REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SLC38A2 Sodium-coupled neutral amino acid transporter 2 [1] 0.46[2] 0.91[3] -0.23[4] -0.98[5] 0.19[6] 0.14[7]
2 ARL6IP5 PRA1 family protein 3 [8] -1.15[9] -2.69[10] -2.28[11] -1.13[12] -0.40[13] -1.56[14]
3 GLS2 Glutaminase liver isoform, mitochondrial [15] -2.96[16] -3.56[17] -6.49[18] -8.19[19] -7.06[20] -0.84[21]
4 SLC1A1 Excitatory amino acid transporter 3 [22] -9.05[23] -10.29[24] -2.11[25] -3.83[26] -4.16[27] 0.78[28]
5 GLS Glutaminase kidney isoform, mitochondrial [29] 0.81[30] 0.46[31] 0.78[32] 1.87[33] 0.88[34] -1.87[35]
6 VAMP2 Vesicle-associated membrane protein 2 [36] -1.82[37] -2.64[38] -0.89[39] -1.56[40] -1.14[41] -1.51[42]
7 PPFIA1 Liprin-alpha-1 [43] 1.13[44] -0.30[45] 1.95[46] 3.09[47] 1.43[48] 0.51[49]
8 UNC13B Protein unc-13 homolog B [50] 1.30[51] 0.22[52] 2.28[53] -0.72[54] 0.49[55] 1.25[56]
9 SLC1A2 Excitatory amino acid transporter 2 [57] 1.14[58] 0.75[59] -4.32[60] -4.57[61] -6.32[62] 3.24[63]
10 RAB3A Ras-related protein Rab-3A [64] -0.55[65] -2.80[66] 0.73[67] -1.90[68] -1.10[69] -2.54[70]
11 STX1A Syntaxin-1A [71] 0.47[72] -0.75[73] -0.84[74] 1.50[75] 1.12[76] -2.48[77]
12 STXBP1 Syntaxin-binding protein 1 [78] 1.26[79] 0.48[80] 2.31[81] 3.10[82] 3.57[83] -0.48[84]
13 CPLX1 Complexin-1 [85] -1.39[86] -3.63[87] 2.60[88] -3.99[89] -3.41[90] -1.13[91]
14 PPFIA3 Liprin-alpha-3 [92] 2.25[93] 1.48[94] 2.87[95] -0.20[96] 0.00[97] -1.24[98]
15 SLC1A3 Excitatory amino acid transporter 1 [99] -3.96[100] -3.51[101] 4.37[102] 3.29[103] 3.66[104] 1.39[105]
16 SNAP25 Synaptosomal-associated protein 25 [106] -3.97[107] -4.96[108] 2.11[109] 1.36[110] 4.02[111] -0.28[112]
17 SLC1A7 Excitatory amino acid transporter 5 [113] 1.20[114] 0.51[115] 5.33[116] -1.19[117] -2.09[118] 0.77[119]
18 SLC1A6 Excitatory amino acid transporter 4 [120] -3.62[121] [122] [123] -4.82[124] [125] -2.06[126]
19 SYT1 Synaptotagmin-1 [127] -2.57[128] -4.51[129] 5.53[130] 6.09[131] 2.88[132] 2.90[133]
20 SLC17A7 Vesicular glutamate transporter 1 [134] 2.57[135] 1.71[136] 2.74[137] 3.00[138] 1.94[139] -0.31[140]
21 PPFIA2 Liprin-alpha-2 [141] 3.72[142] 5.45[143] 6.18[144] -0.37[145] 0.66[146] 5.58[147]
22 RIMS1 Regulating synaptic membrane exocytosis protein 1 [148] [149] [150] [151] [152] [153] [154]
23 TSPOAP1 Peripheral-type benzodiazepine receptor-associated protein 1 [155] [156] [157] [158] [159] [160] [161]
24 PPFIA4 Liprin-alpha-4 [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte SLC38A2
Mean 50.7
Standard deviation 39
Values 60 1.1e+02 24 44 14
[2]
HepG2 SLC38A2
Mean 213
Standard deviation 38
Values 1.9e+02 2.4e+02
[3]
HepG2.C3A SLC38A2
Mean 591
Standard deviation 1.7e+02
Values 7.1e+02 4.7e+02
[4]
HuH.7 SLC38A2
Mean 97.6
Standard deviation 12
Values 1e+02 1.1e+02 84
[5]
SNU475 SLC38A2
Mean 101
Standard deviation 4.3
Values 97 1e+02
[6]
THLE SLC38A2
Mean 166
Standard deviation 13
Values 1.6e+02 1.8e+02
[7]
liver SLC38A2
Mean 198
Standard deviation 71
Values 2.1e+02 1.6e+02 1.3e+02 2.9e+02
[8]
ref_hepatocyte ARL6IP5
Mean 20.3
Standard deviation 11
Values 13 39 20 10 19
[9]
HepG2 ARL6IP5
Mean 28
Standard deviation 11
Values 20 36
[10]
HepG2.C3A ARL6IP5
Mean 19.6
Standard deviation 4.3
Values 16 23
[11]
HuH.7 ARL6IP5
Mean 9.4
Standard deviation 0.63
Values 9.1 9 10
[12]
SNU475 ARL6IP5
Mean 36.4
Standard deviation 8.5
Values 42 30
[13]
THLE ARL6IP5
Mean 44.2
Standard deviation 6.5
Values 40 49
[14]
liver ARL6IP5
Mean 24.4
Standard deviation 16
Values 45 12 29 11
[15]
ref_hepatocyte GLS2
Mean 17.1
Standard deviation 20
Values 1.3 3.2 2.5 36 43
[16]
HepG2 GLS2
Mean 6.74
Standard deviation 0.93
Values 6.1 7.4
[17]
HepG2.C3A GLS2
Mean 9.03
Standard deviation 1.6
Values 7.9 10
[18]
HuH.7 GLS2
Mean 0.429
Standard deviation 0.081
Values 0.4 0.52 0.37
[19]
SNU475 GLS2
Mean 0.231
Standard deviation 0.061
Values 0.27 0.19
[20]
THLE GLS2
Mean 0.37
Standard deviation 0.071
Values 0.42 0.32
[21]
liver GLS2
Mean 33.9
Standard deviation 12
Values 31 35 50 20
[22]
ref_hepatocyte SLC1A1
Mean 10.2
Standard deviation 10
Values 0 5.5 4.3 15 26
[23]
HepG2 SLC1A1
Mean 0.0587
Standard deviation 0.026
Values 0.04 0.077
[24]
HepG2.C3A SLC1A1
Mean 0.0506
Standard deviation 0.011
Values 0.058 0.043
[25]
HuH.7 SLC1A1
Mean 5.33
Standard deviation 0.56
Values 5.6 5.7 4.7
[26]
SNU475 SLC1A1
Mean 2.81
Standard deviation 0.56
Values 3.2 2.4
[27]
THLE SLC1A1
Mean 1.63
Standard deviation 0.41
Values 1.9 1.3
[28]
liver SLC1A1
Mean 62.2
Standard deviation 14
Values 42 68 71 68
[29]
ref_hepatocyte GLS
Mean 9.86
Standard deviation 9.8
Values 16 23 6.9 1 1.5
[30]
HepG2 GLS
Mean 53
Standard deviation 14
Values 43 63
[31]
HepG2.C3A GLS
Mean 84.4
Standard deviation 0.68
Values 85 84
[32]
HuH.7 GLS
Mean 38.2
Standard deviation 5.2
Values 42 32 40
[33]
SNU475 GLS
Mean 142
Standard deviation 34
Values 1.7e+02 1.2e+02
[34]
THLE GLS
Mean 52.3
Standard deviation 7.1
Values 47 57
[35]
liver GLS
Mean 9.55
Standard deviation 3
Values 8.7 12 5.7 11
[36]
ref_hepatocyte VAMP2
Mean 7.38
Standard deviation 2
Values 9.9 5.1 8 8.2 5.7
[37]
HepG2 VAMP2
Mean 6.41
Standard deviation 1.5
Values 7.4 5.4
[38]
HepG2.C3A VAMP2
Mean 7.34
Standard deviation 3
Values 9.5 5.2
[39]
HuH.7 VAMP2
Mean 8.97
Standard deviation 0.78
Values 8.3 8.8 9.8
[40]
SNU475 VAMP2
Mean 9.81
Standard deviation 1.6
Values 11 8.7
[41]
THLE VAMP2
Mean 9.61
Standard deviation 0.14
Values 9.5 9.7
[42]
liver VAMP2
Mean 9.18
Standard deviation 10
Values 22 1 11 1.9
[43]
ref_hepatocyte PPFIA1
Mean 4.38
Standard deviation 1.7
Values 4 5.6 6.7 2.7 2.9
[44]
HepG2 PPFIA1
Mean 29.4
Standard deviation 3.9
Values 27 32
[45]
HepG2.C3A PPFIA1
Mean 22.1
Standard deviation 1.5
Values 23 21
[46]
HuH.7 PPFIA1
Mean 38.2
Standard deviation 5.1
Values 38 43 33
[47]
SNU475 PPFIA1
Mean 146
Standard deviation 15
Values 1.6e+02 1.4e+02
[48]
THLE PPFIA1
Mean 33.9
Standard deviation 4
Values 31 37
[49]
liver PPFIA1
Mean 22.1
Standard deviation 4.2
Values 21 25 16 25
[50]
ref_hepatocyte UNC13B
Mean 3.23
Standard deviation 1.4
Values 2.5 5.5 2.6 3.4 2.1
[51]
HepG2 UNC13B
Mean 24.3
Standard deviation 2.4
Values 23 26
[52]
HepG2.C3A UNC13B
Mean 23.4
Standard deviation 3.3
Values 26 21
[53]
HuH.7 UNC13B
Mean 35.5
Standard deviation 5.6
Values 40 37 29
[54]
SNU475 UNC13B
Mean 7.69
Standard deviation 1.6
Values 8.8 6.5
[55]
THLE UNC13B
Mean 13
Standard deviation 0.26
Values 13 13
[56]
liver UNC13B
Mean 27.3
Standard deviation 11
Values 17 41 19 33
[57]
ref_hepatocyte SLC1A2
Mean 1.83
Standard deviation 2.2
Values 5.5 0.018 0.2 1.7 1.7
[58]
HepG2 SLC1A2
Mean 12.3
Standard deviation 2.5
Values 14 11
[59]
HepG2.C3A SLC1A2
Mean 19.1
Standard deviation 7
Values 24 14
[60]
HuH.7 SLC1A2
Mean 0.206
Standard deviation 0.16
Values 0.11 0.39 0.11
[61]
SNU475 SLC1A2
Mean 0.302
Standard deviation 0.067
Values 0.26 0.35
[62]
THLE SLC1A2
Mean 0.0659
Standard deviation 0.041
Values 0.095 0.037
[63]
liver SLC1A2
Mean 61.3
Standard deviation 67
Values 20 1.6e+02 49 16
[64]
ref_hepatocyte RAB3A
Mean 0.786
Standard deviation 0.29
Values 0.95 0.55 0.49 0.76 1.2
[65]
HepG2 RAB3A
Mean 1.64
Standard deviation 0.46
Values 2 1.3
[66]
HepG2.C3A RAB3A
Mean 0.703
Standard deviation 0.33
Values 0.93 0.47
[67]
HuH.7 RAB3A
Mean 2.95
Standard deviation 0.48
Values 3.5 2.5 2.8
[68]
SNU475 RAB3A
Mean 0.823
Standard deviation 0.069
Values 0.77 0.87
[69]
THLE RAB3A
Mean 1.06
Standard deviation 0.15
Values 1.2 0.95
[70]
liver RAB3A
Mean 0.48
Standard deviation 0.46
Values 0.47 0.19 1.1 0.13
[71]
ref_hepatocyte STX1A
Mean 0.672
Standard deviation 0.98
Values 0.23 0.39 2.4 0.095 0.24
[72]
HepG2 STX1A
Mean 2.85
Standard deviation 0.85
Values 3.4 2.2
[73]
HepG2.C3A STX1A
Mean 2.48
Standard deviation 0.71
Values 3 2
[74]
HuH.7 STX1A
Mean 0.845
Standard deviation 0.25
Values 0.57 0.91 1.1
[75]
SNU475 STX1A
Mean 7.45
Standard deviation 3.6
Values 4.9 10
[76]
THLE STX1A
Mean 4.19
Standard deviation 1.3
Values 5.1 3.3
[77]
liver STX1A
Mean 0.426
Standard deviation 0.18
Values 0.35 0.31 0.69 0.34
[78]
ref_hepatocyte STXBP1
Mean 0.658
Standard deviation 0.63
Values 1.7 0.64 0.69 0.22 0.065
[79]
HepG2 STXBP1
Mean 4.83
Standard deviation 0.73
Values 5.4 4.3
[80]
HepG2.C3A STXBP1
Mean 5.71
Standard deviation 0.79
Values 6.3 5.1
[81]
HuH.7 STXBP1
Mean 7.36
Standard deviation 1.4
Values 8.9 6.5 6.7
[82]
SNU475 STXBP1
Mean 22.1
Standard deviation 0.72
Values 23 22
[83]
THLE STXBP1
Mean 22.4
Standard deviation 6
Values 18 27
[84]
liver STXBP1
Mean 1.67
Standard deviation 0.8
Values 2 1.1 2.6 0.91
[85]
ref_hepatocyte CPLX1
Mean 0.58
Standard deviation 0.61
Values 0.11 0 0.34 1.1 1.4
[86]
HepG2 CPLX1
Mean 0.678
Standard deviation 0.18
Values 0.8 0.55
[87]
HepG2.C3A CPLX1
Mean 0.29
Standard deviation 0.016
Values 0.3 0.28
[88]
HuH.7 CPLX1
Mean 7.91
Standard deviation 0.96
Values 9 7.3 7.4
[89]
SNU475 CPLX1
Mean 0.143
Standard deviation 0.012
Values 0.13 0.15
[90]
THLE CPLX1
Mean 0.156
Standard deviation 0.063
Values 0.2 0.11
[91]
liver CPLX1
Mean 0.943
Standard deviation 0.4
Values 0.73 1.3 0.49 1.3
[92]
ref_hepatocyte PPFIA3
Mean 0.55
Standard deviation 0.41
Values 1.1 0 0.71 0.53 0.39
[93]
HepG2 PPFIA3
Mean 8
Standard deviation 2.9
Values 10 6
[94]
HepG2.C3A PPFIA3
Mean 9.56
Standard deviation 2.5
Values 11 7.8
[95]
HuH.7 PPFIA3
Mean 9.06
Standard deviation 0.25
Values 9.3 9 8.8
[96]
SNU475 PPFIA3
Mean 1.88
Standard deviation 0.44
Values 1.6 2.2
[97]
THLE PPFIA3
Mean 1.58
Standard deviation 0.29
Values 1.8 1.4
[98]
liver PPFIA3
Mean 0.826
Standard deviation 0.32
Values 1 0.4 1.1 0.77
[99]
ref_hepatocyte SLC1A3
Mean 0.241
Standard deviation 0.27
Values 0 0.26 0.7 0.14 0.11
[100]
HepG2 SLC1A3
Mean 0.0472
Standard deviation 0.018
Values 0.034 0.06
[101]
HepG2.C3A SLC1A3
Mean 0.131
Standard deviation 0.034
Values 0.16 0.11
[102]
HuH.7 SLC1A3
Mean 11.2
Standard deviation 4.8
Values 16 6.1 12
[103]
SNU475 SLC1A3
Mean 9.25
Standard deviation 4.3
Values 6.2 12
[104]
THLE SLC1A3
Mean 8.73
Standard deviation 2.6
Values 11 6.9
[105]
liver SLC1A3
Mean 2.25
Standard deviation 0.84
Values 1.5 2.6 1.6 3.3
[106]
ref_hepatocyte SNAP25
Mean 0.146
Standard deviation 0.17
Values 0 0 0.3 0.069 0.36
[107]
HepG2 SNAP25
Mean 0.0286
Standard deviation 0.032
Values 0.0057 0.051
[108]
HepG2.C3A SNAP25
Mean 0.0292
Standard deviation 0.041
Values 0.058 0
[109]
HuH.7 SNAP25
Mean 1.43
Standard deviation 0.14
Values 1.4 1.3 1.6
[110]
SNU475 SNAP25
Mean 1.47
Standard deviation 0.63
Values 1 1.9
[111]
THLE SNAP25
Mean 6.82
Standard deviation 0.47
Values 7.1 6.5
[112]
liver SNAP25
Mean 0.427
Standard deviation 0.11
Values 0.42 0.34 0.36 0.58
[113]
ref_hepatocyte SLC1A7
Mean 0.0871
Standard deviation 0.1
Values 0 0.088 0 0.1 0.24
[114]
HepG2 SLC1A7
Mean 0.613
Standard deviation 0.7
Values 1.1 0.12
[115]
HepG2.C3A SLC1A7
Mean 0.768
Standard deviation 0.51
Values 1.1 0.41
[116]
HuH.7 SLC1A7
Mean 7.87
Standard deviation 1.5
Values 6.3 9.2 8.1
[117]
SNU475 SLC1A7
Mean 0.15
Standard deviation 0.011
Values 0.16 0.14
[118]
THLE SLC1A7
Mean 0.0586
Standard deviation 0.068
Values 0.11 0.011
[119]
liver SLC1A7
Mean 0.529
Standard deviation 0.26
Values 0.26 0.4 0.85 0.61
[120]
ref_hepatocyte SLC1A6
Mean 0.0549
Standard deviation 0.12
Values 0 0 0.27 0 0
[121]
HepG2 SLC1A6
Mean 0.0136
Standard deviation 0.013
Values 0.023 0.0043
[122]
HepG2.C3A SLC1A6
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 SLC1A6
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 SLC1A6
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[125]
THLE SLC1A6
Mean 0
Standard deviation 0
Values 0 0
[126]
liver SLC1A6
Mean 0.0467
Standard deviation 0.029
Values 0.024 0.086 0.051 0.026
[127]
ref_hepatocyte SYT1
Mean 0.0375
Standard deviation 0.071
Values 0 0 0.16 0 0.024
[128]
HepG2 SYT1
Mean 0.0193
Standard deviation 0.021
Values 0.034 0.0043
[129]
HepG2.C3A SYT1
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[130]
HuH.7 SYT1
Mean 3.9
Standard deviation 1.6
Values 3.6 5.6 2.5
[131]
SNU475 SYT1
Mean 10
Standard deviation 0.7
Values 9.5 11
[132]
THLE SYT1
Mean 0.793
Standard deviation 0.075
Values 0.85 0.74
[133]
liver SYT1
Mean 0.992
Standard deviation 0.082
Values 0.94 1.1 0.98 0.94
[134]
ref_hepatocyte SLC17A7
Mean 0.0103
Standard deviation 0.023
Values 0 0 0 0.052 0
[135]
HepG2 SLC17A7
Mean 0.188
Standard deviation 0.042
Values 0.22 0.16
[136]
HepG2.C3A SLC17A7
Mean 0.21
Standard deviation 0.12
Values 0.29 0.13
[137]
HuH.7 SLC17A7
Mean 0.155
Standard deviation 0.18
Values 0.041 0.36 0.066
[138]
SNU475 SLC17A7
Mean 0.324
Standard deviation 0.37
Values 0.065 0.58
[139]
THLE SLC17A7
Mean 0.114
Standard deviation 0.027
Values 0.095 0.13
[140]
liver SLC17A7
Mean 0.0296
Standard deviation 0.027
Values 0 0.014 0.051 0.053
[141]
ref_hepatocyte PPFIA2
Mean 0.00488
Standard deviation 0.011
Values 0 0 0 0 0.024
[142]
HepG2 PPFIA2
Mean 0.196
Standard deviation 0.026
Values 0.18 0.21
[143]
HepG2.C3A PPFIA2
Mean 1.33
Standard deviation 0.86
Values 1.9 0.72
[144]
HuH.7 PPFIA2
Mean 0.797
Standard deviation 0.16
Values 0.71 0.98 0.7
[145]
SNU475 PPFIA2
Mean 0.0148
Standard deviation 0.0078
Values 0.0093 0.02
[146]
THLE PPFIA2
Mean 0.0222
Standard deviation 0.0063
Values 0.018 0.027
[147]
liver PPFIA2
Mean 0.827
Standard deviation 0.62
Values 0.54 0.87 0.23 1.7
[148]
ref_hepatocyte RIMS1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 RIMS1
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A RIMS1
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 RIMS1
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 RIMS1
Mean 0.0774
Standard deviation 0.002
Values 0.079 0.076
[153]
THLE RIMS1
Mean 0.0387
Standard deviation 0.013
Values 0.03 0.048
[154]
liver RIMS1
Mean 0.0607
Standard deviation 0.064
Values 0 0.071 0.026 0.15
[155]
ref_hepatocyte TSPOAP1
Missing
[156]
HepG2 TSPOAP1
Missing
[157]
HepG2.C3A TSPOAP1
Missing
[158]
HuH.7 TSPOAP1
Missing
[159]
SNU475 TSPOAP1
Missing
[160]
THLE TSPOAP1
Missing
[161]
liver TSPOAP1
Missing
[162]
ref_hepatocyte PPFIA4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 PPFIA4
Mean 1.54
Standard deviation 0.4
Values 1.3 1.8
[164]
HepG2.C3A PPFIA4
Mean 1.94
Standard deviation 0.4
Values 1.7 2.2
[165]
HuH.7 PPFIA4
Mean 3.04
Standard deviation 1.1
Values 2.1 4.2 2.9
[166]
SNU475 PPFIA4
Mean 5.33
Standard deviation 1.6
Values 6.5 4.2
[167]
THLE PPFIA4
Mean 2.71
Standard deviation 1.5
Values 3.8 1.6
[168]
liver PPFIA4
Mean 0.136
Standard deviation 0.079
Values 0.19 0.2 0.13 0.026