REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.50[2] 0.44[3] 0.02[4] -0.12[5] 0.08[6] -0.16[7]
2 NRAS GTPase NRas [8] -0.06[9] 0.47[10] 0.34[11] 0.32[12] 0.18[13] -0.71[14]
3 HRAS GTPase HRas [15] -1.70[16] -2.31[17] -3.64[18] -1.62[19] -1.55[20] -3.12[21]
4 KRAS GTPase KRas [22] -1.21[23] -1.13[24] -0.07[25] 0.13[26] 0.07[27] 0.22[28]
5 SOS1 Son of sevenless homolog 1 [29] -0.79[30] 0.84[31] -0.20[32] 0.17[33] -0.31[34] 0.08[35]
6 ERBB2 Receptor tyrosine-protein kinase erbB-2 [36] 1.68[37] 0.60[38] 1.23[39] 0.58[40] 0.47[41] -0.30[42]
7 EGFR Epidermal growth factor receptor [43] -1.39[44] -1.66[45] 0.67[46] -0.24[47] 0.66[48] 2.19[49]
8 HBEGF Proheparin-binding EGF-like growth factor [50] -1.68[51] -2.39[52] -4.00[53] -0.37[54] -0.40[55] -2.89[56]
9 NRG1 Pro-neuregulin-1, membrane-bound isoform [57] -0.36[58] -6.40[59] -4.05[60] 1.38[61] -5.81[62] 0.31[63]
10 BTC Probetacellulin [64] -8.83[65] -9.12[66] -5.45[67] -3.55[68] -3.29[69] -3.37[70]
11 NRG4 Pro-neuregulin-4, membrane-bound isoform [71] -4.79[72] -1.81[73] -2.40[74] -0.39[75] -2.30[76] -1.39[77]
12 EREG Proepiregulin [78] 1.06[79] 1.09[80] -3.87[81] -2.24[82] 3.29[83] -1.93[84]
13 EGF Pro-epidermal growth factor [85] 1.27[86] 3.16[87] 6.23[88] 8.35[89] 6.05[90] 1.12[91]
14 NRG2 Pro-neuregulin-2, membrane-bound isoform [92] [93] [94] [95] [96] [97] [98]
15 ERBB4 Receptor tyrosine-protein kinase erbB-4 [99] [100] [101] [102] [103] [104] [105]
16 NRG3 Pro-neuregulin-3, membrane-bound isoform [106] [107] [108] [109] [110] [111] [112]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[9]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[10]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[11]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[12]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[13]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[14]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[15]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[16]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[17]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[18]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[19]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[20]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[21]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[22]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[23]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[24]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[25]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[26]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[27]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[28]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[29]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[30]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[31]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[32]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[33]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[34]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[35]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[36]
ref_hepatocyte ERBB2
Mean 6.44
Standard deviation 3.8
Values 13 3.9 4.7 3.7 7.1
[37]
HepG2 ERBB2
Mean 73.6
Standard deviation 10
Values 66 81
[38]
HepG2.C3A ERBB2
Mean 29
Standard deviation 6.9
Values 34 24
[39]
HuH.7 ERBB2
Mean 62.5
Standard deviation 7.1
Values 69 55 63
[40]
SNU475 ERBB2
Mean 28.2
Standard deviation 8.4
Values 34 22
[41]
THLE ERBB2
Mean 24.1
Standard deviation 2.7
Values 22 26
[42]
liver ERBB2
Mean 10.2
Standard deviation 3.4
Values 7.9 8.1 9.6 15
[43]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[44]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[45]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[46]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[47]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[48]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[49]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[50]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[51]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[52]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[53]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[54]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[55]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[56]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[57]
ref_hepatocyte NRG1
Mean 1.2
Standard deviation 1
Values 0 1 2.8 1.5 0.74
[58]
HepG2 NRG1
Mean 3.35
Standard deviation 2.7
Values 1.4 5.3
[59]
HepG2.C3A NRG1
Mean 0.0424
Standard deviation 0.046
Values 0.0097 0.075
[60]
HuH.7 NRG1
Mean 0.302
Standard deviation 0.17
Values 0.16 0.49 0.25
[61]
SNU475 NRG1
Mean 9.16
Standard deviation 3.3
Values 12 6.8
[62]
THLE NRG1
Mean 0.0576
Standard deviation 0.031
Values 0.035 0.08
[63]
liver NRG1
Mean 2.92
Standard deviation 2.1
Values 1.2 5.5 3.6 1.2
[64]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[65]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[66]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[67]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[68]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[69]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[70]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[71]
ref_hepatocyte NRG4
Mean 0.631
Standard deviation 0.35
Values 0 0.75 0.81 0.78 0.81
[72]
HepG2 NRG4
Mean 0.0816
Standard deviation 0.03
Values 0.1 0.06
[73]
HepG2.C3A NRG4
Mean 0.534
Standard deviation 0.042
Values 0.56 0.5
[74]
HuH.7 NRG4
Mean 0.494
Standard deviation 0.053
Values 0.43 0.51 0.53
[75]
SNU475 NRG4
Mean 1.41
Standard deviation 0.46
Values 1.7 1.1
[76]
THLE NRG4
Mean 0.345
Standard deviation 0.16
Values 0.46 0.23
[77]
liver NRG4
Mean 0.468
Standard deviation 0.12
Values 0.45 0.41 0.64 0.37
[78]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[79]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[80]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[81]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[82]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[83]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[84]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[85]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[86]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[87]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[88]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[89]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[90]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[91]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[92]
ref_hepatocyte NRG2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 NRG2
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[94]
HepG2.C3A NRG2
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 NRG2
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 NRG2
Mean 0.181
Standard deviation 0.12
Values 0.093 0.27
[97]
THLE NRG2
Mean 0.79
Standard deviation 0.23
Values 0.63 0.95
[98]
liver NRG2
Mean 0.0321
Standard deviation 0.024
Values 0.047 0.029 0 0.053
[99]
ref_hepatocyte ERBB4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 ERBB4
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[101]
HepG2.C3A ERBB4
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[102]
HuH.7 ERBB4
Mean 0.136
Standard deviation 0.15
Values 0.098 0.3 0.0094
[103]
SNU475 ERBB4
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[104]
THLE ERBB4
Mean 0.0662
Standard deviation 0.027
Values 0.047 0.085
[105]
liver ERBB4
Mean 0.308
Standard deviation 0.33
Values 0.14 0.29 0.026 0.78
[106]
ref_hepatocyte NRG3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 NRG3
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A NRG3
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 NRG3
Mean 0.376
Standard deviation 0.32
Values 0.18 0.75 0.2
[110]
SNU475 NRG3
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE NRG3
Mean 0
Standard deviation 0
Values 0 0
[112]
liver NRG3
Mean 0.222
Standard deviation 0.073
Values 0.28 0.2 0.13 0.28