REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.64[2] 0.31[3] 0.14[4] -0.05[5] 0.07[6] -0.15[7]
2 NRAS GTPase NRas [8] 0.07[9] 0.33[10] 0.46[11] 0.40[12] 0.17[13] -0.70[14]
3 HRAS GTPase HRas [15] -1.56[16] -2.44[17] -3.52[18] -1.55[19] -1.57[20] -3.11[21]
4 MAPK1 Mitogen-activated protein kinase 1 [22] 1.15[23] 1.12[24] 0.66[25] 1.25[26] 1.10[27] 1.33[28]
5 RPS6KA3 Ribosomal protein S6 kinase alpha-3 [29] [30] [31] [32] [33] [34] [35]
6 MMP3 Stromelysin-1 [36] -5.07[37] -10.16[38] -12.82[39] -2.35[40] -5.20[41] -8.77[42]
7 KRAS GTPase KRas [43] -1.07[44] -1.26[45] 0.05[46] 0.20[47] 0.06[48] 0.23[49]
8 SOS1 Son of sevenless homolog 1 [50] -0.66[51] 0.70[52] -0.08[53] 0.24[54] -0.32[55] 0.09[56]
9 EGFR Epidermal growth factor receptor [57] -1.25[58] -1.80[59] 0.79[60] -0.17[61] 0.65[62] 2.20[63]
10 RPS6KA1 Ribosomal protein S6 kinase alpha-1 [64] [65] [66] [67] [68] [69] [70]
11 MAPK3 Mitogen-activated protein kinase 3 [71] 1.29[72] 1.17[73] 0.92[74] -0.18[75] 0.04[76] -1.49[77]
12 PRKCA Protein kinase C alpha type [78] 2.28[79] 2.15[80] 2.22[81] 1.55[82] 2.11[83] 1.47[84]
13 HBEGF Proheparin-binding EGF-like growth factor [85] -1.54[86] -2.53[87] -3.88[88] -0.30[89] -0.41[90] -2.88[91]
14 CREB1 Cyclic AMP-responsive element-binding protein 1 [92] 1.17[93] 2.15[94] 2.35[95] 1.94[96] 2.08[97] 1.89[98]
15 RPS6KA2 Ribosomal protein S6 kinase alpha-2 [99] [100] [101] [102] [103] [104] [105]
16 MAPK7 Mitogen-activated protein kinase 7 [106] 0.88[107] 0.01[108] -0.28[109] 1.20[110] 1.50[111] -0.11[112]
17 GAST Gastrin [113] [114] [115] [116] [117] [118] [119]
18 CCKBR Gastrin/cholecystokinin type B receptor [120] [121] [122] [123] [124] [125] [126]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[9]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[10]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[11]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[12]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[13]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[14]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[15]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[16]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[17]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[18]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[19]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[20]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[21]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[22]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[23]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[24]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[25]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[26]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[27]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[28]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[29]
ref_hepatocyte RPS6KA3
Mean 9.94
Standard deviation 10
Values 28 6.9 4.8 4.1 6.3
[30]
HepG2 RPS6KA3
Missing
[31]
HepG2.C3A RPS6KA3
Missing
[32]
HuH.7 RPS6KA3
Missing
[33]
SNU475 RPS6KA3
Missing
[34]
THLE RPS6KA3
Missing
[35]
liver RPS6KA3
Missing
[36]
ref_hepatocyte MMP3
Mean 9.23
Standard deviation 20
Values 0 0.19 45 1.1 0
[37]
HepG2 MMP3
Mean 0.894
Standard deviation 0.62
Values 1.3 0.46
[38]
HepG2.C3A MMP3
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[39]
HuH.7 MMP3
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[40]
SNU475 MMP3
Mean 5.06
Standard deviation 4.7
Values 1.8 8.4
[41]
THLE MMP3
Mean 0.682
Standard deviation 0.55
Values 0.29 1.1
[42]
liver MMP3
Mean 0.0408
Standard deviation 0.05
Values 0.024 0.11 0.026 0
[43]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[44]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[45]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[46]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[47]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[48]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[49]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[50]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[51]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[52]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[53]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[54]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[55]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[56]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[57]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[58]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[59]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[60]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[61]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[62]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[63]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[64]
ref_hepatocyte RPS6KA1
Mean 4.78
Standard deviation 3.4
Values 10 5.6 3.5 2.9 1.5
[65]
HepG2 RPS6KA1
Missing
[66]
HepG2.C3A RPS6KA1
Missing
[67]
HuH.7 RPS6KA1
Missing
[68]
SNU475 RPS6KA1
Missing
[69]
THLE RPS6KA1
Missing
[70]
liver RPS6KA1
Missing
[71]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[72]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[73]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[74]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[75]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[76]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[77]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[78]
ref_hepatocyte PRKCA
Mean 2.45
Standard deviation 2.1
Values 2.7 6 1.1 1.2 1.2
[79]
HepG2 PRKCA
Mean 38.7
Standard deviation 5.6
Values 35 43
[80]
HepG2.C3A PRKCA
Mean 35.5
Standard deviation 4.5
Values 32 39
[81]
HuH.7 PRKCA
Mean 43.7
Standard deviation 11
Values 54 44 33
[82]
SNU475 PRKCA
Mean 20
Standard deviation 4.3
Values 17 23
[83]
THLE PRKCA
Mean 28.8
Standard deviation 11
Values 21 36
[84]
liver PRKCA
Mean 13.2
Standard deviation 7.1
Values 11 17 4.7 21
[85]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[86]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[87]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[88]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[89]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[90]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[91]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[92]
ref_hepatocyte CREB1
Mean 1.8
Standard deviation 1.2
Values 3.7 2.1 1.5 0.96 0.81
[93]
HepG2 CREB1
Mean 13.1
Standard deviation 2.8
Values 11 15
[94]
HepG2.C3A CREB1
Mean 26.1
Standard deviation 3.2
Values 24 28
[95]
HuH.7 CREB1
Mean 35.1
Standard deviation 4
Values 38 36 31
[96]
SNU475 CREB1
Mean 19.3
Standard deviation 0.081
Values 19 19
[97]
THLE CREB1
Mean 20.8
Standard deviation 2.1
Values 22 19
[98]
liver CREB1
Mean 13
Standard deviation 3.1
Values 12 16 9.3 15
[99]
ref_hepatocyte RPS6KA2
Mean 1.31
Standard deviation 0.89
Values 0 1.8 2.4 1.1 1.3
[100]
HepG2 RPS6KA2
Missing
[101]
HepG2.C3A RPS6KA2
Missing
[102]
HuH.7 RPS6KA2
Missing
[103]
SNU475 RPS6KA2
Missing
[104]
THLE RPS6KA2
Missing
[105]
liver RPS6KA2
Missing
[106]
ref_hepatocyte MAPK7
Mean 1.09
Standard deviation 0.71
Values 1.1 0.26 2.2 1 0.89
[107]
HepG2 MAPK7
Mean 6.54
Standard deviation 1.5
Values 5.4 7.6
[108]
HepG2.C3A MAPK7
Mean 3.58
Standard deviation 0.65
Values 4 3.1
[109]
HuH.7 MAPK7
Mean 3.43
Standard deviation 0.61
Values 4 2.8 3.6
[110]
SNU475 MAPK7
Mean 7.01
Standard deviation 0.043
Values 7 7
[111]
THLE MAPK7
Mean 8.39
Standard deviation 0.71
Values 7.9 8.9
[112]
liver MAPK7
Mean 1.96
Standard deviation 0.9
Values 2.9 0.9 2.4 1.6
[113]
ref_hepatocyte GAST
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 GAST
Mean 0.43
Standard deviation 0.49
Values 0.78 0.082
[115]
HepG2.C3A GAST
Mean 0.0555
Standard deviation 0.018
Values 0.068 0.043
[116]
HuH.7 GAST
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 GAST
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE GAST
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[119]
liver GAST
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte CCKBR
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 CCKBR
Missing
[122]
HepG2.C3A CCKBR
Missing
[123]
HuH.7 CCKBR
Missing
[124]
SNU475 CCKBR
Missing
[125]
THLE CCKBR
Missing
[126]
liver CCKBR
Missing