REACTOME_GLUTAMATE_AND_GLUTAMINE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GLUD1 Glutamate dehydrogenase 1, mitochondrial [1] -0.86[2] -0.22[3] -1.06[4] -2.45[5] -1.46[6] 0.12[7]
2 GLUL Glutamine synthetase [8] -0.96[9] -0.52[10] 0.18[11] -1.92[12] -0.56[13] 0.61[14]
3 GOT2 Aspartate aminotransferase, mitochondrial [15] -0.42[16] -1.65[17] -1.06[18] -0.78[19] 0.41[20] -0.20[21]
4 OAT Ornithine aminotransferase, mitochondrial [22] -0.27[23] 0.04[24] -1.16[25] 0.00[26] 1.19[27] -0.73[28]
5 GLS2 Glutaminase liver isoform, mitochondrial [29] -2.50[30] -2.70[31] -6.63[32] -6.13[33] -5.48[34] -0.44[35]
6 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase [36] 1.44[37] 1.79[38] 2.48[39] 0.65[40] 0.92[41] -0.96[42]
7 PYCR2 Pyrroline-5-carboxylate reductase 2 [43] 0.24[44] -0.54[45] 0.40[46] 1.62[47] 0.88[48] -1.78[49]
8 GLS Glutaminase kidney isoform, mitochondrial [50] 1.27[51] 1.32[52] 0.65[53] 3.93[54] 2.46[55] -1.47[56]
9 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial [57] 3.48[58] 2.74[59] 2.38[60] 1.64[61] 0.51[62] -2.81[63]
10 GLUD2 Glutamate dehydrogenase 2, mitochondrial [64] -8.04[65] -7.22[66] 0.02[67] -6.85[68] -4.26[69] -0.82[70]
11 RIMKLB Beta-citrylglutamate synthase B [71] -0.40[72] 0.09[73] 2.01[74] 4.40[75] 5.02[76] 1.76[77]
12 RIMKLA N-acetylaspartylglutamate synthase A [78] 4.93[79] 2.72[80] 1.77[81] 6.01[82] 0.32[83] -0.25[84]
13 KYAT1 Kynurenine--oxoglutarate transaminase 1 [85] [86] [87] [88] [89] [90] [91]
14 PYCR3 Pyrroline-5-carboxylate reductase 3 [92] [93] [94] [95] [96] [97] [98]
[1]
ref_hepatocyte GLUD1
Mean 132
Standard deviation 1.1e+02
Values 2.2e+02 24 15 1.4e+02 2.7e+02
[2]
HepG2 GLUD1
Mean 161
Standard deviation 65
Values 1.2e+02 2.1e+02
[3]
HepG2.C3A GLUD1
Mean 386
Standard deviation 27
Values 4.1e+02 3.7e+02
[4]
HuH.7 GLUD1
Mean 157
Standard deviation 18
Values 1.5e+02 1.8e+02 1.5e+02
[5]
SNU475 GLUD1
Mean 22.7
Standard deviation 0.64
Values 23 22
[6]
THLE GLUD1
Mean 46.4
Standard deviation 7.4
Values 41 52
[7]
liver GLUD1
Mean 386
Standard deviation 1.2e+02
Values 5.5e+02 4.1e+02 2.7e+02 3.1e+02
[8]
ref_hepatocyte GLUL
Mean 74.1
Standard deviation 65
Values 1.8e+02 19 43 41 83
[9]
HepG2 GLUL
Mean 84.8
Standard deviation 1.4
Values 84 86
[10]
HepG2.C3A GLUL
Mean 177
Standard deviation 69
Values 2.3e+02 1.3e+02
[11]
HuH.7 GLUL
Mean 208
Standard deviation 35
Values 1.9e+02 2.5e+02 1.8e+02
[12]
SNU475 GLUL
Mean 18.5
Standard deviation 6.7
Values 23 14
[13]
THLE GLUL
Mean 48.5
Standard deviation 7.4
Values 43 54
[14]
liver GLUL
Mean 304
Standard deviation 1.6e+02
Values 5.2e+02 1.3e+02 2.6e+02 3.1e+02
[15]
ref_hepatocyte GOT2
Mean 58.1
Standard deviation 35
Values 32 39 29 86 1e+02
[16]
HepG2 GOT2
Mean 96.4
Standard deviation 0.81
Values 96 97
[17]
HepG2.C3A GOT2
Mean 63.2
Standard deviation 7.6
Values 58 69
[18]
HuH.7 GOT2
Mean 69
Standard deviation 13
Values 80 55 72
[19]
SNU475 GOT2
Mean 31.9
Standard deviation 2.4
Values 34 30
[20]
THLE GOT2
Mean 74.4
Standard deviation 6.4
Values 70 79
[21]
liver GOT2
Mean 136
Standard deviation 87
Values 1.8e+02 77 2.4e+02 50
[22]
ref_hepatocyte OAT
Mean 20.8
Standard deviation 20
Values 31 5.3 1.5 17 49
[23]
HepG2 OAT
Mean 38.4
Standard deviation 12
Values 30 47
[24]
HepG2.C3A OAT
Mean 72.9
Standard deviation 11
Values 65 81
[25]
HuH.7 OAT
Mean 23.1
Standard deviation 2.5
Values 21 26 23
[26]
SNU475 OAT
Mean 19.6
Standard deviation 6.9
Values 25 15
[27]
THLE OAT
Mean 45.9
Standard deviation 12
Values 37 54
[28]
liver OAT
Mean 33.7
Standard deviation 22
Values 65 14 32 24
[29]
ref_hepatocyte GLS2
Mean 17.1
Standard deviation 20
Values 1.3 3.2 2.5 36 43
[30]
HepG2 GLS2
Mean 6.74
Standard deviation 0.93
Values 6.1 7.4
[31]
HepG2.C3A GLS2
Mean 9.03
Standard deviation 1.6
Values 7.9 10
[32]
HuH.7 GLS2
Mean 0.429
Standard deviation 0.081
Values 0.4 0.52 0.37
[33]
SNU475 GLS2
Mean 0.231
Standard deviation 0.061
Values 0.27 0.19
[34]
THLE GLS2
Mean 0.37
Standard deviation 0.071
Values 0.42 0.32
[35]
liver GLS2
Mean 33.9
Standard deviation 12
Values 31 35 50 20
[36]
ref_hepatocyte ALDH18A1
Mean 15.8
Standard deviation 13
Values 40 9 9.2 11 11
[37]
HepG2 ALDH18A1
Mean 95.7
Standard deviation 18
Values 83 1.1e+02
[38]
HepG2.C3A ALDH18A1
Mean 187
Standard deviation 39
Values 2.1e+02 1.6e+02
[39]
HuH.7 ALDH18A1
Mean 218
Standard deviation 2
Values 2.2e+02 2.2e+02 2.2e+02
[40]
SNU475 ALDH18A1
Mean 23.3
Standard deviation 5.2
Values 27 20
[41]
THLE ALDH18A1
Mean 28.8
Standard deviation 5.2
Values 25 33
[42]
liver ALDH18A1
Mean 21.9
Standard deviation 5.3
Values 15 25 27 20
[43]
ref_hepatocyte PYCR2
Mean 12.7
Standard deviation 8.3
Values 3.6 5.2 22 20 13
[44]
HepG2 PYCR2
Mean 33.5
Standard deviation 0.26
Values 34 33
[45]
HepG2.C3A PYCR2
Mean 30
Standard deviation 1.9
Values 29 31
[46]
HuH.7 PYCR2
Mean 41.6
Standard deviation 19
Values 45 21 59
[47]
SNU475 PYCR2
Mean 36.8
Standard deviation 3
Values 39 35
[48]
THLE PYCR2
Mean 22.6
Standard deviation 1.3
Values 24 22
[49]
liver PYCR2
Mean 10
Standard deviation 5
Values 11 6.2 17 6.2
[50]
ref_hepatocyte GLS
Mean 9.86
Standard deviation 9.8
Values 16 23 6.9 1 1.5
[51]
HepG2 GLS
Mean 53
Standard deviation 14
Values 43 63
[52]
HepG2.C3A GLS
Mean 84.4
Standard deviation 0.68
Values 85 84
[53]
HuH.7 GLS
Mean 38.2
Standard deviation 5.2
Values 42 32 40
[54]
SNU475 GLS
Mean 142
Standard deviation 34
Values 1.7e+02 1.2e+02
[55]
THLE GLS
Mean 52.3
Standard deviation 7.1
Values 47 57
[56]
liver GLS
Mean 9.55
Standard deviation 3
Values 8.7 12 5.7 11
[57]
ref_hepatocyte PYCR1
Mean 8.14
Standard deviation 7
Values 18 1.6 12 6.7 2
[58]
HepG2 PYCR1
Mean 202
Standard deviation 52
Values 2.4e+02 1.7e+02
[59]
HepG2.C3A PYCR1
Mean 185
Standard deviation 66
Values 2.3e+02 1.4e+02
[60]
HuH.7 PYCR1
Mean 105
Standard deviation 35
Values 1.1e+02 68 1.4e+02
[61]
SNU475 PYCR1
Mean 24
Standard deviation 8.4
Values 30 18
[62]
THLE PYCR1
Mean 11.2
Standard deviation 2.1
Values 13 9.7
[63]
liver PYCR1
Mean 3.12
Standard deviation 1.6
Values 4.7 1 4 2.7
[64]
ref_hepatocyte GLUD2
Mean 1.78
Standard deviation 0.84
Values 0.68 1.7 2.9 1.4 2.2
[65]
HepG2 GLUD2
Mean 0.015
Standard deviation 0.021
Values 0 0.03
[66]
HepG2.C3A GLUD2
Mean 0.0409
Standard deviation 0.0028
Values 0.039 0.043
[67]
HuH.7 GLUD2
Mean 4.46
Standard deviation 1.7
Values 3.2 6.4 3.7
[68]
SNU475 GLUD2
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[69]
THLE GLUD2
Mean 0.0896
Standard deviation 0.0012
Values 0.089 0.09
[70]
liver GLUD2
Mean 2.71
Standard deviation 0.95
Values 2.3 3.6 1.6 3.4
[71]
ref_hepatocyte RIMKLB
Mean 0.249
Standard deviation 0.23
Values 0.04 0.56 0.42 0.069 0.16
[72]
HepG2 RIMKLB
Mean 0.419
Standard deviation 0.16
Values 0.53 0.3
[73]
HepG2.C3A RIMKLB
Mean 0.902
Standard deviation 0.29
Values 0.7 1.1
[74]
HuH.7 RIMKLB
Mean 2.49
Standard deviation 0.8
Values 2.6 3.3 1.7
[75]
SNU475 RIMKLB
Mean 4.96
Standard deviation 0.32
Values 5.2 4.7
[76]
THLE RIMKLB
Mean 7.79
Standard deviation 1.2
Values 6.9 8.7
[77]
liver RIMKLB
Mean 2.27
Standard deviation 1.4
Values 0.89 3.7 1.2 3.3
[78]
ref_hepatocyte RIMKLA
Mean 0.105
Standard deviation 0.13
Values 0.26 0.22 0 0.0086 0.033
[79]
HepG2 RIMKLA
Mean 7.08
Standard deviation 2.1
Values 5.6 8.5
[80]
HepG2.C3A RIMKLA
Mean 2.35
Standard deviation 1.9
Values 1 3.7
[81]
HuH.7 RIMKLA
Mean 0.885
Standard deviation 0.24
Values 1.1 0.64 0.88
[82]
SNU475 RIMKLA
Mean 6.36
Standard deviation 0.76
Values 5.8 6.9
[83]
THLE RIMKLA
Mean 0.126
Standard deviation 0.081
Values 0.18 0.069
[84]
liver RIMKLA
Mean 0.236
Standard deviation 0.16
Values 0.094 0.43 0.1 0.32
[85]
ref_hepatocyte KYAT1
Missing
[86]
HepG2 KYAT1
Missing
[87]
HepG2.C3A KYAT1
Missing
[88]
HuH.7 KYAT1
Missing
[89]
SNU475 KYAT1
Missing
[90]
THLE KYAT1
Missing
[91]
liver KYAT1
Missing
[92]
ref_hepatocyte PYCR3
Missing
[93]
HepG2 PYCR3
Missing
[94]
HepG2.C3A PYCR3
Missing
[95]
HuH.7 PYCR3
Missing
[96]
SNU475 PYCR3
Missing
[97]
THLE PYCR3
Missing
[98]
liver PYCR3
Missing