REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -0.50[2] | -1.05[3] | -0.55[4] | -0.86[5] | -0.81[6] | -1.19[7] |
2 | RHOB | Rho-related GTP-binding protein RhoB | [8] | -0.35[9] | -0.97[10] | -2.83[11] | -1.93[12] | -3.19[13] | 0.02[14] |
3 | CDC42 | Cell division control protein 42 homolog | [15] | -0.38[16] | 0.28[17] | -0.45[18] | -0.17[19] | -1.30[20] | -1.95[21] |
4 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [22] | 0.05[23] | -0.33[24] | 0.66[25] | 0.37[26] | -0.04[27] | -0.83[28] |
5 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [29] | 0.89[30] | 1.27[31] | 1.50[32] | 1.25[33] | 1.48[34] | 1.40[35] |
6 | FCER1G | High affinity immunoglobulin epsilon receptor subunit gamma | [36] | -4.63[37] | -3.79[38] | -6.49[39] | -8.10[40] | -6.48[41] | -0.83[42] |
7 | VAV2 | Guanine nucleotide exchange factor VAV2 | [43] | 1.74[44] | 1.94[45] | 1.71[46] | -0.18[47] | -0.16[48] | 0.65[49] |
8 | PRKCZ | Protein kinase C zeta type | [50] | 0.92[51] | 1.24[52] | -0.48[53] | -1.94[54] | -4.54[55] | -1.50[56] |
9 | RHOG | Rho-related GTP-binding protein RhoG | [57] | 0.71[58] | -0.53[59] | -0.31[60] | 0.39[61] | -0.45[62] | -0.56[63] |
10 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [64] | -0.03[65] | 0.04[66] | 1.41[67] | 2.43[68] | 1.53[69] | 3.14[70] |
11 | LYN | Tyrosine-protein kinase Lyn | [71] | -0.42[72] | -0.65[73] | 0.16[74] | 1.41[75] | -0.23[76] | 0.15[77] |
12 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [78] | -0.02[79] | 0.12[80] | 0.98[81] | -6.78[82] | -2.16[83] | -0.04[84] |
13 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [85] | 2.32[86] | 2.49[87] | 3.38[88] | 1.07[89] | 1.22[90] | -0.15[91] |
14 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [92] | -1.27[93] | -7.31[94] | -7.64[95] | -1.03[96] | 2.37[97] | -1.09[98] |
15 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [99] | 2.78[100] | 3.91[101] | 2.90[102] | 1.80[103] | 1.79[104] | 2.64[105] |
16 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.65[106] | 2.11[107] | 2.55[108] | 1.41[109] | 1.16[110] | 1.29[111] | |
17 | FYN | Tyrosine-protein kinase Fyn | [112] | 1.39[113] | -7.27[114] | 1.58[115] | 1.83[116] | 2.95[117] | 1.11[118] |
18 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.06[119] | 1.65[120] | 2.12[121] | 1.49[122] | 1.29[123] | 2.05[124] | |
19 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -0.84[125] | -6.64[126] | 1.09[127] | -2.38[128] | -1.63[129] | 2.85[130] | |
20 | CLEC1B | C-type lectin domain family 1 member B | [131] | [132] | [133] | [134] | -7.35[135] | [136] | 3.25[137] |
21 | LCP2 | Lymphocyte cytosolic protein 2 | [138] | [139] | [140] | [141] | -3.35[142] | [143] | 1.28[144] |
22 | LAT | Linker for activation of T-cells family member 1 | [145] | -1.00[146] | 0.48[147] | -0.84[148] | -1.00[149] | -0.83[150] | -0.28[151] |
23 | VAV3 | Guanine nucleotide exchange factor VAV3 | [152] | 2.25[153] | 0.49[154] | 2.94[155] | 4.04[156] | -2.34[157] | 1.49[158] |
24 | VAV1 | Proto-oncogene vav | [159] | -8.05[160] | -3.28[161] | -4.71[162] | -5.73[163] | -7.39[164] | 1.32[165] |
25 | GP6 | Platelet glycoprotein VI | [166] | -2.98[167] | -1.06[168] | -1.17[169] | -2.04[170] | -2.81[171] | -1.24[172] |
26 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [173] | 2.17[174] | 2.12[175] | 3.25[176] | 3.53[177] | 2.14[178] | 2.81[179] |
27 | COL1A1 | Collagen alpha-1(I) chain | [180] | 5.18[181] | -2.38[182] | -0.28[183] | 7.37[184] | 8.50[185] | 6.49[186] |
28 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [187] | -6.72[188] | [189] | -1.86[190] | -3.56[191] | -3.62[192] | 2.48[193] |
29 | COL1A2 | Collagen alpha-2(I) chain | [194] | -5.71[195] | -5.69[196] | -2.92[197] | 5.34[198] | 4.97[199] | 6.56[200] |
30 | LCK | Tyrosine-protein kinase Lck | [201] | 3.22[202] | 3.25[203] | -6.47[204] | -4.72[205] | -5.33[206] | 1.37[207] |
31 | SYK | Tyrosine-protein kinase SYK | [208] | -7.72[209] | -1.90[210] | -4.64[211] | 0.46[212] | -3.46[213] | 3.50[214] |
32 | PDPN | Podoplanin | [215] | -2.72[216] | -3.68[217] | -1.38[218] | 3.91[219] | 7.79[220] | -0.28[221] |
33 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [222] | [223] | [224] | 1.70[225] | -3.59[226] | 4.24[227] | |
34 | PIK3R6 | Phosphoinositide 3-kinase regulatory subunit 6 | [228] | [229] | [230] | -1.89[231] | [232] | [233] | 1.96[234] |
35 | MPIG6B | Megakaryocyte and platelet inhibitory receptor G6b | [235] | [236] | [237] | [238] | [239] | [240] | [241] |