REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -0.76[2] | -1.40[3] | -0.97[4] | -1.38[5] | -0.79[6] | -1.60[7] |
2 | RHOC | Rho-related GTP-binding protein RhoC | [8] | -1.39[9] | -1.93[10] | -2.16[11] | -1.16[12] | -1.15[13] | -2.97[14] |
3 | RHOB | Rho-related GTP-binding protein RhoB | [15] | -0.61[16] | -1.32[17] | -3.26[18] | -2.45[19] | -3.16[20] | -0.40[21] |
4 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -1.02[22] | -0.99[23] | -1.65[24] | -1.96[25] | -2.09[26] | -1.87[27] | |
5 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | [28] | 1.20[29] | 1.07[30] | 0.79[31] | 1.13[32] | 1.06[33] | -1.52[34] |
6 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | [35] | -0.42[36] | -0.81[37] | -0.27[38] | -0.52[39] | -0.33[40] | -1.88[41] |
7 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -4.52[42] | -4.37[43] | -4.47[44] | -3.97[45] | -3.01[46] | -4.62[47] | |
8 | GNG12 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | -4.57[48] | -7.64[49] | 0.51[50] | 1.72[51] | 1.96[52] | 0.20[53] | |
9 | NET1 | Neuroepithelial cell-transforming gene 1 protein | [54] | 0.48[55] | 0.95[56] | 1.18[57] | 0.03[58] | -0.51[59] | 0.13[60] |
10 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | [61] | 0.30[62] | 0.33[63] | 1.00[64] | 1.04[65] | 0.01[66] | 0.26[67] |
11 | ARHGEF35 | Rho guanine nucleotide exchange factor 35 | [68] | -7.46[69] | -7.27[70] | -6.75[71] | -3.78[72] | -3.07[73] | -3.38[74] |
12 | ITSN1 | Intersectin-1 | [75] | 0.07[76] | 0.04[77] | 1.01[78] | 0.85[79] | 1.25[80] | 1.44[81] |
13 | VAV2 | Guanine nucleotide exchange factor VAV2 | [82] | 1.48[83] | 1.59[84] | 1.29[85] | -0.69[86] | -0.13[87] | 0.23[88] |
14 | ARHGEF10 | Rho guanine nucleotide exchange factor 10-like protein | [89] | 0.69[90] | 2.85[91] | 1.85[92] | -0.24[93] | -1.69[94] | 2.72[95] |
15 | SOS1 | Son of sevenless homolog 1 | [96] | 0.08[97] | 1.47[98] | 1.18[99] | 0.69[100] | 0.06[101] | 0.26[102] |
16 | ROCK1 | Rho-associated protein kinase 1 | [103] | -0.77[104] | 0.61[105] | 1.59[106] | 1.21[107] | 0.69[108] | 1.30[109] |
17 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | [110] | 2.20[111] | 1.82[112] | 1.66[113] | 2.84[114] | 2.14[115] | 3.89[116] |
18 | ARHGEF1 | Rho guanine nucleotide exchange factor 1 | [117] | 1.10[118] | 1.28[119] | 1.80[120] | 0.77[121] | 1.17[122] | 0.11[123] |
19 | ARHGEF2 | Rho guanine nucleotide exchange factor 2 | [124] | 0.82[125] | 0.59[126] | 0.89[127] | 1.69[128] | 2.21[129] | -1.36[130] |
20 | ARHGEF5 | Rho guanine nucleotide exchange factor 5 | [131] | -3.83[132] | -2.73[133] | -2.29[134] | -2.45[135] | -2.24[136] | -2.68[137] |
21 | PLXNB1 | Plexin-B1 | [138] | 2.46[139] | 3.21[140] | 2.95[141] | -1.83[142] | 0.41[143] | 2.97[144] |
22 | ROCK2 | Rho-associated protein kinase 2 | [145] | 1.66[146] | 2.75[147] | 1.43[148] | 2.48[149] | 0.39[150] | 1.64[151] |
23 | GNB5 | Guanine nucleotide-binding protein subunit beta-5 | [152] | 0.28[153] | 0.18[154] | 1.40[155] | 0.64[156] | 0.89[157] | 0.61[158] |
24 | GNA12 | Guanine nucleotide-binding protein subunit alpha-12 | [159] | 2.16[160] | 1.94[161] | 1.47[162] | 1.58[163] | 1.80[164] | -0.19[165] |
25 | ARHGEF40 | Rho guanine nucleotide exchange factor 40 | [166] | 0.89[167] | 1.53[168] | 0.01[169] | 1.72[170] | 1.47[171] | 1.67[172] |
26 | NGEF | Ephexin-1 | [173] | 0.53[174] | 1.29[175] | 1.67[176] | -5.17[177] | -2.43[178] | 0.53[179] |
27 | TRIO | Triple functional domain protein | [180] | 2.18[181] | 1.77[182] | 2.22[183] | 2.45[184] | 3.47[185] | 2.47[186] |
28 | ADRA1A | Alpha-1A adrenergic receptor | [187] | -5.32[188] | -4.93[189] | -4.68[190] | -5.47[191] | -5.65[192] | 3.17[193] |
29 | ECT2 | Protein ECT2 | [194] | 0.86[195] | 2.42[196] | 3.62[197] | 1.97[198] | 2.70[199] | -1.16[200] |
30 | AKAP13 | A-kinase anchor protein 13 | [201] | 1.92[202] | 0.90[203] | 2.07[204] | 2.55[205] | 2.30[206] | 3.86[207] |
31 | ARHGEF7 | Rho guanine nucleotide exchange factor 7 | [208] | 1.80[209] | 1.65[210] | 1.71[211] | 1.66[212] | 1.54[213] | 2.07[214] |
32 | ARHGEF18 | Rho guanine nucleotide exchange factor 18 | [215] | 2.86[216] | 1.81[217] | 2.82[218] | 1.18[219] | 1.65[220] | 1.31[221] |
33 | SOS2 | Son of sevenless homolog 2 | [222] | 0.16[223] | 1.14[224] | 0.57[225] | 1.53[226] | 1.53[227] | 1.56[228] |
34 | ARHGEF26 | Rho guanine nucleotide exchange factor 26 | [229] | -0.77[230] | 0.08[231] | 0.87[232] | 0.22[233] | 1.96[234] | 2.95[235] |
35 | ARHGEF11 | Rho guanine nucleotide exchange factor 11 | [236] | 2.22[237] | 2.19[238] | 2.09[239] | 3.11[240] | 2.54[241] | 2.31[242] |
36 | FGD4 | FYVE, RhoGEF and PH domain-containing protein 4 | [243] | -0.48[244] | 1.50[245] | 1.18[246] | 0.61[247] | 1.20[248] | 3.02[249] |
37 | GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | -8.00[250] | -8.14[251] | -7.25[252] | 2.11[253] | 3.56[254] | 1.95[255] | |
38 | ARHGEF3 | Rho guanine nucleotide exchange factor 3 | [256] | 2.75[257] | 1.32[258] | 0.69[259] | 1.30[260] | 1.69[261] | -0.14[262] |
39 | ADRA1B | Alpha-1B adrenergic receptor | [263] | -8.18[264] | [265] | [266] | -3.06[267] | -2.40[268] | -0.04[269] |
40 | MCF2L | Guanine nucleotide exchange factor DBS | [270] | 2.46[271] | 2.50[272] | 0.51[273] | -4.77[274] | -7.86[275] | 1.23[276] |
41 | ARHGEF16 | Rho guanine nucleotide exchange factor 16 | [277] | 3.06[278] | 4.28[279] | 0.66[280] | 1.81[281] | -1.62[282] | 0.61[283] |
42 | GNG7 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | 1.74[284] | 1.25[285] | 2.25[286] | -2.39[287] | -1.63[288] | -0.26[289] | |
43 | RASGRF2 | Ras-specific guanine nucleotide-releasing factor 2 | [290] | 4.03[291] | 3.14[292] | -0.97[293] | -3.09[294] | -0.72[295] | 0.24[296] |
44 | KALRN | Kalirin | [297] | 1.53[298] | 2.93[299] | 2.63[300] | 1.75[301] | -2.78[302] | 3.28[303] |
45 | ABR | Active breakpoint cluster region-related protein | [304] | 4.13[305] | 3.56[306] | 3.30[307] | 3.28[308] | 4.12[309] | 1.56[310] |
46 | GNG4 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | 3.65[311] | 1.27[312] | 5.28[313] | 1.10[314] | -0.88[315] | -2.83[316] | |
47 | TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1 | [317] | -4.52[318] | -1.99[319] | -6.97[320] | -1.51[321] | 0.67[322] | 3.06[323] |
48 | VAV3 | Guanine nucleotide exchange factor VAV3 | [324] | 1.99[325] | 0.14[326] | 2.52[327] | 3.53[328] | -2.31[329] | 1.07[330] |
49 | ARHGEF9 | Rho guanine nucleotide exchange factor 9 | [331] | -1.26[332] | -2.61[333] | -7.69[334] | 2.02[335] | 2.16[336] | 2.08[337] |
50 | FGD2 | FYVE, RhoGEF and PH domain-containing protein 2 | [338] | -5.38[339] | -6.52[340] | -7.97[341] | -4.21[342] | -6.85[343] | 2.59[344] |
51 | VAV1 | Proto-oncogene vav | [345] | -8.32[346] | -3.63[347] | -5.14[348] | -6.24[349] | -7.37[350] | 0.90[351] |
52 | ARHGEF6 | Rho guanine nucleotide exchange factor 6 | [352] | -5.84[353] | -3.73[354] | -4.14[355] | 3.08[356] | 1.73[357] | 2.86[358] |
53 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | [359] | 1.68[360] | 2.95[361] | 1.68[362] | 1.59[363] | 2.63[364] | 0.59[365] |
54 | PLEKHG2 | Pleckstrin homology domain-containing family G member 2 | [366] | 3.89[367] | 3.18[368] | 4.24[369] | 4.57[370] | 3.75[371] | 1.23[372] |
55 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | -0.23[373] | -6.20[374] | -3.69[375] | 4.96[376] | 3.44[377] | 3.92[378] | |
56 | GNB4 | Guanine nucleotide-binding protein subunit beta-4 | [379] | -0.19[380] | 0.16[381] | 1.37[382] | 2.53[383] | 5.40[384] | 3.81[385] |
57 | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3 | [386] | 0.81[387] | 1.03[388] | -0.03[389] | -0.98[390] | -5.14[391] | 1.99[392] |
58 | GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | -6.10[393] | -7.12[394] | [395] | 2.96[396] | 2.57[397] | 2.50[398] | |
59 | ARHGEF10 | Rho guanine nucleotide exchange factor 10 | [399] | -3.82[400] | -3.49[401] | -4.25[402] | 2.96[403] | 3.97[404] | 1.59[405] |
60 | TBXA2R | Thromboxane A2 receptor | [406] | -1.12[407] | -0.75[408] | 0.66[409] | 0.48[410] | 0.07[411] | 2.68[412] |
61 | ARHGEF37 | Rho guanine nucleotide exchange factor 37 | [413] | 0.96[414] | -4.12[415] | -1.05[416] | 2.05[417] | 1.16[418] | 2.43[419] |
62 | PLEKHG5 | Pleckstrin homology domain-containing family G member 5 | [420] | 3.69[421] | 3.04[422] | 1.99[423] | 2.21[424] | 2.76[425] | 1.18[426] |
63 | BTK | Tyrosine-protein kinase BTK | [427] | -7.20[428] | [429] | -0.30[430] | -3.16[431] | -5.25[432] | 1.55[433] |
64 | ARHGEF17 | Rho guanine nucleotide exchange factor 17 | [434] | 5.37[435] | 5.89[436] | 4.76[437] | 7.60[438] | 5.53[439] | 4.06[440] |
65 | FGD1 | FYVE, RhoGEF and PH domain-containing protein 1 | [441] | 2.93[442] | 3.29[443] | 2.38[444] | 5.08[445] | 4.68[446] | 1.36[447] |
66 | GNGT2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 | [448] | [449] | [450] | -2.22[451] | -6.76[452] | -0.17[453] | |
67 | GNG3 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | -0.67[454] | 1.02[455] | -1.01[456] | -0.86[457] | -1.03[458] | -0.36[459] | |
68 | TIAM2 | T-lymphoma invasion and metastasis-inducing protein 2 | [460] | 4.09[461] | 3.36[462] | 4.99[463] | 4.38[464] | 2.40[465] | -0.31[466] |
69 | ARHGEF15 | Rho guanine nucleotide exchange factor 15 | [467] | [468] | -4.91[469] | [470] | -4.07[471] | [472] | 3.68[473] |
70 | ADRA1D | Alpha-1D adrenergic receptor | [474] | 1.68[475] | -2.93[476] | -4.03[477] | 3.64[478] | -1.49[479] | -3.39[480] |
71 | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | [481] | 1.77[482] | 3.88[483] | 3.39[484] | 0.85[485] | 3.70[486] | -1.96[487] |
72 | OBSCN | Obscurin | [488] | 4.11[489] | 1.37[490] | 2.23[491] | 7.66[492] | 4.96[493] | 6.34[494] |
73 | ARHGEF4 | Rho guanine nucleotide exchange factor 4 | [495] | 2.50[496] | -3.11[497] | -3.81[498] | 4.79[499] | 5.25[500] | 1.68[501] |
74 | ARHGEF38 | Rho guanine nucleotide exchange factor 38 | [502] | -0.59[503] | 1.51[504] | 6.75[505] | 0.21[506] | -0.03[507] | 4.01[508] |
75 | ARHGEF33 | Rho guanine nucleotide exchange factor 33 | [509] | 1.55[510] | 2.87[511] | 1.61[512] | 2.14[513] | 5.28[514] | 4.58[515] |
76 | GNGT1 | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | [516] | [517] | [518] | [519] | [520] | [521] | [522] |
77 | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | [523] | [524] | [525] | [526] | [527] | [528] | |
78 | GNG8 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 | [529] | [530] | [531] | [532] | [533] | [534] | |
79 | MCF2 | Proto-oncogene DBL | [535] | [536] | [537] | [538] | [539] | [540] | [541] |
80 | ARHGEF39 | Rho guanine nucleotide exchange factor 39 | [542] | [543] | [544] | [545] | [546] | [547] | [548] |