REACTOME_HEDGEHOG_LIGAND_BIOGENESIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.32[2] | -1.35[3] | -1.07[4] | -1.33[5] | -0.98[6] | -0.90[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.88[16] | -0.60[17] | -0.71[18] | -0.48[19] | -0.60[20] | -0.45[21] |
4 | P4HB | Protein disulfide-isomerase | [22] | 0.91[23] | 0.91[24] | 0.36[25] | -0.12[26] | -0.10[27] | 1.52[28] |
5 | PSME1 | Proteasome activator complex subunit 1 | [29] | -0.65[30] | -2.19[31] | -1.68[32] | -1.20[33] | -1.83[34] | -1.40[35] |
6 | PSME2 | Proteasome activator complex subunit 2 | [36] | -0.46[37] | -1.81[38] | -1.77[39] | -0.98[40] | -1.36[41] | -1.02[42] |
7 | PSMA7 | Proteasome subunit alpha type-7 | [43] | 0.49[44] | 0.66[45] | -0.52[46] | 0.64[47] | 0.11[48] | 0.00[49] |
8 | PSMB1 | Proteasome subunit beta type-1 | [50] | 0.04[51] | 0.21[52] | -0.72[53] | -0.60[54] | 0.07[55] | -0.16[56] |
9 | PSMB3 | Proteasome subunit beta type-3 | [57] | -0.44[58] | -1.17[59] | 0.01[60] | -0.62[61] | -0.83[62] | -0.46[63] |
10 | PSMB4 | Proteasome subunit beta type-4 | [64] | -0.20[65] | 0.03[66] | 0.30[67] | 0.81[68] | 0.71[69] | -0.79[70] |
11 | PSMB7 | Proteasome subunit beta type-7 | [71] | -1.14[72] | -1.07[73] | -0.79[74] | -0.97[75] | -0.62[76] | -1.22[77] |
12 | PSMB5 | Proteasome subunit beta type-5 | [78] | 1.26[79] | -0.11[80] | -0.04[81] | -0.25[82] | -0.06[83] | -0.75[84] |
13 | VCP | Transitional endoplasmic reticulum ATPase | [85] | 1.12[86] | 1.02[87] | 1.08[88] | 0.94[89] | 1.40[90] | 1.22[91] |
14 | PSMA6 | Proteasome subunit alpha type-6 | [92] | 1.38[93] | 0.17[94] | 0.25[95] | 0.28[96] | 0.21[97] | -0.67[98] |
15 | OS9 | Protein OS-9 | [99] | 0.13[100] | 0.70[101] | 0.58[102] | -0.17[103] | -0.04[104] | 0.94[105] |
16 | PSMA4 | Proteasome subunit alpha type-4 | [106] | -0.54[107] | 0.18[108] | 0.12[109] | 0.58[110] | 0.32[111] | -0.75[112] |
17 | PSMC3 | 26S proteasome regulatory subunit 6A | [113] | -0.58[114] | -0.58[115] | 0.19[116] | -0.61[117] | -0.50[118] | -0.28[119] |
18 | PSMA3 | Proteasome subunit alpha type-3 | [120] | -1.17[121] | -0.10[122] | -0.63[123] | 0.13[124] | -0.40[125] | -0.50[126] |
19 | PSMB6 | Proteasome subunit beta type-6 | [127] | -0.62[128] | -0.40[129] | -0.11[130] | -0.42[131] | -0.77[132] | -0.34[133] |
20 | PSMA2 | Proteasome subunit alpha type-2 | [134] | -0.70[135] | 0.32[136] | 0.80[137] | 0.08[138] | 0.37[139] | -0.12[140] |
21 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [141] | -0.18[142] | -0.10[143] | 0.24[144] | 0.78[145] | 0.16[146] | -0.44[147] |
22 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [148] | -0.27[149] | 0.17[150] | 0.18[151] | -0.30[152] | 0.09[153] | -0.62[154] |
23 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [155] | -0.10[156] | 0.21[157] | 0.49[158] | -0.03[159] | 0.65[160] | -0.59[161] |
24 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [162] | 1.43[163] | 0.68[164] | 0.90[165] | 1.08[166] | 2.29[167] | 0.44[168] |
25 | PSMC1 | 26S proteasome regulatory subunit 4 | [169] | -0.24[170] | -0.11[171] | -0.62[172] | 1.27[173] | 0.71[174] | -0.40[175] |
26 | PSMA1 | Proteasome subunit alpha type-1 | [176] | -0.06[177] | 0.40[178] | 0.61[179] | 0.84[180] | 0.26[181] | 0.09[182] |
27 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [183] | 1.56[184] | 1.64[185] | 2.80[186] | 0.92[187] | 1.62[188] | 0.32[189] |
28 | PSMC5 | 26S proteasome regulatory subunit 8 | [190] | 0.26[191] | 0.22[192] | 0.44[193] | 0.25[194] | 0.58[195] | -0.14[196] |
29 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [197] | 0.65[198] | 0.21[199] | 0.95[200] | 0.78[201] | 0.92[202] | -0.43[203] |
30 | PSMB8 | Proteasome subunit beta type-8 | [204] | -1.74[205] | -2.27[206] | -9.34[207] | 0.75[208] | -0.64[209] | -1.11[210] |
31 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [211] | -0.17[212] | 0.50[213] | 0.91[214] | 0.64[215] | 0.59[216] | -0.57[217] |
32 | PSMC4 | 26S proteasome regulatory subunit 6B | [218] | 0.26[219] | 0.35[220] | 0.44[221] | 0.27[222] | 0.31[223] | -0.09[224] |
33 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [225] | -0.90[226] | -0.35[227] | -1.29[228] | -0.35[229] | 0.38[230] | -0.68[231] |
34 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [232] | 0.30[233] | 0.48[234] | 1.13[235] | 0.71[236] | 0.13[237] | -0.49[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.52[240] | -0.37[241] | -0.53[242] | 0.33[243] | 0.31[244] | -0.57[245] |
36 | PSMC6 | 26S proteasome regulatory subunit 10B | [246] | -0.22[247] | 1.42[248] | 0.39[249] | 0.69[250] | 0.53[251] | 0.08[252] |
37 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [253] | 0.66[254] | 0.34[255] | 1.08[256] | 1.09[257] | 1.17[258] | 0.91[259] |
38 | PSMC2 | 26S proteasome regulatory subunit 7 | [260] | 0.41[261] | 0.88[262] | 0.81[263] | 1.49[264] | 1.23[265] | 0.96[266] |
39 | DERL2 | Derlin-2 | [267] | -1.34[268] | -0.53[269] | -0.92[270] | -0.26[271] | -0.63[272] | -0.19[273] |
40 | PSME3 | Proteasome activator complex subunit 3 | [274] | 1.64[275] | 1.43[276] | 1.26[277] | 1.51[278] | 1.70[279] | 0.53[280] |
41 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [281] | 1.40[282] | 1.79[283] | 1.81[284] | 2.32[285] | 2.24[286] | 1.71[287] |
42 | PSMB10 | Proteasome subunit beta type-10 | [288] | -1.32[289] | -0.66[290] | -2.40[291] | 0.11[292] | -1.14[293] | -0.44[294] |
43 | SYVN1 | E3 ubiquitin-protein ligase synoviolin | [295] | -0.09[296] | 0.41[297] | 0.13[298] | 0.05[299] | 0.07[300] | 1.40[301] |
44 | PSMA5 | Proteasome subunit alpha type-5 | [302] | 1.73[303] | 2.22[304] | 1.93[305] | 2.37[306] | 1.85[307] | 1.55[308] |
45 | PSMF1 | Proteasome inhibitor PI31 subunit | [309] | 2.11[310] | 2.22[311] | 1.17[312] | 1.38[313] | 1.06[314] | 1.49[315] |
46 | ERLEC1 | Endoplasmic reticulum lectin 1 | [316] | 0.63[317] | 2.34[318] | 2.10[319] | 1.29[320] | 1.07[321] | 0.95[322] |
47 | PSMB2 | Proteasome subunit beta type-2 | [323] | 1.89[324] | 1.69[325] | 2.22[326] | 2.67[327] | 2.58[328] | 2.04[329] |
48 | SEL1L | Protein sel-1 homolog 1 | [330] | 1.20[331] | 1.81[332] | 1.85[333] | 2.41[334] | 1.99[335] | 3.80[336] |
49 | PSMB9 | Proteasome subunit beta type-9 | [337] | -2.12[338] | -4.67[339] | -6.83[340] | 1.93[341] | -0.43[342] | -0.86[343] |
50 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [344] | 0.27[345] | 0.82[346] | -0.01[347] | 0.55[348] | 0.91[349] | 0.37[350] |
51 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [351] | 0.82[352] | 1.21[353] | 1.38[354] | 2.22[355] | 1.46[356] | 0.35[357] |
52 | PSME4 | Proteasome activator complex subunit 4 | [358] | 2.35[359] | 3.33[360] | 3.48[361] | 2.78[362] | 2.66[363] | 2.62[364] |
53 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [365] | 1.24[366] | 0.86[367] | 2.57[368] | 2.61[369] | 2.61[370] | 1.80[371] |
54 | NOTUM | Palmitoleoyl-protein carboxylesterase NOTUM | [372] | 5.01[373] | 3.67[374] | -0.82[375] | -4.85[376] | -5.45[377] | -1.73[378] |
55 | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | [379] | 1.56[380] | 1.61[381] | 1.47[382] | 3.19[383] | 2.21[384] | 1.06[385] |
56 | SHH | Sonic hedgehog protein | [386] | 1.26[387] | 1.28[388] | 1.48[389] | -5.73[390] | -5.98[391] | 1.11[392] |
57 | HHAT | Protein-cysteine N-palmitoyltransferase HHAT | [393] | 1.92[394] | 0.76[395] | -0.74[396] | 2.83[397] | 0.00[398] | 1.38[399] |
58 | IHH | Indian hedgehog protein | [400] | 1.94[401] | 0.15[402] | 6.09[403] | -2.85[404] | -3.82[405] | 1.07[406] |
59 | GPC5 | Glypican-5 | [407] | -2.30[408] | -3.46[409] | 1.05[410] | -1.79[411] | -1.39[412] | 4.55[413] |
60 | DISP2 | Protein dispatched homolog 2 | [414] | 3.88[415] | 1.69[416] | 4.76[417] | 5.42[418] | 1.55[419] | 2.25[420] |
61 | SCUBE2 | Signal peptide, CUB and EGF-like domain-containing protein 2 | [421] | -3.73[422] | -1.49[423] | -0.21[424] | 3.79[425] | 2.53[426] | 3.29[427] |
62 | PSMA8 | Proteasome subunit alpha type-7-like | [428] | [429] | [430] | [431] | [432] | [433] | [434] |
63 | SEM1 | Putative protein SEM1, isoform 2 | [435] | [436] | [437] | [438] | [439] | [440] | [441] |
64 | DHH | Desert hedgehog protein | [442] | [443] | [444] | [445] | [446] | [447] | [448] |
65 | PSMB11 | Proteasome subunit beta type-11 | [449] | [450] | [451] | [452] | [453] | [454] | [455] |