REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RHOA Transforming protein RhoA [1] -0.52[2] -0.97[3] -0.67[4] -1.09[5] -0.74[6] -0.55[7]
2 GNG5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 -0.78[8] -0.56[9] -1.35[10] -1.67[11] -2.04[12] -0.81[13]
3 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [14] 1.44[15] 1.50[16] 1.10[17] 1.42[18] 1.11[19] -0.46[20]
4 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [21] -0.18[22] -0.39[23] 0.03[24] -0.23[25] -0.28[26] -0.83[27]
5 AKT1 RAC-alpha serine/threonine-protein kinase [28] 0.50[29] 0.32[30] -0.69[31] 0.09[32] 0.00[33] 0.53[34]
6 GNG10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 -4.28[35] -3.95[36] -4.17[37] -3.67[38] -2.97[39] -3.57[40]
7 GNG12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 -4.33[41] -7.21[42] 0.81[43] 2.02[44] 2.00[45] 1.26[46]
8 AKT2 RAC-beta serine/threonine-protein kinase [47] 1.38[48] 1.70[49] 1.91[50] 0.99[51] 0.68[52] 1.91[53]
9 GNB5 Guanine nucleotide-binding protein subunit beta-5 [54] 0.52[55] 0.61[56] 1.70[57] 0.93[58] 0.94[59] 1.66[60]
10 PDPK1 3-phosphoinositide-dependent protein kinase 1 [61] 2.76[62] 3.99[63] 2.78[64] 1.57[65] 1.86[66] 3.28[67]
11 GNG11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 -7.76[68] -7.71[69] -6.94[70] 2.40[71] 3.61[72] 3.01[73]
12 GNG7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 1.98[74] 1.68[75] 2.56[76] -2.10[77] -1.59[78] 0.80[79]
13 GNG4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 3.89[80] 1.70[81] 5.58[82] 1.39[83] -0.83[84] -1.77[85]
14 GNB4 Guanine nucleotide-binding protein subunit beta-4 [86] 0.05[87] 0.59[88] 1.67[89] 2.82[90] 5.44[91] 4.87[92]
15 AKT3 RAC-gamma serine/threonine-protein kinase [93] -1.42[94] -3.93[95] -3.17[96] 5.98[97] 4.82[98] 4.38[99]
16 PIK3R5 Phosphoinositide 3-kinase regulatory subunit 5 [100] -6.75[101] [102] -1.99[103] -3.79[104] -3.55[105] 3.11[106]
17 GNG2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 -5.86[107] -6.69[108] [109] 3.25[110] 2.62[111] 3.55[112]
18 GNGT2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [113] [114] [115] -1.93[116] -6.71[117] 0.88[118]
19 GNG3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 -0.43[119] 1.45[120] -0.71[121] -0.56[122] -0.99[123] 0.69[124]
20 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [125] [126] [127] 1.48[128] -3.52[129] 4.87[130]
21 GNB3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [131] 2.01[132] 4.31[133] 3.69[134] 1.14[135] 3.75[136] -0.90[137]
22 PIK3R6 Phosphoinositide 3-kinase regulatory subunit 6 [138] [139] [140] -2.02[141] [142] [143] 2.60[144]
23 GNGT1 Guanine nucleotide-binding protein G(T) subunit gamma-T1 [145] [146] [147] [148] [149] [150] [151]
24 GNG13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [152] [153] [154] [155] [156] [157]
25 GNG8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [158] [159] [160] [161] [162] [163]
[1]
ref_hepatocyte RHOA
Mean 177
Standard deviation 1.2e+02
Values 2.2e+02 3.8e+02 1.4e+02 75 79
[2]
HepG2 RHOA
Mean 204
Standard deviation 38
Values 2.3e+02 1.8e+02
[3]
HepG2.C3A RHOA
Mean 129
Standard deviation 1.6
Values 1.3e+02 1.3e+02
[4]
HuH.7 RHOA
Mean 144
Standard deviation 23
Values 1.6e+02 1.2e+02 1.6e+02
[5]
SNU475 RHOA
Mean 139
Standard deviation 21
Values 1.5e+02 1.2e+02
[6]
THLE RHOA
Mean 214
Standard deviation 38
Values 1.9e+02 2.4e+02
[7]
liver RHOA
Mean 101
Standard deviation 59
Values 1.6e+02 54 1.4e+02 46
[8]
ref_hepatocyte GNG5
Mean 71
Standard deviation 24
Values 60 35 85 91 85
[9]
HepG2 GNG5
Mean 68.1
Standard deviation 11
Values 60 76
[10]
HepG2.C3A GNG5
Mean 68.6
Standard deviation 10
Values 61 76
[11]
HuH.7 GNG5
Mean 36.1
Standard deviation 6.8
Values 38 28 42
[12]
SNU475 GNG5
Mean 37.2
Standard deviation 3.1
Values 39 35
[13]
THLE GNG5
Mean 34.8
Standard deviation 0.49
Values 34 35
[14]
liver GNG5
Mean 33.6
Standard deviation 38
Values 75 1.4 56 1.4
[15]
ref_hepatocyte GNB1
Mean 42.7
Standard deviation 15
Values 44 60 53 31 24
[16]
HepG2 GNB1
Mean 190
Standard deviation 15
Values 2e+02 1.8e+02
[17]
HepG2.C3A GNB1
Mean 171
Standard deviation 4.5
Values 1.7e+02 1.7e+02
[18]
HuH.7 GNB1
Mean 118
Standard deviation 23
Values 1.4e+02 93 1.2e+02
[19]
SNU475 GNB1
Mean 191
Standard deviation 19
Values 2e+02 1.8e+02
[20]
THLE GNB1
Mean 185
Standard deviation 12
Values 1.8e+02 1.9e+02
[21]
liver GNB1
Mean 25.7
Standard deviation 5
Values 31 25 19 27
[22]
ref_hepatocyte GNB2
Mean 38.8
Standard deviation 20
Values 15 25 41 67 46
[23]
HepG2 GNB2
Mean 56.5
Standard deviation 6.2
Values 61 52
[24]
HepG2.C3A GNB2
Mean 42.3
Standard deviation 7.9
Values 48 37
[25]
HuH.7 GNB2
Mean 51.2
Standard deviation 3.5
Values 50 49 55
[26]
SNU475 GNB2
Mean 55.4
Standard deviation 5.7
Values 59 51
[27]
THLE GNB2
Mean 64.6
Standard deviation 5.2
Values 61 68
[28]
liver GNB2
Mean 18.2
Standard deviation 7.1
Values 24 11 25 13
[29]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[30]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[31]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[32]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[33]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[34]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[35]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[36]
ref_hepatocyte GNG10
Mean 36.1
Standard deviation 25
Values 54 68 12 12 34
[37]
HepG2 GNG10
Mean 3.07
Standard deviation 0.45
Values 2.8 3.4
[38]
HepG2.C3A GNG10
Mean 3.33
Standard deviation 1.3
Values 2.4 4.3
[39]
HuH.7 GNG10
Mean 2.59
Standard deviation 0.11
Values 2.6 2.5 2.7
[40]
SNU475 GNG10
Mean 4.73
Standard deviation 1.4
Values 5.8 3.7
[41]
THLE GNG10
Mean 9.34
Standard deviation 0.66
Values 8.9 9.8
[42]
liver GNG10
Mean 2.53
Standard deviation 1.2
Values 3.6 2.1 3.3 1.1
[43]
ref_hepatocyte GNG12
Mean 16.5
Standard deviation 18
Values 0.58 46 23 5.6 7.3
[44]
HepG2 GNG12
Mean 1.35
Standard deviation 0.72
Values 1.9 0.84
[45]
HepG2.C3A GNG12
Mean 0.158
Standard deviation 0.011
Values 0.17 0.15
[46]
HuH.7 GNG12
Mean 37.3
Standard deviation 6.6
Values 44 36 31
[47]
SNU475 GNG12
Mean 111
Standard deviation 32
Values 1.3e+02 89
[48]
THLE GNG12
Mean 133
Standard deviation 28
Values 1.1e+02 1.5e+02
[49]
liver GNG12
Mean 32.7
Standard deviation 9.9
Values 36 32 43 19
[50]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[51]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[52]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[53]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[54]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[55]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[56]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[57]
ref_hepatocyte GNB5
Mean 4.79
Standard deviation 2.5
Values 6.3 6.9 2 6.5 2.2
[58]
HepG2 GNB5
Mean 11.3
Standard deviation 2.9
Values 13 9.2
[59]
HepG2.C3A GNB5
Mean 10.4
Standard deviation 1.2
Values 11 9.5
[60]
HuH.7 GNB5
Mean 20.1
Standard deviation 2.5
Values 20 23 18
[61]
SNU475 GNB5
Mean 15.2
Standard deviation 0.29
Values 15 15
[62]
THLE GNB5
Mean 18.5
Standard deviation 0.68
Values 18 19
[63]
liver GNB5
Mean 12.6
Standard deviation 4.4
Values 13 12 18 7.3
[64]
ref_hepatocyte PDPK1
Mean 3.54
Standard deviation 2
Values 6.9 3.4 3.6 1.8 2
[65]
HepG2 PDPK1
Mean 39.4
Standard deviation 5.6
Values 35 43
[66]
HepG2.C3A PDPK1
Mean 80.1
Standard deviation 13
Values 89 71
[67]
HuH.7 PDPK1
Mean 31.4
Standard deviation 4.5
Values 35 33 26
[68]
SNU475 PDPK1
Mean 17.6
Standard deviation 0.21
Values 17 18
[69]
THLE PDPK1
Mean 25.9
Standard deviation 4.6
Values 23 29
[70]
liver PDPK1
Mean 28.5
Standard deviation 5.1
Values 34 27 22 31
[71]
ref_hepatocyte GNG11
Mean 1.51
Standard deviation 1.6
Values 0 0 1.3 3.2 3
[72]
HepG2 GNG11
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[73]
HepG2.C3A GNG11
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[74]
HuH.7 GNG11
Mean 0.0158
Standard deviation 0.022
Values 0.041 0.0064 0
[75]
SNU475 GNG11
Mean 13.3
Standard deviation 2
Values 12 15
[76]
THLE GNG11
Mean 37.1
Standard deviation 6.4
Values 33 42
[77]
liver GNG11
Mean 10.1
Standard deviation 8.8
Values 16 3.1 19 2
[78]
ref_hepatocyte GNG7
Mean 0.972
Standard deviation 0.89
Values 2.2 0.22 0.098 0.76 1.6
[79]
HepG2 GNG7
Mean 6.31
Standard deviation 1.2
Values 7.2 5.5
[80]
HepG2.C3A GNG7
Mean 4.41
Standard deviation 1.7
Values 5.6 3.2
[81]
HuH.7 GNG7
Mean 7.39
Standard deviation 1.1
Values 8.1 6.1 7.9
[82]
SNU475 GNG7
Mean 0.379
Standard deviation 0.19
Values 0.51 0.24
[83]
THLE GNG7
Mean 0.654
Standard deviation 0.35
Values 0.9 0.41
[84]
liver GNG7
Mean 1.4
Standard deviation 0.99
Values 2.8 0.53 1.3 1
[85]
ref_hepatocyte GNG4
Mean 0.665
Standard deviation 1.2
Values 2.8 0.17 0.098 0.15 0.11
[86]
HepG2 GNG4
Mean 16.3
Standard deviation 4.5
Values 19 13
[87]
HepG2.C3A GNG4
Mean 3.08
Standard deviation 0.29
Values 2.9 3.3
[88]
HuH.7 GNG4
Mean 41.2
Standard deviation 8.1
Values 48 32 43
[89]
SNU475 GNG4
Mean 2.92
Standard deviation 0.47
Values 3.3 2.6
[90]
THLE GNG4
Mean 0.755
Standard deviation 0.19
Values 0.89 0.62
[91]
liver GNG4
Mean 0.161
Standard deviation 0.098
Values 0.024 0.26 0.18 0.19
[92]
ref_hepatocyte GNB4
Mean 0.389
Standard deviation 0.25
Values 0.16 0.31 0.7 0.17 0.61
[93]
HepG2 GNB4
Mean 0.666
Standard deviation 0.063
Values 0.71 0.62
[94]
HepG2.C3A GNB4
Mean 0.835
Standard deviation 0.043
Values 0.87 0.8
[95]
HuH.7 GNB4
Mean 1.6
Standard deviation 0.14
Values 1.6 1.7 1.5
[96]
SNU475 GNB4
Mean 4.59
Standard deviation 0.038
Values 4.6 4.6
[97]
THLE GNB4
Mean 34.3
Standard deviation 7.5
Values 29 40
[98]
liver GNB4
Mean 9.42
Standard deviation 4.4
Values 4.9 15 7 11
[99]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[100]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[101]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[102]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[103]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[104]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[105]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4
[106]
ref_hepatocyte PIK3R5
Mean 0.373
Standard deviation 0.52
Values 0 0 1.3 0.29 0.3
[107]
HepG2 PIK3R5
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[108]
HepG2.C3A PIK3R5
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 PIK3R5
Mean 0.122
Standard deviation 0.035
Values 0.09 0.12 0.16
[110]
SNU475 PIK3R5
Mean 0.0452
Standard deviation 0.051
Values 0.0093 0.081
[111]
THLE PIK3R5
Mean 0.0642
Standard deviation 0.068
Values 0.11 0.016
[112]
liver PIK3R5
Mean 2.68
Standard deviation 0.95
Values 1.9 2.9 2 3.9
[113]
ref_hepatocyte GNG2
Mean 0.352
Standard deviation 0.41
Values 0 0.06 0.53 0.18 0.99
[114]
HepG2 GNG2
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[115]
HepG2.C3A GNG2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[116]
HuH.7 GNG2
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 GNG2
Mean 5.62
Standard deviation 1.4
Values 4.6 6.6
[118]
THLE GNG2
Mean 4.37
Standard deviation 0.87
Values 5 3.8
[119]
liver GNG2
Mean 3.44
Standard deviation 0.91
Values 3.5 3.6 4.4 2.2
[120]
ref_hepatocyte GNGT2
Mean 0.154
Standard deviation 0.23
Values 0 0 0.06 0.16 0.54
[121]
HepG2 GNGT2
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A GNGT2
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 GNGT2
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 GNGT2
Mean 0.0673
Standard deviation 0.062
Values 0.023 0.11
[125]
THLE GNGT2
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[126]
liver GNGT2
Mean 0.235
Standard deviation 0.19
Values 0.35 0.086 0.44 0.066
[127]
ref_hepatocyte GNG3
Mean 0.127
Standard deviation 0.2
Values 0 0 0 0.46 0.18
[128]
HepG2 GNG3
Mean 0.155
Standard deviation 0.032
Values 0.18 0.13
[129]
HepG2.C3A GNG3
Mean 0.493
Standard deviation 0.33
Values 0.73 0.26
[130]
HuH.7 GNG3
Mean 0.101
Standard deviation 0.06
Values 0.033 0.15 0.12
[131]
SNU475 GNG3
Mean 0.144
Standard deviation 0.053
Values 0.18 0.11
[132]
THLE GNG3
Mean 0.13
Standard deviation 0.018
Values 0.14 0.12
[133]
liver GNG3
Mean 0.17
Standard deviation 0.089
Values 0.047 0.26 0.21 0.17
[134]
ref_hepatocyte PIK3CG
Mean 0.0637
Standard deviation 0.13
Values 0 0 0 0.026 0.29
[135]
HepG2 PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 PIK3CG
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 PIK3CG
Mean 0.296
Standard deviation 0.1
Values 0.22 0.37
[139]
THLE PIK3CG
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[140]
liver PIK3CG
Mean 1.55
Standard deviation 0.43
Values 0.94 1.9 1.7 1.6
[141]
ref_hepatocyte GNB3
Mean 0.0571
Standard deviation 0.11
Values 0.24 0 0 0 0.041
[142]
HepG2 GNB3
Mean 0.379
Standard deviation 0.11
Values 0.3 0.45
[143]
HepG2.C3A GNB3
Mean 1.61
Standard deviation 0.27
Values 1.4 1.8
[144]
HuH.7 GNB3
Mean 0.95
Standard deviation 0.47
Values 0.98 0.47 1.4
[145]
SNU475 GNB3
Mean 0.211
Standard deviation 0.003
Values 0.21 0.21
[146]
THLE GNB3
Mean 1.55
Standard deviation 0.56
Values 1.9 1.1
[147]
liver GNB3
Mean 0.0253
Standard deviation 0.019
Values 0.047 0.029 0.026 0
[148]
ref_hepatocyte PIK3R6
Mean 0.0299
Standard deviation 0.044
Values 0 0 0 0.052 0.098
[149]
HepG2 PIK3R6
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A PIK3R6
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 PIK3R6
Mean 0.00954
Standard deviation 0.0096
Values 0 0.019 0.0094
[152]
SNU475 PIK3R6
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE PIK3R6
Mean 0
Standard deviation 0
Values 0 0
[154]
liver PIK3R6
Mean 0.15
Standard deviation 0.082
Values 0.19 0.14 0.23 0.04
[155]
ref_hepatocyte GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 GNGT1
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A GNGT1
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 GNGT1
Mean 0.0409
Standard deviation 0.035
Values 0.0082 0.077 0.037
[159]
SNU475 GNGT1
Mean 0.0679
Standard deviation 0.0043
Values 0.065 0.071
[160]
THLE GNGT1
Mean 0
Standard deviation 0
Values 0 0
[161]
liver GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0
[162]
ref_hepatocyte GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 GNG13
Mean 0
Standard deviation 0
Values 0 0
[164]
HepG2.C3A GNG13
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 GNG13
Mean 0.0152
Standard deviation 0.017
Values 0.033 0.013 0
[166]
SNU475 GNG13
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[167]
THLE GNG13
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[168]
liver GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0
[169]
ref_hepatocyte GNG8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 GNG8
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A GNG8
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 GNG8
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 GNG8
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[174]
THLE GNG8
Mean 0
Standard deviation 0
Values 0 0
[175]
liver GNG8
Mean 0
Standard deviation 0
Values 0 0 0 0