REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.46[2] -0.58[3] -0.67[4] -1.02[5] -0.59[6] -0.61[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.01[16] 0.17[17] -0.31[18] -0.16[19] -0.22[20] -0.16[21]
4 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 [22] 0.92[23] 1.31[24] 1.31[25] 1.02[26] 1.46[27] 1.12[28]
5 UBA52 Ubiquitin-60S ribosomal protein L40 [29] 2.42[30] 2.40[31] 3.20[32] 1.23[33] 2.01[34] 0.61[35]
6 STAT3 Signal transducer and activator of transcription 3 [36] 2.29[37] 0.87[38] 1.37[39] 2.00[40] 1.24[41] 3.67[42]
7 STAT1 Signal transducer and activator of transcription 1-alpha/beta [43] 1.67[44] 0.82[45] 1.69[46] 4.29[47] 1.99[48] 2.21[49]
8 RNF7 RING-box protein 2 [50] 1.56[51] 1.85[52] 0.64[53] 0.95[54] 0.98[55] 0.53[56]
9 JAK1 Tyrosine-protein kinase JAK1 [57] 2.26[58] 1.81[59] 1.76[60] 2.39[61] 3.00[62] 2.79[63]
10 SOCS3 Suppressor of cytokine signaling 3 [64] -2.40[65] -2.74[66] -1.26[67] 0.96[68] -0.15[69] 1.40[70]
11 UBE2D2 Ubiquitin-conjugating enzyme E2 D2 [71] 2.74[72] 2.86[73] 1.90[74] 2.56[75] 2.72[76] 1.23[77]
12 LYN Tyrosine-protein kinase Lyn [78] 0.88[79] 0.78[80] 1.07[81] 2.82[82] 1.54[83] 1.28[84]
13 TYK2 Non-receptor tyrosine-protein kinase TYK2 [85] 2.88[86] 3.31[87] 3.20[88] 2.51[89] 3.40[90] 3.25[91]
14 STAT5B Signal transducer and activator of transcription 5B [92] 3.10[93] 2.80[94] 3.26[95] 3.31[96] 2.42[97] 2.89[98]
15 CUL5 Cullin-5 [99] 2.32[100] 3.88[101] 3.12[102] 4.28[103] 3.40[104] 3.59[105]
16 UBE2D1 Ubiquitin-conjugating enzyme E2 D1 [106] 2.54[107] 3.48[108] 3.58[109] 3.28[110] 3.01[111] 1.76[112]
17 STAT5A Signal transducer and activator of transcription 5A [113] -0.21[114] 1.04[115] -0.13[116] 0.92[117] 1.64[118] 1.50[119]
18 SOCS1 Suppressor of cytokine signaling 1 [120] 0.29[121] 1.23[122] 1.26[123] -0.03[124] -1.45[125] -0.20[126]
19 CSF3 Granulocyte colony-stimulating factor [127] -0.43[128] -3.97[129] -4.61[130] -5.18[131] 6.18[132] -6.16[133]
20 HCK Tyrosine-protein kinase HCK [134] -4.10[135] -4.21[136] [137] -3.50[138] -4.47[139] 1.97[140]
21 JAK2 Tyrosine-protein kinase JAK2 [141] 1.97[142] 2.04[143] 1.35[144] 2.53[145] 3.09[146] 3.97[147]
22 CSF3R Granulocyte colony-stimulating factor receptor [148] 2.69[149] 5.10[150] 4.54[151] -4.00[152] -5.97[153] 3.72[154]
23 SYK Tyrosine-protein kinase SYK [155] -6.42[156] -0.48[157] -3.74[158] 1.86[159] -1.69[160] 4.62[161]
24 ELOC Elongin-C [162] [163] [164] [165] [166] [167] [168]
25 ELOB Elongin-B [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBE2D3
Mean 65.1
Standard deviation 16
Values 40 57 79 77 72
[23]
HepG2 UBE2D3
Mean 81.2
Standard deviation 7.1
Values 76 86
[24]
HepG2.C3A UBE2D3
Mean 90.2
Standard deviation 5
Values 87 94
[25]
HuH.7 UBE2D3
Mean 102
Standard deviation 3.4
Values 99 1.1e+02 1e+02
[26]
SNU475 UBE2D3
Mean 71.5
Standard deviation 4.7
Values 75 68
[27]
THLE UBE2D3
Mean 111
Standard deviation 12
Values 1e+02 1.2e+02
[28]
liver UBE2D3
Mean 83.8
Standard deviation 35
Values 1.1e+02 56 1.1e+02 51
[29]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[30]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[31]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[32]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[33]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[34]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[35]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[36]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[37]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[38]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[39]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[40]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[41]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[42]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[43]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[44]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[45]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[46]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[47]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[48]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[49]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[50]
ref_hepatocyte RNF7
Mean 18.8
Standard deviation 4.5
Values 18 25 12 19 20
[51]
HepG2 RNF7
Mean 36.5
Standard deviation 1.3
Values 37 36
[52]
HepG2.C3A RNF7
Mean 38
Standard deviation 4
Values 35 41
[53]
HuH.7 RNF7
Mean 18.6
Standard deviation 2.9
Values 15 21 19
[54]
SNU475 RNF7
Mean 19.8
Standard deviation 2.6
Values 22 18
[55]
THLE RNF7
Mean 23.1
Standard deviation 1.9
Values 22 24
[56]
liver RNF7
Mean 16.1
Standard deviation 14
Values 29 3.9 28 3.5
[57]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10
[58]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56
[59]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29
[60]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29
[61]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39
[62]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[63]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62
[64]
ref_hepatocyte SOCS3
Mean 11.2
Standard deviation 10
Values 1 1.5 19 24 10
[65]
HepG2 SOCS3
Mean 1.4
Standard deviation 0.4
Values 1.7 1.1
[66]
HepG2.C3A SOCS3
Mean 0.939
Standard deviation 0.87
Values 1.6 0.32
[67]
HuH.7 SOCS3
Mean 2.97
Standard deviation 2.7
Values 1.4 6.1 1.4
[68]
SNU475 SOCS3
Mean 11.8
Standard deviation 0.67
Values 12 11
[69]
THLE SOCS3
Mean 6.29
Standard deviation 1.1
Values 7.1 5.5
[70]
liver SOCS3
Mean 17.4
Standard deviation 5.5
Values 15 14 15 26
[71]
ref_hepatocyte UBE2D2
Mean 10.8
Standard deviation 1.4
Values 9.1 10 13 11 11
[72]
HepG2 UBE2D2
Mean 47.6
Standard deviation 2.2
Values 49 46
[73]
HepG2.C3A UBE2D2
Mean 43.8
Standard deviation 3.3
Values 41 46
[74]
HuH.7 UBE2D2
Mean 25.5
Standard deviation 2.4
Values 26 23 27
[75]
SNU475 UBE2D2
Mean 34.3
Standard deviation 1.1
Values 35 34
[76]
THLE UBE2D2
Mean 44.2
Standard deviation 1.7
Values 43 45
[77]
liver UBE2D2
Mean 14.9
Standard deviation 8
Values 22 8.8 21 7.3
[78]
ref_hepatocyte LYN
Mean 5.33
Standard deviation 4.4
Values 0.29 6.8 12 3.7 3.8
[79]
HepG2 LYN
Mean 6.48
Standard deviation 1
Values 5.8 7.2
[80]
HepG2.C3A LYN
Mean 5.11
Standard deviation 2.1
Values 3.6 6.6
[81]
HuH.7 LYN
Mean 7.08
Standard deviation 0.67
Values 7.4 7.5 6.3
[82]
SNU475 LYN
Mean 20.4
Standard deviation 4.4
Values 17 23
[83]
THLE LYN
Mean 9.65
Standard deviation 1.4
Values 8.7 11
[84]
liver LYN
Mean 7.66
Standard deviation 1.7
Values 7.2 9.4 5.5 8.6
[85]
ref_hepatocyte TYK2
Mean 4.82
Standard deviation 1.6
Values 2.6 4 5.2 6.8 5.6
[86]
HepG2 TYK2
Mean 23.5
Standard deviation 0.9
Values 23 24
[87]
HepG2.C3A TYK2
Mean 26.8
Standard deviation 2.6
Values 29 25
[88]
HuH.7 TYK2
Mean 28.1
Standard deviation 8.5
Values 35 19 31
[89]
SNU475 TYK2
Mean 14.9
Standard deviation 0.21
Values 15 15
[90]
THLE TYK2
Mean 31.6
Standard deviation 1.6
Values 33 31
[91]
liver TYK2
Mean 27.2
Standard deviation 3.5
Values 31 24 24 30
[92]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[93]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[94]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[95]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[96]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[97]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[98]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[99]
ref_hepatocyte CUL5
Mean 3.55
Standard deviation 1.9
Values 6 4.8 1.6 1.6 3.8
[100]
HepG2 CUL5
Mean 11.7
Standard deviation 4.4
Values 8.6 15
[101]
HepG2.C3A CUL5
Mean 29.2
Standard deviation 7.1
Values 24 34
[102]
HuH.7 CUL5
Mean 19.6
Standard deviation 1.5
Values 20 21 18
[103]
SNU475 CUL5
Mean 37.4
Standard deviation 5
Values 41 34
[104]
THLE CUL5
Mean 23.2
Standard deviation 2.7
Values 25 21
[105]
liver CUL5
Mean 25.3
Standard deviation 3.6
Values 26 30 22 24
[106]
ref_hepatocyte UBE2D1
Mean 2.43
Standard deviation 1.1
Values 2.2 1.2 4.1 1.7 2.8
[107]
HepG2 UBE2D1
Mean 9.29
Standard deviation 2.7
Values 7.4 11
[108]
HepG2.C3A UBE2D1
Mean 15.1
Standard deviation 2.9
Values 13 17
[109]
HuH.7 UBE2D1
Mean 18.4
Standard deviation 3.8
Values 21 14 20
[110]
SNU475 UBE2D1
Mean 12.8
Standard deviation 0.14
Values 13 13
[111]
THLE UBE2D1
Mean 12.2
Standard deviation 0.065
Values 12 12
[112]
liver UBE2D1
Mean 4.88
Standard deviation 2.6
Values 6.8 2.9 7.4 2.4
[113]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[114]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[115]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[116]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[117]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[118]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[119]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[120]
ref_hepatocyte SOCS1
Mean 2.1
Standard deviation 1.9
Values 1.1 0 1.3 4.7 3.4
[121]
HepG2 SOCS1
Mean 1.7
Standard deviation 0.19
Values 1.8 1.6
[122]
HepG2.C3A SOCS1
Mean 2.76
Standard deviation 1.3
Values 3.7 1.9
[123]
HuH.7 SOCS1
Mean 3.19
Standard deviation 2.1
Values 3.3 1 5.3
[124]
SNU475 SOCS1
Mean 1.11
Standard deviation 0.23
Values 1.3 0.95
[125]
THLE SOCS1
Mean 0.479
Standard deviation 0.076
Values 0.53 0.43
[126]
liver SOCS1
Mean 1.08
Standard deviation 0.8
Values 1.1 0.27 0.8 2.2
[127]
ref_hepatocyte CSF3
Mean 1.66
Standard deviation 3.7
Values 0 0 8.3 0 0
[128]
HepG2 CSF3
Mean 0.813
Standard deviation 0.63
Values 1.3 0.36
[129]
HepG2.C3A CSF3
Mean 0.0593
Standard deviation 0.054
Values 0.097 0.021
[130]
HuH.7 CSF3
Mean 0.0429
Standard deviation 0.021
Values 0.066 0.026 0.037
[131]
SNU475 CSF3
Mean 0.0247
Standard deviation 0.015
Values 0.014 0.035
[132]
THLE CSF3
Mean 74.8
Standard deviation 28
Values 95 55
[133]
liver CSF3
Mean 0.0138
Standard deviation 0.016
Values 0 0.029 0 0.026
[134]
ref_hepatocyte HCK
Mean 1.57
Standard deviation 1.7
Values 0 0 2.7 1.2 3.9
[135]
HepG2 HCK
Mean 0.0602
Standard deviation 0.085
Values 0.12 0
[136]
HepG2.C3A HCK
Mean 0.0473
Standard deviation 0.039
Values 0.019 0.075
[137]
HuH.7 HCK
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 HCK
Mean 0.0747
Standard deviation 0.066
Values 0.028 0.12
[139]
THLE HCK
Mean 0.0438
Standard deviation 0.047
Values 0.077 0.011
[140]
liver HCK
Mean 3.63
Standard deviation 1.3
Values 1.7 4.2 4 4.7
[141]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[142]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[143]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[144]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[145]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[146]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[147]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[148]
ref_hepatocyte CSF3R
Mean 0.568
Standard deviation 0.59
Values 1.2 0 0 0.49 1.1
[149]
HepG2 CSF3R
Mean 2.42
Standard deviation 0.98
Values 3.1 1.7
[150]
HepG2.C3A CSF3R
Mean 10.9
Standard deviation 8.2
Values 17 5.1
[151]
HuH.7 CSF3R
Mean 8.38
Standard deviation 2
Values 6.5 10 8.2
[152]
SNU475 CSF3R
Mean 0.0192
Standard deviation 0.0056
Values 0.023 0.015
[153]
THLE CSF3R
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[154]
liver CSF3R
Mean 4.44
Standard deviation 1.4
Values 3.5 3.1 5 6.2
[155]
ref_hepatocyte SYK
Mean 0.279
Standard deviation 0.38
Values 0 0.17 0 0.31 0.92
[156]
HepG2 SYK
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[157]
HepG2.C3A SYK
Mean 0.112
Standard deviation 0.0066
Values 0.12 0.11
[158]
HuH.7 SYK
Mean 0.0133
Standard deviation 0.0053
Values 0.0082 0.013 0.019
[159]
SNU475 SYK
Mean 0.549
Standard deviation 0.36
Values 0.3 0.8
[160]
THLE SYK
Mean 0.0538
Standard deviation 0.016
Values 0.065 0.043
[161]
liver SYK
Mean 4.07
Standard deviation 1.3
Values 3.6 4.8 2.5 5.4
[162]
ref_hepatocyte ELOC
Missing
[163]
HepG2 ELOC
Missing
[164]
HepG2.C3A ELOC
Missing
[165]
HuH.7 ELOC
Missing
[166]
SNU475 ELOC
Missing
[167]
THLE ELOC
Missing
[168]
liver ELOC
Missing
[169]
ref_hepatocyte ELOB
Missing
[170]
HepG2 ELOB
Missing
[171]
HepG2.C3A ELOB
Missing
[172]
HuH.7 ELOB
Missing
[173]
SNU475 ELOB
Missing
[174]
THLE ELOB
Missing
[175]
liver ELOB
Missing