REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -0.48[2] | -1.13[3] | -0.66[4] | -1.05[5] | -0.60[6] | -0.42[7] |
2 | CDC42 | Cell division control protein 42 homolog | [8] | -0.37[9] | 0.20[10] | -0.56[11] | -0.36[12] | -1.09[13] | -1.18[14] |
3 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.75[15] | -0.72[16] | -1.34[17] | -1.63[18] | -1.90[19] | -0.69[20] | |
4 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | [21] | 1.47[22] | 1.34[23] | 1.11[24] | 1.46[25] | 1.25[26] | -0.34[27] |
5 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | [28] | -0.14[29] | -0.54[30] | 0.04[31] | -0.19[32] | -0.14[33] | -0.70[34] |
6 | AKT1 | RAC-alpha serine/threonine-protein kinase | [35] | 0.54[36] | 0.16[37] | -0.67[38] | 0.12[39] | 0.14[40] | 0.66[41] |
7 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -4.24[42] | -4.10[43] | -4.16[44] | -3.64[45] | -2.83[46] | -3.44[47] | |
8 | GNG12 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | -4.29[48] | -7.37[49] | 0.82[50] | 2.05[51] | 2.15[52] | 1.38[53] | |
9 | AKT2 | RAC-beta serine/threonine-protein kinase | [54] | 1.42[55] | 1.55[56] | 1.92[57] | 1.03[58] | 0.82[59] | 2.03[60] |
10 | GNB5 | Guanine nucleotide-binding protein subunit beta-5 | [61] | 0.56[62] | 0.45[63] | 1.71[64] | 0.96[65] | 1.08[66] | 1.79[67] |
11 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [68] | 2.79[69] | 3.83[70] | 2.79[71] | 1.61[72] | 2.00[73] | 3.40[74] |
12 | PAK1 | Serine/threonine-protein kinase PAK 1 | [75] | 0.45[76] | -0.46[77] | 2.19[78] | -1.68[79] | 2.09[80] | 1.17[81] |
13 | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | [82] | 2.46[83] | 1.80[84] | 2.51[85] | 2.89[86] | 2.52[87] | 1.63[88] |
14 | GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | -7.72[89] | -7.87[90] | -6.93[91] | 2.44[92] | 3.75[93] | 3.13[94] | |
15 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | [95] | 3.25[96] | 4.73[97] | 4.40[98] | 0.96[99] | 1.44[100] | 3.39[101] |
16 | GNG7 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | 2.01[102] | 1.52[103] | 2.57[104] | -2.06[105] | -1.44[106] | 0.92[107] | |
17 | GNG4 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | 3.93[108] | 1.55[109] | 5.59[110] | 1.43[111] | -0.69[112] | -1.65[113] | |
18 | ARHGEF6 | Rho guanine nucleotide exchange factor 6 | [114] | -5.56[115] | -3.46[116] | -3.83[117] | 3.41[118] | 1.92[119] | 4.04[120] |
19 | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | [121] | -1.16[122] | -6.09[123] | -7.69[124] | -1.76[125] | -2.48[126] | 3.13[127] |
20 | GNB4 | Guanine nucleotide-binding protein subunit beta-4 | [128] | 0.09[129] | 0.43[130] | 1.68[131] | 2.86[132] | 5.59[133] | 4.99[134] |
21 | AKT3 | RAC-gamma serine/threonine-protein kinase | [135] | -1.38[136] | -4.09[137] | -3.16[138] | 6.02[139] | 4.96[140] | 4.51[141] |
22 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [142] | -6.71[143] | [144] | -1.98[145] | -3.75[146] | -3.41[147] | 3.24[148] |
23 | GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | -5.82[149] | -6.85[150] | [151] | 3.29[152] | 2.76[153] | 3.68[154] | |
24 | BTK | Tyrosine-protein kinase BTK | [155] | -6.93[156] | [157] | 0.02[158] | -2.83[159] | -5.07[160] | 2.73[161] |
25 | GNGT2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 | [162] | [163] | [164] | -1.89[165] | -6.57[166] | 1.01[167] | |
26 | GNG3 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | -0.40[168] | 1.29[169] | -0.69[170] | -0.53[171] | -0.85[172] | 0.82[173] | |
27 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [174] | [175] | [176] | 1.52[177] | -3.38[178] | 5.00[179] | |
28 | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | [180] | 2.05[181] | 4.15[182] | 3.70[183] | 1.18[184] | 3.89[185] | -0.78[186] |
29 | PIK3R6 | Phosphoinositide 3-kinase regulatory subunit 6 | [187] | [188] | [189] | -2.00[190] | [191] | [192] | 2.73[193] |
30 | GNG8 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 | [194] | [195] | [196] | [197] | [198] | [199] | |
31 | GNGT1 | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | [200] | [201] | [202] | [203] | [204] | [205] | [206] |
32 | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | [207] | [208] | [209] | [210] | [211] | [212] |