REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 0.37[1] | 0.43[2] | 0.13[3] | 0.44[4] | -0.13[5] | -0.92[6] | |
2 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -1.27[7] | -1.06[8] | -1.88[9] | -2.22[10] | -2.28[11] | -1.17[12] | |
3 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | [13] | 0.01[14] | 0.16[15] | 0.36[16] | -0.50[17] | -0.40[18] | 1.01[19] |
4 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | [20] | 0.95[21] | 0.99[22] | 0.56[23] | 0.88[24] | 0.87[25] | -0.82[26] |
5 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | [27] | -0.66[28] | -0.89[29] | -0.51[30] | -0.77[31] | -0.52[32] | -1.19[33] |
6 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -4.76[34] | -4.45[35] | -4.71[36] | -4.22[37] | -3.20[38] | -3.93[39] | |
7 | GNG12 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | -4.81[40] | -7.72[41] | 0.28[42] | 1.47[43] | 1.77[44] | 0.90[45] | |
8 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [46] | -0.23[47] | -0.38[48] | -0.33[49] | -0.88[50] | -0.09[51] | -0.37[52] |
9 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | [53] | -0.01[54] | -0.30[55] | 0.85[56] | -0.69[57] | -0.64[58] | 0.56[59] |
10 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | [60] | 0.91[61] | 0.39[62] | -1.35[63] | -4.51[64] | -1.51[65] | 0.24[66] |
11 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [67] | -0.89[68] | -0.09[69] | 1.24[70] | 1.83[71] | 0.88[72] | 2.13[73] |
12 | ADCY9 | Adenylate cyclase type 9 | [74] | 2.56[75] | 1.77[76] | 2.24[77] | 0.55[78] | 0.29[79] | 2.83[80] |
13 | ADCY6 | Adenylate cyclase type 6 | [81] | 1.99[82] | 2.48[83] | 2.49[84] | 2.10[85] | 2.97[86] | 3.05[87] |
14 | GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | -8.24[88] | -8.22[89] | -7.48[90] | 1.86[91] | 3.37[92] | 2.65[93] | |
15 | GNG7 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | 1.49[94] | 1.17[95] | 2.02[96] | -2.64[97] | -1.82[98] | 0.44[99] | |
16 | ADCY1 | Adenylate cyclase type 1 | [100] | -0.90[101] | -2.74[102] | -2.89[103] | -2.52[104] | -2.33[105] | 5.41[106] |
17 | GNG4 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | 3.41[107] | 1.20[108] | 5.05[109] | 0.85[110] | -1.07[111] | -2.13[112] | |
18 | ADCY7 | Adenylate cyclase type 7 | [113] | 3.45[114] | 3.10[115] | 2.10[116] | 2.90[117] | 2.57[118] | 3.34[119] |
19 | GNB4 | Guanine nucleotide-binding protein subunit beta-4 | [120] | -0.43[121] | 0.09[122] | 1.14[123] | 2.27[124] | 5.21[125] | 4.51[126] |
20 | GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | -6.34[127] | -7.19[128] | [129] | 2.71[130] | 2.38[131] | 3.19[132] | |
21 | GNG3 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | -0.92[133] | 0.94[134] | -1.24[135] | -1.11[136] | -1.22[137] | 0.33[138] | |
22 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | [139] | -2.40[140] | -0.55[141] | 3.78[142] | 4.68[143] | 3.39[144] | 3.73[145] |
23 | ADCY3 | Adenylate cyclase type 3 | [146] | 1.40[147] | 0.18[148] | 3.55[149] | 4.33[150] | 6.06[151] | 3.93[152] |
24 | ADCY2 | Adenylate cyclase type 2 | [153] | -5.44[154] | -3.49[155] | -4.69[156] | -3.14[157] | -4.06[158] | -3.70[159] |
25 | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | [160] | 1.53[161] | 3.81[162] | 3.15[163] | 0.60[164] | 3.51[165] | -1.26[166] |
26 | ADCY5 | Adenylate cyclase type 5 | [167] | 0.09[168] | 1.11[169] | 2.19[170] | 0.24[171] | 1.56[172] | 6.79[173] |
27 | CYSLTR2 | Cysteinyl leukotriene receptor 2 | [174] | [175] | -1.43[176] | [177] | -2.64[178] | -1.39[179] | 2.86[180] |
28 | ADCY4 | Adenylate cyclase type 4 | [181] | 0.03[182] | -1.02[183] | 1.67[184] | [185] | [186] | 8.78[187] |
29 | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | [188] | [189] | [190] | [191] | [192] | [193] | |
30 | ADCY8 | Adenylate cyclase type 8 | [194] | [195] | [196] | [197] | [198] | [199] | [200] |
31 | GNG8 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 | [201] | [202] | [203] | [204] | [205] | [206] | |
32 | GCG | Glucagon | [207] | [208] | [209] | [210] | [211] | [212] | [213] |
33 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [214] | [215] | [216] | [217] | [218] | [219] | [220] |