REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | B2M | Beta-2-microglobulin | [1] | -2.27[2] | -2.09[3] | -2.92[4] | -0.23[5] | -0.41[6] | 0.59[7] |
2 | UBB | Polyubiquitin-B | [8] | -1.18[9] | -1.41[10] | -1.44[11] | -1.73[12] | -1.31[13] | -0.69[14] |
3 | NPM1 | Nucleophosmin | [15] | -0.87[16] | -0.04[17] | 0.47[18] | -1.43[19] | -1.44[20] | -2.75[21] |
4 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [22] | [23] | [24] | [25] | [26] | [27] | [28] |
5 | UBC | Polyubiquitin-C | [29] | -0.74[30] | -0.66[31] | -1.07[32] | -0.88[33] | -0.93[34] | -0.23[35] |
6 | PPIA | Peptidyl-prolyl cis-trans isomerase A | [36] | 0.91[37] | 1.02[38] | 1.18[39] | 0.82[40] | 0.89[41] | 0.81[42] |
7 | HLA-A | HLA class I histocompatibility antigen, A-68 alpha chain | [43] | -0.16[44] | 0.06[45] | -6.10[46] | 0.79[47] | -0.27[48] | -0.89[49] |
8 | SLC25A5 | ADP/ATP translocase 2 | [50] | -0.24[51] | 0.26[52] | 1.17[53] | -0.40[54] | -0.61[55] | -0.43[56] |
9 | PSME1 | Proteasome activator complex subunit 1 | [57] | -0.51[58] | -2.25[59] | -2.04[60] | -1.60[61] | -2.16[62] | -1.19[63] |
10 | ARF1 | ADP-ribosylation factor 1 | [64] | -0.18[65] | 0.00[66] | 0.21[67] | 0.44[68] | 0.08[69] | 0.50[70] |
11 | RAN | GTP-binding nuclear protein Ran | [71] | 0.65[72] | 0.75[73] | -0.08[74] | -0.11[75] | 0.08[76] | -0.75[77] |
12 | PSME2 | Proteasome activator complex subunit 2 | [78] | -0.33[79] | -1.87[80] | -2.13[81] | -1.38[82] | -1.69[83] | -0.81[84] |
13 | PSMA7 | Proteasome subunit alpha type-7 | [85] | 0.63[86] | 0.60[87] | -0.88[88] | 0.24[89] | -0.22[90] | 0.21[91] |
14 | PSMB1 | Proteasome subunit beta type-1 | [92] | 0.17[93] | 0.15[94] | -1.08[95] | -1.00[96] | -0.26[97] | 0.05[98] |
15 | RANBP1 | Ran-specific GTPase-activating protein | [99] | -0.45[100] | -0.52[101] | -0.64[102] | -1.38[103] | -0.75[104] | -1.99[105] |
16 | PSMB3 | Proteasome subunit beta type-3 | [106] | -0.31[107] | -1.24[108] | -0.36[109] | -1.02[110] | -1.16[111] | -0.25[112] |
17 | PSMB4 | Proteasome subunit beta type-4 | [113] | -0.06[114] | -0.04[115] | -0.06[116] | 0.41[117] | 0.38[118] | -0.57[119] |
18 | PSMB7 | Proteasome subunit beta type-7 | [120] | -1.01[121] | -1.14[122] | -1.15[123] | -1.37[124] | -0.95[125] | -1.01[126] |
19 | PSMB5 | Proteasome subunit beta type-5 | [127] | 1.39[128] | -0.18[129] | -0.40[130] | -0.64[131] | -0.39[132] | -0.54[133] |
20 | BANF1 | Barrier-to-autointegration factor | [134] | -1.00[135] | -0.93[136] | -1.53[137] | -0.85[138] | -1.03[139] | -1.62[140] |
21 | PSMA6 | Proteasome subunit alpha type-6 | [141] | 1.52[142] | 0.10[143] | -0.12[144] | -0.12[145] | -0.12[146] | -0.46[147] |
22 | SLC25A6 | ADP/ATP translocase 3 | [148] | [149] | [150] | [151] | [152] | [153] | [154] |
23 | PSMA4 | Proteasome subunit alpha type-4 | [155] | -0.41[156] | 0.12[157] | -0.24[158] | 0.19[159] | -0.01[160] | -0.53[161] |
24 | SKP1 | S-phase kinase-associated protein 1 | [162] | 0.03[163] | 0.40[164] | -0.65[165] | 0.54[166] | 0.72[167] | 0.50[168] |
25 | PSMC3 | 26S proteasome regulatory subunit 6A | [169] | -0.44[170] | -0.64[171] | -0.18[172] | -1.01[173] | -0.83[174] | -0.06[175] |
26 | PSMA3 | Proteasome subunit alpha type-3 | [176] | -1.03[177] | -0.16[178] | -0.99[179] | -0.27[180] | -0.73[181] | -0.29[182] |
27 | HMGA1 | High mobility group protein HMG-I/HMG-Y | [183] | 1.75[184] | 0.66[185] | 0.97[186] | 0.28[187] | 1.39[188] | -3.68[189] |
28 | PSMB6 | Proteasome subunit beta type-6 | [190] | -0.48[191] | -0.47[192] | -0.47[193] | -0.81[194] | -1.10[195] | -0.13[196] |
29 | PSMA2 | Proteasome subunit alpha type-2 | [197] | -0.57[198] | 0.26[199] | 0.44[200] | -0.32[201] | 0.04[202] | 0.09[203] |
30 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [204] | -0.05[205] | -0.17[206] | -0.12[207] | 0.39[208] | -0.17[209] | -0.23[210] |
31 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [211] | -0.13[212] | 0.11[213] | -0.18[214] | -0.70[215] | -0.24[216] | -0.40[217] |
32 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [218] | 0.04[219] | 0.15[220] | 0.13[221] | -0.43[222] | 0.32[223] | -0.38[224] |
33 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [225] | 1.57[226] | 0.62[227] | 0.54[228] | 0.68[229] | 1.96[230] | 0.66[231] |
34 | SEC13 | Protein SEC13 homolog | [232] | 0.06[233] | 0.41[234] | 0.42[235] | -0.68[236] | -0.56[237] | -0.37[238] |
35 | PSMC1 | 26S proteasome regulatory subunit 4 | [239] | -0.11[240] | -0.18[241] | -0.98[242] | 0.87[243] | 0.38[244] | -0.18[245] |
36 | PSMA1 | Proteasome subunit alpha type-1 | [246] | 0.07[247] | 0.33[248] | 0.24[249] | 0.44[250] | -0.07[251] | 0.31[252] |
37 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [253] | 1.69[254] | 1.57[255] | 2.44[256] | 0.52[257] | 1.29[258] | 0.54[259] |
38 | PSMC5 | 26S proteasome regulatory subunit 8 | [260] | 0.39[261] | 0.15[262] | 0.08[263] | -0.15[264] | 0.25[265] | 0.07[266] |
39 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [267] | -1.04[268] | -0.64[269] | -0.93[270] | -1.66[271] | -1.27[272] | -0.91[273] |
40 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [274] | 0.62[275] | 0.26[276] | 0.80[277] | 1.06[278] | 1.01[279] | 0.23[280] |
41 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [281] | 0.79[282] | 0.15[283] | 0.59[284] | 0.38[285] | 0.59[286] | -0.21[287] |
42 | PSMB8 | Proteasome subunit beta type-8 | [288] | -1.61[289] | -2.33[290] | -9.70[291] | 0.36[292] | -0.96[293] | -0.90[294] |
43 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [295] | -0.04[296] | 0.44[297] | 0.54[298] | 0.25[299] | 0.26[300] | -0.36[301] |
44 | PSMC4 | 26S proteasome regulatory subunit 6B | [302] | 0.39[303] | 0.29[304] | 0.07[305] | -0.12[306] | -0.02[307] | 0.12[308] |
45 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [309] | -0.76[310] | -0.41[311] | -1.65[312] | -0.75[313] | 0.05[314] | -0.47[315] |
46 | KPNB1 | Importin subunit beta-1 | [316] | 1.93[317] | 2.06[318] | 2.17[319] | 2.25[320] | 1.81[321] | 0.64[322] |
47 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [323] | 0.43[324] | 0.42[325] | 0.76[326] | 0.31[327] | -0.20[328] | -0.28[329] |
48 | AP2M1 | AP-2 complex subunit mu | [330] | 1.23[331] | 1.01[332] | 0.33[333] | 2.02[334] | 2.50[335] | 1.03[336] |
49 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [337] | -0.39[338] | -0.44[339] | -0.90[340] | -0.07[341] | -0.02[342] | -0.36[343] |
50 | AP2S1 | AP-2 complex subunit sigma | [344] | -0.60[345] | -0.66[346] | -0.13[347] | 0.30[348] | 0.70[349] | 0.17[350] |
51 | PSMC6 | 26S proteasome regulatory subunit 10B | [351] | -0.09[352] | 1.36[353] | 0.02[354] | 0.29[355] | 0.20[356] | 0.29[357] |
52 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [358] | 0.79[359] | 0.28[360] | 0.72[361] | 0.69[362] | 0.84[363] | 1.12[364] |
53 | PSMC2 | 26S proteasome regulatory subunit 7 | [365] | 0.55[366] | 0.82[367] | 0.44[368] | 1.09[369] | 0.90[370] | 1.17[371] |
54 | PSME3 | Proteasome activator complex subunit 3 | [372] | 1.78[373] | 1.36[374] | 0.89[375] | 1.11[376] | 1.37[377] | 0.74[378] |
55 | AP1S1 | AP-1 complex subunit sigma-1A | [379] | 0.01[380] | -0.33[381] | -0.11[382] | 0.05[383] | -0.22[384] | -1.61[385] |
56 | RANGAP1 | Ran GTPase-activating protein 1 | [386] | 1.66[387] | 1.33[388] | 1.01[389] | 0.67[390] | 1.50[391] | 0.22[392] |
57 | RCC1 | Regulator of chromosome condensation | [393] | 1.27[394] | 2.14[395] | 0.67[396] | 0.44[397] | 0.09[398] | -1.29[399] |
58 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [400] | 1.54[401] | 1.72[402] | 1.45[403] | 1.92[404] | 1.91[405] | 1.93[406] |
59 | PSMB10 | Proteasome subunit beta type-10 | [407] | -1.19[408] | -0.72[409] | -2.76[410] | -0.29[411] | -1.47[412] | -0.22[413] |
60 | PSMA5 | Proteasome subunit alpha type-5 | [414] | 1.86[415] | 2.16[416] | 1.57[417] | 1.97[418] | 1.52[419] | 1.76[420] |
61 | PSMF1 | Proteasome inhibitor PI31 subunit | [421] | 2.24[422] | 2.16[423] | 0.81[424] | 0.98[425] | 0.73[426] | 1.71[427] |
62 | AP1M1 | AP-1 complex subunit mu-1 | [428] | 1.00[429] | 0.62[430] | 1.50[431] | 0.52[432] | 0.61[433] | 1.11[434] |
63 | PSMB2 | Proteasome subunit beta type-2 | [435] | 2.02[436] | 1.63[437] | 1.86[438] | 2.28[439] | 2.25[440] | 2.25[441] |
64 | CD4 | T-cell surface glycoprotein CD4 | [442] | -4.74[443] | -2.59[444] | -5.39[445] | -6.40[446] | -8.50[447] | 1.11[448] |
65 | PSMB9 | Proteasome subunit beta type-9 | [449] | -1.98[450] | -4.73[451] | -7.19[452] | 1.53[453] | -0.76[454] | -0.64[455] |
66 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [456] | 0.40[457] | 0.76[458] | -0.38[459] | 0.15[460] | 0.58[461] | 0.58[462] |
67 | XPO1 | Exportin-1 | [463] | 2.37[464] | 3.06[465] | 2.91[466] | 3.18[467] | 3.23[468] | 2.05[469] |
68 | CDK9 | Cyclin-dependent kinase 9 | [470] | 0.64[471] | 0.24[472] | 0.15[473] | 0.89[474] | 0.56[475] | 1.34[476] |
69 | PSIP1 | PC4 and SFRS1-interacting protein | [477] | -0.09[478] | 0.88[479] | 1.33[480] | 1.54[481] | 2.53[482] | 0.45[483] |
70 | RAE1 | mRNA export factor | [484] | 1.59[485] | 1.28[486] | -0.02[487] | 1.63[488] | 0.90[489] | 0.17[490] |
71 | PAK2 | Serine/threonine-protein kinase PAK 2 | [491] | 2.46[492] | 2.18[493] | 2.30[494] | 1.80[495] | 2.31[496] | 2.56[497] |
72 | AP2A1 | AP-2 complex subunit alpha-1 | [498] | 2.22[499] | 1.85[500] | 2.52[501] | 2.45[502] | 2.48[503] | 2.14[504] |
73 | AP1B1 | AP-1 complex subunit beta-1 | [505] | 2.13[506] | 1.43[507] | 3.17[508] | 2.25[509] | 2.02[510] | 2.68[511] |
74 | NUP88 | Nuclear pore complex protein Nup88 | [512] | 0.96[513] | 1.46[514] | 1.39[515] | 0.72[516] | 1.18[517] | 2.31[518] |
75 | SEH1L | Nucleoporin SEH1 | [519] | 1.24[520] | 1.70[521] | 1.98[522] | 1.62[523] | 0.80[524] | 1.37[525] |
76 | SLC25A4 | ADP/ATP translocase 1 | [526] | 0.99[527] | 0.93[528] | -1.70[529] | 0.12[530] | 0.40[531] | 2.36[532] |
77 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [533] | 0.96[534] | 1.15[535] | 1.02[536] | 1.82[537] | 1.13[538] | 0.57[539] |
78 | ATP6V1H | V-type proton ATPase subunit H | [540] | 0.70[541] | 0.56[542] | -0.45[543] | 1.67[544] | 1.53[545] | 0.63[546] |
79 | AP2B1 | AP-2 complex subunit beta | [547] | 3.26[548] | 2.95[549] | 4.51[550] | 3.60[551] | 3.42[552] | 2.13[553] |
80 | NUP35 | Nucleoporin NUP53 | [554] | -0.07[555] | 0.48[556] | 0.29[557] | -0.04[558] | -0.29[559] | -0.03[560] |
81 | AP2A2 | AP-2 complex subunit alpha-2 | [561] | 2.28[562] | 2.09[563] | 2.04[564] | 1.89[565] | 1.50[566] | 1.86[567] |
82 | AP1G1 | AP-1 complex subunit gamma-1 | [568] | 2.42[569] | 2.67[570] | 2.92[571] | 2.76[572] | 2.56[573] | 3.12[574] |
83 | PSME4 | Proteasome activator complex subunit 4 | [575] | 2.48[576] | 3.26[577] | 3.11[578] | 2.38[579] | 2.33[580] | 2.83[581] |
84 | NUP62 | Nuclear pore glycoprotein p62 | [582] | 2.19[583] | 1.77[584] | 2.65[585] | 2.26[586] | 2.30[587] | 1.61[588] |
85 | NUP85 | Nuclear pore complex protein Nup85 | [589] | 1.76[590] | 2.09[591] | 2.15[592] | 1.62[593] | 1.79[594] | 1.41[595] |
86 | AAAS | Aladin | [596] | 1.28[597] | 1.57[598] | 0.99[599] | 1.26[600] | 1.26[601] | 1.01[602] |
87 | NUP50 | Nuclear pore complex protein Nup50 | [603] | 1.79[604] | 2.44[605] | 2.67[606] | 2.03[607] | 2.48[608] | 2.75[609] |
88 | RANBP2 | E3 SUMO-protein ligase RanBP2 | [610] | 1.49[611] | 3.15[612] | 2.71[613] | 2.58[614] | 2.70[615] | 4.14[616] |
89 | AP1S2 | AP-1 complex subunit sigma-2 | [617] | -1.04[618] | -0.41[619] | -1.77[620] | 0.76[621] | 0.74[622] | 0.39[623] |
90 | NUP93 | Nuclear pore complex protein Nup93 | [624] | 2.69[625] | 2.18[626] | 1.99[627] | 1.99[628] | 2.25[629] | 0.68[630] |
91 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [631] | 1.37[632] | 0.80[633] | 2.20[634] | 2.21[635] | 2.28[636] | 2.01[637] |
92 | NUP98 | Nuclear pore complex protein Nup98-Nup96 | [638] | 3.19[639] | 2.84[640] | 2.93[641] | 3.28[642] | 2.79[643] | 3.05[644] |
93 | NUP54 | Nucleoporin p54 | [645] | 1.12[646] | 1.73[647] | 1.56[648] | 1.38[649] | 1.81[650] | 1.20[651] |
94 | KPNA1 | Importin subunit alpha-5 | [652] | 2.07[653] | 2.09[654] | 2.02[655] | 2.63[656] | 2.90[657] | 3.37[658] |
95 | NUP107 | Nuclear pore complex protein Nup107 | [659] | 1.52[660] | 2.60[661] | 2.41[662] | 2.34[663] | 2.22[664] | 1.19[665] |
96 | NUP37 | Nucleoporin Nup37 | [666] | 1.67[667] | 1.93[668] | 1.85[669] | 1.50[670] | 1.45[671] | -0.23[672] |
97 | TPR | Nucleoprotein TPR | [673] | 1.65[674] | 3.48[675] | 3.62[676] | 3.59[677] | 3.78[678] | 3.78[679] |
98 | NUP160 | Nuclear pore complex protein Nup160 | [680] | 2.87[681] | 2.99[682] | 3.42[683] | 2.22[684] | 2.48[685] | 2.66[686] |
99 | POM121 | Nuclear envelope pore membrane protein POM 121 | [687] | 2.46[688] | 2.78[689] | 2.45[690] | 2.60[691] | 2.00[692] | 2.49[693] |
100 | NUP133 | Nuclear pore complex protein Nup133 | [694] | 2.20[695] | 2.52[696] | 3.30[697] | 3.26[698] | 2.56[699] | 2.24[700] |
101 | NUP153 | Nuclear pore complex protein Nup153 | [701] | 3.41[702] | 3.58[703] | 3.05[704] | 4.31[705] | 3.42[706] | 3.13[707] |
102 | NUP43 | Nucleoporin Nup43 | [708] | 2.93[709] | 3.07[710] | 2.65[711] | 3.13[712] | 2.82[713] | 1.50[714] |
103 | CUL5 | Cullin-5 | [715] | 1.59[716] | 3.05[717] | 2.36[718] | 3.57[719] | 2.68[720] | 3.52[721] |
104 | NUP205 | Nuclear pore complex protein Nup205 | [722] | 3.20[723] | 3.08[724] | 4.08[725] | 3.83[726] | 3.96[727] | 2.70[728] |
105 | POM121C | Nuclear envelope pore membrane protein POM 121C | [729] | 2.30[730] | 1.53[731] | 1.03[732] | 2.45[733] | 1.84[734] | 1.62[735] |
106 | CCNT1 | Cyclin-T1 | [736] | 2.05[737] | 2.97[738] | 2.75[739] | 2.96[740] | 2.89[741] | 2.81[742] |
107 | NUP214 | Nuclear pore complex protein Nup214 | [743] | 3.04[744] | 2.32[745] | 3.27[746] | 3.23[747] | 3.12[748] | 2.95[749] |
108 | PACS1 | Phosphofurin acidic cluster sorting protein 1 | [750] | 3.94[751] | 2.25[752] | 2.96[753] | 3.91[754] | 3.89[755] | 1.30[756] |
109 | NUP188 | Nucleoporin NUP188 homolog | [757] | 4.28[758] | 3.63[759] | 4.09[760] | 3.57[761] | 4.70[762] | 3.02[763] |
110 | NUP210 | Nuclear pore membrane glycoprotein 210 | [764] | 4.72[765] | 4.50[766] | 5.43[767] | 3.15[768] | 1.50[769] | 4.18[770] |
111 | AP1S3 | AP-1 complex subunit sigma-3 | [771] | 2.32[772] | 1.91[773] | -0.36[774] | 1.00[775] | 1.13[776] | -0.12[777] |
112 | FYN | Tyrosine-protein kinase Fyn | [778] | 1.96[779] | -6.67[780] | 1.72[781] | 2.52[782] | 4.01[783] | 2.16[784] |
113 | BTRC | F-box/WD repeat-containing protein 1A | [785] | 2.43[786] | 3.19[787] | 2.63[788] | 1.81[789] | 2.30[790] | 2.54[791] |
114 | NUP155 | Nuclear pore complex protein Nup155 | [792] | 3.13[793] | 2.71[794] | 3.52[795] | 3.52[796] | 4.36[797] | 2.93[798] |
115 | AP1M2 | AP-1 complex subunit mu-2 | [799] | 2.36[800] | 3.02[801] | 4.18[802] | 0.95[803] | 0.56[804] | -1.42[805] |
116 | HCK | Tyrosine-protein kinase HCK | [806] | -4.83[807] | -5.04[808] | [809] | -4.22[810] | -5.19[811] | 1.90[812] |
117 | ELMO1 | Engulfment and cell motility protein 1 | [813] | -4.79[814] | -3.14[815] | 0.89[816] | -2.51[817] | -5.36[818] | 4.04[819] |
118 | APOBEC3 | DNA dC->dU-editing enzyme APOBEC-3G | [820] | -0.33[821] | -3.04[822] | -8.16[823] | -2.60[824] | 0.88[825] | 1.04[826] |
119 | CD247 | T-cell surface glycoprotein CD3 zeta chain | [827] | -3.85[828] | -4.55[829] | -6.23[830] | -2.46[831] | -3.89[832] | 1.18[833] |
120 | LCK | Tyrosine-protein kinase Lck | [834] | 3.79[835] | 3.84[836] | -6.33[837] | -4.03[838] | -4.28[839] | 2.43[840] |
121 | DOCK2 | Dedicator of cytokinesis protein 2 | [841] | -3.43[842] | [843] | -5.80[844] | 3.54[845] | 2.38[846] | 5.52[847] |
122 | CD28 | T-cell-specific surface glycoprotein CD28 | [848] | -2.99[849] | -2.15[850] | -2.29[851] | -1.30[852] | -1.39[853] | 2.31[854] |
123 | CD8B | T-cell surface glycoprotein CD8 beta chain | [855] | 2.01[856] | 0.34[857] | 8.76[858] | [859] | -1.01[860] | 4.31[861] |
124 | PSMB11 | Proteasome subunit beta type-11 | [862] | [863] | [864] | [865] | [866] | [867] | [868] |
125 | ELOB | Elongin-B | [869] | [870] | [871] | [872] | [873] | [874] | [875] |
126 | ELOC | Elongin-C | [876] | [877] | [878] | [879] | [880] | [881] | [882] |
127 | NUP58 | Nucleoporin p58/p45 | [883] | [884] | [885] | [886] | [887] | [888] | [889] |
128 | SEM1 | Putative protein SEM1, isoform 2 | [890] | [891] | [892] | [893] | [894] | [895] | [896] |
129 | NUP42 | [897] | [898] | [899] | [900] | [901] | [902] | [903] | |
130 | NDC1 | Nucleoporin NDC1 | [904] | [905] | [906] | [907] | [908] | [909] | [910] |
131 | PSMA8 | Proteasome subunit alpha type-7-like | [911] | [912] | [913] | [914] | [915] | [916] | [917] |