REACTOME_GLUCOCORTICOID_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SERPINA6 Corticosteroid-binding globulin [1] 0.75[2] 0.79[3] 0.72[4] -3.43[5] -7.26[6] -0.25[7]
2 HSD11B1 Corticosteroid 11-beta-dehydrogenase isozyme 1 [8] -10.27[9] -11.01[10] -11.55[11] -0.36[12] 1.20[13] 0.25[14]
3 CYP21A2 Steroid 21-hydroxylase [15] -2.33[16] -1.28[17] -4.00[18] 4.78[19] -4.99[20] 0.23[21]
4 POMC Pro-opiomelanocortin [22] [23] -5.71[24] [25] [26] -2.56[27] -1.68[28]
5 HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 [29] 5.74[30] 4.89[31] 5.71[32] 6.74[33] -0.07[34] 1.15[35]
6 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase [36] 0.79[37] 3.96[38] 2.18[39] 3.27[40] -1.14[41] 2.15[42]
7 HSD3B1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 [43] -1.58[44] -3.11[45] 5.60[46] [47] 1.53[48] -2.43[49]
8 HSD3B2 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 [50] -0.04[51] [52] 3.47[53] [54] 2.32[55] 1.29[56]
9 CYP11B2 Cytochrome P450 11B2, mitochondrial [57] [58] [59] [60] [61] [62] [63]
10 CYP11B1 Cytochrome P450 11B1, mitochondrial [64] [65] [66] [67] [68] [69] [70]
[1]
ref_hepatocyte SERPINA6
Mean 169
Standard deviation 2e+02
Values 52 3 25 3.1e+02 4.6e+02
[2]
HepG2 SERPINA6
Mean 54.4
Standard deviation 9.4
Values 48 61
[3]
HepG2.C3A SERPINA6
Mean 91.4
Standard deviation 7
Values 96 86
[4]
HuH.7 SERPINA6
Mean 26.6
Standard deviation 1.4
Values 25 27 28
[5]
SNU475 SERPINA6
Mean 0.0559
Standard deviation 0.0069
Values 0.051 0.061
[6]
THLE SERPINA6
Mean 0.0964
Standard deviation 0.031
Values 0.12 0.074
[7]
liver SERPINA6
Mean 143
Standard deviation 92
Values 2.2e+02 81 2.2e+02 47
[8]
ref_hepatocyte HSD11B1
Mean 134
Standard deviation 1.2e+02
Values 0 27 1.4e+02 2.2e+02 2.9e+02
[9]
HepG2 HSD11B1
Mean 0.0208
Standard deviation 0.011
Values 0.029 0.013
[10]
HepG2.C3A HSD11B1
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[11]
HuH.7 HSD11B1
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[12]
SNU475 HSD11B1
Mean 0.372
Standard deviation 0.36
Values 0.12 0.62
[13]
THLE HSD11B1
Mean 27
Standard deviation 6.9
Values 32 22
[14]
liver HSD11B1
Mean 160
Standard deviation 98
Values 2.4e+02 1e+02 2.4e+02 51
[15]
ref_hepatocyte CYP21A2
Mean 5.14
Standard deviation 5.5
Values 0.5 0.83 2.4 13 9.3
[16]
HepG2 CYP21A2
Mean 0.195
Standard deviation 0.0088
Values 0.19 0.2
[17]
HepG2.C3A CYP21A2
Mean 0.66
Standard deviation 0.51
Values 1 0.3
[18]
HuH.7 CYP21A2
Mean 0.0306
Standard deviation 0.027
Values 0 0.045 0.047
[19]
SNU475 CYP21A2
Mean 0.502
Standard deviation 0.11
Values 0.43 0.58
[20]
THLE CYP21A2
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[21]
liver CYP21A2
Mean 6.05
Standard deviation 3.4
Values 2 6 10 5.9
[22]
ref_hepatocyte POMC
Mean 0.898
Standard deviation 0.87
Values 0 1.1 0 1.4 2
[23]
HepG2 POMC
Mean 0
Standard deviation 0
Values 0 0
[24]
HepG2.C3A POMC
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[25]
HuH.7 POMC
Mean 0
Standard deviation 0
Values 0 0 0
[26]
SNU475 POMC
Mean 0
Standard deviation 0
Values 0 0
[27]
THLE POMC
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[28]
liver POMC
Mean 0.28
Standard deviation 0.16
Values 0.35 0.17 0.46 0.13
[29]
ref_hepatocyte HSD11B2
Mean 0.44
Standard deviation 0.31
Values 0.31 0 0.47 0.6 0.81
[30]
HepG2 HSD11B2
Mean 4.48
Standard deviation 0.0009
Values 4.5 4.5
[31]
HepG2.C3A HSD11B2
Mean 4.1
Standard deviation 0.84
Values 4.7 3.5
[32]
HuH.7 HSD11B2
Mean 2.2
Standard deviation 1.5
Values 2.8 0.48 3.3
[33]
SNU475 HSD11B2
Mean 0.167
Standard deviation 0.079
Values 0.22 0.11
[34]
THLE HSD11B2
Mean 0.0367
Standard deviation 0.0067
Values 0.041 0.032
[35]
liver HSD11B2
Mean 0.978
Standard deviation 0.63
Values 1.6 0.3 0.59 1.5
[36]
ref_hepatocyte CYP17A1
Mean 0.208
Standard deviation 0.25
Values 0 0 0.31 0.6 0.13
[37]
HepG2 CYP17A1
Mean 0.0687
Standard deviation 0.024
Values 0.086 0.051
[38]
HepG2.C3A CYP17A1
Mean 1.01
Standard deviation 0.19
Values 1.1 0.88
[39]
HuH.7 CYP17A1
Mean 0.0898
Standard deviation 0.047
Values 0.041 0.13 0.094
[40]
SNU475 CYP17A1
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[41]
THLE CYP17A1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[42]
liver CYP17A1
Mean 0.926
Standard deviation 1.4
Values 2.9 0.057 0.21 0.5
[43]
ref_hepatocyte HSD3B1
Mean 0.134
Standard deviation 0.3
Values 0 0 0 0.67 0
[44]
HepG2 HSD3B1
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[45]
HepG2.C3A HSD3B1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[46]
HuH.7 HSD3B1
Mean 0.62
Standard deviation 0.19
Values 0.68 0.41 0.77
[47]
SNU475 HSD3B1
Mean 0
Standard deviation 0
Values 0 0
[48]
THLE HSD3B1
Mean 0.034
Standard deviation 0.01
Values 0.041 0.027
[49]
liver HSD3B1
Mean 0.025
Standard deviation 0.029
Values 0.047 0 0 0.053
[50]
ref_hepatocyte HSD3B2
Mean 0.031
Standard deviation 0.065
Values 0 0 0 0.0086 0.15
[51]
HepG2 HSD3B2
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[52]
HepG2.C3A HSD3B2
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 HSD3B2
Mean 0.0327
Standard deviation 0.028
Values 0.025 0.064 0.0094
[54]
SNU475 HSD3B2
Mean 0
Standard deviation 0
Values 0 0
[55]
THLE HSD3B2
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[56]
liver HSD3B2
Mean 0.0756
Standard deviation 0.044
Values 0.14 0.057 0.051 0.053
[57]
ref_hepatocyte CYP11B2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[58]
HepG2 CYP11B2
Missing
[59]
HepG2.C3A CYP11B2
Missing
[60]
HuH.7 CYP11B2
Missing
[61]
SNU475 CYP11B2
Missing
[62]
THLE CYP11B2
Missing
[63]
liver CYP11B2
Missing
[64]
ref_hepatocyte CYP11B1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[65]
HepG2 CYP11B1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[66]
HepG2.C3A CYP11B1
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 CYP11B1
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 CYP11B1
Mean 0
Standard deviation 0
Values 0 0
[69]
THLE CYP11B1
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[70]
liver CYP11B1
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013