REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 FGG Fibrinogen gamma chain [1] -3.36[2] -2.07[3] -1.98[4] -9.49[5] -11.50[6] -0.71[7]
2 FGA Fibrinogen alpha chain [8] -3.02[9] -2.31[10] -1.87[11] -8.70[12] -11.51[13] -0.04[14]
3 FGB Fibrinogen beta chain [15] -4.23[16] -3.09[17] -0.88[18] -6.82[19] -10.15[20] 0.74[21]
4 FN1 Fibronectin [22] 6.73[23] 6.52[24] 6.24[25] 6.72[26] 6.80[27] 2.15[28]
5 RAP1B Ras-related protein Rap-1b [29] 0.93[30] 1.87[31] 1.48[32] 3.27[33] 2.91[34] -2.04[35]
6 GRB2 Growth factor receptor-bound protein 2 [36] 4.43[37] 4.59[38] 4.54[39] 4.35[40] 4.14[41] 0.15[42]
7 RAP1A Ras-related protein Rap-1A [43] 2.19[44] 2.45[45] 3.11[46] 3.58[47] 3.22[48] -1.44[49]
8 TLN1 Talin-1 [50] 6.23[51] 5.18[52] 5.79[53] 6.91[54] 6.80[55] 3.21[56]
9 APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein -5.30[57] [58] -3.22[59] 0.50[60] -2.39[61] -0.69[62]
10 PTK2 Focal adhesion kinase 1 [63] 3.97[64] 4.78[65] 4.99[66] 5.74[67] 4.82[68] 0.61[69]
11 SOS1 Son of sevenless homolog 1 [70] 3.14[71] 4.99[72] 4.32[73] 4.64[74] 3.75[75] 0.39[76]
12 SRC Proto-oncogene tyrosine-protein kinase Src [77] 6.26[78] 6.57[79] 5.39[80] 6.20[81] 5.25[82] -1.00[83]
13 ITGB3 Integrin beta-3 [84] 1.60[85] -0.78[86] 2.57[87] 6.65[88] 6.20[89] 1.18[90]
14 VWF von Willebrand factor [91] 4.21[92] 2.37[93] -0.18[94] 3.95[95] 1.25[96] 5.56[97]
15 ITGA2B Integrin alpha-IIb [98] 6.84[99] 7.45[100] 7.27[101] 6.82[102] 5.06[103] 2.47[104]
[1]
ref_hepatocyte FGG
Mean 8.49e+03
Standard deviation 1.1e+04
Values 1.5e+03 1.1e+02 9e+02 2.5e+04 1.5e+04
[2]
HepG2 FGG
Mean 194
Standard deviation 1.5e+02
Values 91 3e+02
[3]
HepG2.C3A FGG
Mean 338
Standard deviation 15
Values 3.3e+02 3.5e+02
[4]
HuH.7 FGG
Mean 389
Standard deviation 3e+02
Values 2.1e+02 7.3e+02 2.3e+02
[5]
SNU475 FGG
Mean 1.56
Standard deviation 0.22
Values 1.4 1.7
[6]
THLE FGG
Mean 0.473
Standard deviation 0.016
Values 0.46 0.48
[7]
liver FGG
Mean 8.17e+03
Standard deviation 4.2e+03
Values 5.8e+03 7.5e+03 1.4e+04 5.1e+03
[8]
ref_hepatocyte FGA
Mean 6.91e+03
Standard deviation 9.4e+03
Values 4.5e+02 63 4.3e+02 2.1e+04 1.3e+04
[9]
HepG2 FGA
Mean 200
Standard deviation 1.3e+02
Values 1.1e+02 2.9e+02
[10]
HepG2.C3A FGA
Mean 232
Standard deviation 52
Values 2.7e+02 2e+02
[11]
HuH.7 FGA
Mean 342
Standard deviation 2.4e+02
Values 2e+02 6.2e+02 2e+02
[12]
SNU475 FGA
Mean 2.2
Standard deviation 0.085
Values 2.3 2.1
[13]
THLE FGA
Mean 0.381
Standard deviation 0.064
Values 0.43 0.34
[14]
liver FGA
Mean 1.06e+04
Standard deviation 2.8e+03
Values 7.3e+03 1.4e+04 1e+04 1.1e+04
[15]
ref_hepatocyte FGB
Mean 4.4e+03
Standard deviation 5.7e+03
Values 3.6e+02 3.3e+02 3.9e+02 1.2e+04 8.4e+03
[16]
HepG2 FGB
Mean 55
Standard deviation 32
Values 33 77
[17]
HepG2.C3A FGB
Mean 86.5
Standard deviation 3.3
Values 84 89
[18]
HuH.7 FGB
Mean 431
Standard deviation 3.8e+02
Values 1.9e+02 8.7e+02 2.3e+02
[19]
SNU475 FGB
Mean 5.14
Standard deviation 3.4
Values 2.7 7.6
[20]
THLE FGB
Mean 0.624
Standard deviation 0.0046
Values 0.62 0.63
[21]
liver FGB
Mean 1.16e+04
Standard deviation 4.8e+03
Values 9.6e+03 1.1e+04 1.8e+04 7.3e+03
[22]
ref_hepatocyte FN1
Mean 152
Standard deviation 1.4e+02
Values 1.3e+02 57 27 1.7e+02 3.8e+02
[23]
HepG2 FN1
Mean 3.78e+03
Standard deviation 3.9e+02
Values 4.1e+03 3.5e+03
[24]
HepG2.C3A FN1
Mean 2.34e+03
Standard deviation 1.3e+03
Values 3.2e+03 1.4e+03
[25]
HuH.7 FN1
Mean 2.08e+03
Standard deviation 9.6e+02
Values 1.8e+03 3.1e+03 1.3e+03
[26]
SNU475 FN1
Mean 2.11e+03
Standard deviation 1.4e+02
Values 2e+03 2.2e+03
[27]
THLE FN1
Mean 2.73e+03
Standard deviation 1.5e+03
Values 1.7e+03 3.8e+03
[28]
liver FN1
Mean 1.06e+03
Standard deviation 3.8e+02
Values 5.9e+02 1.3e+03 9.3e+02 1.4e+03
[29]
ref_hepatocyte RAP1B
Mean 100
Standard deviation 77
Values 1.1e+02 2.1e+02 1.3e+02 25 29
[30]
HepG2 RAP1B
Mean 44.7
Standard deviation 8.8
Values 39 51
[31]
HepG2.C3A RAP1B
Mean 61.1
Standard deviation 18
Values 48 74
[32]
HuH.7 RAP1B
Mean 50.2
Standard deviation 5.6
Values 52 44 54
[33]
SNU475 RAP1B
Mean 128
Standard deviation 17
Values 1.4e+02 1.2e+02
[34]
THLE RAP1B
Mean 121
Standard deviation 4
Values 1.2e+02 1.2e+02
[35]
liver RAP1B
Mean 38.3
Standard deviation 18
Values 53 27 54 20
[36]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[37]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[38]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[39]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[40]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[41]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[42]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[43]
ref_hepatocyte RAP1A
Mean 17.1
Standard deviation 7.2
Values 17 20 8.5 13 28
[44]
HepG2 RAP1A
Mean 18.3
Standard deviation 5.4
Values 14 22
[45]
HepG2.C3A RAP1A
Mean 15.6
Standard deviation 1.3
Values 15 17
[46]
HuH.7 RAP1A
Mean 26.7
Standard deviation 1.9
Values 25 29 26
[47]
SNU475 RAP1A
Mean 27.1
Standard deviation 7
Values 32 22
[48]
THLE RAP1A
Mean 25.7
Standard deviation 2.2
Values 24 27
[49]
liver RAP1A
Mean 9.95
Standard deviation 5.1
Values 17 7.4 10 5.3
[50]
ref_hepatocyte TLN1
Mean 12
Standard deviation 5.9
Values 7.9 19 17 9.4 6.1
[51]
HepG2 TLN1
Mean 210
Standard deviation 7.2
Values 2.1e+02 2.2e+02
[52]
HepG2.C3A TLN1
Mean 72.3
Standard deviation 9.8
Values 79 65
[53]
HuH.7 TLN1
Mean 119
Standard deviation 39
Values 1.6e+02 1e+02 90
[54]
SNU475 TLN1
Mean 189
Standard deviation 61
Values 2.3e+02 1.5e+02
[55]
THLE TLN1
Mean 215
Standard deviation 62
Values 1.7e+02 2.6e+02
[56]
liver TLN1
Mean 174
Standard deviation 66
Values 87 2.4e+02 1.7e+02 2e+02
[57]
ref_hepatocyte APBB1IP
Mean 11.5
Standard deviation 7.7
Values 0 20 8.1 15 15
[58]
HepG2 APBB1IP
Mean 0.0688
Standard deviation 0.097
Values 0.14 0
[59]
HepG2.C3A APBB1IP
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 APBB1IP
Mean 0.223
Standard deviation 0.3
Values 0.049 0.56 0.056
[61]
SNU475 APBB1IP
Mean 2.15
Standard deviation 0.36
Values 1.9 2.4
[62]
THLE APBB1IP
Mean 0.354
Standard deviation 0.11
Values 0.43 0.28
[63]
liver APBB1IP
Mean 11.3
Standard deviation 1.6
Values 12 9.3 11 13
[64]
ref_hepatocyte PTK2
Mean 8.92
Standard deviation 4.8
Values 15 11 11 4.1 3.9
[65]
HepG2 PTK2
Mean 32.8
Standard deviation 5.2
Values 29 36
[66]
HepG2.C3A PTK2
Mean 40.9
Standard deviation 2.3
Values 43 39
[67]
HuH.7 PTK2
Mean 51.1
Standard deviation 2.8
Values 53 52 48
[68]
SNU475 PTK2
Mean 63.1
Standard deviation 3.5
Values 66 61
[69]
THLE PTK2
Mean 40.6
Standard deviation 3.7
Values 38 43
[70]
liver PTK2
Mean 21.5
Standard deviation 4.9
Values 19 27 16 24
[71]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[72]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[73]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[74]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[75]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[76]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[77]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[78]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[79]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[80]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[81]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[82]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[83]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[84]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[85]
ref_hepatocyte ITGB3
Mean 1.08
Standard deviation 1.3
Values 0 2.5 2.6 0.15 0.24
[86]
HepG2 ITGB3
Mean 0.771
Standard deviation 0.028
Values 0.79 0.75
[87]
HepG2.C3A ITGB3
Mean 0.105
Standard deviation 0.058
Values 0.15 0.064
[88]
HuH.7 ITGB3
Mean 1.16
Standard deviation 0.088
Values 1.2 1.2 1.1
[89]
SNU475 ITGB3
Mean 14.3
Standard deviation 13
Values 5.4 23
[90]
THLE ITGB3
Mean 12.8
Standard deviation 1.3
Values 14 12
[91]
liver ITGB3
Mean 3.86
Standard deviation 3.6
Values 0.66 8.8 1.7 4.2
[92]
ref_hepatocyte VWF
Mean 0.138
Standard deviation 0.13
Values 0.14 0.026 0 0.32 0.2
[93]
HepG2 VWF
Mean 0.599
Standard deviation 0.15
Values 0.7 0.49
[94]
HepG2.C3A VWF
Mean 0.12
Standard deviation 0.078
Values 0.17 0.064
[95]
HuH.7 VWF
Mean 0.022
Standard deviation 0.031
Values 0.0082 0.058 0
[96]
SNU475 VWF
Mean 0.283
Standard deviation 0.027
Values 0.3 0.26
[97]
THLE VWF
Mean 0.0529
Standard deviation 0.0079
Values 0.047 0.059
[98]
liver VWF
Mean 10.3
Standard deviation 3.3
Values 8.3 10 7.8 15
[99]
ref_hepatocyte ITGA2B
Mean 0.0356
Standard deviation 0.034
Values 0 0.07 0 0.043 0.065
[100]
HepG2 ITGA2B
Mean 0.956
Standard deviation 1
Values 1.7 0.23
[101]
HepG2.C3A ITGA2B
Mean 1.04
Standard deviation 0.35
Values 1.3 0.79
[102]
HuH.7 ITGA2B
Mean 0.994
Standard deviation 0.15
Values 0.93 0.89 1.2
[103]
SNU475 ITGA2B
Mean 0.53
Standard deviation 0.0044
Values 0.53 0.53
[104]
THLE ITGA2B
Mean 0.191
Standard deviation 0.09
Values 0.25 0.13
[105]
liver ITGA2B
Mean 0.311
Standard deviation 0.17
Values 0.38 0.29 0.49 0.093