REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] 0.14[2] -1.01[3] -0.73[4] -0.86[5] -0.74[6] 0.92[7]
2 STAT1 Signal transducer and activator of transcription 1-alpha/beta [8] -0.48[9] -1.05[10] -0.41[11] 1.42[12] 0.01[13] -0.53[14]
3 GHR Growth hormone receptor [15] -8.16[16] -8.91[17] -3.49[18] -9.19[19] -2.44[20] 0.16[21]
4 SOCS3 Suppressor of cytokine signaling 3 [22] -4.55[23] -4.61[24] -3.35[25] -1.91[26] -2.13[27] -1.35[28]
5 MAPK1 Mitogen-activated protein kinase 1 [29] 1.30[30] 1.79[31] 1.15[32] 0.74[33] 1.25[34] 0.29[35]
6 PTPN1 Tyrosine-protein phosphatase non-receptor type 1 [36] 0.71[37] 0.72[38] -0.22[39] 0.72[40] 0.87[41] -1.79[42]
7 LYN Tyrosine-protein kinase Lyn [43] -1.27[44] -1.10[45] -1.03[46] -0.05[47] -0.44[48] -1.47[49]
8 PTPN6 Tyrosine-protein phosphatase non-receptor type 6 [50] -0.87[51] -0.33[52] -0.22[53] -8.25[54] -2.37[55] -1.66[56]
9 ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 [57] 0.27[58] 0.50[59] -0.23[60] 0.64[61] 0.62[62] -1.40[63]
10 CISH Cytokine-inducible SH2-containing protein [64] -3.31[65] -2.78[66] -3.04[67] -3.75[68] -4.34[69] -0.38[70]
11 MAPK3 Mitogen-activated protein kinase 3 [71] 1.44[72] 1.84[73] 1.41[74] -0.68[75] 0.19[76] -2.52[77]
12 STAT5B Signal transducer and activator of transcription 5B [78] 0.95[79] 0.93[80] 1.16[81] 0.44[82] 0.44[83] 0.14[84]
13 SOCS2 Suppressor of cytokine signaling 2 [85] -1.21[86] -3.40[87] -5.62[88] -0.45[89] -5.32[90] 0.16[91]
14 SH2B1 SH2B adapter protein 1 [92] 0.74[93] 1.80[94] 1.01[95] -0.78[96] 0.76[97] -1.39[98]
15 IRS1 Insulin receptor substrate 1 [99] 1.68[100] 1.48[101] 2.44[102] 0.60[103] 1.03[104] 0.63[105]
16 STAT5A Signal transducer and activator of transcription 5A [106] -2.36[107] -0.83[108] -2.23[109] -1.95[110] -0.34[111] -1.25[112]
17 IRS2 Insulin receptor substrate 2 [113] -6.06[114] [115] -3.32[116] -1.77[117] 2.91[118] 0.90[119]
18 SOCS1 Suppressor of cytokine signaling 1 [120] -1.86[121] -0.64[122] -0.84[123] -2.90[124] -3.43[125] -2.95[126]
19 JAK2 Tyrosine-protein kinase JAK2 [127] -0.18[128] 0.16[129] -0.74[130] -0.34[131] 1.11[132] 1.22[133]
20 PRLR Prolactin receptor [134] 0.44[135] 0.96[136] 4.34[137] -6.12[138] -4.13[139] 2.42[140]
21 GH1 Somatotropin [141] [142] [143] [144] [145] [146] [147]
22 GH2 Growth hormone variant [148] [149] [150] [151] [152] [153] [154]
23 PRL Prolactin [155] [156] [157] [158] [159] [160] [161]
24 CSH1 Chorionic somatomammotropin hormone 1 [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[9]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[10]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[11]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[12]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[13]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[14]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[15]
ref_hepatocyte GHR
Mean 11.8
Standard deviation 18
Values 0.44 2.3 1.4 11 44
[16]
HepG2 GHR
Mean 0.121
Standard deviation 0.032
Values 0.14 0.099
[17]
HepG2.C3A GHR
Mean 0.0501
Standard deviation 0.025
Values 0.068 0.032
[18]
HuH.7 GHR
Mean 2.85
Standard deviation 1.7
Values 1.9 4.8 1.8
[19]
SNU475 GHR
Mean 0.0798
Standard deviation 0.0053
Values 0.083 0.076
[20]
THLE GHR
Mean 5.34
Standard deviation 2.3
Values 7 3.7
[21]
liver GHR
Mean 52.3
Standard deviation 30
Values 53 41 22 94
[22]
ref_hepatocyte SOCS3
Mean 11.2
Standard deviation 10
Values 1 1.5 19 24 10
[23]
HepG2 SOCS3
Mean 1.4
Standard deviation 0.4
Values 1.7 1.1
[24]
HepG2.C3A SOCS3
Mean 0.939
Standard deviation 0.87
Values 1.6 0.32
[25]
HuH.7 SOCS3
Mean 2.97
Standard deviation 2.7
Values 1.4 6.1 1.4
[26]
SNU475 SOCS3
Mean 11.8
Standard deviation 0.67
Values 12 11
[27]
THLE SOCS3
Mean 6.29
Standard deviation 1.1
Values 7.1 5.5
[28]
liver SOCS3
Mean 17.4
Standard deviation 5.5
Values 15 14 15 26
[29]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[30]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[31]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[32]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[33]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[34]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[35]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[36]
ref_hepatocyte PTPN1
Mean 8.72
Standard deviation 6.8
Values 20 10 6.8 4.1 2.6
[37]
HepG2 PTPN1
Mean 41.8
Standard deviation 5
Values 38 45
[38]
HepG2.C3A PTPN1
Mean 29.5
Standard deviation 3
Values 27 32
[39]
HuH.7 PTPN1
Mean 20.4
Standard deviation 3.4
Values 24 18 19
[40]
SNU475 PTPN1
Mean 56.7
Standard deviation 1.9
Values 55 58
[41]
THLE PTPN1
Mean 39.1
Standard deviation 7.5
Values 34 44
[42]
liver PTPN1
Mean 10
Standard deviation 0.98
Values 11 10 11 8.6
[43]
ref_hepatocyte LYN
Mean 5.33
Standard deviation 4.4
Values 0.29 6.8 12 3.7 3.8
[44]
HepG2 LYN
Mean 6.48
Standard deviation 1
Values 5.8 7.2
[45]
HepG2.C3A LYN
Mean 5.11
Standard deviation 2.1
Values 3.6 6.6
[46]
HuH.7 LYN
Mean 7.08
Standard deviation 0.67
Values 7.4 7.5 6.3
[47]
SNU475 LYN
Mean 20.4
Standard deviation 4.4
Values 17 23
[48]
THLE LYN
Mean 9.65
Standard deviation 1.4
Values 8.7 11
[49]
liver LYN
Mean 7.66
Standard deviation 1.7
Values 7.2 9.4 5.5 8.6
[50]
ref_hepatocyte PTPN6
Mean 5.33
Standard deviation 3
Values 2.2 3.1 4.4 7.6 9.3
[51]
HepG2 PTPN6
Mean 8.54
Standard deviation 0.054
Values 8.5 8.6
[52]
HepG2.C3A PTPN6
Mean 8.69
Standard deviation 0.18
Values 8.6 8.8
[53]
HuH.7 PTPN6
Mean 12.4
Standard deviation 1.9
Values 13 10 14
[54]
SNU475 PTPN6
Mean 0.0694
Standard deviation 0.026
Values 0.088 0.051
[55]
THLE PTPN6
Mean 2.52
Standard deviation 0.67
Values 2 3
[56]
liver PTPN6
Mean 6.69
Standard deviation 2
Values 7.5 4.8 9.1 5.4
[57]
ref_hepatocyte ADAM17
Mean 5.04
Standard deviation 4.3
Values 10 8.5 4.3 1 1.1
[58]
HepG2 ADAM17
Mean 17.8
Standard deviation 0.96
Values 18 17
[59]
HepG2.C3A ADAM17
Mean 14.6
Standard deviation 0.94
Values 14 15
[60]
HuH.7 ADAM17
Mean 11.7
Standard deviation 1.5
Values 13 12 10
[61]
SNU475 ADAM17
Mean 31
Standard deviation 2.8
Values 33 29
[62]
THLE ADAM17
Mean 19
Standard deviation 2.3
Values 17 21
[63]
liver ADAM17
Mean 7.57
Standard deviation 0.72
Values 7.2 8.6 7 7.4
[64]
ref_hepatocyte CISH
Mean 4.68
Standard deviation 5.7
Values 0.89 0.45 3 14 4.7
[65]
HepG2 CISH
Mean 1.38
Standard deviation 0.087
Values 1.3 1.4
[66]
HepG2.C3A CISH
Mean 1.4
Standard deviation 0.43
Values 1.7 1.1
[67]
HuH.7 CISH
Mean 1.55
Standard deviation 0.25
Values 1.7 1.7 1.3
[68]
SNU475 CISH
Mean 1.37
Standard deviation 0.36
Values 1.6 1.1
[69]
THLE CISH
Mean 0.567
Standard deviation 0.027
Values 0.59 0.55
[70]
liver CISH
Mean 14.3
Standard deviation 12
Values 31 1.8 13 11
[71]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[72]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[73]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[74]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[75]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[76]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[77]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[78]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[79]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[80]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[81]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[82]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[83]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[84]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[85]
ref_hepatocyte SOCS2
Mean 3.66
Standard deviation 2
Values 3.6 6.7 2.3 4.2 1.5
[86]
HepG2 SOCS2
Mean 4.62
Standard deviation 2.2
Values 3.1 6.2
[87]
HepG2.C3A SOCS2
Mean 0.708
Standard deviation 0.27
Values 0.52 0.9
[88]
HuH.7 SOCS2
Mean 0.201
Standard deviation 0.17
Values 0.14 0.4 0.066
[89]
SNU475 SOCS2
Mean 10.6
Standard deviation 6.9
Values 15 5.7
[90]
THLE SOCS2
Mean 0.224
Standard deviation 0.00099
Values 0.22 0.22
[91]
liver SOCS2
Mean 16.3
Standard deviation 15
Values 36 4.4 5.7 19
[92]
ref_hepatocyte SH2B1
Mean 3.45
Standard deviation 1.7
Values 2.4 1.2 5.6 4.8 3.2
[93]
HepG2 SH2B1
Mean 16.9
Standard deviation 1.7
Values 16 18
[94]
HepG2.C3A SH2B1
Mean 24.6
Standard deviation 4.7
Values 28 21
[95]
HuH.7 SH2B1
Mean 18.8
Standard deviation 3
Values 18 16 22
[96]
SNU475 SH2B1
Mean 7.91
Standard deviation 1.9
Values 9.2 6.6
[97]
THLE SH2B1
Mean 14.3
Standard deviation 0.094
Values 14 14
[98]
liver SH2B1
Mean 5.21
Standard deviation 0.68
Values 5.5 5.1 4.3 5.9
[99]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 4.3 1.5 2.7 2.1 4.7
[100]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 35 23
[101]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 22 13
[102]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 49 48 37
[103]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 15 22
[104]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[105]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 23 18 12 22
[106]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[107]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[108]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[109]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[110]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[111]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[112]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[113]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[114]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[115]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[117]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[118]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[119]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17
[120]
ref_hepatocyte SOCS1
Mean 2.1
Standard deviation 1.9
Values 1.1 0 1.3 4.7 3.4
[121]
HepG2 SOCS1
Mean 1.7
Standard deviation 0.19
Values 1.8 1.6
[122]
HepG2.C3A SOCS1
Mean 2.76
Standard deviation 1.3
Values 3.7 1.9
[123]
HuH.7 SOCS1
Mean 3.19
Standard deviation 2.1
Values 3.3 1 5.3
[124]
SNU475 SOCS1
Mean 1.11
Standard deviation 0.23
Values 1.3 0.95
[125]
THLE SOCS1
Mean 0.479
Standard deviation 0.076
Values 0.53 0.43
[126]
liver SOCS1
Mean 1.08
Standard deviation 0.8
Values 1.1 0.27 0.8 2.2
[127]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[128]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[129]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[130]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[131]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[132]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[133]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[134]
ref_hepatocyte PRLR
Mean 0.722
Standard deviation 0.48
Values 0.8 0.085 1.4 0.56 0.74
[135]
HepG2 PRLR
Mean 2.87
Standard deviation 1.7
Values 1.6 4.1
[136]
HepG2.C3A PRLR
Mean 2.88
Standard deviation 0.75
Values 3.4 2.3
[137]
HuH.7 PRLR
Mean 39.8
Standard deviation 25
Values 35 67 17
[138]
SNU475 PRLR
Mean 0.0411
Standard deviation 0.00084
Values 0.042 0.041
[139]
THLE PRLR
Mean 0.101
Standard deviation 0.016
Values 0.11 0.09
[140]
liver PRLR
Mean 15.4
Standard deviation 9.7
Values 9.3 27 6 19
[141]
ref_hepatocyte GH1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 GH1
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A GH1
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 GH1
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 GH1
Mean 0.0101
Standard deviation 0.014
Values 0 0.02
[146]
THLE GH1
Mean 0
Standard deviation 0
Values 0 0
[147]
liver GH1
Mean 0
Standard deviation 0
Values 0 0 0 0
[148]
ref_hepatocyte GH2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 GH2
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A GH2
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 GH2
Mean 0.00856
Standard deviation 0.015
Values 0 0.026 0
[152]
SNU475 GH2
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE GH2
Mean 0
Standard deviation 0
Values 0 0
[154]
liver GH2
Mean 0
Standard deviation 0
Values 0 0 0 0
[155]
ref_hepatocyte PRL
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 PRL
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A PRL
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 PRL
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 PRL
Mean 1.78
Standard deviation 0.62
Values 2.2 1.3
[160]
THLE PRL
Mean 0.0488
Standard deviation 0.031
Values 0.071 0.027
[161]
liver PRL
Mean 0
Standard deviation 0
Values 0 0 0 0
[162]
ref_hepatocyte CSH1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 CSH1
Missing
[164]
HepG2.C3A CSH1
Missing
[165]
HuH.7 CSH1
Missing
[166]
SNU475 CSH1
Missing
[167]
THLE CSH1
Missing
[168]
liver CSH1
Missing