REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GPC3 | Glypican-3 | [1] | 0.95[2] | 1.30[3] | 0.63[4] | -7.76[5] | -7.40[6] | -8.56[7] |
2 | SDC1 | Syndecan-1 | [8] | -1.72[9] | -2.26[10] | -1.22[11] | -2.22[12] | -4.36[13] | 0.45[14] |
3 | SDC4 | Syndecan-4 | [15] | -0.92[16] | -1.32[17] | -1.86[18] | -1.61[19] | 0.09[20] | -0.43[21] |
4 | SDC2 | Syndecan-2 | [22] | -0.82[23] | 0.05[24] | 0.38[25] | -0.05[26] | -3.10[27] | 0.30[28] |
5 | SLC35D2 | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter | [29] | -2.45[30] | -1.56[31] | -0.53[32] | -2.23[33] | -2.96[34] | -2.46[35] |
6 | GUSB | Beta-glucuronidase | [36] | -2.85[37] | -2.61[38] | -1.41[39] | -0.73[40] | -1.09[41] | -0.10[42] |
7 | EXT1 | Exostosin-1 | [43] | -2.23[44] | -2.73[45] | -1.09[46] | 0.26[47] | -0.19[48] | -0.31[49] |
8 | GLB1 | Beta-galactosidase | [50] | -0.58[51] | -1.02[52] | 0.71[53] | -0.37[54] | 0.58[55] | -0.21[56] |
9 | NAGLU | Alpha-N-acetylglucosaminidase | [57] | -1.09[58] | -1.47[59] | -0.33[60] | -0.90[61] | -1.04[62] | -0.59[63] |
10 | HS6ST1 | Heparan-sulfate 6-O-sulfotransferase 1 | [64] | 0.13[65] | -0.05[66] | -1.33[67] | -0.64[68] | -0.01[69] | -0.08[70] |
11 | GPC1 | Glypican-1 | [71] | -0.73[72] | -4.14[73] | -7.46[74] | 2.60[75] | 1.53[76] | -0.85[77] |
12 | B3GAT3 | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 | [78] | -1.35[79] | -1.05[80] | -0.75[81] | -0.24[82] | 0.34[83] | -1.11[84] |
13 | B4GALT7 | Beta-1,4-galactosyltransferase 7 | [85] | -1.75[86] | -1.68[87] | -0.64[88] | -0.94[89] | -0.61[90] | -1.32[91] |
14 | EXT2 | Exostosin-2 | [92] | 0.22[93] | -0.98[94] | -1.23[95] | -0.28[96] | 1.36[97] | 0.51[98] |
15 | IDS | Iduronate 2-sulfatase | [99] | -1.02[100] | -1.65[101] | -1.52[102] | 2.16[103] | 1.49[104] | 0.86[105] |
16 | AGRN | Agrin | [106] | 2.93[107] | 2.28[108] | 2.46[109] | 3.68[110] | 2.88[111] | 0.75[112] |
17 | B3GALT6 | Beta-1,3-galactosyltransferase 6 | [113] | -0.92[114] | -0.02[115] | 0.04[116] | 0.06[117] | -0.17[118] | -1.30[119] |
18 | HS2ST1 | Heparan sulfate 2-O-sulfotransferase 1 | [120] | 2.23[121] | 1.66[122] | 2.38[123] | 2.46[124] | 2.25[125] | 0.72[126] |
19 | HGSNAT | Heparan-alpha-glucosaminide N-acetyltransferase | [127] | -0.75[128] | -1.01[129] | -0.04[130] | 0.74[131] | 0.92[132] | 0.89[133] |
20 | NDST1 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 | [134] | 0.93[135] | 1.11[136] | 1.90[137] | 2.86[138] | 2.61[139] | 2.92[140] |
21 | SGSH | N-sulphoglucosamine sulphohydrolase | [141] | 0.50[142] | -0.36[143] | -1.17[144] | 0.35[145] | 0.60[146] | 0.14[147] |
22 | XYLT2 | Xylosyltransferase 2 | [148] | 0.20[149] | -0.09[150] | 0.98[151] | 1.24[152] | 1.78[153] | 0.16[154] |
23 | HS3ST3B1 | Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 | [155] | -2.19[156] | -1.86[157] | -2.44[158] | -4.56[159] | -2.23[160] | 0.36[161] |
24 | GPC6 | Glypican-6 | [162] | 1.38[163] | 0.48[164] | 1.76[165] | 4.08[166] | 2.32[167] | 2.93[168] |
25 | GLCE | D-glucuronyl C5-epimerase | [169] | -0.31[170] | 0.13[171] | 1.39[172] | 0.58[173] | 1.83[174] | 1.88[175] |
26 | NDST2 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 | [176] | 0.43[177] | 1.12[178] | 0.60[179] | 1.47[180] | 2.05[181] | 1.35[182] |
27 | IDUA | Alpha-L-iduronidase | [183] | -3.63[184] | -3.14[185] | -2.08[186] | 0.89[187] | -0.63[188] | -0.25[189] |
28 | SDC3 | Syndecan-3 | [190] | 1.57[191] | -4.73[192] | -0.03[193] | 3.27[194] | 3.70[195] | 2.42[196] |
29 | GLB1L | Beta-galactosidase-1-like protein | [197] | -1.33[198] | -0.82[199] | -0.19[200] | 0.15[201] | 0.84[202] | -0.60[203] |
30 | DCN | Decorin | [204] | -7.57[205] | -9.38[206] | -5.80[207] | 1.68[208] | 6.00[209] | 5.37[210] |
31 | BGN | Biglycan | [211] | 0.73[212] | -4.58[213] | -6.14[214] | 1.92[215] | -0.45[216] | 5.02[217] |
32 | B3GAT1 | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 | [218] | -9.45[219] | -9.03[220] | [221] | -8.69[222] | -0.95[223] | 0.70[224] |
33 | HSPG2 | Basement membrane-specific heparan sulfate proteoglycan core protein | 6.39[225] | 4.55[226] | 5.63[227] | 6.19[228] | 6.51[229] | 6.04[230] | |
34 | VCAN | Versican core protein | [231] | 3.51[232] | -1.72[233] | 3.09[234] | 1.63[235] | 6.08[236] | 3.50[237] |
35 | GPC4 | Glypican-4 | [238] | -2.24[239] | -6.37[240] | -1.90[241] | 5.62[242] | -1.99[243] | 0.61[244] |
36 | HPSE | Heparanase | [245] | -2.30[246] | -2.30[247] | -0.70[248] | 2.32[249] | 5.08[250] | 1.32[251] |
37 | HS3ST3A1 | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 | [252] | -1.92[253] | -2.69[254] | 0.59[255] | 4.08[256] | 3.62[257] | 1.30[258] |
38 | CSPG5 | Chondroitin sulfate proteoglycan 5 | [259] | -2.45[260] | -5.25[261] | 1.32[262] | 1.29[263] | -0.67[264] | -2.55[265] |
39 | HS6ST2 | Heparan-sulfate 6-O-sulfotransferase 2 | [266] | -1.67[267] | -1.97[268] | 5.99[269] | 0.84[270] | 0.03[271] | -2.32[272] |
40 | GPC5 | Glypican-5 | [273] | -4.42[274] | -5.81[275] | -0.74[276] | -3.10[277] | -2.43[278] | 3.24[279] |
41 | GPC2 | Glypican-2 | [280] | 1.68[281] | 1.04[282] | 3.75[283] | 3.48[284] | 2.48[285] | -3.39[286] |
42 | HS3ST1 | Heparan sulfate glucosamine 3-O-sulfotransferase 1 | [287] | [288] | [289] | -3.99[290] | -0.55[291] | -1.37[292] | 2.17[293] |
43 | NDST3 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 | [294] | -0.79[295] | 0.58[296] | 0.62[297] | 0.75[298] | 1.28[299] | 4.38[300] |
44 | HS3ST6 | Heparan sulfate glucosamine 3-O-sulfotransferase 6 | [301] | -3.06[302] | [303] | -3.25[304] | [305] | -2.96[306] | [307] |
45 | HS3ST2 | Heparan sulfate glucosamine 3-O-sulfotransferase 2 | [308] | [309] | [310] | [311] | -3.08[312] | -1.14[313] | -0.81[314] |
46 | XYLT1 | Xylosyltransferase 1 | [315] | 0.93[316] | [317] | [318] | 1.22[319] | 1.67[320] | 5.57[321] |
47 | NCAN | Neurocan core protein | [322] | 0.47[323] | -2.39[324] | 0.63[325] | -3.42[326] | -0.40[327] | -1.16[328] |
48 | CSPG4 | Chondroitin sulfate proteoglycan 4 | [329] | 2.31[330] | 1.24[331] | 3.73[332] | 7.30[333] | 8.12[334] | 5.47[335] |
49 | BCAN | Brevican core protein | [336] | 6.97[337] | 7.09[338] | 6.01[339] | 7.50[340] | 5.60[341] | 2.38[342] |
50 | HS6ST3 | Heparan-sulfate 6-O-sulfotransferase 3 | [343] | 1.96[344] | -0.56[345] | -0.78[346] | 5.19[347] | 8.51[348] | 0.19[349] |
51 | HS3ST4 | Heparan sulfate glucosamine 3-O-sulfotransferase 4 | [350] | [351] | [352] | [353] | [354] | [355] | [356] |
52 | B3GAT2 | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 | [357] | [358] | [359] | [360] | [361] | [362] | [363] |
53 | HS3ST5 | Heparan sulfate glucosamine 3-O-sulfotransferase 5 | [364] | [365] | [366] | [367] | [368] | [369] | [370] |
54 | NDST4 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 | [371] | [372] | [373] | [374] | [375] | [376] | [377] |
55 | HPSE2 | Inactive heparanase-2 | [378] | [379] | [380] | [381] | [382] | [383] | [384] |