REACTOME_HEDGEHOG_ON_STATE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.13[2] | -1.21[3] | -1.05[4] | -1.44[5] | -1.06[6] | -0.51[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.69[16] | -0.45[17] | -0.69[18] | -0.59[19] | -0.68[20] | -0.06[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.46[23] | -2.04[24] | -1.66[25] | -1.31[26] | -1.91[27] | -1.01[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.28[30] | -1.67[31] | -1.75[32] | -1.09[33] | -1.44[34] | -0.64[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.68[37] | 0.80[38] | -0.50[39] | 0.54[40] | 0.03[41] | 0.39[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.23[44] | 0.35[45] | -0.70[46] | -0.71[47] | -0.01[48] | 0.22[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.26[51] | -1.03[52] | 0.03[53] | -0.73[54] | -0.91[55] | -0.07[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.01[58] | 0.17[59] | 0.33[60] | 0.70[61] | 0.63[62] | -0.40[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -0.95[65] | -0.93[66] | -0.77[67] | -1.08[68] | -0.70[69] | -0.84[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.44[72] | 0.03[73] | -0.01[74] | -0.35[75] | -0.13[76] | -0.36[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.57[79] | 0.31[80] | 0.27[81] | 0.18[82] | 0.13[83] | -0.28[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.36[86] | 0.32[87] | 0.15[88] | 0.48[89] | 0.24[90] | -0.36[91] |
14 | PSMC3 | 26S proteasome regulatory subunit 6A | [92] | -0.39[93] | -0.44[94] | 0.21[95] | -0.72[96] | -0.58[97] | 0.11[98] |
15 | PSMA3 | Proteasome subunit alpha type-3 | [99] | -0.98[100] | 0.05[101] | -0.60[102] | 0.02[103] | -0.48[104] | -0.11[105] |
16 | PSMB6 | Proteasome subunit beta type-6 | [106] | -0.43[107] | -0.26[108] | -0.09[109] | -0.52[110] | -0.85[111] | 0.04[112] |
17 | PSMA2 | Proteasome subunit alpha type-2 | [113] | -0.51[114] | 0.47[115] | 0.83[116] | -0.03[117] | 0.29[118] | 0.27[119] |
18 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [120] | 0.00[121] | 0.04[122] | 0.27[123] | 0.68[124] | 0.09[125] | -0.05[126] |
19 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [127] | -0.08[128] | 0.32[129] | 0.20[130] | -0.41[131] | 0.01[132] | -0.23[133] |
20 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [134] | 0.09[135] | 0.35[136] | 0.52[137] | -0.13[138] | 0.57[139] | -0.20[140] |
21 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [141] | 1.62[142] | 0.82[143] | 0.92[144] | 0.97[145] | 2.21[146] | 0.83[147] |
22 | PSMC1 | 26S proteasome regulatory subunit 4 | [148] | -0.06[149] | 0.03[150] | -0.59[151] | 1.16[152] | 0.63[153] | -0.01[154] |
23 | PSMA1 | Proteasome subunit alpha type-1 | [155] | 0.13[156] | 0.54[157] | 0.63[158] | 0.73[159] | 0.18[160] | 0.48[161] |
24 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [162] | 1.75[163] | 1.78[164] | 2.83[165] | 0.81[166] | 1.54[167] | 0.71[168] |
25 | PSMC5 | 26S proteasome regulatory subunit 8 | [169] | 0.44[170] | 0.36[171] | 0.47[172] | 0.14[173] | 0.50[174] | 0.25[175] |
26 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [176] | -0.99[177] | -0.43[178] | -0.54[179] | -1.37[180] | -1.02[181] | -0.73[182] |
27 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [183] | 0.84[184] | 0.36[185] | 0.98[186] | 0.68[187] | 0.84[188] | -0.04[189] |
28 | PSMB8 | Proteasome subunit beta type-8 | [190] | -1.56[191] | -2.12[192] | -9.31[193] | 0.65[194] | -0.71[195] | -0.73[196] |
29 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [197] | 0.02[198] | 0.65[199] | 0.93[200] | 0.54[201] | 0.52[202] | -0.18[203] |
30 | PSMC4 | 26S proteasome regulatory subunit 6B | [204] | 0.44[205] | 0.50[206] | 0.46[207] | 0.17[208] | 0.23[209] | 0.30[210] |
31 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [211] | -0.71[212] | -0.20[213] | -1.27[214] | -0.46[215] | 0.30[216] | -0.29[217] |
32 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [218] | 0.49[219] | 0.62[220] | 1.15[221] | 0.60[222] | 0.06[223] | -0.11[224] |
33 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [225] | -0.33[226] | -0.23[227] | -0.51[228] | 0.22[229] | 0.23[230] | -0.19[231] |
34 | PSMC6 | 26S proteasome regulatory subunit 10B | [232] | -0.04[233] | 1.56[234] | 0.41[235] | 0.58[236] | 0.46[237] | 0.47[238] |
35 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [239] | 0.85[240] | 0.48[241] | 1.10[242] | 0.99[243] | 1.09[244] | 1.29[245] |
36 | PSMC2 | 26S proteasome regulatory subunit 7 | [246] | 0.60[247] | 1.03[248] | 0.83[249] | 1.38[250] | 1.15[251] | 1.35[252] |
37 | PSME3 | Proteasome activator complex subunit 3 | [253] | 1.83[254] | 1.57[255] | 1.28[256] | 1.41[257] | 1.62[258] | 0.91[259] |
38 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [260] | 1.59[261] | 1.93[262] | 1.84[263] | 2.21[264] | 2.16[265] | 2.10[266] |
39 | PSMB10 | Proteasome subunit beta type-10 | [267] | -1.14[268] | -0.52[269] | -2.38[270] | 0.00[271] | -1.22[272] | -0.05[273] |
40 | CSNK1A1 | Casein kinase I isoform alpha | [274] | 1.41[275] | 1.52[276] | 1.30[277] | 2.17[278] | 2.19[279] | 2.06[280] |
41 | PSMA5 | Proteasome subunit alpha type-5 | [281] | 1.92[282] | 2.37[283] | 1.96[284] | 2.26[285] | 1.77[286] | 1.94[287] |
42 | PSMF1 | Proteasome inhibitor PI31 subunit | [288] | 2.30[289] | 2.36[290] | 1.20[291] | 1.27[292] | 0.98[293] | 1.88[294] |
43 | PSMB2 | Proteasome subunit beta type-2 | [295] | 2.08[296] | 1.83[297] | 2.25[298] | 2.57[299] | 2.50[300] | 2.42[301] |
44 | PSMB9 | Proteasome subunit beta type-9 | [302] | -1.93[303] | -4.53[304] | -6.81[305] | 1.82[306] | -0.50[307] | -0.47[308] |
45 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [309] | 0.45[310] | 0.97[311] | 0.01[312] | 0.44[313] | 0.83[314] | 0.75[315] |
46 | NUMB | Protein numb homolog | [316] | 0.63[317] | 1.82[318] | 0.95[319] | 1.61[320] | 1.70[321] | 1.58[322] |
47 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [323] | 1.01[324] | 1.35[325] | 1.40[326] | 2.12[327] | 1.38[328] | 0.74[329] |
48 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | [330] | 2.41[331] | 3.07[332] | 2.33[333] | 2.87[334] | 2.12[335] | 3.53[336] |
49 | SPOP | Speckle-type POZ protein | [337] | 1.26[338] | 1.97[339] | 1.67[340] | 1.68[341] | 1.63[342] | 2.13[343] |
50 | PSME4 | Proteasome activator complex subunit 4 | [344] | 2.54[345] | 3.47[346] | 3.50[347] | 2.67[348] | 2.58[349] | 3.01[350] |
51 | ARRB2 | Beta-arrestin-2 | [351] | 1.23[352] | 1.75[353] | 1.70[354] | 0.02[355] | 0.75[356] | 0.49[357] |
52 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [358] | 1.43[359] | 1.00[360] | 2.59[361] | 2.50[362] | 2.53[363] | 2.19[364] |
53 | CUL3 | Cullin-3 | [365] | 1.68[366] | 2.72[367] | 2.44[368] | 2.80[369] | 2.81[370] | 2.31[371] |
54 | SPOPL | Speckle-type POZ protein-like | [372] | 1.61[373] | 2.78[374] | 2.69[375] | 2.28[376] | 1.58[377] | 2.24[378] |
55 | SMO | Smoothened homolog | [379] | 2.24[380] | 2.74[381] | 2.90[382] | 2.48[383] | 1.69[384] | 1.61[385] |
56 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | [386] | 2.51[387] | 2.08[388] | 3.00[389] | 2.55[390] | 2.36[391] | 2.75[392] |
57 | CDC73 | Parafibromin | [393] | 2.13[394] | 3.05[395] | 3.38[396] | 4.38[397] | 3.26[398] | 2.92[399] |
58 | ULK3 | Serine/threonine-protein kinase ULK3 | [400] | 1.28[401] | 1.88[402] | 1.20[403] | 1.53[404] | 1.84[405] | 3.02[406] |
59 | GAS8 | Growth arrest-specific protein 8 | [407] | 1.37[408] | 1.86[409] | 1.38[410] | 0.95[411] | 0.67[412] | 0.68[413] |
60 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | [414] | 2.78[415] | 2.94[416] | 1.45[417] | 2.53[418] | 2.89[419] | 1.50[420] |
61 | SUFU | Suppressor of fused homolog | [421] | 2.52[422] | 2.67[423] | 3.62[424] | 2.56[425] | 2.99[426] | 1.73[427] |
62 | KIF3A | Kinesin-like protein KIF3A | [428] | 1.71[429] | 2.87[430] | 1.79[431] | 3.47[432] | 3.12[433] | 1.74[434] |
63 | SHH | Sonic hedgehog protein | [435] | 1.45[436] | 1.42[437] | 1.51[438] | -5.84[439] | -6.06[440] | 1.49[441] |
64 | IQCE | IQ domain-containing protein E | [442] | 2.75[443] | 1.19[444] | 3.96[445] | 2.96[446] | 3.91[447] | 3.26[448] |
65 | EFCAB7 | EF-hand calcium-binding domain-containing protein 7 | [449] | 0.96[450] | 2.17[451] | 2.10[452] | 2.89[453] | 2.73[454] | 1.76[455] |
66 | ARRB1 | Beta-arrestin-1 | [456] | 4.65[457] | 4.58[458] | 3.88[459] | 3.49[460] | 3.22[461] | 4.64[462] |
67 | DZIP1 | Zinc finger protein DZIP1 | [463] | 4.83[464] | 0.02[465] | 0.88[466] | 2.93[467] | 5.25[468] | 1.89[469] |
68 | CDON | Cell adhesion molecule-related/down-regulated by oncogenes | [470] | 4.17[471] | 3.75[472] | 3.56[473] | 5.61[474] | 3.92[475] | 3.66[476] |
69 | EVC | Ellis-van Creveld syndrome protein | [477] | 3.71[478] | 0.88[479] | -3.12[480] | 5.81[481] | 6.27[482] | 3.92[483] |
70 | KIF7 | Kinesin-like protein KIF7 | [484] | 4.51[485] | 2.85[486] | 3.02[487] | 4.37[488] | 4.68[489] | 1.64[490] |
71 | PTCH1 | Protein patched homolog 1 | [491] | 3.70[492] | 4.07[493] | 5.43[494] | 4.67[495] | 3.93[496] | 4.21[497] |
72 | IHH | Indian hedgehog protein | [498] | 2.12[499] | 0.30[500] | 6.11[501] | -2.96[502] | -3.90[503] | 1.46[504] |
73 | GLI1 | Zinc finger protein GLI1 | [505] | -0.58[506] | -0.61[507] | 2.63[508] | 0.25[509] | 2.77[510] | 2.33[511] |
74 | GAS1 | Growth arrest-specific protein 1 | [512] | -3.54[513] | [514] | -2.92[515] | 2.32[516] | 7.28[517] | 3.54[518] |
75 | GPR161 | G-protein coupled receptor 161 | [519] | 4.69[520] | 2.25[521] | 4.58[522] | 7.37[523] | 6.42[524] | 5.31[525] |
76 | PTCH2 | Protein patched homolog 2 | [526] | 4.30[527] | 5.74[528] | 2.15[529] | 1.86[530] | 2.96[531] | 3.29[532] |
77 | GLI2 | Zinc finger protein GLI2 | [533] | 1.71[534] | -1.71[535] | 0.03[536] | 9.81[537] | 8.91[538] | 4.25[539] |
78 | GLI3 | Transcriptional activator GLI3 | [540] | -0.16[541] | [542] | 0.93[543] | 10.27[544] | 8.56[545] | 5.52[546] |
79 | EVC2 | Limbin | [547] | -1.89[548] | -0.69[549] | -1.41[550] | 5.82[551] | 9.19[552] | 7.10[553] |
80 | BOC | Brother of CDO | [554] | 2.59[555] | [556] | 0.78[557] | 9.10[558] | 6.80[559] | 5.92[560] |
81 | PSMB11 | Proteasome subunit beta type-11 | [561] | [562] | [563] | [564] | [565] | [566] | [567] |
82 | DHH | Desert hedgehog protein | [568] | [569] | [570] | [571] | [572] | [573] | [574] |
83 | SEM1 | Putative protein SEM1, isoform 2 | [575] | [576] | [577] | [578] | [579] | [580] | [581] |
84 | PSMA8 | Proteasome subunit alpha type-7-like | [582] | [583] | [584] | [585] | [586] | [587] | [588] |
85 | HHIP | Hedgehog-interacting protein | [589] | [590] | [591] | [592] | [593] | [594] | [595] |
86 | GRK2 | Beta-adrenergic receptor kinase 1 | [596] | [597] | [598] | [599] | [600] | [601] | [602] |