REACTOME_GAP_FILLING_DNA_REPAIR_SYNTHESIS_AND_LIGATION_IN_GG_NER Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.53[2] -0.80[3] -0.89[4] -0.95[5] -0.64[6] -0.05[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.09[16] -0.05[17] -0.52[18] -0.09[19] -0.26[20] 0.40[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.35[23] 2.19[24] 2.99[25] 1.30[26] 1.96[27] 1.17[28]
5 PCNA Proliferating cell nuclear antigen [29] 2.55[30] 2.47[31] 0.82[32] 1.62[33] 1.74[34] -1.25[35]
6 POLD2 DNA polymerase delta subunit 2 [36] 1.07[37] 1.17[38] 1.45[39] 0.97[40] 1.18[41] 1.70[42]
7 POLD4 DNA polymerase delta subunit 4 [43] -0.46[44] -0.88[45] 0.97[46] 3.28[47] -0.46[48] 1.35[49]
8 POLE3 DNA polymerase epsilon subunit 3 [50] 0.88[51] 0.67[52] 0.73[53] 0.78[54] 1.66[55] 0.25[56]
9 POLE4 DNA polymerase epsilon subunit 4 [57] 0.62[58] 1.29[59] -2.40[60] 0.20[61] -0.42[62] 0.02[63]
10 RPA2 Replication protein A 32 kDa subunit [64] 0.21[65] 0.21[66] 0.54[67] 1.09[68] 1.01[69] -0.57[70]
11 RFC4 Replication factor C subunit 4 [71] 0.70[72] 1.26[73] 1.60[74] 0.86[75] 2.05[76] -0.93[77]
12 RFC1 Replication factor C subunit 1 [78] 1.81[79] 3.03[80] 3.18[81] 2.16[82] 2.84[83] 2.60[84]
13 RFC2 Replication factor C subunit 2 [85] 1.40[86] 1.19[87] 1.00[88] 2.01[89] 2.32[90] 1.05[91]
14 RPA1 Replication protein A 70 kDa DNA-binding subunit [92] 2.98[93] 2.65[94] 2.69[95] 3.68[96] 3.55[97] 1.83[98]
15 RPA3 Replication protein A 14 kDa subunit [99] 1.30[100] 2.03[101] 2.52[102] 0.93[103] 1.06[104] 1.13[105]
16 RFC5 Replication factor C subunit 5 [106] 1.80[107] 2.19[108] 2.15[109] 2.10[110] 2.48[111] 0.95[112]
17 XRCC1 DNA repair protein XRCC1 [113] 2.30[114] 2.42[115] 3.26[116] 2.60[117] 2.43[118] 0.90[119]
18 RFC3 Replication factor C subunit 3 [120] 2.84[121] 3.64[122] 3.54[123] 3.08[124] 3.53[125] 0.95[126]
19 LIG3 DNA ligase 3 [127] 2.84[128] 2.82[129] 3.66[130] 2.91[131] 1.81[132] 2.69[133]
20 LIG1 DNA ligase 1 [134] 3.30[135] 3.25[136] 3.65[137] 2.34[138] 2.93[139] 1.45[140]
21 POLD1 DNA polymerase delta catalytic subunit [141] 3.52[142] 3.68[143] 4.27[144] 3.66[145] 4.26[146] 2.49[147]
22 POLK DNA polymerase kappa [148] 0.82[149] 2.23[150] 2.25[151] 3.66[152] 3.24[153] 3.92[154]
23 POLD3 DNA polymerase delta subunit 3 [155] 2.84[156] 2.65[157] 3.38[158] 3.95[159] 4.28[160] 2.81[161]
24 POLE DNA polymerase epsilon catalytic subunit A [162] 4.71[163] 5.27[164] 5.08[165] 4.57[166] 5.43[167] 4.76[168]
25 POLE2 DNA polymerase epsilon subunit 2 [169] 2.37[170] 3.10[171] 3.85[172] 2.99[173] 3.37[174] 0.67[175]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte PCNA
Mean 36
Standard deviation 33
Values 92 37 14 19 17
[30]
HepG2 PCNA
Mean 147
Standard deviation 54
Values 1.1e+02 1.9e+02
[31]
HepG2.C3A PCNA
Mean 130
Standard deviation 86
Values 69 1.9e+02
[32]
HuH.7 PCNA
Mean 46.8
Standard deviation 33
Values 53 10 76
[33]
SNU475 PCNA
Mean 56.8
Standard deviation 7.7
Values 51 62
[34]
THLE PCNA
Mean 77.4
Standard deviation 13
Values 68 86
[35]
liver PCNA
Mean 6.07
Standard deviation 2.5
Values 7.3 5.2 8.8 3
[36]
ref_hepatocyte POLD2
Mean 32.3
Standard deviation 18
Values 10 23 30 58 40
[37]
HepG2 POLD2
Mean 47
Standard deviation 5.6
Values 51 43
[38]
HepG2.C3A POLD2
Mean 47.2
Standard deviation 5.4
Values 43 51
[39]
HuH.7 POLD2
Mean 64.5
Standard deviation 25
Values 79 36 79
[40]
SNU475 POLD2
Mean 32.5
Standard deviation 4.3
Values 29 35
[41]
THLE POLD2
Mean 47.1
Standard deviation 7.9
Values 41 53
[42]
liver POLD2
Mean 42.1
Standard deviation 24
Values 67 21 57 23
[43]
ref_hepatocyte POLD4
Mean 31.5
Standard deviation 27
Values 1.6 16 19 64 57
[44]
HepG2 POLD4
Mean 15.9
Standard deviation 3.9
Values 19 13
[45]
HepG2.C3A POLD4
Mean 11.1
Standard deviation 4
Values 14 8.3
[46]
HuH.7 POLD4
Mean 45.1
Standard deviation 6.1
Values 39 51 46
[47]
SNU475 POLD4
Mean 157
Standard deviation 53
Values 1.9e+02 1.2e+02
[48]
THLE POLD4
Mean 14.6
Standard deviation 1.8
Values 13 16
[49]
liver POLD4
Mean 32.1
Standard deviation 32
Values 48 6 69 5.3
[50]
ref_hepatocyte POLE3
Mean 29.6
Standard deviation 21
Values 23 62 36 15 11
[51]
HepG2 POLE3
Mean 37.9
Standard deviation 13
Values 29 47
[52]
HepG2.C3A POLE3
Mean 30.6
Standard deviation 16
Values 19 42
[53]
HuH.7 POLE3
Mean 36
Standard deviation 15
Values 40 20 48
[54]
SNU475 POLE3
Mean 26.1
Standard deviation 0.99
Values 25 27
[55]
THLE POLE3
Mean 60
Standard deviation 7.2
Values 55 65
[56]
liver POLE3
Mean 14.1
Standard deviation 6.6
Values 15 11 23 7.8
[57]
ref_hepatocyte POLE4
Mean 27.1
Standard deviation 15
Values 28 15 9.6 45 38
[58]
HepG2 POLE4
Mean 28.9
Standard deviation 4.6
Values 26 32
[59]
HepG2.C3A POLE4
Mean 43
Standard deviation 18
Values 30 56
[60]
HuH.7 POLE4
Mean 3.76
Standard deviation 1.5
Values 3.8 2.3 5.3
[61]
SNU475 POLE4
Mean 16.1
Standard deviation 1
Values 17 15
[62]
THLE POLE4
Mean 13
Standard deviation 1.2
Values 12 14
[63]
liver POLE4
Mean 11
Standard deviation 11
Values 24 1.7 18 1.1
[64]
ref_hepatocyte RPA2
Mean 23.6
Standard deviation 12
Values 23 41 28 15 11
[65]
HepG2 RPA2
Mean 19
Standard deviation 3.9
Values 16 22
[66]
HepG2.C3A RPA2
Mean 17.8
Standard deviation 8.2
Values 12 24
[67]
HuH.7 RPA2
Mean 25.2
Standard deviation 11
Values 27 14 35
[68]
SNU475 RPA2
Mean 25.9
Standard deviation 7.9
Values 20 31
[69]
THLE RPA2
Mean 30.6
Standard deviation 2.7
Values 29 33
[70]
liver RPA2
Mean 6.36
Standard deviation 3.6
Values 6.9 4.2 11 3.2
[71]
ref_hepatocyte RFC4
Mean 11
Standard deviation 7.9
Values 17 21 9.8 4.7 2.4
[72]
HepG2 RFC4
Mean 12.4
Standard deviation 2.7
Values 10 14
[73]
HepG2.C3A RFC4
Mean 17
Standard deviation 7.7
Values 12 22
[74]
HuH.7 RFC4
Mean 24.4
Standard deviation 12
Values 26 12 35
[75]
SNU475 RFC4
Mean 10.3
Standard deviation 3.5
Values 7.8 13
[76]
THLE RFC4
Mean 29.1
Standard deviation 0.079
Values 29 29
[77]
liver RFC4
Mean 2.31
Standard deviation 1.2
Values 2.3 1.9 4 1
[78]
ref_hepatocyte RFC1
Mean 9.26
Standard deviation 5.4
Values 15 15 7.1 4.1 5
[79]
HepG2 RFC1
Mean 22.5
Standard deviation 11
Values 15 30
[80]
HepG2.C3A RFC1
Mean 49.1
Standard deviation 4.6
Values 46 52
[81]
HuH.7 RFC1
Mean 61.4
Standard deviation 8.8
Values 66 67 51
[82]
SNU475 RFC1
Mean 21.2
Standard deviation 2
Values 20 23
[83]
THLE RFC1
Mean 42.7
Standard deviation 3.9
Values 45 40
[84]
liver RFC1
Mean 22.6
Standard deviation 3.4
Values 24 26 18 23
[85]
ref_hepatocyte RFC2
Mean 8.95
Standard deviation 3.2
Values 7.3 13 6.2 11 6.5
[86]
HepG2 RFC2
Mean 16.5
Standard deviation 2.8
Values 14 18
[87]
HepG2.C3A RFC2
Mean 13.3
Standard deviation 5.7
Values 9.3 17
[88]
HuH.7 RFC2
Mean 13.1
Standard deviation 6.2
Values 15 6.1 18
[89]
SNU475 RFC2
Mean 18.6
Standard deviation 4.4
Values 16 22
[90]
THLE RFC2
Mean 28.7
Standard deviation 3.4
Values 26 31
[91]
liver RFC2
Mean 7.44
Standard deviation 4.1
Values 10 4.9 11 3.1
[92]
ref_hepatocyte RPA1
Mean 8.25
Standard deviation 3.9
Values 9.2 15 5.5 5.3 6.7
[93]
HepG2 RPA1
Mean 45.3
Standard deviation 8.3
Values 39 51
[94]
HepG2.C3A RPA1
Mean 33.6
Standard deviation 11
Values 26 41
[95]
HuH.7 RPA1
Mean 39
Standard deviation 14
Values 47 23 48
[96]
SNU475 RPA1
Mean 54.6
Standard deviation 1
Values 55 54
[97]
THLE RPA1
Mean 62.1
Standard deviation 11
Values 54 70
[98]
liver RPA1
Mean 11.7
Standard deviation 1.8
Values 12 12 14 9.5
[99]
ref_hepatocyte RPA3
Mean 8.22
Standard deviation 4.8
Values 6.2 7.6 1.9 11 15
[100]
HepG2 RPA3
Mean 14.1
Standard deviation 4
Values 11 17
[101]
HepG2.C3A RPA3
Mean 21.8
Standard deviation 13
Values 13 31
[102]
HuH.7 RPA3
Mean 34.5
Standard deviation 16
Values 35 18 50
[103]
SNU475 RPA3
Mean 8.05
Standard deviation 1.5
Values 9.1 7
[104]
THLE RPA3
Mean 11
Standard deviation 2.9
Values 8.9 13
[105]
liver RPA3
Mean 7.22
Standard deviation 6.1
Values 13 2.4 12 1.4
[106]
ref_hepatocyte RFC5
Mean 5.54
Standard deviation 4.9
Values 13 7.4 0.42 3.6 3.2
[107]
HepG2 RFC5
Mean 13.4
Standard deviation 5.4
Values 9.6 17
[108]
HepG2.C3A RFC5
Mean 16.4
Standard deviation 10
Values 9 24
[109]
HuH.7 RFC5
Mean 18.1
Standard deviation 6.8
Values 23 10 21
[110]
SNU475 RFC5
Mean 12.2
Standard deviation 2.4
Values 11 14
[111]
THLE RFC5
Mean 19.8
Standard deviation 2.4
Values 18 22
[112]
liver RFC5
Mean 4.29
Standard deviation 1.7
Values 4.9 3.5 6.3 2.5
[113]
ref_hepatocyte XRCC1
Mean 3.8
Standard deviation 1.2
Values 5.2 3.1 5 2.8 3
[114]
HepG2 XRCC1
Mean 13
Standard deviation 0.87
Values 12 14
[115]
HepG2.C3A XRCC1
Mean 13.2
Standard deviation 1.4
Values 14 12
[116]
HuH.7 XRCC1
Mean 26.8
Standard deviation 4.3
Values 31 22 27
[117]
SNU475 XRCC1
Mean 11.8
Standard deviation 1.2
Values 11 13
[118]
THLE XRCC1
Mean 13.1
Standard deviation 0.99
Values 12 14
[119]
liver XRCC1
Mean 2.84
Standard deviation 1.8
Values 3.7 1.7 5 1
[120]
ref_hepatocyte RFC3
Mean 3.17
Standard deviation 3.1
Values 6.3 6.7 1.4 0.35 1.1
[121]
HepG2 RFC3
Mean 15.8
Standard deviation 7.8
Values 10 21
[122]
HepG2.C3A RFC3
Mean 25.6
Standard deviation 17
Values 14 37
[123]
HuH.7 RFC3
Mean 27.1
Standard deviation 12
Values 35 14 33
[124]
SNU475 RFC3
Mean 13.8
Standard deviation 3.5
Values 11 16
[125]
THLE RFC3
Mean 23.5
Standard deviation 5.4
Values 20 27
[126]
liver RFC3
Mean 2.46
Standard deviation 0.85
Values 2 2.9 3.4 1.5
[127]
ref_hepatocyte LIG3
Mean 3.12
Standard deviation 1.4
Values 3.1 3.1 5.3 2.2 1.8
[128]
HepG2 LIG3
Mean 15.6
Standard deviation 1.4
Values 15 17
[129]
HepG2.C3A LIG3
Mean 14.3
Standard deviation 1.2
Values 15 13
[130]
HuH.7 LIG3
Mean 28.9
Standard deviation 9.5
Values 36 18 32
[131]
SNU475 LIG3
Mean 12.1
Standard deviation 1.6
Values 13 11
[132]
THLE LIG3
Mean 7.01
Standard deviation 1.3
Values 6.1 7.9
[133]
liver LIG3
Mean 8.07
Standard deviation 3.2
Values 3.9 9.5 7.4 11
[134]
ref_hepatocyte LIG1
Mean 3.08
Standard deviation 2.7
Values 7.4 3.8 0.82 2.1 1.3
[135]
HepG2 LIG1
Mean 21.1
Standard deviation 4.6
Values 18 24
[136]
HepG2.C3A LIG1
Mean 19
Standard deviation 5
Values 15 23
[137]
HuH.7 LIG1
Mean 28.4
Standard deviation 13
Values 35 13 37
[138]
SNU475 LIG1
Mean 8.05
Standard deviation 0.33
Values 8.3 7.8
[139]
THLE LIG1
Mean 15.1
Standard deviation 4
Values 12 18
[140]
liver LIG1
Mean 3.39
Standard deviation 0.66
Values 3.3 3.3 4.3 2.7
[141]
ref_hepatocyte POLD1
Mean 2.41
Standard deviation 0.8
Values 2 3.5 2.7 2.4 1.4
[142]
HepG2 POLD1
Mean 19.3
Standard deviation 1.9
Values 21 18
[143]
HepG2.C3A POLD1
Mean 20.1
Standard deviation 2.3
Values 18 22
[144]
HuH.7 POLD1
Mean 34
Standard deviation 15
Values 42 16 44
[145]
SNU475 POLD1
Mean 15.6
Standard deviation 2.9
Values 14 18
[146]
THLE POLD1
Mean 29.7
Standard deviation 2.6
Values 28 32
[147]
liver POLD1
Mean 5.43
Standard deviation 0.68
Values 6.2 4.7 5.8 5.1
[148]
ref_hepatocyte POLK
Mean 2.2
Standard deviation 1.6
Values 1 4.7 2.2 0.59 2.5
[149]
HepG2 POLK
Mean 2.71
Standard deviation 0.4
Values 2.4 3
[150]
HepG2.C3A POLK
Mean 6.72
Standard deviation 1.5
Values 5.7 7.8
[151]
HuH.7 POLK
Mean 7.69
Standard deviation 1.2
Values 8.1 8.7 6.3
[152]
SNU475 POLK
Mean 14.4
Standard deviation 1
Values 15 14
[153]
THLE POLK
Mean 13.4
Standard deviation 2.8
Values 15 11
[154]
liver POLK
Mean 13.4
Standard deviation 3.4
Values 11 18 11 13
[155]
ref_hepatocyte POLD3
Mean 1.46
Standard deviation 0.56
Values 1.9 1.9 1 1.8 0.71
[156]
HepG2 POLD3
Mean 7.29
Standard deviation 0.95
Values 6.6 8
[157]
HepG2.C3A POLD3
Mean 5.94
Standard deviation 4
Values 3.1 8.8
[158]
HuH.7 POLD3
Mean 11.2
Standard deviation 6.1
Values 15 4.1 14
[159]
SNU475 POLD3
Mean 11.6
Standard deviation 3.7
Values 9 14
[160]
THLE POLD3
Mean 18.3
Standard deviation 1.6
Values 17 19
[161]
liver POLD3
Mean 4.11
Standard deviation 1.1
Values 3.6 4.3 5.6 3
[162]
ref_hepatocyte POLE
Mean 1.41
Standard deviation 0.61
Values 1.7 0.95 0.68 1.5 2.2
[163]
HepG2 POLE
Mean 25.6
Standard deviation 5.9
Values 22 30
[164]
HepG2.C3A POLE
Mean 35.2
Standard deviation 15
Values 24 46
[165]
HuH.7 POLE
Mean 35.1
Standard deviation 18
Values 50 15 40
[166]
SNU475 POLE
Mean 17.2
Standard deviation 0.14
Values 17 17
[167]
THLE POLE
Mean 39
Standard deviation 5
Values 35 43
[168]
liver POLE
Mean 15.3
Standard deviation 8.7
Values 11 19 6 25
[169]
ref_hepatocyte POLE2
Mean 1.24
Standard deviation 0.85
Values 1.7 2.2 0.24 1.6 0.46
[170]
HepG2 POLE2
Mean 4.44
Standard deviation 2.1
Values 3 5.9
[171]
HepG2.C3A POLE2
Mean 6.88
Standard deviation 5.4
Values 3.1 11
[172]
HuH.7 POLE2
Mean 13.1
Standard deviation 7.8
Values 15 4.4 20
[173]
SNU475 POLE2
Mean 5.05
Standard deviation 2
Values 3.6 6.4
[174]
THLE POLE2
Mean 8.23
Standard deviation 0.9
Values 7.6 8.9
[175]
liver POLE2
Mean 0.788
Standard deviation 0.23
Values 0.68 1 0.9 0.53