REACTOME_GLUCURONIDATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UGT1A6 UDP-glucuronosyltransferase 1-6 [1] -5.99[2] -14.42[3] -7.24[4] -4.65[5] -9.19[6] -3.64[7]
2 UGT2B4 UDP-glucuronosyltransferase 2B4 [8] -6.61[9] -7.47[10] -0.93[11] -7.88[12] -10.08[13] 1.02[14]
3 UGDH UDP-glucose 6-dehydrogenase [15] 1.81[16] 1.03[17] 1.25[18] 1.81[19] -0.04[20] -0.32[21]
4 UGP2 UTP--glucose-1-phosphate uridylyltransferase [22] 0.65[23] 0.59[24] 1.30[25] 1.42[26] 2.24[27] 0.00[28]
5 UGT2B7 UDP-glucuronosyltransferase 2B7 [29] -0.50[30] -1.04[31] -5.22[32] -9.10[33] -9.37[34] -0.27[35]
6 UGT2B10 UDP-glucuronosyltransferase 2B10 [36] -0.93[37] 1.02[38] -5.35[39] -9.23[40] -11.40[41] -1.35[42]
7 UGT2B15 UDP-glucuronosyltransferase 2B15 [43] -8.84[44] -7.97[45] -5.97[46] -8.97[47] -8.21[48] -0.73[49]
8 UGT1A1 UDP-glucuronosyltransferase 1-1 [50] -3.53[51] -10.46[52] -4.02[53] 0.88[54] -7.83[55] 0.20[56]
9 UGT1A4 UDP-glucuronosyltransferase 1-4 [57] -10.90[58] [59] -9.92[60] -8.40[61] [62] 0.39[63]
10 UGT1A9 UDP-glucuronosyltransferase 1-9 [64] -4.87[65] -10.43[66] -5.33[67] -3.46[68] -7.42[69] -0.38[70]
11 UGT2B17 UDP-glucuronosyltransferase 2B17 [71] -8.19[72] -8.25[73] -9.78[74] [75] [76] -1.10[77]
12 SLC35D1 UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter [78] 3.50[79] 3.15[80] 4.62[81] 2.37[82] 4.29[83] 3.21[84]
13 UGT2A3 UDP-glucuronosyltransferase 2A3 [85] 4.12[86] 5.30[87] -0.82[88] -3.83[89] -5.37[90] 1.76[91]
14 ABHD10 Mycophenolic acid acyl-glucuronide esterase, mitochondrial [92] 2.58[93] 2.68[94] 4.32[95] 3.29[96] 4.90[97] 0.85[98]
15 UGT3A1 UDP-glucuronosyltransferase 3A1 [99] [100] -8.09[101] [102] [103] -7.81[104] 2.05[105]
16 UGT1A3 UDP-glucuronosyltransferase 1-3 [106] -0.12[107] [108] -6.18[109] -3.20[110] -7.01[111] 1.49[112]
17 UGT2A2 [113] [114] [115] [116] [117] [118] [119]
18 UGT1A5 UDP-glucuronosyltransferase 1-5 [120] -3.41[121] [122] -3.99[123] -0.06[124] [125] 1.56[126]
19 UGT2B11 UDP-glucuronosyltransferase 2B11 [127] 3.05[128] 1.02[129] 3.55[130] -3.06[131] [132] 1.07[133]
20 UGT2B28 UDP-glucuronosyltransferase 2B28 [134] 2.82[135] 2.66[136] -0.31[137] -3.65[138] [139] 1.02[140]
21 UGT3A2 UDP-glucuronosyltransferase 3A2 [141] -1.89[142] [143] [144] -1.30[145] 1.74[146] -0.78[147]
22 UGT1A7 UDP-glucuronosyltransferase 1-7 [148] 2.01[149] [150] 1.89[151] 7.92[152] 3.84[153] 3.50[154]
23 UGT1A10 UDP-glucuronosyltransferase 1-10 [155] [156] [157] [158] [159] [160] [161]
24 UGT1A8 UDP-glucuronosyltransferase 1-8 [162] [163] [164] [165] [166] [167] [168]
25 UGT2A1 UDP-glucuronosyltransferase 2A1 [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte UGT1A6
Mean 242
Standard deviation 2.6e+02
Values 0.45 1.7e+02 11 4.3e+02 5.9e+02
[2]
HepG2 UGT1A6
Mean 1.17
Standard deviation 0.86
Values 1.8 0.56
[3]
HepG2.C3A UGT1A6
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[4]
HuH.7 UGT1A6
Mean 0.277
Standard deviation 0.33
Values 0.041 0.65 0.14
[5]
SNU475 UGT1A6
Mean 1.9
Standard deviation 0.11
Values 2 1.8
[6]
THLE UGT1A6
Mean 0.0372
Standard deviation 0.053
Values 0 0.074
[7]
liver UGT1A6
Mean 23.2
Standard deviation 17
Values 9 34 42 8.2
[8]
ref_hepatocyte UGT2B4
Mean 210
Standard deviation 2.5e+02
Values 0.056 68 15 4.6e+02 5e+02
[9]
HepG2 UGT2B4
Mean 0.666
Standard deviation 0.42
Values 0.96 0.37
[10]
HepG2.C3A UGT2B4
Mean 0.523
Standard deviation 0.23
Values 0.36 0.69
[11]
HuH.7 UGT2B4
Mean 19.1
Standard deviation 13
Values 11 34 12
[12]
SNU475 UGT2B4
Mean 0.176
Standard deviation 0.04
Values 0.2 0.15
[13]
THLE UGT2B4
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[14]
liver UGT2B4
Mean 509
Standard deviation 93
Values 4.5e+02 5.3e+02 6.3e+02 4.3e+02
[15]
ref_hepatocyte UGDH
Mean 162
Standard deviation 1.3e+02
Values 3.1e+02 3.1e+02 88 49 58
[16]
HepG2 UGDH
Mean 175
Standard deviation 29
Values 2e+02 1.5e+02
[17]
HepG2.C3A UGDH
Mean 146
Standard deviation 14
Values 1.4e+02 1.6e+02
[18]
HuH.7 UGDH
Mean 67
Standard deviation 29
Values 53 1e+02 48
[19]
SNU475 UGDH
Mean 113
Standard deviation 49
Values 1.5e+02 78
[20]
THLE UGDH
Mean 14.2
Standard deviation 2.7
Values 12 16
[21]
liver UGDH
Mean 155
Standard deviation 1.2e+02
Values 56 1.9e+02 3.2e+02 61
[22]
ref_hepatocyte UGP2
Mean 149
Standard deviation 1.1e+02
Values 46 3.1e+02 44 1.6e+02 1.9e+02
[23]
HepG2 UGP2
Mean 72.3
Standard deviation 27
Values 53 92
[24]
HepG2.C3A UGP2
Mean 98.6
Standard deviation 16
Values 87 1.1e+02
[25]
HuH.7 UGP2
Mean 63.6
Standard deviation 4.1
Values 60 68 63
[26]
SNU475 UGP2
Mean 79
Standard deviation 17
Values 91 67
[27]
THLE UGP2
Mean 63.1
Standard deviation 2.6
Values 65 61
[28]
liver UGP2
Mean 178
Standard deviation 1.6e+02
Values 4.1e+02 85 1.3e+02 89
[29]
ref_hepatocyte UGT2B7
Mean 122
Standard deviation 1.9e+02
Values 3.3 8.1 5.3 1.6e+02 4.3e+02
[30]
HepG2 UGT2B7
Mean 26.6
Standard deviation 9
Values 33 20
[31]
HepG2.C3A UGT2B7
Mean 26.2
Standard deviation 13
Values 17 35
[32]
HuH.7 UGT2B7
Mean 0.568
Standard deviation 0.44
Values 0.3 1.1 0.34
[33]
SNU475 UGT2B7
Mean 0.0439
Standard deviation 0.0096
Values 0.037 0.051
[34]
THLE UGT2B7
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[35]
liver UGT2B7
Mean 121
Standard deviation 61
Values 1.7e+02 77 1.7e+02 61
[36]
ref_hepatocyte UGT2B10
Mean 89.2
Standard deviation 1.3e+02
Values 13 1.3 2.6 1.2e+02 3.1e+02
[37]
HepG2 UGT2B10
Mean 14.5
Standard deviation 5.1
Values 11 18
[38]
HepG2.C3A UGT2B10
Mean 79.3
Standard deviation 33
Values 56 1e+02
[39]
HuH.7 UGT2B10
Mean 0.379
Standard deviation 0.38
Values 0.098 0.82 0.22
[40]
SNU475 UGT2B10
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[41]
THLE UGT2B10
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[42]
liver UGT2B10
Mean 41.7
Standard deviation 22
Values 16 68 33 50
[43]
ref_hepatocyte UGT2B15
Mean 72.3
Standard deviation 99
Values 0.2 13 3.3 1.2e+02 2.3e+02
[44]
HepG2 UGT2B15
Mean 0.0487
Standard deviation 0.004
Values 0.046 0.051
[45]
HepG2.C3A UGT2B15
Mean 0.127
Standard deviation 0.013
Values 0.14 0.12
[46]
HuH.7 UGT2B15
Mean 0.2
Standard deviation 0.22
Values 0.066 0.45 0.084
[47]
SNU475 UGT2B15
Mean 0.0285
Standard deviation 0.019
Values 0.042 0.015
[48]
THLE UGT2B15
Mean 0.0219
Standard deviation 0.014
Values 0.012 0.032
[49]
liver UGT2B15
Mean 52
Standard deviation 21
Values 66 56 64 21
[50]
ref_hepatocyte UGT1A1
Mean 67.2
Standard deviation 89
Values 0.52 12 15 2.1e+02 96
[51]
HepG2 UGT1A1
Mean 1.8
Standard deviation 0.2
Values 1.9 1.7
[52]
HepG2.C3A UGT1A1
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[53]
HuH.7 UGT1A1
Mean 0.72
Standard deviation 0.5
Values 0.57 1.3 0.31
[54]
SNU475 UGT1A1
Mean 24.4
Standard deviation 21
Values 39 9.8
[55]
THLE UGT1A1
Mean 0.0266
Standard deviation 0.038
Values 0 0.053
[56]
liver UGT1A1
Mean 92.4
Standard deviation 46
Values 1.1e+02 83 1.4e+02 34
[57]
ref_hepatocyte UGT1A4
Mean 53.1
Standard deviation 73
Values 0 4.2 2.5 99 1.6e+02
[58]
HepG2 UGT1A4
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[59]
HepG2.C3A UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 UGT1A4
Mean 0.00954
Standard deviation 0.0096
Values 0 0.019 0.0094
[61]
SNU475 UGT1A4
Mean 0.031
Standard deviation 0.015
Values 0.042 0.02
[62]
THLE UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[63]
liver UGT1A4
Mean 83.1
Standard deviation 65
Values 36 95 1.7e+02 32
[64]
ref_hepatocyte UGT1A9
Mean 15.2
Standard deviation 13
Values 0 21 2.6 26 27
[65]
HepG2 UGT1A9
Mean 0.16
Standard deviation 0.057
Values 0.2 0.12
[66]
HepG2.C3A UGT1A9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[67]
HuH.7 UGT1A9
Mean 0.0656
Standard deviation 0.056
Values 0.066 0.12 0.0094
[68]
SNU475 UGT1A9
Mean 0.273
Standard deviation 0.34
Values 0.51 0.03
[69]
THLE UGT1A9
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[70]
liver UGT1A9
Mean 13.9
Standard deviation 9.6
Values 8.7 22 22 3
[71]
ref_hepatocyte UGT2B17
Mean 10.8
Standard deviation 16
Values 0 1.3 1.3 15 37
[72]
HepG2 UGT2B17
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[73]
HepG2.C3A UGT2B17
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[74]
HuH.7 UGT2B17
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[75]
SNU475 UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[76]
THLE UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[77]
liver UGT2B17
Mean 6
Standard deviation 4.8
Values 3.7 8.6 11 0.5
[78]
ref_hepatocyte SLC35D1
Mean 8.48
Standard deviation 5.2
Values 14 5.1 2.5 6.8 14
[79]
HepG2 SLC35D1
Mean 29.7
Standard deviation 14
Values 20 40
[80]
HepG2.C3A SLC35D1
Mean 33
Standard deviation 8.8
Values 27 39
[81]
HuH.7 SLC35D1
Mean 36.2
Standard deviation 6.9
Values 44 30 35
[82]
SNU475 SLC35D1
Mean 8.66
Standard deviation 1.5
Values 9.7 7.6
[83]
THLE SLC35D1
Mean 14.9
Standard deviation 3.7
Values 12 17
[84]
liver SLC35D1
Mean 93.9
Standard deviation 31
Values 69 1e+02 69 1.3e+02
[85]
ref_hepatocyte UGT2A3
Mean 7.91
Standard deviation 6.4
Values 18 5.7 0.33 9.3 6.3
[86]
HepG2 UGT2A3
Mean 42.4
Standard deviation 14
Values 33 52
[87]
HepG2.C3A UGT2A3
Mean 137
Standard deviation 28
Values 1.2e+02 1.6e+02
[88]
HuH.7 UGT2A3
Mean 0.775
Standard deviation 0.72
Values 0.33 1.6 0.39
[89]
SNU475 UGT2A3
Mean 0.11
Standard deviation 0.13
Values 0.2 0.02
[90]
THLE UGT2A3
Mean 0.0172
Standard deviation 0.0092
Values 0.024 0.011
[91]
liver UGT2A3
Mean 31.9
Standard deviation 15
Values 55 24 25 24
[92]
ref_hepatocyte ABHD10
Mean 6.69
Standard deviation 2.6
Values 6.9 7.7 2.9 5.7 10
[93]
HepG2 ABHD10
Mean 12.4
Standard deviation 3.9
Values 9.6 15
[94]
HepG2.C3A ABHD10
Mean 18.9
Standard deviation 5.6
Values 15 23
[95]
HuH.7 ABHD10
Mean 23.2
Standard deviation 5.6
Values 27 17 26
[96]
SNU475 ABHD10
Mean 12.9
Standard deviation 2.5
Values 15 11
[97]
THLE ABHD10
Mean 17.9
Standard deviation 1.5
Values 17 19
[98]
liver ABHD10
Mean 14.4
Standard deviation 6.6
Values 18 12 21 6.5
[99]
ref_hepatocyte UGT3A1
Mean 6.65
Standard deviation 8.4
Values 0.16 0.89 0.52 16 16
[100]
HepG2 UGT3A1
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A UGT3A1
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[102]
HuH.7 UGT3A1
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 UGT3A1
Mean 0
Standard deviation 0
Values 0 0
[104]
THLE UGT3A1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[105]
liver UGT3A1
Mean 33
Standard deviation 5.7
Values 36 25 36 34
[106]
ref_hepatocyte UGT1A3
Mean 4.24
Standard deviation 4.8
Values 0 2.3 0.37 7.9 11
[107]
HepG2 UGT1A3
Mean 1.2
Standard deviation 0.2
Values 1.3 1.1
[108]
HepG2.C3A UGT1A3
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 UGT1A3
Mean 0.0101
Standard deviation 0.0024
Values 0.0082 0.013 0.0094
[110]
SNU475 UGT1A3
Mean 0.0911
Standard deviation 0.029
Values 0.11 0.071
[111]
THLE UGT1A3
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[112]
liver UGT1A3
Mean 14.2
Standard deviation 12
Values 2.5 21 28 5.8
[113]
ref_hepatocyte UGT2A2
Mean 0.438
Standard deviation 0.59
Values 0 0.18 0 0.6 1.4
[114]
HepG2 UGT2A2
Missing
[115]
HepG2.C3A UGT2A2
Missing
[116]
HuH.7 UGT2A2
Missing
[117]
SNU475 UGT2A2
Missing
[118]
THLE UGT2A2
Missing
[119]
liver UGT2A2
Missing
[120]
ref_hepatocyte UGT1A5
Mean 0.393
Standard deviation 0.32
Values 0 0.38 0.19 0.82 0.58
[121]
HepG2 UGT1A5
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[122]
HepG2.C3A UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 UGT1A5
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[124]
SNU475 UGT1A5
Mean 0.0747
Standard deviation 0.012
Values 0.083 0.066
[125]
THLE UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[126]
liver UGT1A5
Mean 1.38
Standard deviation 1.4
Values 0.31 3.4 0.98 0.85
[127]
ref_hepatocyte UGT2B11
Mean 0.391
Standard deviation 0.65
Values 0 0 0 1.5 0.46
[128]
HepG2 UGT2B11
Mean 1
Standard deviation 0.2
Values 0.86 1.1
[129]
HepG2.C3A UGT2B11
Mean 0.348
Standard deviation 0.19
Values 0.21 0.48
[130]
HuH.7 UGT2B11
Mean 0.795
Standard deviation 0.79
Values 0.31 1.7 0.37
[131]
SNU475 UGT2B11
Mean 0.00928
Standard deviation 0.013
Values 0.019 0
[132]
THLE UGT2B11
Mean 0
Standard deviation 0
Values 0 0
[133]
liver UGT2B11
Mean 0.98
Standard deviation 0.68
Values 2 0.59 0.49 0.87
[134]
ref_hepatocyte UGT2B28
Mean 0.294
Standard deviation 0.52
Values 0 0 0 0.28 1.2
[135]
HepG2 UGT2B28
Mean 0.642
Standard deviation 0.23
Values 0.81 0.48
[136]
HepG2.C3A UGT2B28
Mean 0.816
Standard deviation 0.45
Values 0.5 1.1
[137]
HuH.7 UGT2B28
Mean 0.0413
Standard deviation 0.043
Values 0.025 0.09 0.0094
[138]
SNU475 UGT2B28
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[139]
THLE UGT2B28
Mean 0
Standard deviation 0
Values 0 0
[140]
liver UGT2B28
Mean 0.714
Standard deviation 0.87
Values 0 1.1 1.8 0.013
[141]
ref_hepatocyte UGT3A2
Mean 0.276
Standard deviation 0.2
Values 0 0.15 0.52 0.31 0.39
[142]
HepG2 UGT3A2
Mean 0.0229
Standard deviation 0.0081
Values 0.029 0.017
[143]
HepG2.C3A UGT3A2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 UGT3A2
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 UGT3A2
Mean 0.0222
Standard deviation 0.012
Values 0.014 0.03
[146]
THLE UGT3A2
Mean 0.0828
Standard deviation 0.042
Values 0.11 0.053
[147]
liver UGT3A2
Mean 0.191
Standard deviation 0.21
Values 0.49 0.1 0.026 0.15
[148]
ref_hepatocyte UGT1A7
Mean 0.0431
Standard deviation 0.096
Values 0 0 0 0.22 0
[149]
HepG2 UGT1A7
Mean 0.0537
Standard deviation 0.021
Values 0.069 0.039
[150]
HepG2.C3A UGT1A7
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 UGT1A7
Mean 0.0277
Standard deviation 0.011
Values 0.016 0.039 0.028
[152]
SNU475 UGT1A7
Mean 2.06
Standard deviation 1.2
Values 1.2 2.9
[153]
THLE UGT1A7
Mean 0.0556
Standard deviation 0.012
Values 0.047 0.064
[154]
liver UGT1A7
Mean 0.582
Standard deviation 0.83
Values 0.094 1.8 0.1 0.32
[155]
ref_hepatocyte UGT1A10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 UGT1A10
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[157]
HepG2.C3A UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 UGT1A10
Mean 0.115
Standard deviation 0.078
Values 0.066 0.21 0.075
[159]
SNU475 UGT1A10
Mean 0.012
Standard deviation 0.0027
Values 0.014 0.01
[160]
THLE UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[161]
liver UGT1A10
Mean 0.0104
Standard deviation 0.014
Values 0 0.029 0 0.013
[162]
ref_hepatocyte UGT1A8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[164]
HepG2.C3A UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 UGT1A8
Mean 0.0407
Standard deviation 0.027
Values 0.033 0.071 0.019
[166]
SNU475 UGT1A8
Mean 0.152
Standard deviation 0.028
Values 0.17 0.13
[167]
THLE UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[168]
liver UGT1A8
Mean 0.0104
Standard deviation 0.014
Values 0 0.029 0 0.013
[169]
ref_hepatocyte UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 UGT2A1
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[171]
HepG2.C3A UGT2A1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[172]
HuH.7 UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 UGT2A1
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[174]
THLE UGT2A1
Mean 0
Standard deviation 0
Values 0 0
[175]
liver UGT2A1
Mean 0.00999
Standard deviation 0.012
Values 0 0.014 0.026 0