REACTOME_HEDGEHOG_OFF_STATE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.24[2] | -1.33[3] | -1.13[4] | -1.65[5] | -1.20[6] | -0.51[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.80[16] | -0.58[17] | -0.76[18] | -0.79[19] | -0.82[20] | -0.06[21] |
4 | TUBA1B | Tubulin alpha-1B chain | [22] | 0.12[23] | 0.24[24] | 0.53[25] | 0.18[26] | 0.73[27] | -1.18[28] |
5 | TUBA1C | Tubulin alpha-1C chain | [29] | -0.49[30] | -0.46[31] | -0.91[32] | -0.48[33] | -0.87[34] | -2.41[35] |
6 | PSME1 | Proteasome activator complex subunit 1 | [36] | -0.57[37] | -2.17[38] | -1.73[39] | -1.51[40] | -2.05[41] | -1.01[42] |
7 | TUBB4B | Tubulin beta-4B chain | [43] | 0.17[44] | 0.18[45] | 0.21[46] | -0.51[47] | 0.37[48] | -0.09[49] |
8 | PSME2 | Proteasome activator complex subunit 2 | [50] | -0.38[51] | -1.79[52] | -1.82[53] | -1.30[54] | -1.58[55] | -0.63[56] |
9 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 1.39[57] | 1.53[58] | 1.24[59] | 1.98[60] | 1.20[61] | 0.03[62] | |
10 | PSMA7 | Proteasome subunit alpha type-7 | [63] | 0.57[64] | 0.68[65] | -0.57[66] | 0.33[67] | -0.11[68] | 0.39[69] |
11 | PSMB1 | Proteasome subunit beta type-1 | [70] | 0.12[71] | 0.23[72] | -0.77[73] | -0.92[74] | -0.15[75] | 0.23[76] |
12 | PSMB3 | Proteasome subunit beta type-3 | [77] | -0.36[78] | -1.15[79] | -0.05[80] | -0.94[81] | -1.05[82] | -0.07[83] |
13 | PSMB4 | Proteasome subunit beta type-4 | [84] | -0.12[85] | 0.05[86] | 0.25[87] | 0.49[88] | 0.49[89] | -0.40[90] |
14 | PSMB7 | Proteasome subunit beta type-7 | [91] | -1.06[92] | -1.06[93] | -0.84[94] | -1.28[95] | -0.84[96] | -0.84[97] |
15 | PSMB5 | Proteasome subunit beta type-5 | [98] | 1.34[99] | -0.09[100] | -0.09[101] | -0.56[102] | -0.28[103] | -0.36[104] |
16 | PSMA6 | Proteasome subunit alpha type-6 | [105] | 1.46[106] | 0.18[107] | 0.19[108] | -0.03[109] | -0.01[110] | -0.28[111] |
17 | PSMA4 | Proteasome subunit alpha type-4 | [112] | -0.47[113] | 0.20[114] | 0.07[115] | 0.27[116] | 0.10[117] | -0.36[118] |
18 | SKP1 | S-phase kinase-associated protein 1 | [119] | -0.02[120] | 0.48[121] | -0.34[122] | 0.63[123] | 0.83[124] | 0.67[125] |
19 | TUBA4A | Tubulin alpha-4A chain | [126] | -3.09[127] | -3.15[128] | -3.87[129] | -0.67[130] | -0.85[131] | -1.25[132] |
20 | PSMC3 | 26S proteasome regulatory subunit 6A | [133] | -0.50[134] | -0.56[135] | 0.13[136] | -0.93[137] | -0.72[138] | 0.11[139] |
21 | PSMA3 | Proteasome subunit alpha type-3 | [140] | -1.09[141] | -0.08[142] | -0.68[143] | -0.18[144] | -0.62[145] | -0.11[146] |
22 | PSMB6 | Proteasome subunit beta type-6 | [147] | -0.54[148] | -0.39[149] | -0.16[150] | -0.73[151] | -0.99[152] | 0.05[153] |
23 | PSMA2 | Proteasome subunit alpha type-2 | [154] | -0.62[155] | 0.34[156] | 0.75[157] | -0.23[158] | 0.15[159] | 0.27[160] |
24 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [161] | -0.10[162] | -0.09[163] | 0.19[164] | 0.47[165] | -0.06[166] | -0.05[167] |
25 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [168] | -0.19[169] | 0.19[170] | 0.13[171] | -0.62[172] | -0.13[173] | -0.23[174] |
26 | TUBB2A | Tubulin beta-2A chain | [175] | -2.27[176] | -2.26[177] | -0.94[178] | -1.00[179] | -3.28[180] | -1.41[181] |
27 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [182] | -0.02[183] | 0.23[184] | 0.44[185] | -0.34[186] | 0.43[187] | -0.20[188] |
28 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [189] | 1.51[190] | 0.70[191] | 0.84[192] | 0.77[193] | 2.07[194] | 0.83[195] |
29 | PSMC1 | 26S proteasome regulatory subunit 4 | [196] | -0.16[197] | -0.10[198] | -0.67[199] | 0.95[200] | 0.49[201] | -0.01[202] |
30 | PSMA1 | Proteasome subunit alpha type-1 | [203] | 0.02[204] | 0.41[205] | 0.55[206] | 0.53[207] | 0.04[208] | 0.48[209] |
31 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [210] | 1.64[211] | 1.65[212] | 2.75[213] | 0.60[214] | 1.40[215] | 0.71[216] |
32 | PSMC5 | 26S proteasome regulatory subunit 8 | [217] | 0.34[218] | 0.24[219] | 0.39[220] | -0.06[221] | 0.36[222] | 0.25[223] |
33 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [224] | -1.10[225] | -0.56[226] | -0.62[227] | -1.57[228] | -1.16[229] | -0.73[230] |
34 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | [231] | 1.04[232] | 1.27[233] | 1.47[234] | 1.04[235] | 0.92[236] | 1.96[237] |
35 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [238] | 0.73[239] | 0.23[240] | 0.90[241] | 0.47[242] | 0.70[243] | -0.04[244] |
36 | PSMB8 | Proteasome subunit beta type-8 | [245] | -1.66[246] | -2.25[247] | -9.39[248] | 0.44[249] | -0.86[250] | -0.72[251] |
37 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [252] | -0.09[253] | 0.52[254] | 0.85[255] | 0.33[256] | 0.37[257] | -0.18[258] |
38 | PSMC4 | 26S proteasome regulatory subunit 6B | [259] | 0.34[260] | 0.37[261] | 0.38[262] | -0.04[263] | 0.09[264] | 0.30[265] |
39 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [266] | -0.82[267] | -0.33[268] | -1.34[269] | -0.67[270] | 0.16[271] | -0.29[272] |
40 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [273] | 0.38[274] | 0.50[275] | 1.07[276] | 0.39[277] | -0.09[278] | -0.11[279] |
41 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [280] | -0.44[281] | -0.36[282] | -0.59[283] | 0.01[284] | 0.09[285] | -0.18[286] |
42 | PSMC6 | 26S proteasome regulatory subunit 10B | [287] | -0.14[288] | 1.44[289] | 0.33[290] | 0.37[291] | 0.31[292] | 0.47[293] |
43 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [294] | 0.74[295] | 0.36[296] | 1.03[297] | 0.78[298] | 0.95[299] | 1.30[300] |
44 | PSMC2 | 26S proteasome regulatory subunit 7 | [301] | 0.49[302] | 0.90[303] | 0.75[304] | 1.17[305] | 1.01[306] | 1.35[307] |
45 | PSME3 | Proteasome activator complex subunit 3 | [308] | 1.72[309] | 1.44[310] | 1.20[311] | 1.20[312] | 1.48[313] | 0.91[314] |
46 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [315] | 1.48[316] | 1.81[317] | 1.76[318] | 2.00[319] | 2.02[320] | 2.10[321] |
47 | PSMB10 | Proteasome subunit beta type-10 | [322] | -1.24[323] | -0.64[324] | -2.45[325] | -0.21[326] | -1.36[327] | -0.05[328] |
48 | CSNK1A1 | Casein kinase I isoform alpha | [329] | 1.30[330] | 1.39[331] | 1.22[332] | 1.97[333] | 2.05[334] | 2.06[335] |
49 | PSMA5 | Proteasome subunit alpha type-5 | [336] | 1.81[337] | 2.24[338] | 1.88[339] | 2.06[340] | 1.63[341] | 1.94[342] |
50 | PSMF1 | Proteasome inhibitor PI31 subunit | [343] | 2.19[344] | 2.24[345] | 1.12[346] | 1.06[347] | 0.84[348] | 1.88[349] |
51 | PSMB2 | Proteasome subunit beta type-2 | [350] | 1.97[351] | 1.71[352] | 2.17[353] | 2.36[354] | 2.36[355] | 2.43[356] |
52 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [357] | 0.80[358] | 0.73[359] | 0.78[360] | 0.66[361] | 1.24[362] | 0.59[363] |
53 | PSMB9 | Proteasome subunit beta type-9 | [364] | -2.04[365] | -4.65[366] | -6.88[367] | 1.61[368] | -0.65[369] | -0.47[370] |
54 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [371] | 0.35[372] | 0.84[373] | -0.07[374] | 0.24[375] | 0.69[376] | 0.76[377] |
55 | CUL1 | Cullin-1 | [378] | 0.58[379] | 1.36[380] | 0.97[381] | 1.71[382] | 1.35[383] | 2.11[384] |
56 | NUMB | Protein numb homolog | [385] | 0.52[386] | 1.70[387] | 0.88[388] | 1.40[389] | 1.56[390] | 1.59[391] |
57 | TUBB3 | Tubulin beta-3 chain | [392] | 3.32[393] | 2.37[394] | -1.74[395] | 2.16[396] | -0.97[397] | -6.40[398] |
58 | TUBB6 | Tubulin beta-6 chain | [399] | 1.76[400] | -0.22[401] | 1.45[402] | 2.86[403] | 3.18[404] | -0.31[405] |
59 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [406] | 0.90[407] | 1.23[408] | 1.33[409] | 1.91[410] | 1.24[411] | 0.74[412] |
60 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | [413] | 2.31[414] | 2.94[415] | 2.26[416] | 2.66[417] | 1.98[418] | 3.54[419] |
61 | PSME4 | Proteasome activator complex subunit 4 | [420] | 2.43[421] | 3.34[422] | 3.42[423] | 2.47[424] | 2.44[425] | 3.01[426] |
62 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | [427] | 1.01[428] | 0.80[429] | 1.96[430] | 0.85[431] | 0.69[432] | 1.51[433] |
63 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [434] | 1.32[435] | 0.88[436] | 2.51[437] | 2.29[438] | 2.39[439] | 2.19[440] |
64 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | [441] | 1.93[442] | 1.49[443] | -0.24[444] | -2.97[445] | -0.18[446] | 1.20[447] |
65 | TUBB2B | Tubulin beta-2B chain | [448] | 1.63[449] | 0.61[450] | 0.63[451] | 0.70[452] | -3.23[453] | -2.84[454] |
66 | IFT52 | Intraflagellar transport protein 52 homolog | [455] | 1.99[456] | 2.27[457] | 0.62[458] | 1.69[459] | 0.83[460] | -0.77[461] |
67 | GSK3B | Glycogen synthase kinase-3 beta | [462] | 2.23[463] | 1.97[464] | 2.60[465] | 2.95[466] | 2.76[467] | 2.53[468] |
68 | SMO | Smoothened homolog | [469] | 2.13[470] | 2.61[471] | 2.82[472] | 2.28[473] | 1.55[474] | 1.62[475] |
69 | TUBA1A | Tubulin alpha-1A chain | [476] | 3.13[477] | -0.14[478] | -3.29[479] | 5.22[480] | 2.72[481] | 1.37[482] |
70 | TULP3 | Tubby-related protein 3 | [483] | 1.07[484] | 0.99[485] | 1.89[486] | 1.32[487] | 1.75[488] | 1.09[489] |
71 | IFT88 | Intraflagellar transport protein 88 homolog | [490] | -0.01[491] | 1.71[492] | 1.32[493] | 1.33[494] | 0.75[495] | 2.64[496] |
72 | IFT57 | Intraflagellar transport protein 57 homolog | [497] | 0.10[498] | 0.22[499] | -6.32[500] | 0.71[501] | 2.30[502] | 1.48[503] |
73 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [504] | 0.13[505] | 1.01[506] | 2.35[507] | 3.37[508] | 2.21[509] | 3.08[510] |
74 | ADCY9 | Adenylate cyclase type 9 | [511] | 3.58[512] | 2.87[513] | 3.35[514] | 2.09[515] | 1.62[516] | 3.78[517] |
75 | MKS1 | Meckel syndrome type 1 protein | [518] | 1.58[519] | 1.78[520] | 1.24[521] | 0.33[522] | 0.81[523] | 0.84[524] |
76 | OFD1 | Oral-facial-digital syndrome 1 protein | [525] | 0.49[526] | 2.34[527] | 2.33[528] | 1.93[529] | 1.63[530] | 2.67[531] |
77 | BTRC | F-box/WD repeat-containing protein 1A | [532] | 2.37[533] | 3.27[534] | 2.94[535] | 1.89[536] | 2.41[537] | 2.71[538] |
78 | ADCY6 | Adenylate cyclase type 6 | [539] | 3.01[540] | 3.58[541] | 3.59[542] | 3.64[543] | 4.29[544] | 4.00[545] |
79 | SUFU | Suppressor of fused homolog | [546] | 2.42[547] | 2.54[548] | 3.54[549] | 2.35[550] | 2.85[551] | 1.73[552] |
80 | WDR19 | WD repeat-containing protein 19 | [553] | 1.55[554] | 2.57[555] | 3.07[556] | 1.96[557] | 2.67[558] | 4.16[559] |
81 | FUZ | Protein fuzzy homolog | [560] | -4.39[561] | -4.15[562] | -4.74[563] | -1.21[564] | 2.36[565] | 0.90[566] |
82 | IFT122 | Intraflagellar transport protein 122 homolog | [567] | 2.11[568] | 2.49[569] | 2.92[570] | 2.44[571] | 2.89[572] | 3.28[573] |
83 | TTC21B | Tetratricopeptide repeat protein 21B | [574] | 2.40[575] | 5.22[576] | 4.11[577] | 3.30[578] | 3.22[579] | 3.81[580] |
84 | KIF3A | Kinesin-like protein KIF3A | [581] | 1.60[582] | 2.74[583] | 1.72[584] | 3.26[585] | 2.98[586] | 1.74[587] |
85 | WDR35 | WD repeat-containing protein 35 | [588] | 3.13[589] | 4.87[590] | 3.81[591] | 3.30[592] | 3.81[593] | 3.37[594] |
86 | ADCY1 | Adenylate cyclase type 1 | [595] | 0.12[596] | -1.64[597] | -1.79[598] | -0.98[599] | -1.01[600] | 6.36[601] |
87 | IFT172 | Intraflagellar transport protein 172 homolog | [602] | 2.60[603] | 3.53[604] | 2.94[605] | 3.73[606] | 3.75[607] | 3.05[608] |
88 | IFT140 | Intraflagellar transport protein 140 homolog | [609] | 3.71[610] | 3.53[611] | 4.03[612] | 2.84[613] | 2.65[614] | 3.21[615] |
89 | RPGRIP1L | Protein fantom | [616] | 2.48[617] | 3.47[618] | 2.85[619] | 3.13[620] | 3.66[621] | 1.78[622] |
90 | ADCY7 | Adenylate cyclase type 7 | [623] | 4.47[624] | 4.20[625] | 3.21[626] | 4.44[627] | 3.90[628] | 4.29[629] |
91 | ADCY10 | Adenylate cyclase type 10 | [630] | -1.24[631] | -2.01[632] | 4.18[633] | 0.18[634] | -2.63[635] | 4.13[636] |
92 | KIF7 | Kinesin-like protein KIF7 | [637] | 4.40[638] | 2.73[639] | 2.94[640] | 4.17[641] | 4.54[642] | 1.64[643] |
93 | PTCH1 | Protein patched homolog 1 | [644] | 3.60[645] | 3.94[646] | 5.36[647] | 4.46[648] | 3.78[649] | 4.21[650] |
94 | INTU | Protein inturned | [651] | 2.48[652] | 3.24[653] | 3.73[654] | 2.48[655] | 3.17[656] | 3.01[657] |
95 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | [658] | -1.38[659] | 0.55[660] | 4.89[661] | 6.22[662] | 4.72[663] | 4.68[664] |
96 | ADCY3 | Adenylate cyclase type 3 | [665] | 2.42[666] | 1.28[667] | 4.66[668] | 5.87[669] | 7.39[670] | 4.88[671] |
97 | GLI1 | Zinc finger protein GLI1 | [672] | -0.68[673] | -0.73[674] | 2.56[675] | 0.04[676] | 2.63[677] | 2.33[678] |
98 | TUBA3D | [679] | -1.03[680] | -0.19[681] | -0.99[682] | 0.65[683] | -0.66[684] | 1.38[685] | |
99 | ADCY2 | Adenylate cyclase type 2 | [686] | -4.42[687] | -2.38[688] | -3.58[689] | -1.60[690] | -2.73[691] | -2.75[692] |
100 | DYNC2H1 | Cytoplasmic dynein 2 heavy chain 1 | [693] | 2.41[694] | 2.83[695] | -0.38[696] | 7.21[697] | 7.32[698] | 6.85[699] |
101 | TUBB1 | Tubulin beta-1 chain | [700] | 5.54[701] | 7.50[702] | 3.38[703] | 3.93[704] | 2.58[705] | 4.92[706] |
102 | TUBB4A | Tubulin beta-4A chain | [707] | 2.78[708] | -1.23[709] | 5.36[710] | 4.77[711] | 3.32[712] | 3.21[713] |
103 | GPR161 | G-protein coupled receptor 161 | [714] | 4.58[715] | 2.12[716] | 4.50[717] | 7.16[718] | 6.28[719] | 5.31[720] |
104 | TUBA3C | Tubulin alpha-3C/D chain | [721] | [722] | -3.19[723] | [724] | 2.32[725] | -4.07[726] | -2.87[727] |
105 | ADCY5 | Adenylate cyclase type 5 | [728] | 1.11[729] | 2.22[730] | 3.30[731] | 1.78[732] | 2.89[733] | 7.74[734] |
106 | GLI2 | Zinc finger protein GLI2 | [735] | 1.60[736] | -1.84[737] | -0.04[738] | 9.60[739] | 8.77[740] | 4.25[741] |
107 | GLI3 | Transcriptional activator GLI3 | [742] | -0.27[743] | [744] | 0.85[745] | 10.07[746] | 8.42[747] | 5.52[748] |
108 | ADCY4 | Adenylate cyclase type 4 | [749] | 1.05[750] | 0.08[751] | 2.78[752] | [753] | [754] | 9.74[755] |
109 | ADCY8 | Adenylate cyclase type 8 | [756] | [757] | [758] | [759] | [760] | [761] | [762] |
110 | PSMB11 | Proteasome subunit beta type-11 | [763] | [764] | [765] | [766] | [767] | [768] | [769] |
111 | SEM1 | Putative protein SEM1, isoform 2 | [770] | [771] | [772] | [773] | [774] | [775] | [776] |
112 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [777] | [778] | [779] | [780] | [781] | [782] | [783] |
113 | PSMA8 | Proteasome subunit alpha type-7-like | [784] | [785] | [786] | [787] | [788] | [789] | [790] |