0.77
[102]
HuH.7 MEFV
Mean 0.43
Standard deviation 0.13
Values 0.39 0.58 0.32
[103]
SNU475 MEFV
Mean 0.429
Standard deviation 0.003
Values 0.43 0.43
[104]
THLE MEFV
Mean 0.467
Standard deviation 0.043
Values 0.5 0.44
[105]
liver MEFV
Mean 1.22
Standard deviation 1.1
Values 0.38 1.5 0.33 2.7
[106]
ref_hepatocyte NLRP1
Mean 0.279
Standard deviation 0.28
Values 0.024 0.07 0.3 0.28 0.72
[107]
HepG2 NLRP1
Mean 0.653
Standard deviation 0.34
Values 0.89 0.41
[108]
HepG2.C3A NLRP1
Mean 0.0613
Standard deviation 0.0043
Values 0.058 0.064
[109]
HuH.7 NLRP1
Mean 22.4
Standard deviation 0.9
Values 21 23 23
[110]
SNU475 NLRP1
Mean 0.332
Standard deviation 0.15
Values 0.22 0.44
[111]
THLE NLRP1
Mean 9.83
Standard deviation 0.37
Values 10 9.6
[112]
liver NLRP1
Mean 4.04
Standard deviation 0.2
Values 3.8 4 4.2 4.2
[113]
ref_hepatocyte PSTPIP1
Mean 0.267
Standard deviation 0.16
Values 0.32 0 0.45 0.3 0.27
[114]
HepG2 PSTPIP1
Mean 0.695
Standard deviation 0.03
Values 0.72 0.67
[115]
HepG2.C3A PSTPIP1
Mean 2.05
Standard deviation 0.68
Values 2.5 1.6
[116]
HuH.7 PSTPIP1
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 PSTPIP1
Mean 0.0251
Standard deviation 0.029
Values 0.0046 0.046
[118]
THLE PSTPIP1
Mean 0.707
Standard deviation 0.26
Values 0.53 0.89
[119]
liver PSTPIP1
Mean 0.607
Standard deviation 0.18
Values 0.52 0.47 0.57 0.87
[120]
ref_hepatocyte NLRC4
Mean 0.121
Standard deviation 0.1
Values 0.073 0 0.18 0.086 0.27
[121]
HepG2 NLRC4
Mean 0.147
Standard deviation 0.044
Values 0.18 0.12
[122]
HepG2.C3A NLRC4
Mean 0.925
Standard deviation 0.25
Values 1.1 0.75
[123]
HuH.7 NLRC4
Mean 0.559
Standard deviation 0.068
Values 0.52 0.51 0.64
[124]
SNU475 NLRC4
Mean 0.426
Standard deviation 0.21
Values 0.28 0.57
[125]
THLE NLRC4
Mean 0.233
Standard deviation 0.097
Values 0.3 0.16
[126]
liver NLRC4
Mean 1.41
Standard deviation 0.51
Values 1.1 1.9 0.85 1.8
[127]
ref_hepatocyte NLRP3
Mean 0.117
Standard deviation 0.12
Values 0 0.11 0 0.28 0.19
[128]
HepG2 NLRP3
Mean 0.0207
Standard deviation 0.013
Values 0.011 0.03
[129]
HepG2.C3A NLRP3
Mean 0.0871
Standard deviation 0.013
Values 0.078 0.097
[130]
HuH.7 NLRP3
Mean 0.024
Standard deviation 0.036
Values 0 0.0064 0.066
[131]
SNU475 NLRP3
Mean 0.0819
Standard deviation 0.063
Values 0.037 0.13
[132]
THLE NLRP3
Mean 0.513
Standard deviation 0.15
Values 0.62 0.4
[133]
liver NLRP3
Mean 0.499
Standard deviation 0.28
Values 0.19 0.84 0.39 0.58
[134]
ref_hepatocyte BCL2
Mean 0.0984
Standard deviation 0.087
Values 0.019 0 0.15 0.12 0.2
[135]
HepG2 BCL2
Mean 0.0301
Standard deviation 0.0061
Values 0.034 0.026
[136]
HepG2.C3A BCL2
Mean 1.13
Standard deviation 0.21
Values 1.3 0.99
[137]
HuH.7 BCL2
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[138]
SNU475 BCL2
Mean 0.618
Standard deviation 0.094
Values 0.55 0.68
[139]
THLE BCL2
Mean 0.568
Standard deviation 0.0088
Values 0.56 0.57
[140]
liver BCL2
Mean 1.31
Standard deviation 1
Values 0.49 1.8 0.49 2.5
[141]
ref_hepatocyte AIM2
Mean 0.0325
Standard deviation 0.073
Values 0 0 0 0 0.16
[142]
HepG2 AIM2
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A AIM2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 AIM2
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 AIM2
Mean 0.272
Standard deviation 0.19
Values 0.14 0.41
[146]
THLE AIM2
Mean 0.101
Standard deviation 0.016
Values 0.11 0.09
[147]
liver AIM2
Mean 0.182
Standard deviation 0.051
Values 0.19 0.24 0.18 0.12