REACTOME_HEME_DEGRADATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ALB Serum albumin [1] 0.09[2] 0.21[3] 0.05[4] -5.06[5] -3.55[6] 0.17[7]
2 FABP1 Fatty acid-binding protein, liver [8] -6.26[9] -2.60[10] -0.65[11] -6.41[12] -5.01[13] -1.94[14]
3 GSTA1 Glutathione S-transferase A1 [15] -2.26[16] -8.53[17] -0.56[18] -1.03[19] -4.51[20] -3.32[21]
4 BLVRB Flavin reductase (NADPH) [22] -0.14[23] -2.30[24] 0.30[25] 3.56[26] 4.58[27] -1.27[28]
5 UGT1A1 UDP-glucuronosyltransferase 1-1 [29] -2.99[30] -11.75[31] -4.82[32] 4.65[33] -4.01[34] 0.25[35]
6 UGT1A4 UDP-glucuronosyltransferase 1-4 [36] -10.37[37] [38] -10.72[39] -4.63[40] [41] 0.44[42]
7 HMOX1 Heme oxygenase 1 [43] 2.89[44] -0.53[45] 0.12[46] 5.39[47] 6.50[48] -1.79[49]
8 SLCO1B1 Solute carrier organic anion transporter family member 1B1 [50] -11.80[51] -10.51[52] -3.52[53] -5.35[54] [55] 1.87[56]
9 HMOX2 Heme oxygenase 2 [57] 2.16[58] -0.26[59] -0.39[60] 4.37[61] 6.44[62] -0.18[63]
10 ABCC2 Canalicular multispecific organic anion transporter 1 [64] 4.21[65] 3.28[66] 3.46[67] 6.75[68] 1.30[69] 2.25[70]
11 SLCO2B1 Solute carrier organic anion transporter family member 2B1 [71] 1.81[72] 0.73[73] 3.52[74] 6.35[75] -0.05[76] 2.03[77]
12 SLCO1B3 Solute carrier organic anion transporter family member 1B3 [78] -4.33[79] -5.42[80] 1.20[81] -3.61[82] -2.40[83] 2.24[84]
13 BLVRA Biliverdin reductase A [85] 4.35[86] 1.63[87] 0.41[88] 7.62[89] 8.34[90] -2.19[91]
14 ABCG2 ATP-binding cassette sub-family G member 2 [92] 3.43[93] 0.82[94] 3.72[95] 6.64[96] 6.87[97] 0.57[98]
15 ABCC1 Multidrug resistance-associated protein 1 [99] 8.62[100] 3.32[101] 4.16[102] 11.41[103] 11.18[104] 1.07[105]
[1]
ref_hepatocyte ALB
Mean 1.45e+04
Standard deviation 2e+04
Values 3e+03 3.5e+02 7.4e+02 2.1e+04 4.8e+04
[2]
HepG2 ALB
Mean 3.29e+03
Standard deviation 9.9e+02
Values 2.6e+03 4e+03
[3]
HepG2.C3A ALB
Mean 1.8e+04
Standard deviation 4.3e+03
Values 2.1e+04 1.5e+04
[4]
HuH.7 ALB
Mean 4.54e+03
Standard deviation 1.4e+03
Values 3.4e+03 6.1e+03 4.1e+03
[5]
SNU475 ALB
Mean 6.25
Standard deviation 1.4
Values 5.3 7.2
[6]
THLE ALB
Mean 7.91
Standard deviation 4.5
Values 11 4.7
[7]
liver ALB
Mean 1.88e+04
Standard deviation 4.8e+03
Values 2.2e+04 2.3e+04 1.8e+04 1.3e+04
[8]
ref_hepatocyte FABP1
Mean 2.26e+03
Standard deviation 2.9e+03
Values 2.8e+02 26 2.8e+02 4.6e+03 6.1e+03
[9]
HepG2 FABP1
Mean 6.27
Standard deviation 5.2
Values 2.6 9.9
[10]
HepG2.C3A FABP1
Mean 398
Standard deviation 1.7e+02
Values 5.2e+02 2.8e+02
[11]
HuH.7 FABP1
Mean 435
Standard deviation 1.5e+02
Values 3e+02 6e+02 4.1e+02
[12]
SNU475 FABP1
Mean 0.385
Standard deviation 0.072
Values 0.33 0.44
[13]
THLE FABP1
Mean 0.449
Standard deviation 0.1
Values 0.52 0.38
[14]
liver FABP1
Mean 682
Standard deviation 8e+02
Values 6.8e+02 1.3e+02 1.8e+03 1e+02
[15]
ref_hepatocyte GSTA1
Mean 456
Standard deviation 5.8e+02
Values 1.3e+02 2.2e+02 8.4 4.8e+02 1.4e+03
[16]
HepG2 GSTA1
Mean 20.3
Standard deviation 5.9
Values 16 24
[17]
HepG2.C3A GSTA1
Mean 1.31
Standard deviation 0.69
Values 0.83 1.8
[18]
HuH.7 GSTA1
Mean 93.3
Standard deviation 39
Values 95 53 1.3e+02
[19]
SNU475 GSTA1
Mean 3.21
Standard deviation 3.3
Values 5.5 0.88
[20]
THLE GSTA1
Mean 0.127
Standard deviation 0.11
Values 0.21 0.048
[21]
liver GSTA1
Mean 52.8
Standard deviation 52
Values 48 29 1.3e+02 6.8
[22]
ref_hepatocyte BLVRB
Mean 108
Standard deviation 63
Values 37 68 86 1.7e+02 1.8e+02
[23]
HepG2 BLVRB
Mean 20.9
Standard deviation 12
Values 29 12
[24]
HepG2.C3A BLVRB
Mean 23.5
Standard deviation 8.3
Values 29 18
[25]
HuH.7 BLVRB
Mean 40.3
Standard deviation 5.7
Values 36 38 47
[26]
SNU475 BLVRB
Mean 18.4
Standard deviation 8.6
Values 24 12
[27]
THLE BLVRB
Mean 16.5
Standard deviation 1.3
Values 16 17
[28]
liver BLVRB
Mean 51.7
Standard deviation 37
Values 72 27 93 15
[29]
ref_hepatocyte UGT1A1
Mean 67.2
Standard deviation 89
Values 0.52 12 15 2.1e+02 96
[30]
HepG2 UGT1A1
Mean 1.8
Standard deviation 0.2
Values 1.9 1.7
[31]
HepG2.C3A UGT1A1
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[32]
HuH.7 UGT1A1
Mean 0.72
Standard deviation 0.5
Values 0.57 1.3 0.31
[33]
SNU475 UGT1A1
Mean 24.4
Standard deviation 21
Values 39 9.8
[34]
THLE UGT1A1
Mean 0.0266
Standard deviation 0.038
Values 0 0.053
[35]
liver UGT1A1
Mean 92.4
Standard deviation 46
Values 1.1e+02 83 1.4e+02 34
[36]
ref_hepatocyte UGT1A4
Mean 53.1
Standard deviation 73
Values 0 4.2 2.5 99 1.6e+02
[37]
HepG2 UGT1A4
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[38]
HepG2.C3A UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[39]
HuH.7 UGT1A4
Mean 0.00954
Standard deviation 0.0096
Values 0 0.019 0.0094
[40]
SNU475 UGT1A4
Mean 0.031
Standard deviation 0.015
Values 0.042 0.02
[41]
THLE UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[42]
liver UGT1A4
Mean 83.1
Standard deviation 65
Values 36 95 1.7e+02 32
[43]
ref_hepatocyte HMOX1
Mean 45.4
Standard deviation 44
Values 19 4.5 1.2e+02 47 37
[44]
HepG2 HMOX1
Mean 71.8
Standard deviation 29
Values 92 52
[45]
HepG2.C3A HMOX1
Mean 33.6
Standard deviation 4.7
Values 30 37
[46]
HuH.7 HMOX1
Mean 14.9
Standard deviation 6.3
Values 10 22 12
[47]
SNU475 HMOX1
Mean 27.6
Standard deviation 4.6
Values 24 31
[48]
THLE HMOX1
Mean 26.2
Standard deviation 9.7
Values 19 33
[49]
liver HMOX1
Mean 15.2
Standard deviation 2.1
Values 16 13 18 15
[50]
ref_hepatocyte SLCO1B1
Mean 35.9
Standard deviation 41
Values 0 40 1.4 37 1e+02
[51]
HepG2 SLCO1B1
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[52]
HepG2.C3A SLCO1B1
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[53]
HuH.7 SLCO1B1
Mean 0.948
Standard deviation 1.4
Values 0.074 2.6 0.22
[54]
SNU475 SLCO1B1
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[55]
THLE SLCO1B1
Mean 0
Standard deviation 0
Values 0 0
[56]
liver SLCO1B1
Mean 152
Standard deviation 42
Values 1.8e+02 1.8e+02 1.5e+02 95
[57]
ref_hepatocyte HMOX2
Mean 32.5
Standard deviation 12
Values 22 37 52 31 21
[58]
HepG2 HMOX2
Mean 31
Standard deviation 1.1
Values 30 32
[59]
HepG2.C3A HMOX2
Mean 28.9
Standard deviation 2.9
Values 31 27
[60]
HuH.7 HMOX2
Mean 7.51
Standard deviation 3.3
Values 8.7 3.8 10
[61]
SNU475 HMOX2
Mean 9.69
Standard deviation 0.56
Values 9.3 10
[62]
THLE HMOX2
Mean 18
Standard deviation 3.7
Values 15 21
[63]
liver HMOX2
Mean 33.2
Standard deviation 19
Values 42 23 56 12
[64]
ref_hepatocyte ABCC2
Mean 31.6
Standard deviation 23
Values 68 40 16 17 17
[65]
HepG2 ABCC2
Mean 125
Standard deviation 1.3
Values 1.2e+02 1.3e+02
[66]
HepG2.C3A ABCC2
Mean 328
Standard deviation 1.2
Values 3.3e+02 3.3e+02
[67]
HuH.7 ABCC2
Mean 105
Standard deviation 48
Values 88 1.6e+02 68
[68]
SNU475 ABCC2
Mean 48.9
Standard deviation 12
Values 57 41
[69]
THLE ABCC2
Mean 0.497
Standard deviation 0.041
Values 0.53 0.47
[70]
liver ABCC2
Mean 174
Standard deviation 96
Values 89 3e+02 1.1e+02 1.9e+02
[71]
ref_hepatocyte SLCO2B1
Mean 21.2
Standard deviation 24
Values 7.8 2.1 1.8 41 53
[72]
HepG2 SLCO2B1
Mean 15.8
Standard deviation 6.6
Values 11 20
[73]
HepG2.C3A SLCO2B1
Mean 37.6
Standard deviation 6.7
Values 42 33
[74]
HuH.7 SLCO2B1
Mean 73.5
Standard deviation 12
Values 71 87 63
[75]
SNU475 SLCO2B1
Mean 24.9
Standard deviation 6.3
Values 29 20
[76]
THLE SLCO2B1
Mean 0.131
Standard deviation 0.018
Values 0.12 0.14
[77]
liver SLCO2B1
Mean 100
Standard deviation 31
Values 75 98 1.4e+02 84
[78]
ref_hepatocyte SLCO1B3
Mean 16.4
Standard deviation 25
Values 0 3.8 0.31 18 60
[79]
HepG2 SLCO1B3
Mean 0.173
Standard deviation 0.087
Values 0.23 0.11
[80]
HepG2.C3A SLCO1B3
Mean 0.409
Standard deviation 0.26
Values 0.59 0.23
[81]
HuH.7 SLCO1B3
Mean 11.4
Standard deviation 8.7
Values 5.7 21 7.1
[82]
SNU475 SLCO1B3
Mean 0.0194
Standard deviation 0.0012
Values 0.019 0.02
[83]
THLE SLCO1B3
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[84]
liver SLCO1B3
Mean 89.3
Standard deviation 67
Values 1.9e+02 52 44 75
[85]
ref_hepatocyte BLVRA
Mean 7.79
Standard deviation 8
Values 21 8.6 4.4 2.1 2.6
[86]
HepG2 BLVRA
Mean 33.8
Standard deviation 5.2
Values 38 30
[87]
HepG2.C3A BLVRA
Mean 25.7
Standard deviation 0.37
Values 26 25
[88]
HuH.7 BLVRA
Mean 3.14
Standard deviation 0.36
Values 3.1 2.8 3.5
[89]
SNU475 BLVRA
Mean 22.1
Standard deviation 6.3
Values 27 18
[90]
THLE BLVRA
Mean 16.1
Standard deviation 1.7
Values 15 17
[91]
liver BLVRA
Mean 1.98
Standard deviation 1.2
Values 2.3 1.1 3.5 1
[92]
ref_hepatocyte ABCG2
Mean 3
Standard deviation 1.8
Values 1.1 5.2 2.9 1.5 4.4
[93]
HepG2 ABCG2
Mean 6.88
Standard deviation 0.34
Values 7.1 6.6
[94]
HepG2.C3A ABCG2
Mean 5.65
Standard deviation 0.97
Values 5 6.3
[95]
HuH.7 ABCG2
Mean 11.9
Standard deviation 1.2
Values 13 11 11
[96]
SNU475 ABCG2
Mean 4.32
Standard deviation 1
Values 3.6 5
[97]
THLE ABCG2
Mean 2.24
Standard deviation 1.1
Values 1.4 3
[98]
liver ABCG2
Mean 5.14
Standard deviation 1.6
Values 3.4 7.3 4.8 5
[99]
ref_hepatocyte ABCC1
Mean 1.64
Standard deviation 2.8
Values 6.7 0.55 0.55 0.18 0.21
[100]
HepG2 ABCC1
Mean 138
Standard deviation 32
Values 1.6e+02 1.2e+02
[101]
HepG2.C3A ABCC1
Mean 17.5
Standard deviation 0.7
Values 18 17
[102]
HuH.7 ABCC1
Mean 8.92
Standard deviation 1.5
Values 11 8.1 8.1
[103]
SNU475 ABCC1
Mean 64.4
Standard deviation 27
Values 83 45
[104]
THLE ABCC1
Mean 24.5
Standard deviation 8.1
Values 19 30
[105]
liver ABCC1
Mean 4
Standard deviation 2.2
Values 2.8 4.5 1.8 6.8