REACTOME_HOMOLOGY_DIRECTED_REPAIR | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.14[2] | -1.54[3] | -1.58[4] | -1.72[5] | -1.40[6] | -0.53[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.69[16] | -0.79[17] | -1.22[18] | -0.86[19] | -1.02[20] | -0.08[21] |
4 | SUMO1 | Small ubiquitin-related modifier 1 | [22] | -0.53[23] | -0.58[24] | -1.14[25] | -0.41[26] | -0.60[27] | -0.20[28] |
5 | SUMO2 | Small ubiquitin-related modifier 2 | [29] | 1.10[30] | 1.10[31] | 0.94[32] | 0.43[33] | 0.26[34] | -0.23[35] |
6 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [36] | 1.74[37] | 1.45[38] | 2.29[39] | 0.53[40] | 1.21[41] | 0.69[42] |
7 | PPP4C | Serine/threonine-protein phosphatase 4 catalytic subunit | [43] | 0.80[44] | 0.82[45] | 0.10[46] | -0.75[47] | -0.85[48] | -0.11[49] |
8 | PARP1 | Poly [ADP-ribose] polymerase 1 | [50] | 1.19[51] | 0.74[52] | 1.29[53] | 1.59[54] | 0.96[55] | 0.93[56] |
9 | PCNA | Proliferating cell nuclear antigen | [57] | 1.95[58] | 1.73[59] | 0.13[60] | 0.85[61] | 0.99[62] | -1.73[63] |
10 | POLD2 | DNA polymerase delta subunit 2 | [64] | 0.46[65] | 0.43[66] | 0.75[67] | 0.20[68] | 0.42[69] | 1.22[70] |
11 | POLD4 | DNA polymerase delta subunit 4 | [71] | -1.07[72] | -1.62[73] | 0.27[74] | 2.51[75] | -1.22[76] | 0.87[77] |
12 | POLE3 | DNA polymerase epsilon subunit 3 | [78] | 0.28[79] | -0.07[80] | 0.03[81] | 0.01[82] | 0.90[83] | -0.23[84] |
13 | POLE4 | DNA polymerase epsilon subunit 4 | [85] | 0.02[86] | 0.55[87] | -3.10[88] | -0.56[89] | -1.17[90] | -0.46[91] |
14 | BABAM1 | BRISC and BRCA1-A complex member 1 | [92] | 0.24[93] | 0.25[94] | 0.95[95] | 0.03[96] | 0.56[97] | -0.13[98] |
15 | RPA2 | Replication protein A 32 kDa subunit | [99] | -0.40[100] | -0.53[101] | -0.16[102] | 0.32[103] | 0.25[104] | -1.05[105] |
16 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [106] | 1.75[107] | 2.02[108] | 0.65[109] | 1.38[110] | 1.13[111] | 0.63[112] |
17 | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2 | [113] | -0.39[114] | 0.42[115] | 0.70[116] | 1.14[117] | 0.79[118] | 0.74[119] |
18 | PPP4R2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | [120] | -0.06[121] | 0.83[122] | -0.27[123] | -0.35[124] | 0.32[125] | 0.55[126] |
19 | ERCC1 | DNA excision repair protein ERCC-1 | [127] | 0.57[128] | 0.22[129] | 0.19[130] | 0.41[131] | 0.69[132] | 0.28[133] |
20 | CDK2 | Cyclin-dependent kinase 2 | [134] | 0.65[135] | 0.61[136] | 0.79[137] | 1.04[138] | 1.49[139] | -0.84[140] |
21 | RFC4 | Replication factor C subunit 4 | [141] | 0.09[142] | 0.52[143] | 0.91[144] | 0.10[145] | 1.29[146] | -1.41[147] |
22 | UBE2I | SUMO-conjugating enzyme UBC9 | [148] | 2.35[149] | 1.82[150] | 2.02[151] | 1.39[152] | 1.81[153] | 0.79[154] |
23 | RAD51C | DNA repair protein RAD51 homolog 3 | [155] | 0.65[156] | 0.68[157] | 0.32[158] | -1.12[159] | 0.28[160] | -0.91[161] |
24 | SLX1B | [162] | [163] | [164] | [165] | [166] | [167] | [168] | |
25 | SLX1A | Structure-specific endonuclease subunit SLX1 | [169] | [170] | [171] | [172] | [173] | [174] | [175] |
26 | RNF4 | E3 ubiquitin-protein ligase RNF4 | [176] | 2.18[177] | 1.40[178] | 2.65[179] | 3.00[180] | 1.87[181] | 1.52[182] |
27 | PARP2 | Poly [ADP-ribose] polymerase 2 | [183] | 0.99[184] | 0.41[185] | 0.98[186] | 0.79[187] | 1.42[188] | -0.13[189] |
28 | RFC1 | Replication factor C subunit 1 | [190] | 1.20[191] | 2.29[192] | 2.48[193] | 1.39[194] | 2.08[195] | 2.12[196] |
29 | RFC2 | Replication factor C subunit 2 | [197] | 0.80[198] | 0.45[199] | 0.30[200] | 1.24[201] | 1.56[202] | 0.57[203] |
30 | FEN1 | Flap endonuclease 1 | [204] | 2.09[205] | 1.68[206] | 2.34[207] | 1.74[208] | 2.50[209] | 0.25[210] |
31 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [211] | 2.37[212] | 1.91[213] | 1.99[214] | 2.91[215] | 2.79[216] | 1.35[217] |
32 | RPA3 | Replication protein A 14 kDa subunit | [218] | 0.69[219] | 1.29[220] | 1.82[221] | 0.16[222] | 0.30[223] | 0.65[224] |
33 | RAD17 | Cell cycle checkpoint protein RAD17 | [225] | 0.21[226] | 1.10[227] | 0.95[228] | 0.72[229] | 0.93[230] | 0.91[231] |
34 | KAT5 | Histone acetyltransferase KAT5 | [232] | 0.28[233] | 0.49[234] | -0.73[235] | 0.23[236] | 0.00[237] | 0.27[238] |
35 | MUS81 | Crossover junction endonuclease MUS81 | [239] | 0.85[240] | 0.86[241] | 0.41[242] | 1.47[243] | 1.06[244] | 0.78[245] |
36 | NBN | Nibrin | [246] | 0.64[247] | 1.62[248] | 1.18[249] | 2.57[250] | 1.54[251] | 2.62[252] |
37 | RFC5 | Replication factor C subunit 5 | [253] | 1.19[254] | 1.45[255] | 1.45[256] | 1.33[257] | 1.72[258] | 0.47[259] |
38 | SIRT6 | NAD-dependent protein deacetylase sirtuin-6 | [260] | 0.37[261] | -0.13[262] | 0.40[263] | -0.11[264] | 0.26[265] | -0.31[266] |
39 | UIMC1 | BRCA1-A complex subunit RAP80 | [267] | 1.43[268] | 1.46[269] | 1.71[270] | 1.14[271] | 1.14[272] | 1.05[273] |
40 | BRCC3 | Lys-63-specific deubiquitinase BRCC36 | [274] | 0.59[275] | 1.33[276] | 0.43[277] | 0.84[278] | 0.86[279] | 1.78[280] |
41 | RAD51 | DNA repair protein RAD51 homolog 1 | [281] | 0.81[282] | 0.42[283] | 0.33[284] | 0.88[285] | 0.71[286] | -2.60[287] |
42 | ABL1 | Tyrosine-protein kinase ABL1 | [288] | 3.29[289] | 2.48[290] | 3.08[291] | 3.13[292] | 3.68[293] | 2.28[294] |
43 | RAD50 | DNA repair protein RAD50 | [295] | 1.21[296] | 3.14[297] | 2.10[298] | 2.33[299] | 2.68[300] | 3.55[301] |
44 | RMI2 | RecQ-mediated genome instability protein 2 | [302] | 2.31[303] | 1.39[304] | 1.16[305] | -0.13[306] | 0.03[307] | -3.09[308] |
45 | XRCC1 | DNA repair protein XRCC1 | [309] | 1.70[310] | 1.68[311] | 2.57[312] | 1.83[313] | 1.67[314] | 0.42[315] |
46 | RBBP8 | DNA endonuclease RBBP8 | [316] | 1.26[317] | 2.47[318] | 0.90[319] | 2.50[320] | 2.56[321] | 1.59[322] |
47 | TIMELESS | Protein timeless homolog | [323] | 2.99[324] | 3.07[325] | 3.41[326] | 2.98[327] | 3.47[328] | 2.60[329] |
48 | PIAS4 | E3 SUMO-protein ligase PIAS4 | [330] | 1.30[331] | 0.62[332] | 1.17[333] | 0.54[334] | 0.50[335] | 0.93[336] |
49 | TOPBP1 | DNA topoisomerase 2-binding protein 1 | [337] | 2.09[338] | 2.91[339] | 2.88[340] | 3.19[341] | 3.46[342] | 2.22[343] |
50 | CCNA2 | Cyclin-A2 | [344] | 3.27[345] | 4.08[346] | 3.23[347] | 3.07[348] | 4.31[349] | 0.12[350] |
51 | RNF8 | E3 ubiquitin-protein ligase RNF8 | [351] | 2.40[352] | 2.27[353] | 0.74[354] | 2.34[355] | 1.68[356] | 1.25[357] |
52 | RFC3 | Replication factor C subunit 3 | [358] | 2.24[359] | 2.90[360] | 2.85[361] | 2.32[362] | 2.77[363] | 0.47[364] |
53 | LIG3 | DNA ligase 3 | [365] | 2.24[366] | 2.08[367] | 2.96[368] | 2.14[369] | 1.05[370] | 2.21[371] |
54 | HUS1 | Checkpoint protein HUS1 | [372] | 0.34[373] | 0.42[374] | 0.77[375] | 0.95[376] | 0.61[377] | 2.72[378] |
55 | TIPIN | TIMELESS-interacting protein | [379] | 0.88[380] | 0.40[381] | 0.84[382] | 1.21[383] | 1.62[384] | -0.71[385] |
56 | CHEK1 | Serine/threonine-protein kinase Chk1 | [386] | 2.60[387] | 2.76[388] | 2.13[389] | 3.21[390] | 3.30[391] | -0.68[392] |
57 | POLD1 | DNA polymerase delta catalytic subunit | [393] | 2.92[394] | 2.94[395] | 3.57[396] | 2.89[397] | 3.50[398] | 2.01[399] |
58 | RNF168 | E3 ubiquitin-protein ligase RNF168 | [400] | 1.45[401] | 1.90[402] | 2.70[403] | 1.14[404] | 2.16[405] | 3.43[406] |
59 | POLK | DNA polymerase kappa | [407] | 0.22[408] | 1.49[409] | 1.55[410] | 2.89[411] | 2.48[412] | 3.44[413] |
60 | POLH | DNA polymerase eta | [414] | 3.18[415] | 2.47[416] | 0.84[417] | 3.06[418] | 2.71[419] | 2.68[420] |
61 | MDC1 | Mediator of DNA damage checkpoint protein 1 | [421] | 3.55[422] | 3.75[423] | 3.90[424] | 3.96[425] | 3.74[426] | 2.79[427] |
62 | TOP3A | DNA topoisomerase 3-alpha | [428] | 3.03[429] | 2.50[430] | 2.60[431] | 2.91[432] | 3.16[433] | 3.14[434] |
63 | RAD1 | Cell cycle checkpoint protein RAD1 | [435] | 2.43[436] | 2.90[437] | 3.25[438] | 2.87[439] | 3.62[440] | 2.25[441] |
64 | PALB2 | Partner and localizer of BRCA2 | [442] | 2.83[443] | 2.92[444] | 2.36[445] | 1.77[446] | 2.11[447] | 2.02[448] |
65 | RAD9A | Cell cycle checkpoint control protein RAD9A | [449] | 1.13[450] | 1.21[451] | 2.83[452] | 3.39[453] | 1.08[454] | 1.17[455] |
66 | BRCA1 | Breast cancer type 1 susceptibility protein | [456] | 2.73[457] | 3.78[458] | 3.98[459] | 3.21[460] | 3.59[461] | 3.02[462] |
67 | HERC2 | E3 ubiquitin-protein ligase HERC2 | [463] | 3.52[464] | 3.01[465] | 3.38[466] | 4.15[467] | 4.08[468] | 5.51[469] |
68 | ATRIP | ATR-interacting protein | [470] | 1.31[471] | 1.35[472] | 2.03[473] | 0.72[474] | 1.65[475] | 1.18[476] |
69 | ATR | Serine/threonine-protein kinase ATR | [477] | 2.16[478] | 2.95[479] | 2.84[480] | 3.59[481] | 3.41[482] | 4.89[483] |
70 | POLD3 | DNA polymerase delta subunit 3 | [484] | 2.23[485] | 1.90[486] | 2.68[487] | 3.18[488] | 3.52[489] | 2.33[490] |
71 | TP53BP1 | TP53-binding protein 1 | [491] | 3.64[492] | 2.95[493] | 3.72[494] | 5.00[495] | 4.31[496] | 3.62[497] |
72 | POLE | DNA polymerase epsilon catalytic subunit A | [498] | 4.10[499] | 4.53[500] | 4.39[501] | 3.80[502] | 4.67[503] | 4.28[504] |
73 | RTEL1 | Regulator of telomere elongation helicase 1 | [505] | -0.64[506] | 0.29[507] | -1.72[508] | -1.22[509] | -0.79[510] | -0.31[511] |
74 | WRN | Werner syndrome ATP-dependent helicase | [512] | 1.67[513] | 2.93[514] | 4.67[515] | 2.76[516] | 2.43[517] | 3.31[518] |
75 | RAD51D | DNA repair protein RAD51 homolog 4 | [519] | 1.79[520] | 1.60[521] | 2.14[522] | 2.12[523] | 1.41[524] | 1.10[525] |
76 | RAD52 | DNA repair protein RAD52 homolog | [526] | 1.44[527] | 2.00[528] | 1.92[529] | 0.65[530] | 0.96[531] | 2.10[532] |
77 | CLSPN | Claspin | [533] | 2.42[534] | 2.65[535] | 2.73[536] | 3.81[537] | 4.06[538] | 0.20[539] |
78 | POLE2 | DNA polymerase epsilon subunit 2 | [540] | 1.76[541] | 2.36[542] | 3.16[543] | 2.22[544] | 2.61[545] | 0.19[546] |
79 | RAD51AP1 | RAD51-associated protein 1 | [547] | 2.56[548] | 3.82[549] | 4.32[550] | 3.13[551] | 3.80[552] | -0.17[553] |
80 | RMI1 | RecQ-mediated genome instability protein 1 | [554] | 1.64[555] | 2.68[556] | 2.93[557] | 3.14[558] | 3.84[559] | 2.33[560] |
81 | XRCC2 | DNA repair protein XRCC2 | [561] | 1.24[562] | 1.82[563] | 1.98[564] | 1.87[565] | 1.97[566] | -0.92[567] |
82 | ATM | Serine-protein kinase ATM | [568] | 4.09[569] | 5.49[570] | 5.02[571] | 5.22[572] | 4.56[573] | 6.33[574] |
83 | RAD51B | DNA repair protein RAD51 homolog 2 | [575] | 0.92[576] | 0.83[577] | 0.66[578] | 1.13[579] | 0.80[580] | 0.80[581] |
84 | GEN1 | Flap endonuclease GEN homolog 1 | [582] | 2.17[583] | 4.16[584] | 3.07[585] | 3.60[586] | 3.72[587] | 3.83[588] |
85 | ERCC4 | DNA repair endonuclease XPF | [589] | 3.27[590] | 2.76[591] | 2.73[592] | 3.29[593] | 3.30[594] | 3.76[595] |
86 | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2 | [596] | 2.82[597] | 4.39[598] | 3.40[599] | 3.71[600] | 3.23[601] | 2.90[602] |
87 | EXO1 | Exonuclease 1 | [603] | 2.97[604] | 3.05[605] | 4.03[606] | 4.84[607] | 3.98[608] | -0.13[609] |
88 | XRCC3 | DNA repair protein XRCC3 | [610] | 4.11[611] | 4.08[612] | 3.59[613] | 4.25[614] | 4.55[615] | 3.06[616] |
89 | BRIP1 | Fanconi anemia group J protein | [617] | 3.21[618] | 4.40[619] | 4.22[620] | 4.27[621] | 4.17[622] | 3.30[623] |
90 | BLM | Bloom syndrome protein | [624] | 2.61[625] | 3.76[626] | 4.37[627] | 3.96[628] | 3.89[629] | 0.96[630] |
91 | EME1 | Crossover junction endonuclease EME1 | [631] | 3.63[632] | 4.06[633] | 4.66[634] | 3.94[635] | 3.69[636] | -0.14[637] |
92 | BARD1 | BRCA1-associated RING domain protein 1 | [638] | 2.38[639] | 3.16[640] | 2.99[641] | 3.76[642] | 3.70[643] | 3.21[644] |
93 | POLQ | DNA polymerase theta | [645] | 3.53[646] | 4.40[647] | 4.57[648] | 4.42[649] | 4.94[650] | 1.85[651] |
94 | SLX4 | Structure-specific endonuclease subunit SLX4 | [652] | 3.98[653] | 3.95[654] | 4.30[655] | 4.16[656] | 4.24[657] | 3.61[658] |
95 | RAD9B | Cell cycle checkpoint control protein RAD9B | [659] | -2.27[660] | 0.73[661] | -0.16[662] | 1.50[663] | 0.69[664] | 0.55[665] |
96 | BRCA2 | Breast cancer type 2 susceptibility protein | [666] | 3.86[667] | 6.15[668] | 6.13[669] | 5.54[670] | 5.55[671] | 4.78[672] |
97 | EME2 | Probable crossover junction endonuclease EME2 | [673] | 2.81[674] | 3.14[675] | 2.40[676] | 2.41[677] | 2.53[678] | 4.16[679] |
98 | CCNA1 | Cyclin-A1 | [680] | [681] | -2.53[682] | [683] | 0.27[684] | 7.54[685] | [686] |
99 | H2AX | [687] | [688] | [689] | [690] | [691] | [692] | [693] | |
100 | ABRAXAS | BRCA1-A complex subunit Abraxas 1 | [694] | [695] | [696] | [697] | [698] | [699] | [700] |
101 | MRE11 | Double-strand break repair protein MRE11 | [701] | [702] | [703] | [704] | [705] | [706] | [707] |
102 | NSD2 | Histone-lysine N-methyltransferase NSD2 | [708] | [709] | [710] | [711] | [712] | [713] | [714] |
103 | H2BC4 | [715] | [716] | [717] | [718] | [719] | [720] | [721] | |
104 | H4C6 | [722] | [723] | [724] | [725] | [726] | [727] | [728] | |
105 | H4C14 | [729] | [730] | [731] | [732] | [733] | [734] | [735] | |
106 | H2BC17 | [736] | [737] | [738] | [739] | [740] | [741] | [742] | |
107 | H2BC21 | [743] | [744] | [745] | [746] | [747] | [748] | [749] | |
108 | SPIDR | DNA repair-scaffolding protein | [750] | [751] | [752] | [753] | [754] | [755] | [756] |
109 | H2BC5 | [757] | [758] | [759] | [760] | [761] | [762] | [763] | |
110 | H4C15 | [764] | [765] | [766] | [767] | [768] | [769] | [770] | |
111 | H4C1 | [771] | [772] | [773] | [774] | [775] | [776] | [777] | |
112 | H2BC14 | [778] | [779] | [780] | [781] | [782] | [783] | [784] | |
113 | H2BC8 | [785] | [786] | [787] | [788] | [789] | [790] | [791] | |
114 | H2BC12 | [792] | [793] | [794] | [795] | [796] | [797] | [798] | |
115 | H2BC13 | [799] | [800] | [801] | [802] | [803] | [804] | [805] | |
116 | H4C2 | [806] | [807] | [808] | [809] | [810] | [811] | [812] | |
117 | H2BC11 | [813] | [814] | [815] | [816] | [817] | [818] | [819] | |
118 | H2BS1 | [820] | [821] | [822] | [823] | [824] | [825] | [826] | |
119 | H4C9 | [827] | [828] | [829] | [830] | [831] | [832] | [833] | |
120 | H4C12 | [834] | [835] | [836] | [837] | [838] | [839] | [840] | |
121 | BABAM2 | BRISC and BRCA1-A complex member 2 | [841] | [842] | [843] | [844] | [845] | [846] | [847] |
122 | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 | [848] | [849] | [850] | [851] | [852] | [853] | [854] |
123 | H4C3 | [855] | [856] | [857] | [858] | [859] | [860] | [861] | |
124 | H2BC3 | [862] | [863] | [864] | [865] | [866] | [867] | [868] | |
125 | H4C13 | [869] | [870] | [871] | [872] | [873] | [874] | [875] | |
126 | H2BC7 | [876] | [877] | [878] | [879] | [880] | [881] | [882] | |
127 | H2BC9 | [883] | [884] | [885] | [886] | [887] | [888] | [889] | |
128 | H4-16 | [890] | [891] | [892] | [893] | [894] | [895] | [896] | |
129 | H3-4 | [897] | [898] | [899] | [900] | [901] | [902] | [903] | |
130 | H2BC15 | [904] | [905] | [906] | [907] | [908] | [909] | [910] | |
131 | H4C4 | [911] | [912] | [913] | [914] | [915] | [916] | [917] | |
132 | H4C11 | [918] | [919] | [920] | [921] | [922] | [923] | [924] | |
133 | H2BC1 | [925] | [926] | [927] | [928] | [929] | [930] | [931] | |
134 | H4C8 | [932] | [933] | [934] | [935] | [936] | [937] | [938] | |
135 | H4C5 | [939] | [940] | [941] | [942] | [943] | [944] | [945] | |
136 | H2BC6 | [946] | [947] | [948] | [949] | [950] | [951] | [952] | |
137 | H2BC10 | [953] | [954] | [955] | [956] | [957] | [958] | [959] | |
138 | H2BU1 | [960] | [961] | [962] | [963] | [964] | [965] | [966] |