REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
VASP |
Vasodilator-stimulated phosphoprotein |
[1] |
-0.16[2] |
0.20[3] |
0.00[4] |
-0.23[5] |
-0.66[6] |
-2.52[7] |
2 |
HLA-DRA |
HLA class II histocompatibility antigen, DR alpha chain |
[8] |
-13.29[9] |
[10] |
-14.10[11] |
-5.75[12] |
-7.23[13] |
-0.17[14] |
3 |
HLA-DRB1 |
HLA class II histocompatibility antigen, DRB1-15 beta chain |
[15] |
-8.46[16] |
[17] |
[18] |
-6.11[19] |
-10.73[20] |
-1.26[21] |
4 |
CD4 |
T-cell surface glycoprotein CD4 |
[22] |
-5.77[23] |
-2.84[24] |
-6.03[25] |
-7.45[26] |
-9.06[27] |
0.32[28] |
5 |
EVL |
Ena/VASP-like protein |
[29] |
-1.21[30] |
-4.96[31] |
-2.09[32] |
-1.07[33] |
-1.65[34] |
-0.52[35] |
6 |
NCK1 |
Cytoplasmic protein NCK1 |
[36] |
-1.62[37] |
-0.76[38] |
-1.21[39] |
-0.56[40] |
-0.01[41] |
-0.07[42] |
7 |
PAK2 |
Serine/threonine-protein kinase PAK 2 |
[43] |
1.43[44] |
1.92[45] |
1.66[46] |
0.75[47] |
1.74[48] |
1.76[49] |
8 |
HLA-DPA1 |
HLA class II histocompatibility antigen, DP alpha 1 chain |
[50] |
-6.96[51] |
-9.71[52] |
[53] |
-5.10[54] |
-6.51[55] |
0.12[56] |
9 |
HLA-DRB5 |
HLA class II histocompatibility antigen, DR beta 5 chain |
[57] |
-11.11[58] |
[59] |
[60] |
-8.36[61] |
[62] |
-5.45[63] |
10 |
ENAH |
Protein enabled homolog |
[64] |
3.51[65] |
2.14[66] |
3.68[67] |
4.08[68] |
3.57[69] |
1.00[70] |
11 |
PLCG1 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-1 |
3.47[71] |
3.84[72] |
2.62[73] |
2.82[74] |
2.76[75] |
0.74[76] |
12 |
HLA-DPB1 |
HLA class II histocompatibility antigen, DP beta 1 chain |
[77] |
-9.06[78] |
-9.38[79] |
[80] |
-3.94[81] |
-1.50[82] |
0.91[83] |
13 |
PAK1 |
Serine/threonine-protein kinase PAK 1 |
[84] |
-0.03[85] |
-0.04[86] |
1.81[87] |
-1.86[88] |
2.37[89] |
0.67[90] |
14 |
HLA-DQA1 |
HLA class II histocompatibility antigen, DQ alpha 1 chain |
[91] |
[92] |
[93] |
[94] |
-6.78[95] |
-9.97[96] |
-0.47[97] |
15 |
HLA-DQB1 |
HLA class II histocompatibility antigen, DQ beta 1 chain |
[98] |
-4.97[99] |
[100] |
[101] |
-3.79[102] |
[103] |
-0.56[104] |
16 |
HLA-DQA2 |
HLA class II histocompatibility antigen, DQ alpha 2 chain |
[105] |
[106] |
[107] |
[108] |
-8.73[109] |
[110] |
-3.08[111] |
17 |
PLCG2 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-2 |
-1.30[112] |
-6.30[113] |
0.60[114] |
-2.73[115] |
-1.14[116] |
3.12[117] |
18 |
WAS |
Wiskott-Aldrich syndrome protein |
[118] |
-5.74[119] |
-4.44[120] |
-1.55[121] |
-3.51[122] |
-4.11[123] |
-0.01[124] |
19 |
LCP2 |
Lymphocyte cytosolic protein 2 |
[125] |
[126] |
[127] |
[128] |
-3.71[129] |
[130] |
1.55[131] |
20 |
LAT |
Linker for activation of T-cells family member 1 |
[132] |
-1.47[133] |
0.82[134] |
-1.33[135] |
-1.36[136] |
-0.34[137] |
-0.02[138] |
21 |
CD3E |
T-cell surface glycoprotein CD3 epsilon chain |
[139] |
-8.88[140] |
[141] |
-5.21[142] |
[143] |
[144] |
-0.21[145] |
22 |
CD247 |
T-cell surface glycoprotein CD3 zeta chain |
[146] |
-4.89[147] |
-4.81[148] |
-6.87[149] |
-3.51[150] |
-4.45[151] |
0.38[152] |
23 |
CD3D |
T-cell surface glycoprotein CD3 delta chain |
[153] |
1.38[154] |
0.12[155] |
-2.81[156] |
-6.50[157] |
-4.06[158] |
0.07[159] |
24 |
LCK |
Tyrosine-protein kinase Lck |
[160] |
2.76[161] |
3.59[162] |
-6.96[163] |
-5.08[164] |
-4.84[165] |
1.63[166] |
25 |
CD3G |
T-cell surface glycoprotein CD3 gamma chain |
[167] |
-3.61[168] |
-2.11[169] |
-3.72[170] |
-4.61[171] |
-3.58[172] |
0.06[173] |
26 |
ZAP70 |
Tyrosine-protein kinase ZAP-70 |
[174] |
0.98[175] |
1.95[176] |
-4.83[177] |
-5.54[178] |
-3.75[179] |
2.56[180] |
27 |
HLA-DQB2 |
HLA class II histocompatibility antigen, DQ beta 2 chain |
[181] |
[182] |
[183] |
[184] |
-3.41[185] |
[186] |
-2.56[187] |
28 |
ITK |
Tyrosine-protein kinase ITK/TSK |
[188] |
-6.92[189] |
-3.19[190] |
[191] |
-0.16[192] |
-4.46[193] |
2.59[194] |
29 |
PAK3 |
Serine/threonine-protein kinase PAK 3 |
[195] |
-6.43[196] |
[197] |
[198] |
-1.60[199] |
0.56[200] |
1.18[201] |
30 |
GRAP2 |
GRB2-related adapter protein 2 |
[202] |
-5.87[203] |
[204] |
-2.06[205] |
-1.98[206] |
-0.49[207] |
1.24[208] |
31 |
CD101 |
Immunoglobulin superfamily member 2 |
[209] |
-1.57[210] |
1.16[211] |
1.27[212] |
0.99[213] |
0.41[214] |
2.78[215] |
32 |
TRAV8-4 |
T-cell receptor alpha variable 8-4 (Fragment) |
[216] |
[217] |
[218] |
[219] |
[220] |
[221] |
[222] |
33 |
TRBV7-9 |
T-cell receptor beta variable 7-9 (Fragment) |
[223] |
[224] |
[225] |
[226] |
[227] |
[228] |
[229] |
34 |
FYB1 |
FYN-binding protein 1 |
[230] |
[231] |
[232] |
[233] |
[234] |
[235] |
[236] |
35 |
TRAV29DV5 |
[237] |
[238] |
[239] |
[240] |
[241] |
[242] |
[243] |
36 |
TRBV12-3 |
T-cell receptor beta chain V region YT35 |
[244] |
[245] |
[246] |
[247] |
[248] |
[249] |
[250] |
37 |
TRAV19 |
T-cell receptor alpha variable 19 (Fragment) |
[251] |
[252] |
[253] |
[254] |
[255] |
[256] |
[257] |
38 |
HLA-DRB3 |
HLA class II histocompatibility antigen, DR beta 3 chain |
[258] |
[259] |
[260] |
[261] |
[262] |
[263] |
[264] |
39 |
HLA-DRB4 |
HLA class II histocompatibility antigen, DR beta 4 chain |
[265] |
[266] |
[267] |
[268] |
[269] |
[270] |
[271] |
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