REACTOME_G_PROTEIN_ACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GNG5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 -0.77[1] -0.57[2] -1.54[3] -1.95[4] -2.31[5] -0.64[6]
2 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [7] 1.44[8] 1.49[9] 0.90[10] 1.14[11] 0.83[12] -0.28[13]
3 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [14] -0.17[15] -0.39[16] -0.17[17] -0.51[18] -0.55[19] -0.65[20]
4 GNG10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 -4.27[21] -3.95[22] -4.37[23] -3.95[24] -3.24[25] -3.39[26]
5 GNG12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 -4.32[27] -7.22[28] 0.62[29] 1.74[30] 1.73[31] 1.44[32]
6 GNA11 Guanine nucleotide-binding protein subunit alpha-11 [33] -0.24[34] -0.29[35] -0.44[36] -1.32[37] -0.63[38] -0.31[39]
7 GNB5 Guanine nucleotide-binding protein subunit beta-5 [40] 0.53[41] 0.60[42] 1.51[43] 0.65[44] 0.66[45] 1.84[46]
8 GNAQ Guanine nucleotide-binding protein G(q) subunit alpha [47] 0.50[48] 1.31[49] 1.72[50] 1.45[51] 1.56[52] 2.39[53]
9 GNG11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 -7.75[54] -7.72[55] -7.14[56] 2.12[57] 3.34[58] 3.19[59]
10 GNG7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 1.99[60] 1.67[61] 2.36[62] -2.38[63] -1.86[64] 0.98[65]
11 POMC Pro-opiomelanocortin [66] [67] -7.90[68] [69] [70] -7.36[71] -1.24[72]
12 GNG4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 3.90[73] 1.70[74] 5.39[75] 1.12[76] -1.10[77] -1.60[78]
13 GNB4 Guanine nucleotide-binding protein subunit beta-4 [79] 0.06[80] 0.59[81] 1.48[82] 2.54[83] 5.17[84] 5.04[85]
14 GNG2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 -5.85[86] -6.70[87] [88] 2.98[89] 2.35[90] 3.73[91]
15 GNA15 Guanine nucleotide-binding protein subunit alpha-15 [92] -2.95[93] -4.63[94] [95] -6.17[96] -2.71[97] 1.05[98]
16 GNA14 Guanine nucleotide-binding protein subunit alpha-14 [99] -5.63[100] -5.99[101] -4.95[102] -6.43[103] -3.44[104] 4.19[105]
17 GNGT2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [106] [107] [108] -2.21[109] -6.98[110] 1.06[111]
18 GNG3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 -0.42[112] 1.44[113] -0.90[114] -0.84[115] -1.26[116] 0.87[117]
19 GNB3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [118] 2.02[119] 4.30[120] 3.49[121] 0.87[122] 3.48[123] -0.73[124]
20 OPRM1 Mu-type opioid receptor [125] [126] -1.94[127] [128] [129] -3.42[130] -1.53[131]
21 GNG13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [132] [133] [134] [135] [136] [137]
22 GNGT1 Guanine nucleotide-binding protein G(T) subunit gamma-T1 [138] [139] [140] [141] [142] [143] [144]
23 GNG8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [145] [146] [147] [148] [149] [150]
24 PDYN Proenkephalin-B [151] [152] [153] [154] [155] [156] [157]
[1]
ref_hepatocyte GNG5
Mean 71
Standard deviation 24
Values 60 35 85 91 85
[2]
HepG2 GNG5
Mean 68.1
Standard deviation 11
Values 60 76
[3]
HepG2.C3A GNG5
Mean 68.6
Standard deviation 10
Values 61 76
[4]
HuH.7 GNG5
Mean 36.1
Standard deviation 6.8
Values 38 28 42
[5]
SNU475 GNG5
Mean 37.2
Standard deviation 3.1
Values 39 35
[6]
THLE GNG5
Mean 34.8
Standard deviation 0.49
Values 34 35
[7]
liver GNG5
Mean 33.6
Standard deviation 38
Values 75 1.4 56 1.4
[8]
ref_hepatocyte GNB1
Mean 42.7
Standard deviation 15
Values 44 60 53 31 24
[9]
HepG2 GNB1
Mean 190
Standard deviation 15
Values 2e+02 1.8e+02
[10]
HepG2.C3A GNB1
Mean 171
Standard deviation 4.5
Values 1.7e+02 1.7e+02
[11]
HuH.7 GNB1
Mean 118
Standard deviation 23
Values 1.4e+02 93 1.2e+02
[12]
SNU475 GNB1
Mean 191
Standard deviation 19
Values 2e+02 1.8e+02
[13]
THLE GNB1
Mean 185
Standard deviation 12
Values 1.8e+02 1.9e+02
[14]
liver GNB1
Mean 25.7
Standard deviation 5
Values 31 25 19 27
[15]
ref_hepatocyte GNB2
Mean 38.8
Standard deviation 20
Values 15 25 41 67 46
[16]
HepG2 GNB2
Mean 56.5
Standard deviation 6.2
Values 61 52
[17]
HepG2.C3A GNB2
Mean 42.3
Standard deviation 7.9
Values 48 37
[18]
HuH.7 GNB2
Mean 51.2
Standard deviation 3.5
Values 50 49 55
[19]
SNU475 GNB2
Mean 55.4
Standard deviation 5.7
Values 59 51
[20]
THLE GNB2
Mean 64.6
Standard deviation 5.2
Values 61 68
[21]
liver GNB2
Mean 18.2
Standard deviation 7.1
Values 24 11 25 13
[22]
ref_hepatocyte GNG10
Mean 36.1
Standard deviation 25
Values 54 68 12 12 34
[23]
HepG2 GNG10
Mean 3.07
Standard deviation 0.45
Values 2.8 3.4
[24]
HepG2.C3A GNG10
Mean 3.33
Standard deviation 1.3
Values 2.4 4.3
[25]
HuH.7 GNG10
Mean 2.59
Standard deviation 0.11
Values 2.6 2.5 2.7
[26]
SNU475 GNG10
Mean 4.73
Standard deviation 1.4
Values 5.8 3.7
[27]
THLE GNG10
Mean 9.34
Standard deviation 0.66
Values 8.9 9.8
[28]
liver GNG10
Mean 2.53
Standard deviation 1.2
Values 3.6 2.1 3.3 1.1
[29]
ref_hepatocyte GNG12
Mean 16.5
Standard deviation 18
Values 0.58 46 23 5.6 7.3
[30]
HepG2 GNG12
Mean 1.35
Standard deviation 0.72
Values 1.9 0.84
[31]
HepG2.C3A GNG12
Mean 0.158
Standard deviation 0.011
Values 0.17 0.15
[32]
HuH.7 GNG12
Mean 37.3
Standard deviation 6.6
Values 44 36 31
[33]
SNU475 GNG12
Mean 111
Standard deviation 32
Values 1.3e+02 89
[34]
THLE GNG12
Mean 133
Standard deviation 28
Values 1.1e+02 1.5e+02
[35]
liver GNG12
Mean 32.7
Standard deviation 9.9
Values 36 32 43 19
[36]
ref_hepatocyte GNA11
Mean 10
Standard deviation 6.7
Values 19 12 12 3.8 2.8
[37]
HepG2 GNA11
Mean 14
Standard deviation 0.12
Values 14 14
[38]
HepG2.C3A GNA11
Mean 11.8
Standard deviation 0.77
Values 11 12
[39]
HuH.7 GNA11
Mean 10.9
Standard deviation 2.1
Values 13 11 8.6
[40]
SNU475 GNA11
Mean 8.12
Standard deviation 0.83
Values 8.7 7.5
[41]
THLE GNA11
Mean 15.8
Standard deviation 3.1
Values 14 18
[42]
liver GNA11
Mean 5.97
Standard deviation 1.7
Values 6.1 7 3.6 7.3
[43]
ref_hepatocyte GNB5
Mean 4.79
Standard deviation 2.5
Values 6.3 6.9 2 6.5 2.2
[44]
HepG2 GNB5
Mean 11.3
Standard deviation 2.9
Values 13 9.2
[45]
HepG2.C3A GNB5
Mean 10.4
Standard deviation 1.2
Values 11 9.5
[46]
HuH.7 GNB5
Mean 20.1
Standard deviation 2.5
Values 20 23 18
[47]
SNU475 GNB5
Mean 15.2
Standard deviation 0.29
Values 15 15
[48]
THLE GNB5
Mean 18.5
Standard deviation 0.68
Values 18 19
[49]
liver GNB5
Mean 12.6
Standard deviation 4.4
Values 13 12 18 7.3
[50]
ref_hepatocyte GNAQ
Mean 1.88
Standard deviation 1
Values 1.6 2 3.6 1.1 1.1
[51]
HepG2 GNAQ
Mean 4.36
Standard deviation 1.2
Values 3.5 5.2
[52]
HepG2.C3A GNAQ
Mean 6.67
Standard deviation 0.93
Values 6 7.3
[53]
HuH.7 GNAQ
Mean 9.12
Standard deviation 3.7
Values 11 11 4.8
[54]
SNU475 GNAQ
Mean 10.4
Standard deviation 1.4
Values 11 9.4
[55]
THLE GNAQ
Mean 13.5
Standard deviation 3.4
Values 11 16
[56]
liver GNAQ
Mean 7.23
Standard deviation 3.8
Values 5.1 11 3 9.6
[57]
ref_hepatocyte GNG11
Mean 1.51
Standard deviation 1.6
Values 0 0 1.3 3.2 3
[58]
HepG2 GNG11
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[59]
HepG2.C3A GNG11
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[60]
HuH.7 GNG11
Mean 0.0158
Standard deviation 0.022
Values 0.041 0.0064 0
[61]
SNU475 GNG11
Mean 13.3
Standard deviation 2
Values 12 15
[62]
THLE GNG11
Mean 37.1
Standard deviation 6.4
Values 33 42
[63]
liver GNG11
Mean 10.1
Standard deviation 8.8
Values 16 3.1 19 2
[64]
ref_hepatocyte GNG7
Mean 0.972
Standard deviation 0.89
Values 2.2 0.22 0.098 0.76 1.6
[65]
HepG2 GNG7
Mean 6.31
Standard deviation 1.2
Values 7.2 5.5
[66]
HepG2.C3A GNG7
Mean 4.41
Standard deviation 1.7
Values 5.6 3.2
[67]
HuH.7 GNG7
Mean 7.39
Standard deviation 1.1
Values 8.1 6.1 7.9
[68]
SNU475 GNG7
Mean 0.379
Standard deviation 0.19
Values 0.51 0.24
[69]
THLE GNG7
Mean 0.654
Standard deviation 0.35
Values 0.9 0.41
[70]
liver GNG7
Mean 1.4
Standard deviation 0.99
Values 2.8 0.53 1.3 1
[71]
ref_hepatocyte POMC
Mean 0.898
Standard deviation 0.87
Values 0 1.1 0 1.4 2
[72]
HepG2 POMC
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A POMC
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[74]
HuH.7 POMC
Mean 0
Standard deviation 0
Values 0 0 0
[75]
SNU475 POMC
Mean 0
Standard deviation 0
Values 0 0
[76]
THLE POMC
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[77]
liver POMC
Mean 0.28
Standard deviation 0.16
Values 0.35 0.17 0.46 0.13
[78]
ref_hepatocyte GNG4
Mean 0.665
Standard deviation 1.2
Values 2.8 0.17 0.098 0.15 0.11
[79]
HepG2 GNG4
Mean 16.3
Standard deviation 4.5
Values 19 13
[80]
HepG2.C3A GNG4
Mean 3.08
Standard deviation 0.29
Values 2.9 3.3
[81]
HuH.7 GNG4
Mean 41.2
Standard deviation 8.1
Values 48 32 43
[82]
SNU475 GNG4
Mean 2.92
Standard deviation 0.47
Values 3.3 2.6
[83]
THLE GNG4
Mean 0.755
Standard deviation 0.19
Values 0.89 0.62
[84]
liver GNG4
Mean 0.161
Standard deviation 0.098
Values 0.024 0.26 0.18 0.19
[85]
ref_hepatocyte GNB4
Mean 0.389
Standard deviation 0.25
Values 0.16 0.31 0.7 0.17 0.61
[86]
HepG2 GNB4
Mean 0.666
Standard deviation 0.063
Values 0.71 0.62
[87]
HepG2.C3A GNB4
Mean 0.835
Standard deviation 0.043
Values 0.87 0.8
[88]
HuH.7 GNB4
Mean 1.6
Standard deviation 0.14
Values 1.6 1.7 1.5
[89]
SNU475 GNB4
Mean 4.59
Standard deviation 0.038
Values 4.6 4.6
[90]
THLE GNB4
Mean 34.3
Standard deviation 7.5
Values 29 40
[91]
liver GNB4
Mean 9.42
Standard deviation 4.4
Values 4.9 15 7 11
[92]
ref_hepatocyte GNG2
Mean 0.352
Standard deviation 0.41
Values 0 0.06 0.53 0.18 0.99
[93]
HepG2 GNG2
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[94]
HepG2.C3A GNG2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 GNG2
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 GNG2
Mean 5.62
Standard deviation 1.4
Values 4.6 6.6
[97]
THLE GNG2
Mean 4.37
Standard deviation 0.87
Values 5 3.8
[98]
liver GNG2
Mean 3.44
Standard deviation 0.91
Values 3.5 3.6 4.4 2.2
[99]
ref_hepatocyte GNA15
Mean 0.271
Standard deviation 0.31
Values 0 0 0.27 0.33 0.76
[100]
HepG2 GNA15
Mean 0.0573
Standard deviation 0.081
Values 0.11 0
[101]
HepG2.C3A GNA15
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[102]
HuH.7 GNA15
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 GNA15
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[104]
THLE GNA15
Mean 0.101
Standard deviation 0.0083
Values 0.095 0.11
[105]
liver GNA15
Mean 0.411
Standard deviation 0.3
Values 0.047 0.6 0.28 0.71
[106]
ref_hepatocyte GNA14
Mean 0.216
Standard deviation 0.25
Values 0 0.19 0 0.28 0.61
[107]
HepG2 GNA14
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[108]
HepG2.C3A GNA14
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[109]
HuH.7 GNA14
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[110]
SNU475 GNA14
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[111]
THLE GNA14
Mean 0.0485
Standard deviation 0.023
Values 0.065 0.032
[112]
liver GNA14
Mean 2.89
Standard deviation 0.64
Values 3.5 2.1 3.3 2.7
[113]
ref_hepatocyte GNGT2
Mean 0.154
Standard deviation 0.23
Values 0 0 0.06 0.16 0.54
[114]
HepG2 GNGT2
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A GNGT2
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 GNGT2
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 GNGT2
Mean 0.0673
Standard deviation 0.062
Values 0.023 0.11
[118]
THLE GNGT2
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[119]
liver GNGT2
Mean 0.235
Standard deviation 0.19
Values 0.35 0.086 0.44 0.066
[120]
ref_hepatocyte GNG3
Mean 0.127
Standard deviation 0.2
Values 0 0 0 0.46 0.18
[121]
HepG2 GNG3
Mean 0.155
Standard deviation 0.032
Values 0.18 0.13
[122]
HepG2.C3A GNG3
Mean 0.493
Standard deviation 0.33
Values 0.73 0.26
[123]
HuH.7 GNG3
Mean 0.101
Standard deviation 0.06
Values 0.033 0.15 0.12
[124]
SNU475 GNG3
Mean 0.144
Standard deviation 0.053
Values 0.18 0.11
[125]
THLE GNG3
Mean 0.13
Standard deviation 0.018
Values 0.14 0.12
[126]
liver GNG3
Mean 0.17
Standard deviation 0.089
Values 0.047 0.26 0.21 0.17
[127]
ref_hepatocyte GNB3
Mean 0.0571
Standard deviation 0.11
Values 0.24 0 0 0 0.041
[128]
HepG2 GNB3
Mean 0.379
Standard deviation 0.11
Values 0.3 0.45
[129]
HepG2.C3A GNB3
Mean 1.61
Standard deviation 0.27
Values 1.4 1.8
[130]
HuH.7 GNB3
Mean 0.95
Standard deviation 0.47
Values 0.98 0.47 1.4
[131]
SNU475 GNB3
Mean 0.211
Standard deviation 0.003
Values 0.21 0.21
[132]
THLE GNB3
Mean 1.55
Standard deviation 0.56
Values 1.9 1.1
[133]
liver GNB3
Mean 0.0253
Standard deviation 0.019
Values 0.047 0.029 0.026 0
[134]
ref_hepatocyte OPRM1
Mean 0.013
Standard deviation 0.029
Values 0 0 0 0 0.065
[135]
HepG2 OPRM1
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A OPRM1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[137]
HuH.7 OPRM1
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 OPRM1
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE OPRM1
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[140]
liver OPRM1
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013
[141]
ref_hepatocyte GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 GNG13
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A GNG13
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 GNG13
Mean 0.0152
Standard deviation 0.017
Values 0.033 0.013 0
[145]
SNU475 GNG13
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[146]
THLE GNG13
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[147]
liver GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0
[148]
ref_hepatocyte GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 GNGT1
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A GNGT1
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 GNGT1
Mean 0.0409
Standard deviation 0.035
Values 0.0082 0.077 0.037
[152]
SNU475 GNGT1
Mean 0.0679
Standard deviation 0.0043
Values 0.065 0.071
[153]
THLE GNGT1
Mean 0
Standard deviation 0
Values 0 0
[154]
liver GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0
[155]
ref_hepatocyte GNG8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 GNG8
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A GNG8
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 GNG8
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 GNG8
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[160]
THLE GNG8
Mean 0
Standard deviation 0
Values 0 0
[161]
liver GNG8
Mean 0
Standard deviation 0
Values 0 0 0 0
[162]
ref_hepatocyte PDYN
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 PDYN
Mean 0.0408
Standard deviation 0.0091
Values 0.034 0.047
[164]
HepG2.C3A PDYN
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[165]
HuH.7 PDYN
Mean 0.0109
Standard deviation 0.019
Values 0.033 0 0
[166]
SNU475 PDYN
Mean 0
Standard deviation 0
Values 0 0
[167]
THLE PDYN
Mean 0
Standard deviation 0
Values 0 0
[168]
liver PDYN
Mean 0
Standard deviation 0
Values 0 0 0 0