REACTOME_HEME_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ALB Serum albumin [1] -0.08[2] 0.00[3] -0.06[4] -4.72[5] -4.80[6] -0.01[7]
2 ALAS1 5-aminolevulinate synthase, nonspecific, mitochondrial [8] 1.50[9] -1.41[10] 1.17[11] 5.44[12] 5.46[13] 1.21[14]
3 UROD Uroporphyrinogen decarboxylase [15] 2.25[16] -0.01[17] 1.24[18] 5.69[19] 6.18[20] -0.74[21]
4 UROS Uroporphyrinogen-III synthase [22] 1.01[23] -1.67[24] 0.37[25] 4.12[26] 4.85[27] -1.82[28]
5 ALAD Delta-aminolevulinic acid dehydratase [29] 1.86[30] 0.35[31] 1.84[32] 5.74[33] 6.61[34] 0.68[35]
6 HMBS Porphobilinogen deaminase [36] 3.58[37] 1.24[38] 2.54[39] 7.39[40] 6.73[41] -0.17[42]
7 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial [43] 3.71[44] 1.26[45] 3.65[46] 6.88[47] 7.42[48] -0.17[49]
8 FECH Ferrochelatase, mitochondrial [50] 4.41[51] 1.17[52] 2.69[53] 9.08[54] 8.08[55] 2.51[56]
9 COX15 Cytochrome c oxidase assembly protein COX15 homolog [57] 5.01[58] 2.92[59] 5.39[60] 8.65[61] 8.66[62] 2.16[63]
10 COX10 Protoheme IX farnesyltransferase, mitochondrial [64] 3.21[65] 0.90[66] 3.31[67] 7.22[68] 6.87[69] 0.51[70]
11 ABCG2 ATP-binding cassette sub-family G member 2 [71] 3.26[72] 0.60[73] 3.61[74] 6.98[75] 5.62[76] 0.40[77]
12 PPOX Protoporphyrinogen oxidase [78] 3.05[79] 0.83[80] 3.08[81] 7.83[82] 6.99[83] -0.14[84]
13 FLVCR1 Feline leukemia virus subgroup C receptor-related protein 1 [85] 4.15[86] 2.96[87] 4.61[88] 8.52[89] 7.25[90] 0.43[91]
14 ALAS2 5-aminolevulinate synthase, erythroid-specific, mitochondrial [92] 1.54[93] -3.98[94] -0.19[95] [96] 0.50[97] -0.13[98]
[1]
ref_hepatocyte ALB
Mean 1.45e+04
Standard deviation 2e+04
Values 3e+03 3.5e+02 7.4e+02 2.1e+04 4.8e+04
[2]
HepG2 ALB
Mean 3.29e+03
Standard deviation 9.9e+02
Values 2.6e+03 4e+03
[3]
HepG2.C3A ALB
Mean 1.8e+04
Standard deviation 4.3e+03
Values 2.1e+04 1.5e+04
[4]
HuH.7 ALB
Mean 4.54e+03
Standard deviation 1.4e+03
Values 3.4e+03 6.1e+03 4.1e+03
[5]
SNU475 ALB
Mean 6.25
Standard deviation 1.4
Values 5.3 7.2
[6]
THLE ALB
Mean 7.91
Standard deviation 4.5
Values 11 4.7
[7]
liver ALB
Mean 1.88e+04
Standard deviation 4.8e+03
Values 2.2e+04 2.3e+04 1.8e+04 1.3e+04
[8]
ref_hepatocyte ALAS1
Mean 47.5
Standard deviation 33
Values 11 22 55 94 55
[9]
HepG2 ALAS1
Mean 32.4
Standard deviation 1.9
Values 31 34
[10]
HepG2.C3A ALAS1
Mean 22.2
Standard deviation 3.9
Values 25 19
[11]
HuH.7 ALAS1
Mean 34.9
Standard deviation 9.3
Values 28 46 31
[12]
SNU475 ALAS1
Mean 23.5
Standard deviation 9.9
Values 17 30
[13]
THLE ALAS1
Mean 31.9
Standard deviation 2.3
Values 30 34
[14]
liver ALAS1
Mean 143
Standard deviation 85
Values 1.1e+02 1.5e+02 2.5e+02 52
[15]
ref_hepatocyte UROD
Mean 43.3
Standard deviation 13
Values 24 37 56 53 46
[16]
HepG2 UROD
Mean 49.6
Standard deviation 4.3
Values 47 53
[17]
HepG2.C3A UROD
Mean 53.3
Standard deviation 16
Values 42 65
[18]
HuH.7 UROD
Mean 33.5
Standard deviation 11
Values 35 22 44
[19]
SNU475 UROD
Mean 25.4
Standard deviation 2.6
Values 27 24
[20]
THLE UROD
Mean 47.7
Standard deviation 6.8
Values 43 52
[21]
liver UROD
Mean 33.9
Standard deviation 21
Values 53 18 52 13
[22]
ref_hepatocyte UROS
Mean 34
Standard deviation 34
Values 46 89 2.9 18 14
[23]
HepG2 UROS
Mean 16.4
Standard deviation 3.9
Values 14 19
[24]
HepG2.C3A UROS
Mean 13.2
Standard deviation 2.7
Values 11 15
[25]
HuH.7 UROS
Mean 14.4
Standard deviation 5.8
Values 17 7.8 19
[26]
SNU475 UROS
Mean 6.73
Standard deviation 4.2
Values 9.7 3.7
[27]
THLE UROS
Mean 14.9
Standard deviation 2
Values 13 16
[28]
liver UROS
Mean 12.6
Standard deviation 8.6
Values 22 5.1 18 5.4
[29]
ref_hepatocyte ALAD
Mean 20.2
Standard deviation 20
Values 8.7 6.8 2.9 34 49
[30]
HepG2 ALAD
Mean 17.6
Standard deviation 4.8
Values 14 21
[31]
HepG2.C3A ALAD
Mean 32
Standard deviation 11
Values 40 24
[32]
HuH.7 ALAD
Mean 23.7
Standard deviation 3.5
Values 21 28 23
[33]
SNU475 ALAD
Mean 12.3
Standard deviation 4
Values 15 9.4
[34]
THLE ALAD
Mean 29.9
Standard deviation 1.2
Values 31 29
[35]
liver ALAD
Mean 42.2
Standard deviation 15
Values 55 24 35 55
[36]
ref_hepatocyte HMBS
Mean 9.21
Standard deviation 3.5
Values 5.7 11 6.3 14 8.8
[37]
HepG2 HMBS
Mean 26.5
Standard deviation 0.29
Values 27 26
[38]
HepG2.C3A HMBS
Mean 26.9
Standard deviation 7.8
Values 21 32
[39]
HuH.7 HMBS
Mean 17.5
Standard deviation 8.5
Values 18 9 26
[40]
SNU475 HMBS
Mean 17.6
Standard deviation 1.4
Values 19 17
[41]
THLE HMBS
Mean 14.8
Standard deviation 0.63
Values 14 15
[42]
liver HMBS
Mean 10.7
Standard deviation 10
Values 20 1.8 19 1.6
[43]
ref_hepatocyte CPOX
Mean 8.09
Standard deviation 4.1
Values 14 6.6 3.2 7.5 8.7
[44]
HepG2 CPOX
Mean 25.5
Standard deviation 6
Values 21 30
[45]
HepG2.C3A CPOX
Mean 24
Standard deviation 4
Values 21 27
[46]
HuH.7 CPOX
Mean 33.2
Standard deviation 5.6
Values 37 27 36
[47]
SNU475 CPOX
Mean 10.8
Standard deviation 1.9
Values 9.5 12
[48]
THLE CPOX
Mean 21.1
Standard deviation 4.2
Values 18 24
[49]
liver CPOX
Mean 9.36
Standard deviation 2.1
Values 10 12 7.4 7.9
[50]
ref_hepatocyte FECH
Mean 3.81
Standard deviation 1.3
Values 2.6 5.1 2.2 4.4 4.7
[51]
HepG2 FECH
Mean 19.5
Standard deviation 4.1
Values 22 17
[52]
HepG2.C3A FECH
Mean 10.7
Standard deviation 3.1
Values 8.5 13
[53]
HuH.7 FECH
Mean 8.02
Standard deviation 1.9
Values 8.5 5.9 9.6
[54]
SNU475 FECH
Mean 23.5
Standard deviation 11
Values 31 16
[55]
THLE FECH
Mean 15.7
Standard deviation 1.5
Values 15 17
[56]
liver FECH
Mean 28.4
Standard deviation 7.8
Values 22 30 39 23
[57]
ref_hepatocyte COX15
Mean 3.5
Standard deviation 1.3
Values 3.4 4.8 1.5 3.1 4.6
[58]
HepG2 COX15
Mean 27.2
Standard deviation 2.3
Values 26 29
[59]
HepG2.C3A COX15
Mean 32.9
Standard deviation 1.4
Values 32 34
[60]
HuH.7 COX15
Mean 48
Standard deviation 7.7
Values 55 40 49
[61]
SNU475 COX15
Mean 16
Standard deviation 2.2
Values 18 14
[62]
THLE COX15
Mean 21.5
Standard deviation 1.6
Values 20 23
[63]
liver COX15
Mean 20.4
Standard deviation 4.8
Values 16 22 27 17
[64]
ref_hepatocyte COX10
Mean 3.24
Standard deviation 1.6
Values 4 2.6 5.5 2.7 1.4
[65]
HepG2 COX10
Mean 7.23
Standard deviation 0.24
Values 7.4 7.1
[66]
HepG2.C3A COX10
Mean 7.51
Standard deviation 0.29
Values 7.7 7.3
[67]
HuH.7 COX10
Mean 10.5
Standard deviation 1.7
Values 11 12 8.8
[68]
SNU475 COX10
Mean 5.49
Standard deviation 0.18
Values 5.6 5.4
[69]
THLE COX10
Mean 5.75
Standard deviation 0.3
Values 5.5 6
[70]
liver COX10
Mean 6.02
Standard deviation 2.3
Values 8.3 4.3 7.7 3.8
[71]
ref_hepatocyte ABCG2
Mean 3
Standard deviation 1.8
Values 1.1 5.2 2.9 1.5 4.4
[72]
HepG2 ABCG2
Mean 6.88
Standard deviation 0.34
Values 7.1 6.6
[73]
HepG2.C3A ABCG2
Mean 5.65
Standard deviation 0.97
Values 5 6.3
[74]
HuH.7 ABCG2
Mean 11.9
Standard deviation 1.2
Values 13 11 11
[75]
SNU475 ABCG2
Mean 4.32
Standard deviation 1
Values 3.6 5
[76]
THLE ABCG2
Mean 2.24
Standard deviation 1.1
Values 1.4 3
[77]
liver ABCG2
Mean 5.14
Standard deviation 1.6
Values 3.4 7.3 4.8 5
[78]
ref_hepatocyte PPOX
Mean 2.47
Standard deviation 1.4
Values 1.7 2.8 0.53 3.4 3.9
[79]
HepG2 PPOX
Mean 4.91
Standard deviation 0.76
Values 5.4 4.4
[80]
HepG2.C3A PPOX
Mean 5.46
Standard deviation 0.59
Values 5.9 5
[81]
HuH.7 PPOX
Mean 6.81
Standard deviation 2.6
Values 7.4 4 9
[82]
SNU475 PPOX
Mean 6.37
Standard deviation 0.37
Values 6.6 6.1
[83]
THLE PPOX
Mean 4.78
Standard deviation 0.24
Values 4.6 4.9
[84]
liver PPOX
Mean 2.92
Standard deviation 2.1
Values 4.7 0.93 4.7 1.3
[85]
ref_hepatocyte FLVCR1
Mean 2.12
Standard deviation 3.1
Values 7.6 0.89 1.2 0.53 0.42
[86]
HepG2 FLVCR1
Mean 9.02
Standard deviation 4.8
Values 5.6 12
[87]
HepG2.C3A FLVCR1
Mean 20.5
Standard deviation 4.1
Values 23 18
[88]
HuH.7 FLVCR1
Mean 16.9
Standard deviation 3.4
Values 16 21 14
[89]
SNU475 FLVCR1
Mean 8.85
Standard deviation 0.31
Values 8.6 9.1
[90]
THLE FLVCR1
Mean 4.9
Standard deviation 0.14
Values 4.8 5
[91]
liver FLVCR1
Mean 3.72
Standard deviation 0.82
Values 2.8 3.7 3.6 4.8
[92]
ref_hepatocyte ALAS2
Mean 0.124
Standard deviation 0.17
Values 0 0 0 0.28 0.33
[93]
HepG2 ALAS2
Mean 0.0865
Standard deviation 0.09
Values 0.023 0.15
[94]
HepG2.C3A ALAS2
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[95]
HuH.7 ALAS2
Mean 0.0355
Standard deviation 0.024
Values 0.0082 0.051 0.047
[96]
SNU475 ALAS2
Mean 0
Standard deviation 0
Values 0 0
[97]
THLE ALAS2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[98]
liver ALAS2
Mean 0.148
Standard deviation 0.22
Values 0 0.13 0.46 0