REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.73[2] | -1.17[3] | -1.19[4] | -1.33[5] | -1.01[6] | -0.34[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.29[16] | -0.42[17] | -0.82[18] | -0.48[19] | -0.63[20] | 0.12[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 2.15[23] | 1.82[24] | 2.69[25] | 0.92[26] | 1.59[27] | 0.88[28] |
5 | PCNA | Proliferating cell nuclear antigen | [29] | 2.36[30] | 2.10[31] | 0.52[32] | 1.23[33] | 1.37[34] | -1.53[35] |
6 | POLD2 | DNA polymerase delta subunit 2 | [36] | 0.87[37] | 0.80[38] | 1.14[39] | 0.58[40] | 0.81[41] | 1.42[42] |
7 | POLD4 | DNA polymerase delta subunit 4 | [43] | -0.66[44] | -1.25[45] | 0.66[46] | 2.89[47] | -0.84[48] | 1.06[49] |
8 | POLE3 | DNA polymerase epsilon subunit 3 | [50] | 0.68[51] | 0.30[52] | 0.43[53] | 0.39[54] | 1.29[55] | -0.03[56] |
9 | POLE4 | DNA polymerase epsilon subunit 4 | [57] | 0.42[58] | 0.92[59] | -2.70[60] | -0.18[61] | -0.79[62] | -0.27[63] |
10 | RPA2 | Replication protein A 32 kDa subunit | [64] | 0.01[65] | -0.15[66] | 0.24[67] | 0.70[68] | 0.64[69] | -0.86[70] |
11 | RFC4 | Replication factor C subunit 4 | [71] | 0.50[72] | 0.89[73] | 1.30[74] | 0.48[75] | 1.67[76] | -1.21[77] |
12 | RAD51C | DNA repair protein RAD51 homolog 3 | [78] | 1.06[79] | 1.05[80] | 0.71[81] | -0.73[82] | 0.67[83] | -0.72[84] |
13 | SLX1B | [85] | [86] | [87] | [88] | [89] | [90] | [91] | |
14 | SLX1A | Structure-specific endonuclease subunit SLX1 | [92] | [93] | [94] | [95] | [96] | [97] | [98] |
15 | RFC1 | Replication factor C subunit 1 | [99] | 1.61[100] | 2.66[101] | 2.87[102] | 1.77[103] | 2.47[104] | 2.32[105] |
16 | RFC2 | Replication factor C subunit 2 | [106] | 1.20[107] | 0.82[108] | 0.69[109] | 1.63[110] | 1.95[111] | 0.77[112] |
17 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [113] | 2.78[114] | 2.28[115] | 2.38[116] | 3.30[117] | 3.18[118] | 1.54[119] |
18 | RPA3 | Replication protein A 14 kDa subunit | [120] | 1.10[121] | 1.66[122] | 2.21[123] | 0.54[124] | 0.69[125] | 0.85[126] |
19 | RAD17 | Cell cycle checkpoint protein RAD17 | [127] | 0.62[128] | 1.47[129] | 1.35[130] | 1.11[131] | 1.32[132] | 1.11[133] |
20 | KAT5 | Histone acetyltransferase KAT5 | [134] | 0.69[135] | 0.86[136] | -0.34[137] | 0.61[138] | 0.39[139] | 0.47[140] |
21 | MUS81 | Crossover junction endonuclease MUS81 | [141] | 1.26[142] | 1.23[143] | 0.81[144] | 1.85[145] | 1.45[146] | 0.98[147] |
22 | NBN | Nibrin | [148] | 1.05[149] | 1.99[150] | 1.58[151] | 2.95[152] | 1.93[153] | 2.81[154] |
23 | RFC5 | Replication factor C subunit 5 | [155] | 1.60[156] | 1.82[157] | 1.85[158] | 1.71[159] | 2.10[160] | 0.66[161] |
24 | RAD51 | DNA repair protein RAD51 homolog 1 | [162] | 1.22[163] | 0.80[164] | 0.72[165] | 1.27[166] | 1.09[167] | -2.41[168] |
25 | RAD50 | DNA repair protein RAD50 | [169] | 1.62[170] | 3.51[171] | 2.50[172] | 2.72[173] | 3.06[174] | 3.74[175] |
26 | RMI2 | RecQ-mediated genome instability protein 2 | [176] | 2.72[177] | 1.76[178] | 1.55[179] | 0.25[180] | 0.42[181] | -2.89[182] |
27 | RBBP8 | DNA endonuclease RBBP8 | [183] | 1.66[184] | 2.84[185] | 1.29[186] | 2.88[187] | 2.95[188] | 1.79[189] |
28 | TOPBP1 | DNA topoisomerase 2-binding protein 1 | [190] | 2.49[191] | 3.29[192] | 3.27[193] | 3.58[194] | 3.84[195] | 2.42[196] |
29 | RFC3 | Replication factor C subunit 3 | [197] | 2.64[198] | 3.27[199] | 3.24[200] | 2.70[201] | 3.16[202] | 0.67[203] |
30 | HUS1 | Checkpoint protein HUS1 | [204] | 0.75[205] | 0.79[206] | 1.16[207] | 1.34[208] | 1.00[209] | 2.91[210] |
31 | CHEK1 | Serine/threonine-protein kinase Chk1 | [211] | 3.00[212] | 3.13[213] | 2.52[214] | 3.60[215] | 3.69[216] | -0.49[217] |
32 | POLD1 | DNA polymerase delta catalytic subunit | [218] | 3.33[219] | 3.31[220] | 3.96[221] | 3.27[222] | 3.89[223] | 2.21[224] |
33 | POLK | DNA polymerase kappa | [225] | 0.63[226] | 1.86[227] | 1.95[228] | 3.28[229] | 2.87[230] | 3.63[231] |
34 | POLH | DNA polymerase eta | [232] | 3.58[233] | 2.84[234] | 1.23[235] | 3.45[236] | 3.10[237] | 2.87[238] |
35 | TOP3A | DNA topoisomerase 3-alpha | [239] | 3.43[240] | 2.87[241] | 3.00[242] | 3.30[243] | 3.54[244] | 3.33[245] |
36 | RAD1 | Cell cycle checkpoint protein RAD1 | [246] | 2.83[247] | 3.28[248] | 3.64[249] | 3.25[250] | 4.00[251] | 2.45[252] |
37 | PALB2 | Partner and localizer of BRCA2 | [253] | 3.23[254] | 3.30[255] | 2.75[256] | 2.15[257] | 2.50[258] | 2.21[259] |
38 | RAD9A | Cell cycle checkpoint control protein RAD9A | [260] | 1.54[261] | 1.58[262] | 3.22[263] | 3.78[264] | 1.46[265] | 1.37[266] |
39 | BRCA1 | Breast cancer type 1 susceptibility protein | [267] | 3.14[268] | 4.15[269] | 4.37[270] | 3.59[271] | 3.98[272] | 3.21[273] |
40 | ATRIP | ATR-interacting protein | [274] | 1.71[275] | 1.72[276] | 2.42[277] | 1.10[278] | 2.04[279] | 1.38[280] |
41 | ATR | Serine/threonine-protein kinase ATR | [281] | 2.56[282] | 3.32[283] | 3.23[284] | 3.98[285] | 3.80[286] | 5.09[287] |
42 | POLD3 | DNA polymerase delta subunit 3 | [288] | 2.64[289] | 2.28[290] | 3.08[291] | 3.56[292] | 3.91[293] | 2.52[294] |
43 | POLE | DNA polymerase epsilon catalytic subunit A | [295] | 4.51[296] | 4.90[297] | 4.78[298] | 4.19[299] | 5.06[300] | 4.48[301] |
44 | RTEL1 | Regulator of telomere elongation helicase 1 | [302] | -0.24[303] | 0.66[304] | -1.33[305] | -0.84[306] | -0.40[307] | -0.11[308] |
45 | WRN | Werner syndrome ATP-dependent helicase | [309] | 2.08[310] | 3.30[311] | 5.07[312] | 3.15[313] | 2.82[314] | 3.51[315] |
46 | RAD51D | DNA repair protein RAD51 homolog 4 | [316] | 2.20[317] | 1.97[318] | 2.53[319] | 2.50[320] | 1.80[321] | 1.30[322] |
47 | POLE2 | DNA polymerase epsilon subunit 2 | [323] | 2.17[324] | 2.73[325] | 3.55[326] | 2.60[327] | 3.00[328] | 0.38[329] |
48 | RAD51AP1 | RAD51-associated protein 1 | [330] | 2.97[331] | 4.19[332] | 4.71[333] | 3.51[334] | 4.18[335] | 0.03[336] |
49 | RMI1 | RecQ-mediated genome instability protein 1 | [337] | 2.05[338] | 3.05[339] | 3.33[340] | 3.52[341] | 4.23[342] | 2.52[343] |
50 | XRCC2 | DNA repair protein XRCC2 | [344] | 1.65[345] | 2.20[346] | 2.38[347] | 2.25[348] | 2.36[349] | -0.72[350] |
51 | ATM | Serine-protein kinase ATM | [351] | 4.50[352] | 5.87[353] | 5.42[354] | 5.61[355] | 4.95[356] | 6.53[357] |
52 | RAD51B | DNA repair protein RAD51 homolog 2 | [358] | 1.32[359] | 1.20[360] | 1.05[361] | 1.52[362] | 1.19[363] | 0.99[364] |
53 | GEN1 | Flap endonuclease GEN homolog 1 | [365] | 2.57[366] | 4.53[367] | 3.46[368] | 3.98[369] | 4.11[370] | 4.03[371] |
54 | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2 | [372] | 3.23[373] | 4.76[374] | 3.79[375] | 4.10[376] | 3.62[377] | 3.10[378] |
55 | EXO1 | Exonuclease 1 | [379] | 3.37[380] | 3.42[381] | 4.42[382] | 5.23[383] | 4.37[384] | 0.07[385] |
56 | XRCC3 | DNA repair protein XRCC3 | [386] | 4.51[387] | 4.45[388] | 3.99[389] | 4.63[390] | 4.94[391] | 3.25[392] |
57 | BRIP1 | Fanconi anemia group J protein | [393] | 3.61[394] | 4.78[395] | 4.61[396] | 4.66[397] | 4.56[398] | 3.50[399] |
58 | BLM | Bloom syndrome protein | [400] | 3.01[401] | 4.13[402] | 4.76[403] | 4.34[404] | 4.28[405] | 1.16[406] |
59 | EME1 | Crossover junction endonuclease EME1 | [407] | 4.04[408] | 4.43[409] | 5.05[410] | 4.32[411] | 4.08[412] | 0.06[413] |
60 | BARD1 | BRCA1-associated RING domain protein 1 | [414] | 2.78[415] | 3.53[416] | 3.38[417] | 4.15[418] | 4.09[419] | 3.41[420] |
61 | SLX4 | Structure-specific endonuclease subunit SLX4 | [421] | 4.38[422] | 4.32[423] | 4.70[424] | 4.54[425] | 4.63[426] | 3.81[427] |
62 | RAD9B | Cell cycle checkpoint control protein RAD9B | [428] | -1.86[429] | 1.10[430] | 0.24[431] | 1.88[432] | 1.08[433] | 0.75[434] |
63 | BRCA2 | Breast cancer type 2 susceptibility protein | [435] | 4.27[436] | 6.52[437] | 6.52[438] | 5.92[439] | 5.94[440] | 4.98[441] |
64 | EME2 | Probable crossover junction endonuclease EME2 | [442] | 3.22[443] | 3.51[444] | 2.79[445] | 2.79[446] | 2.91[447] | 4.36[448] |
65 | MRE11 | Double-strand break repair protein MRE11 | [449] | [450] | [451] | [452] | [453] | [454] | [455] |
66 | SPIDR | DNA repair-scaffolding protein | [456] | [457] | [458] | [459] | [460] | [461] | [462] |
67 | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 | [463] | [464] | [465] | [466] | [467] | [468] | [469] |