REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SEC11C Signal peptidase complex catalytic subunit SEC11C [1] -3.70[2] -1.78[3] -4.36[4] -3.64[5] -4.83[6] -1.32[7]
2 SEC11A Signal peptidase complex catalytic subunit SEC11A [8] -1.30[9] -0.97[10] -1.18[11] -1.12[12] -1.52[13] -2.05[14]
3 SPCS1 Signal peptidase complex subunit 1 [15] -1.81[16] -2.07[17] -3.20[18] -2.34[19] -1.76[20] -0.69[21]
4 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [22] 1.43[23] 1.21[24] 0.49[25] 1.97[26] 1.62[27] -0.53[28]
5 CTNNB1 Catenin beta-1 [29] 2.03[30] 1.29[31] 1.95[32] 1.44[33] 1.53[34] 1.81[35]
6 SPCS2 Signal peptidase complex subunit 2 [36] 0.77[37] 0.49[38] -0.43[39] 0.57[40] 0.42[41] 1.08[42]
7 SPCS3 Signal peptidase complex subunit 3 [43] 0.29[44] 1.03[45] 1.32[46] 1.19[47] 1.38[48] 1.79[49]
8 DPP4 Dipeptidyl peptidase 4 [50] 0.36[51] 1.64[52] 1.42[53] -0.32[54] 0.78[55] 0.14[56]
9 GATA4 Transcription factor GATA-4 [57] 1.20[58] 0.91[59] 2.09[60] -0.54[61] 2.26[62] 1.29[63]
10 TCF7L2 Transcription factor 7-like 2 [64] 1.28[65] 1.81[66] 1.78[67] 1.38[68] 1.22[69] 2.43[70]
11 PAX6 Paired box protein Pax-6 [71] 6.08[72] 4.18[73] 5.61[74] 5.44[75] 2.14[76] 3.07[77]
12 GPR119 Glucose-dependent insulinotropic receptor [78] 0.49[79] 2.39[80] -1.59[81] [82] [83] [84]
13 GNB3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [85] 2.00[86] 4.02[87] 3.08[88] 1.69[89] 4.27[90] -0.98[91]
14 PCSK1 Neuroendocrine convertase 1 [92] -2.96[93] 0.44[94] 0.39[95] 5.00[96] 6.65[97] 5.91[98]
15 LEP Leptin [99] -0.92[100] -0.17[101] -0.95[102] -0.17[103] -1.63[104] 3.01[105]
16 CDX2 Homeobox protein CDX-2 [106] 3.15[107] 2.53[108] 11.72[109] 2.18[110] 1.26[111] -0.62[112]
17 GNAT3 Guanine nucleotide-binding protein G(t) subunit alpha-3 [113] [114] [115] [116] [117] [118] [119]
18 FFAR1 Free fatty acid receptor 1 [120] [121] [122] [123] [124] [125] [126]
19 GIP Gastric inhibitory polypeptide [127] [128] [129] [130] [131] [132] [133]
20 GRP Gastrin-releasing peptide [134] [135] [136] [137] [138] [139] [140]
21 ISL1 Insulin gene enhancer protein ISL-1 [141] [142] [143] [144] [145] [146] [147]
22 GCG Glucagon [148] [149] [150] [151] [152] [153] [154]
23 GNG13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [155] [156] [157] [158] [159] [160]
24 FFAR4 Free fatty acid receptor 4 [161] [162] [163] [164] [165] [166] [167]
[1]
ref_hepatocyte SEC11C
Mean 123
Standard deviation 68
Values 1.8e+02 82 36 2e+02 1.1e+02
[2]
HepG2 SEC11C
Mean 15.7
Standard deviation 7
Values 11 21
[3]
HepG2.C3A SEC11C
Mean 61.9
Standard deviation 9.3
Values 55 69
[4]
HuH.7 SEC11C
Mean 11.7
Standard deviation 0.95
Values 11 12 12
[5]
SNU475 SEC11C
Mean 11.3
Standard deviation 0.13
Values 11 11
[6]
THLE SEC11C
Mean 6.07
Standard deviation 1.5
Values 5 7.1
[7]
liver SEC11C
Mean 43
Standard deviation 37
Values 57 12 88 15
[8]
ref_hepatocyte SEC11A
Mean 93.2
Standard deviation 63
Values 1.8e+02 1.4e+02 33 63 51
[9]
HepG2 SEC11A
Mean 63
Standard deviation 4.4
Values 60 66
[10]
HepG2.C3A SEC11A
Mean 82.3
Standard deviation 6.8
Values 87 77
[11]
HuH.7 SEC11A
Mean 81
Standard deviation 11
Values 69 90 84
[12]
SNU475 SEC11A
Mean 48.9
Standard deviation 4.9
Values 52 45
[13]
THLE SEC11A
Mean 45.9
Standard deviation 8.2
Values 40 52
[14]
liver SEC11A
Mean 19.7
Standard deviation 6.9
Values 27 15 24 13
[15]
ref_hepatocyte SPCS1
Mean 80.6
Standard deviation 34
Values 1.1e+02 1.1e+02 27 67 92
[16]
HepG2 SPCS1
Mean 38
Standard deviation 2.5
Values 36 40
[17]
HepG2.C3A SPCS1
Mean 33.4
Standard deviation 3.4
Values 31 36
[18]
HuH.7 SPCS1
Mean 17.2
Standard deviation 3.4
Values 17 14 20
[19]
SNU475 SPCS1
Mean 18.1
Standard deviation 0.47
Values 18 18
[20]
THLE SPCS1
Mean 33.7
Standard deviation 6.1
Values 29 38
[21]
liver SPCS1
Mean 43.7
Standard deviation 42
Values 81 8.3 79 7.2
[22]
ref_hepatocyte GNB1
Mean 42.7
Standard deviation 15
Values 44 60 53 31 24
[23]
HepG2 GNB1
Mean 190
Standard deviation 15
Values 2e+02 1.8e+02
[24]
HepG2.C3A GNB1
Mean 171
Standard deviation 4.5
Values 1.7e+02 1.7e+02
[25]
HuH.7 GNB1
Mean 118
Standard deviation 23
Values 1.4e+02 93 1.2e+02
[26]
SNU475 GNB1
Mean 191
Standard deviation 19
Values 2e+02 1.8e+02
[27]
THLE GNB1
Mean 185
Standard deviation 12
Values 1.8e+02 1.9e+02
[28]
liver GNB1
Mean 25.7
Standard deviation 5
Values 31 25 19 27
[29]
ref_hepatocyte CTNNB1
Mean 37.2
Standard deviation 16
Values 57 53 22 23 31
[30]
HepG2 CTNNB1
Mean 252
Standard deviation 27
Values 2.3e+02 2.7e+02
[31]
HepG2.C3A CTNNB1
Mean 158
Standard deviation 34
Values 1.3e+02 1.8e+02
[32]
HuH.7 CTNNB1
Mean 282
Standard deviation 64
Values 3.3e+02 2.1e+02 3.1e+02
[33]
SNU475 CTNNB1
Mean 115
Standard deviation 10
Values 1.2e+02 1.1e+02
[34]
THLE CTNNB1
Mean 151
Standard deviation 19
Values 1.4e+02 1.6e+02
[35]
liver CTNNB1
Mean 114
Standard deviation 15
Values 98 1.3e+02 1.2e+02 1.1e+02
[36]
ref_hepatocyte SPCS2
Mean 21
Standard deviation 13
Values 15 9.9 9.3 33 38
[37]
HepG2 SPCS2
Mean 59.3
Standard deviation 8.6
Values 53 65
[38]
HepG2.C3A SPCS2
Mean 51.1
Standard deviation 0.48
Values 51 51
[39]
HuH.7 SPCS2
Mean 30.6
Standard deviation 2
Values 29 30 33
[40]
SNU475 SPCS2
Mean 35.4
Standard deviation 6
Values 40 31
[41]
THLE SPCS2
Mean 39.6
Standard deviation 3.9
Values 37 42
[42]
liver SPCS2
Mean 38.6
Standard deviation 36
Values 56 9.1 81 8.2
[43]
ref_hepatocyte SPCS3
Mean 20.8
Standard deviation 14
Values 37 34 5.4 12 15
[44]
HepG2 SPCS3
Mean 42.3
Standard deviation 7
Values 37 47
[45]
HepG2.C3A SPCS3
Mean 73.6
Standard deviation 12
Values 65 82
[46]
HuH.7 SPCS3
Mean 102
Standard deviation 15
Values 1.1e+02 85 1.1e+02
[47]
SNU475 SPCS3
Mean 54.2
Standard deviation 18
Values 67 41
[48]
THLE SPCS3
Mean 76.2
Standard deviation 2.2
Values 75 78
[49]
liver SPCS3
Mean 62.6
Standard deviation 25
Values 35 95 53 67
[50]
ref_hepatocyte DPP4
Mean 19.8
Standard deviation 30
Values 74 7.8 4.1 4.3 9
[51]
HepG2 DPP4
Mean 42.3
Standard deviation 17
Values 31 54
[52]
HepG2.C3A DPP4
Mean 107
Standard deviation 2.2
Values 1.1e+02 1.1e+02
[53]
HuH.7 DPP4
Mean 105
Standard deviation 6.7
Values 1.1e+02 1e+02 1e+02
[54]
SNU475 DPP4
Mean 18.1
Standard deviation 4.2
Values 15 21
[55]
THLE DPP4
Mean 48.1
Standard deviation 14
Values 38 58
[56]
liver DPP4
Mean 19.1
Standard deviation 2.2
Values 22 17 18 19
[57]
ref_hepatocyte GATA4
Mean 3.97
Standard deviation 2.3
Values 6.3 1 2.3 6 4.3
[58]
HepG2 GATA4
Mean 15.1
Standard deviation 1.5
Values 14 16
[59]
HepG2.C3A GATA4
Mean 12.9
Standard deviation 0.72
Values 13 12
[60]
HuH.7 GATA4
Mean 33.3
Standard deviation 6.5
Values 30 41 29
[61]
SNU475 GATA4
Mean 3.13
Standard deviation 0.12
Values 3.2 3
[62]
THLE GATA4
Mean 26.9
Standard deviation 1.1
Values 26 28
[63]
liver GATA4
Mean 8.47
Standard deviation 2.5
Values 12 6.8 9.2 6.2
[64]
ref_hepatocyte TCF7L2
Mean 2.36
Standard deviation 1.2
Values 1.7 1.3 4.4 1.9 2.5
[65]
HepG2 TCF7L2
Mean 9.52
Standard deviation 1.6
Values 11 8.4
[66]
HepG2.C3A TCF7L2
Mean 14.4
Standard deviation 3.4
Values 17 12
[67]
HuH.7 TCF7L2
Mean 15.9
Standard deviation 1.6
Values 18 16 15
[68]
SNU475 TCF7L2
Mean 7.02
Standard deviation 1.3
Values 7.9 6.1
[69]
THLE TCF7L2
Mean 7.78
Standard deviation 0.97
Values 7.1 8.5
[70]
liver TCF7L2
Mean 11.1
Standard deviation 8.5
Values 21 3.4 14 5
[71]
ref_hepatocyte PAX6
Mean 0.0716
Standard deviation 0.088
Values 0 0 0.052 0.095 0.21
[72]
HepG2 PAX6
Mean 8.03
Standard deviation 2.9
Values 10 6
[73]
HepG2.C3A PAX6
Mean 2.25
Standard deviation 0.65
Values 2.7 1.8
[74]
HuH.7 PAX6
Mean 6.86
Standard deviation 0.41
Values 7.3 6.8 6.5
[75]
SNU475 PAX6
Mean 3.54
Standard deviation 0.9
Values 2.9 4.2
[76]
THLE PAX6
Mean 0.444
Standard deviation 0.12
Values 0.53 0.36
[77]
liver PAX6
Mean 0.523
Standard deviation 0.14
Values 0.73 0.4 0.46 0.5
[78]
ref_hepatocyte GPR119
Mean 0.0598
Standard deviation 0.13
Values 0.3 0 0 0 0
[79]
HepG2 GPR119
Mean 0.139
Standard deviation 0.034
Values 0.11 0.16
[80]
HepG2.C3A GPR119
Mean 0.544
Standard deviation 0.25
Values 0.37 0.72
[81]
HuH.7 GPR119
Mean 0.0391
Standard deviation 0.039
Values 0.025 0.083 0.0094
[82]
SNU475 GPR119
Mean 0
Standard deviation 0
Values 0 0
[83]
THLE GPR119
Mean 0
Standard deviation 0
Values 0 0
[84]
liver GPR119
Mean 0
Standard deviation 0
Values 0 0 0 0
[85]
ref_hepatocyte GNB3
Mean 0.0571
Standard deviation 0.11
Values 0.24 0 0 0 0.041
[86]
HepG2 GNB3
Mean 0.379
Standard deviation 0.11
Values 0.3 0.45
[87]
HepG2.C3A GNB3
Mean 1.61
Standard deviation 0.27
Values 1.4 1.8
[88]
HuH.7 GNB3
Mean 0.95
Standard deviation 0.47
Values 0.98 0.47 1.4
[89]
SNU475 GNB3
Mean 0.211
Standard deviation 0.003
Values 0.21 0.21
[90]
THLE GNB3
Mean 1.55
Standard deviation 0.56
Values 1.9 1.1
[91]
liver GNB3
Mean 0.0253
Standard deviation 0.019
Values 0.047 0.029 0.026 0
[92]
ref_hepatocyte PCSK1
Mean 0.0201
Standard deviation 0.045
Values 0 0 0.1 0 0
[93]
HepG2 PCSK1
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[94]
HepG2.C3A PCSK1
Mean 0.0473
Standard deviation 0.039
Values 0.019 0.075
[95]
HuH.7 PCSK1
Mean 0.0518
Standard deviation 0.022
Values 0.041 0.077 0.037
[96]
SNU475 PCSK1
Mean 0.734
Standard deviation 0.56
Values 0.34 1.1
[97]
THLE PCSK1
Mean 2.86
Standard deviation 0.33
Values 3.1 2.6
[98]
liver PCSK1
Mean 1.05
Standard deviation 1
Values 0.24 2.2 0.1 1.7
[99]
ref_hepatocyte LEP
Mean 0.0195
Standard deviation 0.035
Values 0 0 0.016 0 0.081
[100]
HepG2 LEP
Mean 0.0172
Standard deviation 2.3e-05
Values 0.017 0.017
[101]
HepG2.C3A LEP
Mean 0.0302
Standard deviation 0.012
Values 0.039 0.021
[102]
HuH.7 LEP
Mean 0.0199
Standard deviation 0.0091
Values 0.025 0.026 0.0094
[103]
SNU475 LEP
Mean 0.0198
Standard deviation 0.015
Values 0.0093 0.03
[104]
THLE LEP
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[105]
liver LEP
Mean 0.137
Standard deviation 0.14
Values 0 0.27 0.026 0.25
[106]
ref_hepatocyte CDX2
Mean 0.0104
Standard deviation 0.023
Values 0.052 0 0 0 0
[107]
HepG2 CDX2
Mean 0.152
Standard deviation 0.076
Values 0.21 0.099
[108]
HepG2.C3A CDX2
Mean 0.104
Standard deviation 0.087
Values 0.17 0.043
[109]
HuH.7 CDX2
Mean 68.9
Standard deviation 15
Values 58 86 63
[110]
SNU475 CDX2
Mean 0.0534
Standard deviation 0.0034
Values 0.051 0.056
[111]
THLE CDX2
Mean 0.0349
Standard deviation 0.034
Values 0.059 0.011
[112]
liver CDX2
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[113]
ref_hepatocyte GNAT3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 GNAT3
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A GNAT3
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 GNAT3
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 GNAT3
Mean 0.0287
Standard deviation 0.012
Values 0.037 0.02
[118]
THLE GNAT3
Mean 0
Standard deviation 0
Values 0 0
[119]
liver GNAT3
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte FFAR1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 FFAR1
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[122]
HepG2.C3A FFAR1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[123]
HuH.7 FFAR1
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 FFAR1
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE FFAR1
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[126]
liver FFAR1
Mean 0
Standard deviation 0
Values 0 0 0 0
[127]
ref_hepatocyte GIP
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 GIP
Mean 0.864
Standard deviation 0.31
Values 0.64 1.1
[129]
HepG2.C3A GIP
Mean 0.166
Standard deviation 0.084
Values 0.11 0.23
[130]
HuH.7 GIP
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[131]
SNU475 GIP
Mean 0.532
Standard deviation 0.17
Values 0.65 0.41
[132]
THLE GIP
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[133]
liver GIP
Mean 0
Standard deviation 0
Values 0 0 0 0
[134]
ref_hepatocyte GRP
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 GRP
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A GRP
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 GRP
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 GRP
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE GRP
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[140]
liver GRP
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte ISL1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 ISL1
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[143]
HepG2.C3A ISL1
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 ISL1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[145]
SNU475 ISL1
Mean 0.0657
Standard deviation 0.086
Values 0.0046 0.13
[146]
THLE ISL1
Mean 0.868
Standard deviation 0.089
Values 0.8 0.93
[147]
liver ISL1
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[148]
ref_hepatocyte GCG
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 GCG
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A GCG
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 GCG
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 GCG
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[153]
THLE GCG
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[154]
liver GCG
Mean 0
Standard deviation 0
Values 0 0 0 0
[155]
ref_hepatocyte GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 GNG13
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A GNG13
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 GNG13
Mean 0.0152
Standard deviation 0.017
Values 0.033 0.013 0
[159]
SNU475 GNG13
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[160]
THLE GNG13
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[161]
liver GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0
[162]
ref_hepatocyte FFAR4
Missing
[163]
HepG2 FFAR4
Mean 0.0587
Standard deviation 0.051
Values 0.023 0.094
[164]
HepG2.C3A FFAR4
Mean 0.144
Standard deviation 0.11
Values 0.22 0.064
[165]
HuH.7 FFAR4
Mean 0.732
Standard deviation 0.27
Values 0.67 0.5 1
[166]
SNU475 FFAR4
Mean 0.0895
Standard deviation 0.0047
Values 0.093 0.086
[167]
THLE FFAR4
Mean 0.0571
Standard deviation 0.028
Values 0.077 0.037
[168]
liver FFAR4
Mean 0.383
Standard deviation 0.2
Values 0.26 0.2 0.44 0.64