REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HSPA8 Heat shock cognate 71 kDa protein [1] -0.10[2] -0.04[3] -0.07[4] 0.11[5] 0.13[6] -0.73[7]
2 ABAT 4-aminobutyrate aminotransferase, mitochondrial [8] -0.32[9] -0.55[10] -1.61[11] -9.22[12] -7.07[13] 1.52[14]
3 ALDH5A1 Succinate-semialdehyde dehydrogenase, mitochondrial [15] -0.01[16] 0.19[17] -0.99[18] -1.63[19] -3.46[20] 0.90[21]
4 VAMP2 Vesicle-associated membrane protein 2 [22] -1.12[23] -0.71[24] 0.31[25] -0.32[26] -0.19[27] 0.16[28]
5 DNAJC5 DnaJ homolog subfamily C member 5 [29] 2.99[30] 2.65[31] 2.65[32] 2.36[33] 2.20[34] 1.58[35]
6 SLC6A12 Sodium- and chloride-dependent betaine transporter [36] -1.71[37] -3.33[38] -1.39[39] -5.22[40] -8.27[41] 0.89[42]
7 SLC6A11 Sodium- and chloride-dependent GABA transporter 3 [43] 0.68[44] 0.77[45] 1.79[46] -8.76[47] -7.25[48] -8.14[49]
8 SLC6A1 Sodium- and chloride-dependent GABA transporter 1 [50] -11.27[51] [52] -10.39[53] -11.26[54] -10.88[55] 3.20[56]
9 SLC6A13 Sodium- and chloride-dependent GABA transporter 2 [57] -7.16[58] -5.65[59] -2.08[60] -5.11[61] -5.60[62] 0.63[63]
10 RAB3A Ras-related protein Rab-3A [64] 0.15[65] -0.86[66] 1.93[67] -0.67[68] -0.14[69] -0.87[70]
11 STX1A Syntaxin-1A [71] 1.17[72] 1.18[73] 0.36[74] 2.74[75] 2.07[76] -0.82[77]
12 STXBP1 Syntaxin-binding protein 1 [78] 1.96[79] 2.42[80] 3.51[81] 4.34[82] 4.52[83] 1.19[84]
13 CPLX1 Complexin-1 [85] -0.69[86] -1.70[87] 3.80[88] -2.75[89] -2.46[90] 0.54[91]
14 SNAP25 Synaptosomal-associated protein 25 [92] -3.27[93] -3.03[94] 3.31[95] 2.60[96] 4.97[97] 1.39[98]
15 GAD1 Glutamate decarboxylase 1 [99] 1.04[100] 1.41[101] 5.44[102] -1.12[103] 0.37[104] -3.44[105]
16 SYT1 Synaptotagmin-1 [106] -1.87[107] -2.57[108] 6.73[109] 7.33[110] 3.83[111] 4.57[112]
17 GAD2 Glutamate decarboxylase 2 [113] [114] [115] [116] [117] [118] [119]
18 SLC32A1 Vesicular inhibitory amino acid transporter [120] [121] [122] [123] [124] [125] [126]
19 RIMS1 Regulating synaptic membrane exocytosis protein 1 [127] [128] [129] [130] [131] [132] [133]
[1]
ref_hepatocyte HSPA8
Mean 426
Standard deviation 1.7e+02
Values 2.7e+02 6.5e+02 5.6e+02 3.4e+02 3.1e+02
[2]
HepG2 HSPA8
Mean 753
Standard deviation 2.8e+02
Values 5.5e+02 9.5e+02
[3]
HepG2.C3A HSPA8
Mean 671
Standard deviation 1.8e+02
Values 5.4e+02 8e+02
[4]
HuH.7 HSPA8
Mean 398
Standard deviation 32
Values 4.3e+02 3.6e+02 4e+02
[5]
SNU475 HSPA8
Mean 762
Standard deviation 89
Values 7e+02 8.2e+02
[6]
THLE HSPA8
Mean 692
Standard deviation 1.9e+02
Values 5.6e+02 8.2e+02
[7]
liver HSPA8
Mean 287
Standard deviation 81
Values 2e+02 3.1e+02 2.5e+02 3.9e+02
[8]
ref_hepatocyte ABAT
Mean 56.9
Standard deviation 75
Values 15 6 8.5 74 1.8e+02
[9]
HepG2 ABAT
Mean 86
Standard deviation 44
Values 55 1.2e+02
[10]
HepG2.C3A ABAT
Mean 63.3
Standard deviation 4.5
Values 60 66
[11]
HuH.7 ABAT
Mean 18.3
Standard deviation 4.1
Values 16 23 16
[12]
SNU475 ABAT
Mean 0.158
Standard deviation 0.027
Values 0.14 0.18
[13]
THLE ABAT
Mean 0.628
Standard deviation 0.091
Values 0.69 0.56
[14]
liver ABAT
Mean 182
Standard deviation 14
Values 1.8e+02 2e+02 1.7e+02 1.9e+02
[15]
ref_hepatocyte ALDH5A1
Mean 14.8
Standard deviation 13
Values 26 5.4 1.3 10 31
[16]
HepG2 ALDH5A1
Mean 27.7
Standard deviation 12
Values 19 36
[17]
HepG2.C3A ALDH5A1
Mean 27.4
Standard deviation 7.8
Values 22 33
[18]
HuH.7 ALDH5A1
Mean 7.32
Standard deviation 1.8
Values 8.6 5.2 8.1
[19]
SNU475 ALDH5A1
Mean 7.97
Standard deviation 2.7
Values 9.9 6.1
[20]
THLE ALDH5A1
Mean 2
Standard deviation 0.67
Values 1.5 2.5
[21]
liver ALDH5A1
Mean 30.8
Standard deviation 7.4
Values 41 24 29 29
[22]
ref_hepatocyte VAMP2
Mean 7.38
Standard deviation 2
Values 9.9 5.1 8 8.2 5.7
[23]
HepG2 VAMP2
Mean 6.41
Standard deviation 1.5
Values 7.4 5.4
[24]
HepG2.C3A VAMP2
Mean 7.34
Standard deviation 3
Values 9.5 5.2
[25]
HuH.7 VAMP2
Mean 8.97
Standard deviation 0.78
Values 8.3 8.8 9.8
[26]
SNU475 VAMP2
Mean 9.81
Standard deviation 1.6
Values 11 8.7
[27]
THLE VAMP2
Mean 9.61
Standard deviation 0.14
Values 9.5 9.7
[28]
liver VAMP2
Mean 9.18
Standard deviation 10
Values 22 1 11 1.9
[29]
ref_hepatocyte DNAJC5
Mean 6.89
Standard deviation 4.1
Values 12 7.1 9.4 3.7 2.1
[30]
HepG2 DNAJC5
Mean 104
Standard deviation 0.3
Values 1e+02 1e+02
[31]
HepG2.C3A DNAJC5
Mean 70.2
Standard deviation 13
Values 80 61
[32]
HuH.7 DNAJC5
Mean 42.6
Standard deviation 4.5
Values 48 40 40
[33]
SNU475 DNAJC5
Mean 58.9
Standard deviation 4.2
Values 62 56
[34]
THLE DNAJC5
Mean 47
Standard deviation 7.5
Values 42 52
[35]
liver DNAJC5
Mean 22.9
Standard deviation 6.5
Values 20 25 16 31
[36]
ref_hepatocyte SLC6A12
Mean 6.4
Standard deviation 8.3
Values 2 0.55 0.4 9.2 20
[37]
HepG2 SLC6A12
Mean 3.71
Standard deviation 0.83
Values 3.1 4.3
[38]
HepG2.C3A SLC6A12
Mean 1.03
Standard deviation 0.4
Values 0.75 1.3
[39]
HuH.7 SLC6A12
Mean 2.4
Standard deviation 0.86
Values 2.1 3.4 1.8
[40]
SNU475 SLC6A12
Mean 0.285
Standard deviation 0.14
Values 0.19 0.39
[41]
THLE SLC6A12
Mean 0.0307
Standard deviation 0.0017
Values 0.03 0.032
[42]
liver SLC6A12
Mean 13.3
Standard deviation 4.9
Values 20 9.9 12 10
[43]
ref_hepatocyte SLC6A11
Mean 3.81
Standard deviation 8.5
Values 19 0 0 0.069 0
[44]
HepG2 SLC6A11
Mean 11.6
Standard deviation 1.9
Values 10 13
[45]
HepG2.C3A SLC6A11
Mean 10.5
Standard deviation 1.4
Values 9.5 12
[46]
HuH.7 SLC6A11
Mean 13
Standard deviation 2.5
Values 16 11 12
[47]
SNU475 SLC6A11
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[48]
THLE SLC6A11
Mean 0.0373
Standard deviation 0.023
Values 0.053 0.021
[49]
liver SLC6A11
Mean 0.0151
Standard deviation 0.022
Values 0.047 0 0 0.013
[50]
ref_hepatocyte SLC6A1
Mean 3.75
Standard deviation 4.9
Values 0.054 0 0.71 7.2 11
[51]
HepG2 SLC6A1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[52]
HepG2.C3A SLC6A1
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 SLC6A1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[54]
SNU475 SLC6A1
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[55]
THLE SLC6A1
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[56]
liver SLC6A1
Mean 38.4
Standard deviation 22
Values 60 18 20 55
[57]
ref_hepatocyte SLC6A13
Mean 1.9
Standard deviation 2.6
Values 0 0 0.32 3.3 5.9
[58]
HepG2 SLC6A13
Mean 0.025
Standard deviation 0.019
Values 0.011 0.039
[59]
HepG2.C3A SLC6A13
Mean 0.0613
Standard deviation 0.0043
Values 0.058 0.064
[60]
HuH.7 SLC6A13
Mean 0.44
Standard deviation 0.18
Values 0.28 0.63 0.41
[61]
SNU475 SLC6A13
Mean 0.0914
Standard deviation 0.057
Values 0.051 0.13
[62]
THLE SLC6A13
Mean 0.0582
Standard deviation 0.015
Values 0.047 0.069
[63]
liver SLC6A13
Mean 3.28
Standard deviation 0.74
Values 3.7 2.6 2.7 4.1
[64]
ref_hepatocyte RAB3A
Mean 0.786
Standard deviation 0.29
Values 0.95 0.55 0.49 0.76 1.2
[65]
HepG2 RAB3A
Mean 1.64
Standard deviation 0.46
Values 2 1.3
[66]
HepG2.C3A RAB3A
Mean 0.703
Standard deviation 0.33
Values 0.93 0.47
[67]
HuH.7 RAB3A
Mean 2.95
Standard deviation 0.48
Values 3.5 2.5 2.8
[68]
SNU475 RAB3A
Mean 0.823
Standard deviation 0.069
Values 0.77 0.87
[69]
THLE RAB3A
Mean 1.06
Standard deviation 0.15
Values 1.2 0.95
[70]
liver RAB3A
Mean 0.48
Standard deviation 0.46
Values 0.47 0.19 1.1 0.13
[71]
ref_hepatocyte STX1A
Mean 0.672
Standard deviation 0.98
Values 0.23 0.39 2.4 0.095 0.24
[72]
HepG2 STX1A
Mean 2.85
Standard deviation 0.85
Values 3.4 2.2
[73]
HepG2.C3A STX1A
Mean 2.48
Standard deviation 0.71
Values 3 2
[74]
HuH.7 STX1A
Mean 0.845
Standard deviation 0.25
Values 0.57 0.91 1.1
[75]
SNU475 STX1A
Mean 7.45
Standard deviation 3.6
Values 4.9 10
[76]
THLE STX1A
Mean 4.19
Standard deviation 1.3
Values 5.1 3.3
[77]
liver STX1A
Mean 0.426
Standard deviation 0.18
Values 0.35 0.31 0.69 0.34
[78]
ref_hepatocyte STXBP1
Mean 0.658
Standard deviation 0.63
Values 1.7 0.64 0.69 0.22 0.065
[79]
HepG2 STXBP1
Mean 4.83
Standard deviation 0.73
Values 5.4 4.3
[80]
HepG2.C3A STXBP1
Mean 5.71
Standard deviation 0.79
Values 6.3 5.1
[81]
HuH.7 STXBP1
Mean 7.36
Standard deviation 1.4
Values 8.9 6.5 6.7
[82]
SNU475 STXBP1
Mean 22.1
Standard deviation 0.72
Values 23 22
[83]
THLE STXBP1
Mean 22.4
Standard deviation 6
Values 18 27
[84]
liver STXBP1
Mean 1.67
Standard deviation 0.8
Values 2 1.1 2.6 0.91
[85]
ref_hepatocyte CPLX1
Mean 0.58
Standard deviation 0.61
Values 0.11 0 0.34 1.1 1.4
[86]
HepG2 CPLX1
Mean 0.678
Standard deviation 0.18
Values 0.8 0.55
[87]
HepG2.C3A CPLX1
Mean 0.29
Standard deviation 0.016
Values 0.3 0.28
[88]
HuH.7 CPLX1
Mean 7.91
Standard deviation 0.96
Values 9 7.3 7.4
[89]
SNU475 CPLX1
Mean 0.143
Standard deviation 0.012
Values 0.13 0.15
[90]
THLE CPLX1
Mean 0.156
Standard deviation 0.063
Values 0.2 0.11
[91]
liver CPLX1
Mean 0.943
Standard deviation 0.4
Values 0.73 1.3 0.49 1.3
[92]
ref_hepatocyte SNAP25
Mean 0.146
Standard deviation 0.17
Values 0 0 0.3 0.069 0.36
[93]
HepG2 SNAP25
Mean 0.0286
Standard deviation 0.032
Values 0.0057 0.051
[94]
HepG2.C3A SNAP25
Mean 0.0292
Standard deviation 0.041
Values 0.058 0
[95]
HuH.7 SNAP25
Mean 1.43
Standard deviation 0.14
Values 1.4 1.3 1.6
[96]
SNU475 SNAP25
Mean 1.47
Standard deviation 0.63
Values 1 1.9
[97]
THLE SNAP25
Mean 6.82
Standard deviation 0.47
Values 7.1 6.5
[98]
liver SNAP25
Mean 0.427
Standard deviation 0.11
Values 0.42 0.34 0.36 0.58
[99]
ref_hepatocyte GAD1
Mean 0.132
Standard deviation 0.29
Values 0 0.66 0 0 0
[100]
HepG2 GAD1
Mean 0.511
Standard deviation 0.23
Values 0.67 0.35
[101]
HepG2.C3A GAD1
Mean 0.567
Standard deviation 0.17
Values 0.45 0.69
[102]
HuH.7 GAD1
Mean 5.59
Standard deviation 0.85
Values 4.9 6.5 5.4
[103]
SNU475 GAD1
Mean 0.101
Standard deviation 0.044
Values 0.07 0.13
[104]
THLE GAD1
Mean 0.253
Standard deviation 0.1
Values 0.33 0.18
[105]
liver GAD1
Mean 0.0135
Standard deviation 0.019
Values 0 0.014 0 0.04
[106]
ref_hepatocyte SYT1
Mean 0.0375
Standard deviation 0.071
Values 0 0 0.16 0 0.024
[107]
HepG2 SYT1
Mean 0.0193
Standard deviation 0.021
Values 0.034 0.0043
[108]
HepG2.C3A SYT1
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[109]
HuH.7 SYT1
Mean 3.9
Standard deviation 1.6
Values 3.6 5.6 2.5
[110]
SNU475 SYT1
Mean 10
Standard deviation 0.7
Values 9.5 11
[111]
THLE SYT1
Mean 0.793
Standard deviation 0.075
Values 0.85 0.74
[112]
liver SYT1
Mean 0.992
Standard deviation 0.082
Values 0.94 1.1 0.98 0.94
[113]
ref_hepatocyte GAD2
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[114]
HepG2 GAD2
Missing
[115]
HepG2.C3A GAD2
Missing
[116]
HuH.7 GAD2
Missing
[117]
SNU475 GAD2
Missing
[118]
THLE GAD2
Missing
[119]
liver GAD2
Missing
[120]
ref_hepatocyte SLC32A1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 SLC32A1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[122]
HepG2.C3A SLC32A1
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 SLC32A1
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 SLC32A1
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[125]
THLE SLC32A1
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[126]
liver SLC32A1
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013
[127]
ref_hepatocyte RIMS1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 RIMS1
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A RIMS1
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 RIMS1
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 RIMS1
Mean 0.0774
Standard deviation 0.002
Values 0.079 0.076
[132]
THLE RIMS1
Mean 0.0387
Standard deviation 0.013
Values 0.03 0.048
[133]
liver RIMS1
Mean 0.0607
Standard deviation 0.064
Values 0 0.071 0.026 0.15