REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 0.15[1] | 0.28[2] | 0.05[3] | 0.29[4] | -0.38[5] | -1.23[6] | |
2 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -1.48[7] | -1.22[8] | -1.96[9] | -2.36[10] | -2.53[11] | -1.48[12] | |
3 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | [13] | -0.20[14] | 0.01[15] | 0.28[16] | -0.64[17] | -0.65[18] | 0.70[19] |
4 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | [20] | 0.74[21] | 0.84[22] | 0.48[23] | 0.73[24] | 0.62[25] | -1.12[26] |
5 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | [27] | -0.88[28] | -1.04[29] | -0.58[30] | -0.92[31] | -0.77[32] | -1.49[33] |
6 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -4.98[34] | -4.60[35] | -4.78[36] | -4.36[37] | -3.45[38] | -4.23[39] | |
7 | RAP1A | Ras-related protein Rap-1A | [40] | -1.32[41] | -1.30[42] | -0.34[43] | -0.77[44] | -0.91[45] | -1.18[46] |
8 | GNG12 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | -5.03[47] | -7.87[48] | 0.20[49] | 1.33[50] | 1.52[51] | 0.59[52] | |
9 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [53] | -0.44[54] | -0.53[55] | -0.41[56] | -1.02[57] | -0.34[58] | -0.67[59] |
10 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | [60] | -0.22[61] | -0.45[62] | 0.78[63] | -0.84[64] | -0.89[65] | 0.26[66] |
11 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | [67] | 0.70[68] | 0.24[69] | -1.43[70] | -4.65[71] | -1.76[72] | -0.06[73] |
12 | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 | [74] | 0.64[75] | 2.18[76] | 0.76[77] | -0.55[78] | -0.32[79] | 3.98[80] |
13 | GNB5 | Guanine nucleotide-binding protein subunit beta-5 | [81] | -0.18[82] | -0.05[83] | 1.09[84] | 0.24[85] | 0.45[86] | 1.00[87] |
14 | IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | [88] | 1.58[89] | 1.21[90] | 1.75[91] | 3.42[92] | 3.35[93] | 2.14[94] |
15 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [95] | -1.11[96] | -0.25[97] | 1.16[98] | 1.68[99] | 0.63[100] | 1.82[101] |
16 | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 | [102] | 5.02[103] | 3.95[104] | 2.56[105] | 1.80[106] | 4.06[107] | 0.34[108] |
17 | ADCY6 | Adenylate cyclase type 6 | [109] | 1.77[110] | 2.32[111] | 2.41[112] | 1.95[113] | 2.72[114] | 2.75[115] |
18 | GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | -8.46[116] | -8.37[117] | -7.56[118] | 1.71[119] | 3.12[120] | 2.35[121] | |
19 | RAPGEF4 | Rap guanine nucleotide exchange factor 4 | [122] | -4.29[123] | -2.41[124] | -1.37[125] | -2.22[126] | 0.28[127] | 3.01[128] |
20 | GNG7 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | 1.28[129] | 1.02[130] | 1.94[131] | -2.79[132] | -2.07[133] | 0.13[134] | |
21 | KCNS3 | Potassium voltage-gated channel subfamily S member 3 | [135] | -4.76[136] | [137] | -5.94[138] | -2.90[139] | -1.68[140] | 0.67[141] |
22 | GNG4 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | 3.19[142] | 1.05[143] | 4.97[144] | 0.70[145] | -1.32[146] | -2.44[147] | |
23 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | [148] | 2.86[149] | 2.83[150] | 4.11[151] | 2.30[152] | 3.26[153] | 4.76[154] |
24 | GNB4 | Guanine nucleotide-binding protein subunit beta-4 | [155] | -0.64[156] | -0.06[157] | 1.06[158] | 2.13[159] | 4.96[160] | 4.20[161] |
25 | GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | -6.55[162] | -7.35[163] | [164] | 2.56[165] | 2.13[166] | 2.89[167] | |
26 | AKAP5 | A-kinase anchor protein 5 | [168] | 0.81[169] | 1.34[170] | 1.74[171] | 3.57[172] | 2.02[173] | 2.31[174] |
27 | GNGT2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 | [175] | [176] | [177] | -2.62[178] | -7.20[179] | 0.22[180] | |
28 | GNG3 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | -1.13[181] | 0.79[182] | -1.32[183] | -1.25[184] | -1.48[185] | 0.03[186] | |
29 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | [187] | -2.61[188] | -0.70[189] | 3.70[190] | 4.53[191] | 3.14[192] | 3.42[193] |
30 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 | [194] | 1.55[195] | 1.31[196] | 0.87[197] | 1.33[198] | 0.07[199] | 3.92[200] |
31 | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | [201] | 1.31[202] | 3.65[203] | 3.07[204] | 0.45[205] | 3.26[206] | -1.57[207] |
32 | KCNB1 | Potassium voltage-gated channel subfamily B member 1 | [208] | [209] | [210] | -0.81[211] | -3.77[212] | -1.62[213] | 6.32[214] |
33 | ADCY5 | Adenylate cyclase type 5 | [215] | -0.12[216] | 0.96[217] | 2.11[218] | 0.10[219] | 1.31[220] | 6.48[221] |
34 | KCNG2 | Potassium voltage-gated channel subfamily G member 2 | [222] | [223] | [224] | [225] | [226] | [227] | [228] |
35 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [229] | [230] | [231] | [232] | [233] | [234] | [235] |
36 | GCG | Glucagon | [236] | [237] | [238] | [239] | [240] | [241] | [242] |
37 | GNG8 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 | [243] | [244] | [245] | [246] | [247] | [248] | |
38 | KCNC2 | Potassium voltage-gated channel subfamily C member 2 | [249] | [250] | [251] | [252] | [253] | [254] | [255] |
39 | ADCY8 | Adenylate cyclase type 8 | [256] | [257] | [258] | [259] | [260] | [261] | [262] |
40 | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | [263] | [264] | [265] | [266] | [267] | [268] | |
41 | GNGT1 | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | [269] | [270] | [271] | [272] | [273] | [274] | [275] |
42 | GLP1R | Glucagon-like peptide 1 receptor | [276] | [277] | [278] | [279] | [280] | [281] | [282] |