REACTOME_HS_GAG_DEGRADATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GPC3 Glypican-3 [1] 0.85[2] 1.17[3] 0.64[4] -7.66[5] -6.94[6] -8.36[7]
2 SDC1 Syndecan-1 [8] -1.82[9] -2.39[10] -1.21[11] -2.12[12] -3.90[13] 0.65[14]
3 SDC4 Syndecan-4 [15] -1.02[16] -1.45[17] -1.85[18] -1.52[19] 0.55[20] -0.24[21]
4 SDC2 Syndecan-2 [22] -0.92[23] -0.08[24] 0.39[25] 0.05[26] -2.64[27] 0.50[28]
5 GUSB Beta-glucuronidase [29] -2.95[30] -2.74[31] -1.40[32] -0.64[33] -0.63[34] 0.09[35]
6 GLB1 Beta-galactosidase [36] -0.68[37] -1.15[38] 0.72[39] -0.28[40] 1.04[41] -0.01[42]
7 NAGLU Alpha-N-acetylglucosaminidase [43] -1.19[44] -1.60[45] -0.32[46] -0.81[47] -0.58[48] -0.39[49]
8 GPC1 Glypican-1 [50] -0.83[51] -4.27[52] -7.45[53] 2.69[54] 1.99[55] -0.66[56]
9 IDS Iduronate 2-sulfatase [57] -1.12[58] -1.79[59] -1.51[60] 2.25[61] 1.94[62] 1.06[63]
10 AGRN Agrin [64] 2.83[65] 2.15[66] 2.47[67] 3.77[68] 3.34[69] 0.94[70]
11 HGSNAT Heparan-alpha-glucosaminide N-acetyltransferase [71] -0.85[72] -1.14[73] -0.03[74] 0.84[75] 1.38[76] 1.09[77]
12 SGSH N-sulphoglucosamine sulphohydrolase [78] 0.40[79] -0.49[80] -1.17[81] 0.45[82] 1.05[83] 0.34[84]
13 GPC6 Glypican-6 [85] 1.27[86] 0.35[87] 1.77[88] 4.18[89] 2.78[90] 3.13[91]
14 IDUA Alpha-L-iduronidase [92] -3.73[93] -3.27[94] -2.07[95] 0.98[96] -0.17[97] -0.06[98]
15 SDC3 Syndecan-3 [99] 1.47[100] -4.87[101] -0.02[102] 3.36[103] 4.16[104] 2.62[105]
16 GLB1L Beta-galactosidase-1-like protein [106] -1.43[107] -0.95[108] -0.18[109] 0.24[110] 1.30[111] -0.40[112]
17 HSPG2 Basement membrane-specific heparan sulfate proteoglycan core protein 6.29[113] 4.42[114] 5.64[115] 6.28[116] 6.96[117] 6.24[118]
18 GPC4 Glypican-4 [119] -2.34[120] -6.50[121] -1.90[122] 5.71[123] -1.53[124] 0.81[125]
19 HPSE Heparanase [126] -2.40[127] -2.43[128] -0.69[129] 2.41[130] 5.54[131] 1.51[132]
20 GPC5 Glypican-5 [133] -4.52[134] -5.94[135] -0.73[136] -3.01[137] -1.97[138] 3.44[139]
21 GPC2 Glypican-2 [140] 1.58[141] 0.91[142] 3.76[143] 3.57[144] 2.94[145] -3.20[146]
22 HPSE2 Inactive heparanase-2 [147] [148] [149] [150] [151] [152] [153]
[1]
ref_hepatocyte GPC3
Mean 126
Standard deviation 2.8e+02
Values 6.3e+02 0.054 0.022 0.2 0.45
[2]
HepG2 GPC3
Mean 1.26e+03
Standard deviation 9.2
Values 1.3e+03 1.3e+03
[3]
HepG2.C3A GPC3
Mean 1.5e+03
Standard deviation 6.5e+02
Values 2e+03 1e+03
[4]
HuH.7 GPC3
Mean 561
Standard deviation 1.5e+02
Values 4.3e+02 7.2e+02 5.4e+02
[5]
SNU475 GPC3
Mean 0.967
Standard deviation 0.21
Values 1.1 0.82
[6]
THLE GPC3
Mean 1.25
Standard deviation 0.31
Values 1.5 1
[7]
liver GPC3
Mean 0.594
Standard deviation 0.31
Values 0.47 0.46 1.1 0.4
[8]
ref_hepatocyte SDC1
Mean 90.9
Standard deviation 70
Values 30 69 33 1.3e+02 1.9e+02
[9]
HepG2 SDC1
Mean 143
Standard deviation 14
Values 1.5e+02 1.3e+02
[10]
HepG2.C3A SDC1
Mean 92.1
Standard deviation 9.8
Values 85 99
[11]
HuH.7 SDC1
Mean 113
Standard deviation 31
Values 1.3e+02 77 1.3e+02
[12]
SNU475 SDC1
Mean 32.6
Standard deviation 5
Values 36 29
[13]
THLE SDC1
Mean 7.4
Standard deviation 0.31
Values 7.6 7.2
[14]
liver SDC1
Mean 222
Standard deviation 69
Values 1.8e+02 2.1e+02 3.2e+02 1.7e+02
[15]
ref_hepatocyte SDC4
Mean 75.2
Standard deviation 11
Values 84 85 60 78 68
[16]
HepG2 SDC4
Mean 206
Standard deviation 1.1e+02
Values 2.8e+02 1.3e+02
[17]
HepG2.C3A SDC4
Mean 146
Standard deviation 40
Values 1.7e+02 1.2e+02
[18]
HuH.7 SDC4
Mean 59.9
Standard deviation 26
Values 47 90 43
[19]
SNU475 SDC4
Mean 41
Standard deviation 1.5
Values 42 40
[20]
THLE SDC4
Mean 134
Standard deviation 15
Values 1.2e+02 1.4e+02
[21]
liver SDC4
Mean 99.2
Standard deviation 32
Values 1.1e+02 74 1.4e+02 74
[22]
ref_hepatocyte SDC2
Mean 42.2
Standard deviation 32
Values 57 12 12 42 87
[23]
HepG2 SDC2
Mean 124
Standard deviation 1.5
Values 1.2e+02 1.3e+02
[24]
HepG2.C3A SDC2
Mean 212
Standard deviation 41
Values 2.4e+02 1.8e+02
[25]
HuH.7 SDC2
Mean 158
Standard deviation 56
Values 1.2e+02 2.2e+02 1.3e+02
[26]
SNU475 SDC2
Mean 68
Standard deviation 21
Values 83 53
[27]
THLE SDC2
Mean 8.21
Standard deviation 1.9
Values 9.6 6.9
[28]
liver SDC2
Mean 92.5
Standard deviation 51
Values 1.7e+02 61 82 60
[29]
ref_hepatocyte GUSB
Mean 25.3
Standard deviation 23
Values 7 7.5 11 52 49
[30]
HepG2 GUSB
Mean 18.3
Standard deviation 3.5
Values 21 16
[31]
HepG2.C3A GUSB
Mean 20.1
Standard deviation 2
Values 22 19
[32]
HuH.7 GUSB
Mean 27.5
Standard deviation 3.9
Values 26 25 32
[33]
SNU475 GUSB
Mean 25.3
Standard deviation 2.9
Values 23 27
[34]
THLE GUSB
Mean 20
Standard deviation 0.097
Values 20 20
[35]
liver GUSB
Mean 42.1
Standard deviation 30
Values 54 22 79 14
[36]
ref_hepatocyte GLB1
Mean 15.3
Standard deviation 5.7
Values 22 9.9 8.6 18 18
[37]
HepG2 GLB1
Mean 53.1
Standard deviation 4.7
Values 56 50
[38]
HepG2.C3A GLB1
Mean 36.7
Standard deviation 8.2
Values 42 31
[39]
HuH.7 GLB1
Mean 72.4
Standard deviation 9.9
Values 62 81 75
[40]
SNU475 GLB1
Mean 19.7
Standard deviation 1.4
Values 19 21
[41]
THLE GLB1
Mean 38.2
Standard deviation 4.9
Values 35 42
[42]
liver GLB1
Mean 23.6
Standard deviation 8.2
Values 23 20 35 16
[43]
ref_hepatocyte NAGLU
Mean 11.6
Standard deviation 11
Values 4.4 2.3 5.1 22 24
[44]
HepG2 NAGLU
Mean 28.5
Standard deviation 0.22
Values 28 29
[45]
HepG2.C3A NAGLU
Mean 20.4
Standard deviation 4
Values 23 18
[46]
HuH.7 NAGLU
Mean 26.8
Standard deviation 6.6
Values 26 20 34
[47]
SNU475 NAGLU
Mean 10.4
Standard deviation 3.9
Values 13 7.6
[48]
THLE NAGLU
Mean 9.46
Standard deviation 2.1
Values 7.9 11
[49]
liver NAGLU
Mean 13.8
Standard deviation 2.3
Values 16 11 15 14
[50]
ref_hepatocyte GPC1
Mean 11.5
Standard deviation 7.6
Values 1.4 21 16 9.6 8.7
[51]
HepG2 GPC1
Mean 35.9
Standard deviation 11
Values 44 28
[52]
HepG2.C3A GPC1
Mean 3.16
Standard deviation 0.57
Values 2.8 3.6
[53]
HuH.7 GPC1
Mean 0.188
Standard deviation 0.13
Values 0.3 0.23 0.037
[54]
SNU475 GPC1
Mean 115
Standard deviation 39
Values 1.4e+02 88
[55]
THLE GPC1
Mean 55.5
Standard deviation 8.3
Values 50 61
[56]
liver GPC1
Mean 11.3
Standard deviation 3.4
Values 7.6 13 15 9.6
[57]
ref_hepatocyte IDS
Mean 6.6
Standard deviation 4
Values 1.7 8.7 12 5 5.4
[58]
HepG2 IDS
Mean 16.9
Standard deviation 2.4
Values 19 15
[59]
HepG2.C3A IDS
Mean 10.2
Standard deviation 0.54
Values 9.8 11
[60]
HuH.7 IDS
Mean 6.65
Standard deviation 2.1
Values 5.9 9 5
[61]
SNU475 IDS
Mean 49.1
Standard deviation 1.7
Values 50 48
[62]
THLE IDS
Mean 30.9
Standard deviation 4
Values 28 34
[63]
liver IDS
Mean 21.3
Standard deviation 4.6
Values 27 15 22 22
[64]
ref_hepatocyte AGRN
Mean 5.08
Standard deviation 2.6
Values 4.9 9.5 3.2 4.4 3.4
[65]
HepG2 AGRN
Mean 201
Standard deviation 74
Values 2.5e+02 1.5e+02
[66]
HepG2.C3A AGRN
Mean 120
Standard deviation 34
Values 1.4e+02 95
[67]
HuH.7 AGRN
Mean 80.8
Standard deviation 15
Values 96 66 80
[68]
SNU475 AGRN
Mean 108
Standard deviation 64
Values 1.5e+02 63
[69]
THLE AGRN
Mean 62.4
Standard deviation 19
Values 49 76
[70]
liver AGRN
Mean 15.2
Standard deviation 13
Values 4 26 3.2 28
[71]
ref_hepatocyte HGSNAT
Mean 4.04
Standard deviation 1.6
Values 5.4 2.4 2.6 4 5.8
[72]
HepG2 HGSNAT
Mean 12.5
Standard deviation 3.7
Values 9.8 15
[73]
HepG2.C3A HGSNAT
Mean 9.74
Standard deviation 2.6
Values 12 7.9
[74]
HuH.7 HGSNAT
Mean 11.4
Standard deviation 1.7
Values 12 12 9.4
[75]
SNU475 HGSNAT
Mean 11.2
Standard deviation 4.7
Values 15 7.9
[76]
THLE HGSNAT
Mean 12.8
Standard deviation 2.9
Values 11 15
[77]
liver HGSNAT
Mean 13.4
Standard deviation 1.5
Values 12 14 15 13
[78]
ref_hepatocyte SGSH
Mean 3.8
Standard deviation 3.4
Values 9.9 1.8 2.8 1.9 2.6
[79]
HepG2 SGSH
Mean 27.9
Standard deviation 0.23
Values 28 28
[80]
HepG2.C3A SGSH
Mean 14.4
Standard deviation 5.6
Values 18 10
[81]
HuH.7 SGSH
Mean 4.87
Standard deviation 0.69
Values 5.2 4.1 5.4
[82]
SNU475 SGSH
Mean 8.08
Standard deviation 1.6
Values 9.2 6.9
[83]
THLE SGSH
Mean 9.61
Standard deviation 1.2
Values 8.8 10
[84]
liver SGSH
Mean 7.46
Standard deviation 5.8
Values 15 2.3 9 3.6
[85]
ref_hepatocyte GPC6
Mean 2.38
Standard deviation 1.5
Values 3.3 1.3 0.41 2.8 4
[86]
HepG2 GPC6
Mean 32
Standard deviation 10
Values 25 39
[87]
HepG2.C3A GPC6
Mean 16.1
Standard deviation 1.8
Values 15 17
[88]
HuH.7 GPC6
Mean 23.3
Standard deviation 7.4
Values 21 31 17
[89]
SNU475 GPC6
Mean 67.1
Standard deviation 28
Values 87 47
[90]
THLE GPC6
Mean 19.9
Standard deviation 5
Values 16 23
[91]
liver GPC6
Mean 32.3
Standard deviation 8.7
Values 38 30 21 40
[92]
ref_hepatocyte IDUA
Mean 1.21
Standard deviation 1.4
Values 0 0.052 0.69 3.2 2.1
[93]
HepG2 IDUA
Mean 0.506
Standard deviation 0.019
Values 0.49 0.52
[94]
HepG2.C3A IDUA
Mean 0.666
Standard deviation 0.49
Values 1 0.32
[95]
HuH.7 IDUA
Mean 0.828
Standard deviation 0.42
Values 0.39 1.2 0.85
[96]
SNU475 IDUA
Mean 3.72
Standard deviation 1.5
Values 4.8 2.7
[97]
THLE IDUA
Mean 1.31
Standard deviation 0.3
Values 1.5 1.1
[98]
liver IDUA
Mean 1.81
Standard deviation 0.66
Values 2.7 1.1 1.9 1.6
[99]
ref_hepatocyte SDC3
Mean 1.04
Standard deviation 0.71
Values 0.11 0.84 0.73 1.7 1.8
[100]
HepG2 SDC3
Mean 16
Standard deviation 2.6
Values 18 14
[101]
HepG2.C3A SDC3
Mean 0.19
Standard deviation 0.035
Values 0.17 0.21
[102]
HuH.7 SDC3
Mean 2.95
Standard deviation 1.2
Values 4 1.7 3.2
[103]
SNU475 SDC3
Mean 16.7
Standard deviation 0.42
Values 17 16
[104]
THLE SDC3
Mean 22.7
Standard deviation 0.49
Values 22 23
[105]
liver SDC3
Mean 9.95
Standard deviation 2.5
Values 9.5 13 7.1 10
[106]
ref_hepatocyte GLB1L
Mean 1.01
Standard deviation 0.33
Values 0.78 0.72 1.5 0.85 1.2
[107]
HepG2 GLB1L
Mean 2.08
Standard deviation 0.079
Values 2 2.1
[108]
HepG2.C3A GLB1L
Mean 2.77
Standard deviation 0.12
Values 2.9 2.7
[109]
HuH.7 GLB1L
Mean 2.55
Standard deviation 1
Values 3.2 1.4 3
[110]
SNU475 GLB1L
Mean 1.86
Standard deviation 0.34
Values 2.1 1.6
[111]
THLE GLB1L
Mean 3.01
Standard deviation 0.17
Values 2.9 3.1
[112]
liver GLB1L
Mean 1.18
Standard deviation 0.44
Values 1.1 1.2 1.8 0.7
[113]
ref_hepatocyte HSPG2
Mean 0.417
Standard deviation 0.41
Values 1.1 0.16 0.49 0.16 0.18
[114]
HepG2 HSPG2
Mean 181
Standard deviation 62
Values 2.3e+02 1.4e+02
[115]
HepG2.C3A HSPG2
Mean 47.5
Standard deviation 2.4
Values 46 49
[116]
HuH.7 HSPG2
Mean 59.8
Standard deviation 39
Values 1e+02 34 40
[117]
SNU475 HSPG2
Mean 50.5
Standard deviation 35
Values 75 26
[118]
THLE HSPG2
Mean 63.4
Standard deviation 18
Values 50 76
[119]
liver HSPG2
Mean 49
Standard deviation 38
Values 14 64 22 96
[120]
ref_hepatocyte GPC4
Mean 0.349
Standard deviation 0.51
Values 0.13 0.065 1.2 0 0.33
[121]
HepG2 GPC4
Mean 0.383
Standard deviation 0.074
Values 0.44 0.33
[122]
HepG2.C3A GPC4
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[123]
HuH.7 GPC4
Mean 0.269
Standard deviation 0.25
Values 0.18 0.55 0.075
[124]
SNU475 GPC4
Mean 28.5
Standard deviation 18
Values 41 16
[125]
THLE GPC4
Mean 0.147
Standard deviation 0.048
Values 0.11 0.18
[126]
liver GPC4
Mean 0.949
Standard deviation 0.44
Values 0.71 1.1 0.51 1.5
[127]
ref_hepatocyte HPSE
Mean 0.271
Standard deviation 0.14
Values 0.35 0.15 0.47 0.24 0.15
[128]
HepG2 HPSE
Mean 0.286
Standard deviation 0.017
Values 0.3 0.27
[129]
HepG2.C3A HPSE
Mean 0.267
Standard deviation 0.062
Values 0.22 0.31
[130]
HuH.7 HPSE
Mean 0.483
Standard deviation 0.063
Values 0.41 0.51 0.52
[131]
SNU475 HPSE
Mean 2.25
Standard deviation 0.14
Values 2.3 2.1
[132]
THLE HPSE
Mean 15.4
Standard deviation 1.3
Values 14 16
[133]
liver HPSE
Mean 1.2
Standard deviation 0.48
Values 0.63 1.8 1.2 1.1
[134]
ref_hepatocyte GPC5
Mean 0.0619
Standard deviation 0.066
Values 0 0 0.14 0.052 0.11
[135]
HepG2 GPC5
Mean 0.015
Standard deviation 0.0031
Values 0.017 0.013
[136]
HepG2.C3A GPC5
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[137]
HuH.7 GPC5
Mean 0.107
Standard deviation 0.094
Values 0.082 0.21 0.028
[138]
SNU475 GPC5
Mean 0.012
Standard deviation 0.0027
Values 0.014 0.01
[139]
THLE GPC5
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[140]
liver GPC5
Mean 1.04
Standard deviation 0.64
Values 2 0.83 0.72 0.64
[141]
ref_hepatocyte GPC2
Mean 0.0542
Standard deviation 0.044
Values 0.094 0 0.019 0.06 0.098
[142]
HepG2 GPC2
Mean 0.9
Standard deviation 0.41
Values 1.2 0.61
[143]
HepG2.C3A GPC2
Mean 0.541
Standard deviation 0.0087
Values 0.53 0.55
[144]
HuH.7 GPC2
Mean 2.11
Standard deviation 0.72
Values 2.1 1.4 2.8
[145]
SNU475 GPC2
Mean 1.01
Standard deviation 0.087
Values 0.95 1.1
[146]
THLE GPC2
Mean 0.506
Standard deviation 0.038
Values 0.53 0.48
[147]
liver GPC2
Mean 0.00918
Standard deviation 0.011
Values 0.024 0 0 0.013
[148]
ref_hepatocyte HPSE2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 HPSE2
Mean 0.17
Standard deviation 0.13
Values 0.26 0.077
[150]
HepG2.C3A HPSE2
Mean 0.0302
Standard deviation 0.012
Values 0.039 0.021
[151]
HuH.7 HPSE2
Mean 2.68
Standard deviation 1.4
Values 3.7 1.1 3.1
[152]
SNU475 HPSE2
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[153]
THLE HPSE2
Mean 0
Standard deviation 0
Values 0 0
[154]
liver HPSE2
Mean 0
Standard deviation 0
Values 0 0 0 0