REACTOME_IL_6_TYPE_CYTOKINE_RECEPTOR_LIGAND_INTERACTIONS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 IL6ST Interleukin-6 receptor subunit beta [1] -1.78[2] -0.33[3] 0.04[4] 0.24[5] 0.65[6] 0.88[7]
2 JAK1 Tyrosine-protein kinase JAK1 [8] -1.53[9] -1.84[10] -0.81[11] -0.86[12] -0.97[13] -1.37[14]
3 OSMR Oncostatin-M-specific receptor subunit beta [15] -0.03[16] -0.11[17] -0.66[18] 0.23[19] 0.63[20] -1.40[21]
4 TYK2 Non-receptor tyrosine-protein kinase TYK2 [22] -0.91[23] -0.34[24] 0.64[25] -0.74[26] -0.57[27] -0.91[28]
5 IL11RA Interleukin-11 receptor subunit alpha [29] -4.02[30] -1.53[31] -2.07[32] -3.03[33] -3.89[34] -1.74[35]
6 LIF Leukemia inhibitory factor [36] 0.24[37] 0.28[38] 1.96[39] 0.13[40] 0.39[41] -8.08[42]
7 CNTFR Ciliary neurotrophic factor receptor subunit alpha [43] -8.69[44] [45] -3.40[46] -4.95[47] -8.36[48] -4.12[49]
8 CRLF1 Cytokine receptor-like factor 1 [50] 4.73[51] 4.16[52] -1.42[53] -4.47[54] -5.17[55] -6.82[56]
9 CLCF1 Cardiotrophin-like cytokine factor 1 [57] -1.80[58] -3.61[59] -1.32[60] 2.80[61] -0.39[62] -4.82[63]
10 JAK2 Tyrosine-protein kinase JAK2 [64] -1.82[65] -1.61[66] -1.21[67] -0.73[68] -0.88[69] -0.19[70]
11 LIFR Leukemia inhibitory factor receptor [71] -1.12[72] 1.78[73] 3.20[74] 2.58[75] 1.31[76] 3.62[77]
12 CTF1 Cardiotrophin-1 [78] -0.35[79] -0.42[80] -2.15[81] -5.33[82] -1.05[83] -5.27[84]
13 OSM Oncostatin-M [85] -7.34[86] -2.57[87] -6.48[88] -6.70[89] -7.39[90] -4.63[91]
14 IL11 Interleukin-11 [92] 4.45[93] 1.02[94] -0.64[95] 1.69[96] 0.86[97] -4.54[98]
15 IL31RA Interleukin-31 receptor subunit alpha [99] -1.37[100] -0.47[101] 0.23[102] 2.40[103] -0.11[104] -3.45[105]
16 CNTF Ciliary neurotrophic factor [106] [107] -3.12[108] -4.32[109] -2.59[110] -5.42[111] -2.18[112]
17 IL31 Interleukin-31 [113] [114] [115] [116] [117] [118] [119]
[1]
ref_hepatocyte IL6ST
Mean 16.5
Standard deviation 5.8
Values 24 18 9.5 12 19
[2]
HepG2 IL6ST
Mean 43.6
Standard deviation 25
Values 26 61
[3]
HepG2.C3A IL6ST
Mean 92.3
Standard deviation 8.3
Values 86 98
[4]
HuH.7 IL6ST
Mean 63.5
Standard deviation 38
Values 50 1.1e+02 35
[5]
SNU475 IL6ST
Mean 100
Standard deviation 15
Values 90 1.1e+02
[6]
THLE IL6ST
Mean 252
Standard deviation 68
Values 3e+02 2e+02
[7]
liver IL6ST
Mean 321
Standard deviation 1.1e+02
Values 2.5e+02 4.2e+02 2.1e+02 4.1e+02
[8]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10
[9]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56
[10]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29
[11]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29
[12]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39
[13]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[14]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62
[15]
ref_hepatocyte OSMR
Mean 5.91
Standard deviation 3.2
Values 5 6.1 11 4.8 2.6
[16]
HepG2 OSMR
Mean 52.7
Standard deviation 9
Values 46 59
[17]
HepG2.C3A OSMR
Mean 38.5
Standard deviation 3.3
Values 41 36
[18]
HuH.7 OSMR
Mean 14
Standard deviation 8.7
Values 11 24 7.5
[19]
SNU475 OSMR
Mean 35.7
Standard deviation 8.4
Values 30 42
[20]
THLE OSMR
Mean 88.8
Standard deviation 9.2
Values 95 82
[21]
liver OSMR
Mean 23.7
Standard deviation 9.9
Values 11 34 21 29
[22]
ref_hepatocyte TYK2
Mean 4.82
Standard deviation 1.6
Values 2.6 4 5.2 6.8 5.6
[23]
HepG2 TYK2
Mean 23.5
Standard deviation 0.9
Values 23 24
[24]
HepG2.C3A TYK2
Mean 26.8
Standard deviation 2.6
Values 29 25
[25]
HuH.7 TYK2
Mean 28.1
Standard deviation 8.5
Values 35 19 31
[26]
SNU475 TYK2
Mean 14.9
Standard deviation 0.21
Values 15 15
[27]
THLE TYK2
Mean 31.6
Standard deviation 1.6
Values 33 31
[28]
liver TYK2
Mean 27.2
Standard deviation 3.5
Values 31 24 24 30
[29]
ref_hepatocyte IL11RA
Mean 2.14
Standard deviation 2.3
Values 1.1 0.21 0.14 4.7 4.6
[30]
HepG2 IL11RA
Mean 1.2
Standard deviation 0.66
Values 1.7 0.73
[31]
HepG2.C3A IL11RA
Mean 5.21
Standard deviation 2.1
Values 6.7 3.7
[32]
HuH.7 IL11RA
Mean 1.91
Standard deviation 0.76
Values 1.1 2.7 1.9
[33]
SNU475 IL11RA
Mean 1.35
Standard deviation 0.4
Values 1.6 1.1
[34]
THLE IL11RA
Mean 1.4
Standard deviation 0.38
Values 1.7 1.1
[35]
liver IL11RA
Mean 6.78
Standard deviation 2.4
Values 8.8 3.5 6.2 8.5
[36]
ref_hepatocyte LIF
Mean 1.54
Standard deviation 2
Values 0.49 2.4 4.6 0.078 0.041
[37]
HepG2 LIF
Mean 16.5
Standard deviation 6.4
Values 21 12
[38]
HepG2.C3A LIF
Mean 13.1
Standard deviation 6.5
Values 18 8.6
[39]
HuH.7 LIF
Mean 22.4
Standard deviation 16
Values 12 41 14
[40]
SNU475 LIF
Mean 8.67
Standard deviation 1.2
Values 7.8 9.5
[41]
THLE LIF
Mean 19.6
Standard deviation 9.5
Values 13 26
[42]
liver LIF
Mean 0.0602
Standard deviation 0.032
Values 0.024 0.1 0.051 0.066
[43]
ref_hepatocyte CNTFR
Mean 1.43
Standard deviation 1.9
Values 0 0.55 4.8 1.4 0.46
[44]
HepG2 CNTFR
Mean 0.0315
Standard deviation 0.045
Values 0.063 0
[45]
HepG2.C3A CNTFR
Mean 0
Standard deviation 0
Values 0 0
[46]
HuH.7 CNTFR
Mean 0.507
Standard deviation 0.38
Values 0.66 0.077 0.79
[47]
SNU475 CNTFR
Mean 0.239
Standard deviation 0.049
Values 0.2 0.27
[48]
THLE CNTFR
Mean 0.0426
Standard deviation 0.015
Values 0.053 0.032
[49]
liver CNTFR
Mean 0.871
Standard deviation 0.67
Values 1.6 0.19 0.46 1.2
[50]
ref_hepatocyte CRLF1
Mean 1.05
Standard deviation 2.3
Values 5.2 0 0 0 0.041
[51]
HepG2 CRLF1
Mean 254
Standard deviation 1.2e+02
Values 3.4e+02 1.7e+02
[52]
HepG2.C3A CRLF1
Mean 132
Standard deviation 17
Values 1.4e+02 1.2e+02
[53]
HuH.7 CRLF1
Mean 1.48
Standard deviation 0.28
Values 1.6 1.2 1.7
[54]
SNU475 CRLF1
Mean 0.245
Standard deviation 0.06
Values 0.29 0.2
[55]
THLE CRLF1
Mean 0.285
Standard deviation 0.16
Values 0.17 0.4
[56]
liver CRLF1
Mean 0.0989
Standard deviation 0.15
Values 0.024 0.029 0.026 0.32
[57]
ref_hepatocyte CLCF1
Mean 0.92
Standard deviation 1.2
Values 0 1.5 2.7 0.4 0.041
[58]
HepG2 CLCF1
Mean 2.41
Standard deviation 1.5
Values 3.4 1.4
[59]
HepG2.C3A CLCF1
Mean 0.529
Standard deviation 0.4
Values 0.24 0.82
[60]
HuH.7 CLCF1
Mean 1.38
Standard deviation 0.079
Values 1.3 1.3 1.5
[61]
SNU475 CLCF1
Mean 33
Standard deviation 1.4
Values 34 32
[62]
THLE CLCF1
Mean 6.85
Standard deviation 0.81
Values 6.3 7.4
[63]
liver CLCF1
Mean 0.345
Standard deviation 0.26
Values 0.12 0.37 0.69 0.2
[64]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[65]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[66]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[67]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[68]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[69]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[70]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[71]
ref_hepatocyte LIFR
Mean 0.724
Standard deviation 1
Values 2.6 0.25 0.18 0.2 0.41
[72]
HepG2 LIFR
Mean 3.03
Standard deviation 1.3
Values 2.1 3.9
[73]
HepG2.C3A LIFR
Mean 17.4
Standard deviation 0.87
Values 18 17
[74]
HuH.7 LIFR
Mean 24.9
Standard deviation 7.5
Values 27 31 17
[75]
SNU475 LIFR
Mean 22.3
Standard deviation 5.6
Values 18 26
[76]
THLE LIFR
Mean 17.5
Standard deviation 6.4
Values 22 13
[77]
liver LIFR
Mean 94.5
Standard deviation 28
Values 84 1.1e+02 59 1.2e+02
[78]
ref_hepatocyte CTF1
Mean 0.176
Standard deviation 0.17
Values 0 0 0.28 0.24 0.36
[79]
HepG2 CTF1
Mean 1.26
Standard deviation 0.65
Values 1.7 0.81
[80]
HepG2.C3A CTF1
Mean 0.921
Standard deviation 0.64
Values 1.4 0.47
[81]
HuH.7 CTF1
Mean 0.148
Standard deviation 0.0013
Values 0.15 0.15 0.15
[82]
SNU475 CTF1
Mean 0.0226
Standard deviation 0.025
Values 0.0046 0.041
[83]
THLE CTF1
Mean 0.832
Standard deviation 0.078
Values 0.89 0.78
[84]
liver CTF1
Mean 0.0486
Standard deviation 0.062
Values 0.14 0.014 0.026 0.013
[85]
ref_hepatocyte OSM
Mean 0.102
Standard deviation 0.17
Values 0 0 0 0.38 0.13
[86]
HepG2 OSM
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[87]
HepG2.C3A OSM
Mean 0.12
Standard deviation 0.064
Values 0.17 0.075
[88]
HuH.7 OSM
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[89]
SNU475 OSM
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[90]
THLE OSM
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[91]
liver OSM
Mean 0.0435
Standard deviation 0.033
Values 0 0.057 0.077 0.04
[92]
ref_hepatocyte IL11
Mean 0.101
Standard deviation 0.16
Values 0.38 0 0.095 0 0.033
[93]
HepG2 IL11
Mean 20
Standard deviation 20
Values 34 5.8
[94]
HepG2.C3A IL11
Mean 1.43
Standard deviation 0.25
Values 1.3 1.6
[95]
HuH.7 IL11
Mean 0.242
Standard deviation 0.062
Values 0.25 0.3 0.18
[96]
SNU475 IL11
Mean 1.68
Standard deviation 2
Values 0.26 3.1
[97]
THLE IL11
Mean 1.79
Standard deviation 0.084
Values 1.7 1.8
[98]
liver IL11
Mean 0.0459
Standard deviation 0.075
Values 0 0.16 0 0.026
[99]
ref_hepatocyte IL31RA
Mean 0.0641
Standard deviation 0.056
Values 0 0.057 0.15 0.052 0.057
[100]
HepG2 IL31RA
Mean 0.226
Standard deviation 0.053
Values 0.26 0.19
[101]
HepG2.C3A IL31RA
Mean 0.324
Standard deviation 0.087
Values 0.26 0.39
[102]
HuH.7 IL31RA
Mean 0.282
Standard deviation 0.1
Values 0.21 0.4 0.24
[103]
SNU475 IL31RA
Mean 1.75
Standard deviation 0.66
Values 1.3 2.2
[104]
THLE IL31RA
Mean 0.578
Standard deviation 0.095
Values 0.64 0.51
[105]
liver IL31RA
Mean 0.062
Standard deviation 0.067
Values 0 0.16 0.051 0.04
[106]
ref_hepatocyte CNTF
Mean 0.026
Standard deviation 0.058
Values 0 0 0 0 0.13
[107]
HepG2 CNTF
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A CNTF
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[109]
HuH.7 CNTF
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[110]
SNU475 CNTF
Mean 0.0224
Standard deviation 0.019
Values 0.0093 0.035
[111]
THLE CNTF
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[112]
liver CNTF
Mean 0.0609
Standard deviation 0.058
Values 0.024 0.11 0 0.11
[113]
ref_hepatocyte IL31
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 IL31
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A IL31
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 IL31
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[117]
SNU475 IL31
Mean 0.0101
Standard deviation 0.014
Values 0 0.02
[118]
THLE IL31
Mean 0
Standard deviation 0
Values 0 0
[119]
liver IL31
Mean 0
Standard deviation 0
Values 0 0 0 0