REACTOME_GLUTATHIONE_SYNTHESIS_AND_RECYCLING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CNDP2 Cytosolic non-specific dipeptidase [1] 0.08[2] 0.10[3] -0.78[4] -1.45[5] -0.63[6] 0.83[7]
2 GCLC Glutamate--cysteine ligase catalytic subunit [8] -0.04[9] 0.34[10] -0.46[11] 0.98[12] -0.54[13] 0.16[14]
3 GGCT Gamma-glutamylcyclotransferase [15] -1.64[16] -0.84[17] 0.64[18] -1.42[19] -0.20[20] -2.41[21]
4 GCLM Glutamate--cysteine ligase regulatory subunit [22] -0.66[23] -1.40[24] -0.52[25] 0.88[26] 0.26[27] -1.09[28]
5 GSS Glutathione synthetase [29] 1.02[30] 0.75[31] 0.51[32] 0.36[33] 0.95[34] -0.49[35]
6 GGT1 Glutathione hydrolase 1 proenzyme [36] -0.36[37] -0.60[38] -0.41[39] -2.16[40] -5.50[41] 0.46[42]
7 CHAC1 Glutathione-specific gamma-glutamylcyclotransferase 1 [43] -5.08[44] -2.70[45] 0.19[46] -3.70[47] 0.39[48] -3.93[49]
8 OPLAH 5-oxoprolinase [50] 1.26[51] 1.33[52] 0.22[53] -0.39[54] -1.23[55] 1.42[56]
9 CHAC2 Glutathione-specific gamma-glutamylcyclotransferase 2 [57] -0.79[58] -0.28[59] -0.74[60] -0.58[61] 0.73[62] -1.41[63]
10 GGT7 Glutathione hydrolase 7 [64] 2.10[65] 2.45[66] 2.42[67] 1.99[68] 2.31[69] 0.10[70]
11 GGT6 Glutathione hydrolase 6 [71] 0.64[72] 1.20[73] -0.12[74] -0.96[75] -0.47[76] -0.26[77]
12 GGT5 Glutathione hydrolase 5 proenzyme [78] 4.89[79] 2.30[80] -2.17[81] 3.94[82] 5.27[83] 5.38[84]
[1]
ref_hepatocyte CNDP2
Mean 26.6
Standard deviation 12
Values 15 43 14 31 30
[2]
HepG2 CNDP2
Mean 50
Standard deviation 3.6
Values 52 47
[3]
HepG2.C3A CNDP2
Mean 44.2
Standard deviation 8.3
Values 50 38
[4]
HuH.7 CNDP2
Mean 17.3
Standard deviation 3.4
Values 18 13 20
[5]
SNU475 CNDP2
Mean 17.5
Standard deviation 5.3
Values 21 14
[6]
THLE CNDP2
Mean 15.1
Standard deviation 2.3
Values 14 17
[7]
liver CNDP2
Mean 80
Standard deviation 34
Values 1e+02 58 1.2e+02 44
[8]
ref_hepatocyte GCLC
Mean 23.9
Standard deviation 11
Values 14 17 36 16 37
[9]
HepG2 GCLC
Mean 41.2
Standard deviation 0.21
Values 41 41
[10]
HepG2.C3A GCLC
Mean 47.1
Standard deviation 0.68
Values 48 47
[11]
HuH.7 GCLC
Mean 19.4
Standard deviation 7.4
Values 15 28 15
[12]
SNU475 GCLC
Mean 84.8
Standard deviation 9.1
Values 91 78
[13]
THLE GCLC
Mean 14.4
Standard deviation 0.55
Values 15 14
[14]
liver GCLC
Mean 45.3
Standard deviation 20
Values 37 59 22 64
[15]
ref_hepatocyte GGCT
Mean 22.9
Standard deviation 5.2
Values 29 25 25 18 17
[16]
HepG2 GGCT
Mean 13.1
Standard deviation 2.8
Values 11 15
[17]
HepG2.C3A GGCT
Mean 19.9
Standard deviation 7.3
Values 15 25
[18]
HuH.7 GGCT
Mean 40
Standard deviation 16
Values 42 23 55
[19]
SNU475 GGCT
Mean 15.4
Standard deviation 3.1
Values 13 18
[20]
THLE GGCT
Mean 17.5
Standard deviation 1.8
Values 16 19
[21]
liver GGCT
Mean 7.28
Standard deviation 5.4
Values 11 3.4 13 1.9
[22]
ref_hepatocyte GCLM
Mean 20.7
Standard deviation 17
Values 12 45 32 8.4 5.2
[23]
HepG2 GCLM
Mean 23.3
Standard deviation 15
Values 34 13
[24]
HepG2.C3A GCLM
Mean 12.1
Standard deviation 3.1
Values 9.9 14
[25]
HuH.7 GCLM
Mean 16.1
Standard deviation 2.7
Values 16 19 13
[26]
SNU475 GCLM
Mean 68.3
Standard deviation 0.053
Values 68 68
[27]
THLE GCLM
Mean 21.6
Standard deviation 2.7
Values 20 24
[28]
liver GCLM
Mean 16.4
Standard deviation 8.1
Values 18 14 27 7
[29]
ref_hepatocyte GSS
Mean 17.2
Standard deviation 2.6
Values 14 16 20 20 17
[30]
HepG2 GSS
Mean 61.8
Standard deviation 7.1
Values 57 67
[31]
HepG2.C3A GSS
Mean 45
Standard deviation 7.3
Values 40 50
[32]
HuH.7 GSS
Mean 27.4
Standard deviation 7
Values 27 20 34
[33]
SNU475 GSS
Mean 39.8
Standard deviation 5.9
Values 44 36
[34]
THLE GSS
Mean 29.3
Standard deviation 2.5
Values 27 31
[35]
liver GSS
Mean 20.8
Standard deviation 9.9
Values 26 14 32 11
[36]
ref_hepatocyte GGT1
Mean 15.1
Standard deviation 12
Values 0.7 20 4.1 29 22
[37]
HepG2 GGT1
Mean 20.9
Standard deviation 6.9
Values 26 16
[38]
HepG2.C3A GGT1
Mean 15.5
Standard deviation 4.3
Values 19 12
[39]
HuH.7 GGT1
Mean 12.7
Standard deviation 3.6
Values 11 17 9.9
[40]
SNU475 GGT1
Mean 6.1
Standard deviation 1.7
Values 7.3 4.9
[41]
THLE GGT1
Mean 0.294
Standard deviation 0.0057
Values 0.29 0.3
[42]
liver GGT1
Mean 35.2
Standard deviation 23
Values 65 15 40 21
[43]
ref_hepatocyte CHAC1
Mean 7.82
Standard deviation 13
Values 0 0.15 8.8 30 0.24
[44]
HepG2 CHAC1
Mean 0.411
Standard deviation 0.35
Values 0.66 0.16
[45]
HepG2.C3A CHAC1
Mean 1.87
Standard deviation 1.2
Values 2.7 1
[46]
HuH.7 CHAC1
Mean 9.92
Standard deviation 2.9
Values 11 6.7 12
[47]
SNU475 CHAC1
Mean 1.08
Standard deviation 0.32
Values 0.85 1.3
[48]
THLE CHAC1
Mean 8.99
Standard deviation 2
Values 10 7.5
[49]
liver CHAC1
Mean 0.871
Standard deviation 1.1
Values 2.4 0.057 0.69 0.29
[50]
ref_hepatocyte OPLAH
Mean 4.64
Standard deviation 4.4
Values 2.4 0.7 1.9 7.2 11
[51]
HepG2 OPLAH
Mean 19.7
Standard deviation 2.6
Values 22 18
[52]
HepG2.C3A OPLAH
Mean 18.1
Standard deviation 9.1
Values 25 12
[53]
HuH.7 OPLAH
Mean 6.03
Standard deviation 0.25
Values 6.2 5.7 6.2
[54]
SNU475 OPLAH
Mean 6.37
Standard deviation 3.8
Values 9.1 3.7
[55]
THLE OPLAH
Mean 1.73
Standard deviation 0.08
Values 1.7 1.8
[56]
liver OPLAH
Mean 21
Standard deviation 13
Values 14 19 10 40
[57]
ref_hepatocyte CHAC2
Mean 3.12
Standard deviation 3.4
Values 2.7 9 0.74 1.3 1.9
[58]
HepG2 CHAC2
Mean 3.2
Standard deviation 0.94
Values 2.5 3.9
[59]
HepG2.C3A CHAC2
Mean 4
Standard deviation 3.7
Values 1.4 6.6
[60]
HuH.7 CHAC2
Mean 2.09
Standard deviation 1.1
Values 2.5 0.87 3
[61]
SNU475 CHAC2
Mean 3.76
Standard deviation 0.68
Values 3.3 4.2
[62]
THLE CHAC2
Mean 4.56
Standard deviation 0.51
Values 4.2 4.9
[63]
liver CHAC2
Mean 1.99
Standard deviation 1.1
Values 3.4 1.3 2.3 0.94
[64]
ref_hepatocyte GGT7
Mean 1.61
Standard deviation 1.1
Values 1.5 0.71 0.35 2.8 2.6
[65]
HepG2 GGT7
Mean 12.2
Standard deviation 0.96
Values 13 12
[66]
HepG2.C3A GGT7
Mean 13.6
Standard deviation 5.5
Values 18 9.8
[67]
HuH.7 GGT7
Mean 9.57
Standard deviation 2.2
Values 7.5 12 9.5
[68]
SNU475 GGT7
Mean 11.5
Standard deviation 1.7
Values 13 10
[69]
THLE GGT7
Mean 7.01
Standard deviation 1.9
Values 8.3 5.7
[70]
liver GGT7
Mean 2.93
Standard deviation 1
Values 2.2 4.2 2.1 3.3
[71]
ref_hepatocyte GGT6
Mean 0.301
Standard deviation 0.36
Values 0.92 0.06 0.2 0.06 0.28
[72]
HepG2 GGT6
Mean 0.834
Standard deviation 0.027
Values 0.85 0.82
[73]
HepG2.C3A GGT6
Mean 1.08
Standard deviation 0.082
Values 1 1.1
[74]
HuH.7 GGT6
Mean 0.31
Standard deviation 0.14
Values 0.24 0.47 0.22
[75]
SNU475 GGT6
Mean 0.28
Standard deviation 0.044
Values 0.31 0.25
[76]
THLE GGT6
Mean 0.19
Standard deviation 0.077
Values 0.14 0.24
[77]
liver GGT6
Mean 0.426
Standard deviation 0.13
Values 0.61 0.3 0.41 0.38
[78]
ref_hepatocyte GGT5
Mean 0.17
Standard deviation 0.18
Values 0.15 0 0 0.41 0.3
[79]
HepG2 GGT5
Mean 8.97
Standard deviation 6.7
Values 14 4.3
[80]
HepG2.C3A GGT5
Mean 1.3
Standard deviation 0.47
Values 0.97 1.6
[81]
HuH.7 GGT5
Mean 0.0424
Standard deviation 0.034
Values 0.074 0.0064 0.047
[82]
SNU475 GGT5
Mean 4.71
Standard deviation 2.8
Values 2.7 6.7
[83]
THLE GGT5
Mean 5.79
Standard deviation 1.9
Values 4.5 7.1
[84]
liver GGT5
Mean 12
Standard deviation 7.3
Values 13 4.2 21 9.1