REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.22[2] -0.50[3] -0.45[4] -0.45[5] -0.38[6] -0.27[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] 0.22[16] 0.25[17] -0.08[18] 0.40[19] -0.01[20] 0.18[21]
4 CD14 Monocyte differentiation antigen CD14 [22] -6.36[23] -6.52[24] -3.80[25] -2.47[26] -4.05[27] 1.10[28]
5 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 [29] 1.15[30] 1.39[31] 1.53[32] 1.59[33] 1.67[34] 1.46[35]
6 UBA52 Ubiquitin-60S ribosomal protein L40 [36] 2.66[37] 2.48[38] 3.43[39] 1.80[40] 2.22[41] 0.95[42]
7 UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 [43] -1.90[44] -2.17[45] -2.12[46] -1.56[47] -2.60[48] -3.40[49]
8 IKBKG NF-kappa-B essential modulator [50] 1.09[51] 1.15[52] -1.19[53] 1.48[54] -0.13[55] 1.00[56]
9 UBE2N Ubiquitin-conjugating enzyme E2 N [57] 2.66[58] 3.06[59] 1.79[60] 2.65[61] 2.15[62] 0.89[63]
10 BIRC3 Baculoviral IAP repeat-containing protein 3 [64] -1.14[65] -0.20[66] -2.69[67] -0.79[68] 2.58[69] -0.47[70]
11 UBE2D2 Ubiquitin-conjugating enzyme E2 D2 [71] 2.98[72] 2.94[73] 2.12[74] 3.13[75] 2.93[76] 1.57[77]
12 BIRC2 Baculoviral IAP repeat-containing protein 2 [78] 2.22[79] 3.09[80] 1.95[81] 2.75[82] 3.14[83] 2.33[84]
13 TICAM1 TIR domain-containing adapter molecule 1 [85] 1.26[86] 0.08[87] 0.92[88] 1.11[89] 1.76[90] 1.11[91]
14 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 [92] 2.26[93] 2.34[94] 1.93[95] 3.41[96] 2.54[97] 3.09[98]
15 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha [99] 2.88[100] 4.02[101] 3.88[102] 2.98[103] 3.40[104] 3.12[105]
16 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta [106] 2.50[107] 2.47[108] 2.48[109] 2.59[110] 2.29[111] 2.79[112]
17 LY96 Lymphocyte antigen 96 [113] -0.68[114] -1.15[115] -7.66[116] 0.97[117] -3.04[118] 0.25[119]
18 UBE2D1 Ubiquitin-conjugating enzyme E2 D1 [120] 2.77[121] 3.56[122] 3.81[123] 3.85[124] 3.22[125] 2.11[126]
19 TRAF6 TNF receptor-associated factor 6 [127] 3.07[128] 2.87[129] 3.34[130] 3.99[131] 3.05[132] 4.52[133]
20 TLR4 Toll-like receptor 4 [134] 2.25[135] -2.99[136] -3.97[137] -2.77[138] 7.26[139] 6.07[140]
21 TICAM2 TIR domain-containing adapter molecule 2 [141] -5.90[142] [143] -5.50[144] 0.84[145] 0.78[146] -0.37[147]
22 RIPK3 Receptor-interacting serine/threonine-protein kinase 3 [148] -4.67[149] [150] -3.52[151] [152] -3.44[153] 2.16[154]
23 SARM1 Sterile alpha and TIR motif-containing protein 1 [155] 0.40[156] 0.59[157] 2.19[158] 1.01[159] 5.91[160] 4.61[161]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte CD14
Mean 148
Standard deviation 1.9e+02
Values 0.7 1.6 16 3.4e+02 3.8e+02
[23]
HepG2 CD14
Mean 1.01
Standard deviation 0.084
Values 1.1 0.95
[24]
HepG2.C3A CD14
Mean 0.856
Standard deviation 0.32
Values 1.1 0.63
[25]
HuH.7 CD14
Mean 5.78
Standard deviation 1.1
Values 5.8 4.7 6.9
[26]
SNU475 CD14
Mean 9.74
Standard deviation 1.9
Values 8.4 11
[27]
THLE CD14
Mean 4.8
Standard deviation 0.97
Values 5.5 4.1
[28]
liver CD14
Mean 148
Standard deviation 88
Values 2.1e+02 68 2.4e+02 77
[29]
ref_hepatocyte UBE2D3
Mean 65.1
Standard deviation 16
Values 40 57 79 77 72
[30]
HepG2 UBE2D3
Mean 81.2
Standard deviation 7.1
Values 76 86
[31]
HepG2.C3A UBE2D3
Mean 90.2
Standard deviation 5
Values 87 94
[32]
HuH.7 UBE2D3
Mean 102
Standard deviation 3.4
Values 99 1.1e+02 1e+02
[33]
SNU475 UBE2D3
Mean 71.5
Standard deviation 4.7
Values 75 68
[34]
THLE UBE2D3
Mean 111
Standard deviation 12
Values 1e+02 1.2e+02
[35]
liver UBE2D3
Mean 83.8
Standard deviation 35
Values 1.1e+02 56 1.1e+02 51
[36]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[37]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[38]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[39]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[40]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[41]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[42]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[43]
ref_hepatocyte UBE2V1
Mean 30.9
Standard deviation 6.6
Values 41 25 33 29 27
[44]
HepG2 UBE2V1
Mean 4.65
Standard deviation 0.14
Values 4.6 4.7
[45]
HepG2.C3A UBE2V1
Mean 3.63
Standard deviation 0.17
Values 3.8 3.5
[46]
HuH.7 UBE2V1
Mean 3.85
Standard deviation 0.39
Values 4.3 3.8 3.5
[47]
SNU475 UBE2V1
Mean 3.83
Standard deviation 0.48
Values 4.2 3.5
[48]
THLE UBE2V1
Mean 2.74
Standard deviation 0.61
Values 2.3 3.2
[49]
liver UBE2V1
Mean 1.36
Standard deviation 0.64
Values 1.9 0.84 2 0.78
[50]
ref_hepatocyte IKBKG
Mean 22.7
Standard deviation 14
Values 7.4 36 37 24 10
[51]
HepG2 IKBKG
Mean 27.1
Standard deviation 5.7
Values 31 23
[52]
HepG2.C3A IKBKG
Mean 26.7
Standard deviation 4
Values 30 24
[53]
HuH.7 IKBKG
Mean 5.4
Standard deviation 1.3
Values 5.4 4.1 6.7
[54]
SNU475 IKBKG
Mean 23.2
Standard deviation 3.5
Values 21 26
[55]
THLE IKBKG
Mean 11.2
Standard deviation 1
Values 10 12
[56]
liver IKBKG
Mean 21.3
Standard deviation 6.6
Values 20 22 29 13
[57]
ref_hepatocyte UBE2N
Mean 19.2
Standard deviation 7.8
Values 19 28 25 11 12
[58]
HepG2 UBE2N
Mean 68.4
Standard deviation 19
Values 55 82
[59]
HepG2.C3A UBE2N
Mean 84.8
Standard deviation 36
Values 60 1.1e+02
[60]
HuH.7 UBE2N
Mean 36
Standard deviation 8.3
Values 38 27 43
[61]
SNU475 UBE2N
Mean 44
Standard deviation 3.7
Values 47 41
[62]
THLE UBE2N
Mean 45.7
Standard deviation 8
Values 40 51
[63]
liver UBE2N
Mean 16.6
Standard deviation 11
Values 25 8.3 27 5.9
[64]
ref_hepatocyte BIRC3
Mean 15.6
Standard deviation 19
Values 1.2 29 43 1.5 3.2
[65]
HepG2 BIRC3
Mean 3.98
Standard deviation 0.49
Values 4.3 3.6
[66]
HepG2.C3A BIRC3
Mean 7.2
Standard deviation 0.46
Values 6.9 7.5
[67]
HuH.7 BIRC3
Mean 1.31
Standard deviation 1.3
Values 0.65 2.8 0.49
[68]
SNU475 BIRC3
Mean 3.3
Standard deviation 0.79
Values 2.7 3.9
[69]
THLE BIRC3
Mean 50.3
Standard deviation 18
Values 63 37
[70]
liver BIRC3
Mean 5.25
Standard deviation 1.9
Values 5.1 5 3.2 7.7
[71]
ref_hepatocyte UBE2D2
Mean 10.8
Standard deviation 1.4
Values 9.1 10 13 11 11
[72]
HepG2 UBE2D2
Mean 47.6
Standard deviation 2.2
Values 49 46
[73]
HepG2.C3A UBE2D2
Mean 43.8
Standard deviation 3.3
Values 41 46
[74]
HuH.7 UBE2D2
Mean 25.5
Standard deviation 2.4
Values 26 23 27
[75]
SNU475 UBE2D2
Mean 34.3
Standard deviation 1.1
Values 35 34
[76]
THLE UBE2D2
Mean 44.2
Standard deviation 1.7
Values 43 45
[77]
liver UBE2D2
Mean 14.9
Standard deviation 8
Values 22 8.8 21 7.3
[78]
ref_hepatocyte BIRC2
Mean 10
Standard deviation 3.6
Values 13 14 11 6.4 5.8
[79]
HepG2 BIRC2
Mean 26.2
Standard deviation 3.4
Values 24 29
[80]
HepG2.C3A BIRC2
Mean 45.2
Standard deviation 3.6
Values 43 48
[81]
HuH.7 BIRC2
Mean 21
Standard deviation 4
Values 18 25 20
[82]
SNU475 BIRC2
Mean 24.6
Standard deviation 0.14
Values 24 25
[83]
THLE BIRC2
Mean 47.5
Standard deviation 12
Values 56 39
[84]
liver BIRC2
Mean 23.6
Standard deviation 3.9
Values 25 25 27 18
[85]
ref_hepatocyte TICAM1
Mean 4.75
Standard deviation 6.4
Values 0 1.4 16 3.4 3
[86]
HepG2 TICAM1
Mean 6.41
Standard deviation 2.9
Values 8.5 4.3
[87]
HepG2.C3A TICAM1
Mean 2.66
Standard deviation 0.59
Values 3.1 2.2
[88]
HuH.7 TICAM1
Mean 4.87
Standard deviation 0.33
Values 5.2 4.5 4.9
[89]
SNU475 TICAM1
Mean 3.73
Standard deviation 0.28
Values 3.5 3.9
[90]
THLE TICAM1
Mean 8.64
Standard deviation 1.3
Values 7.7 9.5
[91]
liver TICAM1
Mean 4.77
Standard deviation 3.4
Values 7.9 1.4 7.4 2.3
[92]
ref_hepatocyte RIPK1
Mean 4.28
Standard deviation 0.89
Values 3.7 4.4 3.1 5.4 4.8
[93]
HepG2 RIPK1
Mean 11.5
Standard deviation 4
Values 8.7 14
[94]
HepG2.C3A RIPK1
Mean 11.5
Standard deviation 0.53
Values 11 12
[95]
HuH.7 RIPK1
Mean 8.85
Standard deviation 0.42
Values 8.4 9.3 8.8
[96]
SNU475 RIPK1
Mean 16.6
Standard deviation 2.9
Values 19 15
[97]
THLE RIPK1
Mean 13.4
Standard deviation 1
Values 13 14
[98]
liver RIPK1
Mean 17
Standard deviation 5.1
Values 12 21 13 22
[99]
ref_hepatocyte CHUK
Mean 3.93
Standard deviation 1.2
Values 4.2 5.7 2.3 3.4 4.1
[100]
HepG2 CHUK
Mean 16.2
Standard deviation 6.4
Values 12 21
[101]
HepG2.C3A CHUK
Mean 33.6
Standard deviation 13
Values 25 43
[102]
HuH.7 CHUK
Mean 31.4
Standard deviation 3.3
Values 34 28 32
[103]
SNU475 CHUK
Mean 11.3
Standard deviation 1.1
Values 11 12
[104]
THLE CHUK
Mean 22.3
Standard deviation 0.15
Values 22 22
[105]
liver CHUK
Mean 16
Standard deviation 3.3
Values 13 21 15 15
[106]
ref_hepatocyte IKBKB
Mean 3.48
Standard deviation 0.8
Values 2.9 4.3 4.2 3.5 2.5
[107]
HepG2 IKBKB
Mean 11
Standard deviation 0.46
Values 11 11
[108]
HepG2.C3A IKBKB
Mean 10.2
Standard deviation 1
Values 11 9.5
[109]
HuH.7 IKBKB
Mean 10.6
Standard deviation 1.9
Values 11 8.4 12
[110]
SNU475 IKBKB
Mean 7.65
Standard deviation 1.8
Values 8.9 6.4
[111]
THLE IKBKB
Mean 9.14
Standard deviation 0.21
Values 9.3 9
[112]
liver IKBKB
Mean 11.2
Standard deviation 0.34
Values 11 11 11 12
[113]
ref_hepatocyte LY96
Mean 2.98
Standard deviation 1.7
Values 3 4.2 0 4 3.7
[114]
HepG2 LY96
Mean 1.05
Standard deviation 0.03
Values 1 1.1
[115]
HepG2.C3A LY96
Mean 0.711
Standard deviation 0.08
Values 0.77 0.65
[116]
HuH.7 LY96
Mean 0.008
Standard deviation 0.0015
Values 0.0082 0.0064 0.0094
[117]
SNU475 LY96
Mean 2.13
Standard deviation 0.56
Values 2.5 1.7
[118]
THLE LY96
Mean 0.194
Standard deviation 0.13
Values 0.1 0.29
[119]
liver LY96
Mean 1.65
Standard deviation 1.4
Values 2.6 0.6 3 0.34
[120]
ref_hepatocyte UBE2D1
Mean 2.43
Standard deviation 1.1
Values 2.2 1.2 4.1 1.7 2.8
[121]
HepG2 UBE2D1
Mean 9.29
Standard deviation 2.7
Values 7.4 11
[122]
HepG2.C3A UBE2D1
Mean 15.1
Standard deviation 2.9
Values 13 17
[123]
HuH.7 UBE2D1
Mean 18.4
Standard deviation 3.8
Values 21 14 20
[124]
SNU475 UBE2D1
Mean 12.8
Standard deviation 0.14
Values 13 13
[125]
THLE UBE2D1
Mean 12.2
Standard deviation 0.065
Values 12 12
[126]
liver UBE2D1
Mean 4.88
Standard deviation 2.6
Values 6.8 2.9 7.4 2.4
[127]
ref_hepatocyte TRAF6
Mean 0.965
Standard deviation 0.32
Values 0.82 1 1.5 0.7 0.8
[128]
HepG2 TRAF6
Mean 4.54
Standard deviation 0.72
Values 4 5
[129]
HepG2.C3A TRAF6
Mean 3.74
Standard deviation 0.086
Values 3.8 3.7
[130]
HuH.7 TRAF6
Mean 5.32
Standard deviation 1
Values 5 6.4 4.5
[131]
SNU475 TRAF6
Mean 5.61
Standard deviation 0.46
Values 5.9 5.3
[132]
THLE TRAF6
Mean 4.31
Standard deviation 0.54
Values 3.9 4.7
[133]
liver TRAF6
Mean 10.3
Standard deviation 0.99
Values 9.7 12 9.8 10
[134]
ref_hepatocyte TLR4
Mean 0.547
Standard deviation 0.41
Values 0 1.1 0.33 0.64 0.66
[135]
HepG2 TLR4
Mean 1.46
Standard deviation 0.9
Values 0.82 2.1
[136]
HepG2.C3A TLR4
Mean 0.0365
Standard deviation 0.024
Values 0.019 0.054
[137]
HuH.7 TLR4
Mean 0.0189
Standard deviation 0.019
Values 0 0.019 0.037
[138]
SNU475 TLR4
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[139]
THLE TLR4
Mean 45
Standard deviation 10
Values 52 38
[140]
liver TLR4
Mean 17.2
Standard deviation 6.3
Values 13 19 11 25
[141]
ref_hepatocyte TICAM2
Mean 0.456
Standard deviation 0.51
Values 0 0.53 0 0.51 1.2
[142]
HepG2 TICAM2
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[143]
HepG2.C3A TICAM2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 TICAM2
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[145]
SNU475 TICAM2
Mean 0.297
Standard deviation 0.053
Values 0.26 0.33
[146]
THLE TICAM2
Mean 0.422
Standard deviation 0.036
Values 0.4 0.45
[147]
liver TICAM2
Mean 0.164
Standard deviation 0.11
Values 0.21 0.14 0.026 0.28
[148]
ref_hepatocyte RIPK3
Mean 0.227
Standard deviation 0.15
Values 0 0.37 0.33 0.15 0.29
[149]
HepG2 RIPK3
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[150]
HepG2.C3A RIPK3
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 RIPK3
Mean 0.0107
Standard deviation 0.019
Values 0 0.032 0
[152]
SNU475 RIPK3
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE RIPK3
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[154]
liver RIPK3
Mean 0.474
Standard deviation 0.21
Values 0.78 0.43 0.36 0.33
[155]
ref_hepatocyte SARM1
Mean 0.16
Standard deviation 0.097
Values 0.066 0.067 0.16 0.29 0.21
[156]
HepG2 SARM1
Mean 0.118
Standard deviation 0.021
Values 0.1 0.13
[157]
HepG2.C3A SARM1
Mean 0.127
Standard deviation 0.013
Values 0.14 0.12
[158]
HuH.7 SARM1
Mean 0.395
Standard deviation 0.092
Values 0.3 0.49 0.39
[159]
SNU475 SARM1
Mean 0.117
Standard deviation 0.028
Values 0.097 0.14
[160]
THLE SARM1
Mean 5.16
Standard deviation 0.78
Values 4.6 5.7
[161]
liver SARM1
Mean 1.82
Standard deviation 0.21
Values 1.6 2 1.7 1.9