REACTOME_GABA_RECEPTOR_ACTIVATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -1.09[1] | -0.78[2] | -1.84[3] | -2.17[4] | -2.59[5] | -1.31[6] | |
2 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | [7] | 1.13[8] | 1.28[9] | 0.61[10] | 0.93[11] | 0.56[12] | -0.96[13] |
3 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | [14] | -0.48[15] | -0.60[16] | -0.46[17] | -0.72[18] | -0.83[19] | -1.33[20] |
4 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -4.58[21] | -4.16[22] | -4.66[23] | -4.17[24] | -3.51[25] | -4.07[26] | |
5 | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | [27] | 0.18[28] | -0.74[29] | -0.77[30] | -0.53[31] | 0.38[32] | 0.08[33] |
6 | NPTN | Neuroplastin | [34] | 0.30[35] | 0.58[36] | 0.79[37] | 0.04[38] | 0.05[39] | -0.67[40] |
7 | GNG12 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | -4.63[41] | -7.43[42] | 0.32[43] | 1.52[44] | 1.46[45] | 0.76[46] | |
8 | GNAI3 | Guanine nucleotide-binding protein G(k) subunit alpha | [47] | 0.24[48] | 0.92[49] | 0.83[50] | 0.75[51] | 0.22[52] | 0.51[53] |
9 | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | [54] | -1.53[55] | -2.34[56] | -0.39[57] | 0.86[58] | 0.07[59] | 1.11[60] |
10 | GNB5 | Guanine nucleotide-binding protein subunit beta-5 | [61] | 0.22[62] | 0.39[63] | 1.21[64] | 0.43[65] | 0.39[66] | 1.16[67] |
11 | ADCY9 | Adenylate cyclase type 9 | [68] | 2.74[69] | 2.06[70] | 2.29[71] | 0.60[72] | -0.02[73] | 2.69[74] |
12 | ADCY6 | Adenylate cyclase type 6 | [75] | 2.17[76] | 2.76[77] | 2.53[78] | 2.15[79] | 2.66[80] | 2.91[81] |
13 | GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | -8.06[82] | -7.93[83] | -7.43[84] | 1.91[85] | 3.06[86] | 2.51[87] | |
14 | GNG7 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | 1.67[88] | 1.46[89] | 2.07[90] | -2.59[91] | -2.13[92] | 0.30[93] | |
15 | ADCY1 | Adenylate cyclase type 1 | [94] | -0.72[95] | -2.45[96] | -2.85[97] | -2.46[98] | -2.64[99] | 5.27[100] |
16 | GNG4 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | 3.59[101] | 1.49[102] | 5.09[103] | 0.90[104] | -1.38[105] | -2.27[106] | |
17 | ARHGEF9 | Rho guanine nucleotide exchange factor 9 | [107] | -1.32[108] | -2.39[109] | -7.87[110] | 1.82[111] | 1.66[112] | 2.63[113] |
18 | KCNJ5 | G protein-activated inward rectifier potassium channel 4 | [114] | -2.41[115] | -0.98[116] | -1.67[117] | -2.58[118] | -2.98[119] | -1.80[120] |
19 | ADCY7 | Adenylate cyclase type 7 | [121] | 3.63[122] | 3.38[123] | 2.15[124] | 2.95[125] | 2.26[126] | 3.20[127] |
20 | GNB4 | Guanine nucleotide-binding protein subunit beta-4 | [128] | -0.25[129] | 0.38[130] | 1.18[131] | 2.33[132] | 4.90[133] | 4.37[134] |
21 | GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | -6.16[135] | -6.91[136] | [137] | 2.76[138] | 2.07[139] | 3.06[140] | |
22 | GABRR3 | Gamma-aminobutyric acid receptor subunit rho-3 | [141] | -5.36[142] | -3.66[143] | -2.09[144] | -5.96[145] | [146] | -5.33[147] |
23 | GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 | [148] | -6.14[149] | [150] | [151] | -1.08[152] | -6.79[153] | 2.14[154] |
24 | GNAL | Guanine nucleotide-binding protein G(olf) subunit alpha | [155] | 1.96[156] | 2.90[157] | 2.97[158] | 1.75[159] | 1.56[160] | 2.82[161] |
25 | GNGT2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 | [162] | [163] | [164] | -2.42[165] | -7.26[166] | 0.38[167] | |
26 | KCNJ4 | Inward rectifier potassium channel 4 | [168] | 0.37[169] | 0.58[170] | 1.86[171] | -5.35[172] | -2.34[173] | -0.87[174] |
27 | GNG3 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | -0.74[175] | 1.23[176] | -1.19[177] | -1.06[178] | -1.53[179] | 0.19[180] | |
28 | ADCY3 | Adenylate cyclase type 3 | [181] | 1.58[182] | 0.47[183] | 3.60[184] | 4.38[185] | 5.75[186] | 3.79[187] |
29 | GABRA5 | Gamma-aminobutyric acid receptor subunit alpha-5 | [188] | [189] | [190] | [191] | [192] | [193] | -2.55[194] |
30 | ADCY2 | Adenylate cyclase type 2 | [195] | -5.26[196] | -3.20[197] | -4.65[198] | -3.09[199] | -4.37[200] | -3.84[201] |
31 | GABRB1 | Gamma-aminobutyric acid receptor subunit beta-1 | [202] | -5.59[203] | [204] | 3.17[205] | -4.04[206] | -6.23[207] | -1.76[208] |
32 | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | [209] | 1.71[210] | 4.09[211] | 3.20[212] | 0.65[213] | 3.20[214] | -1.40[215] |
33 | GABRR2 | Gamma-aminobutyric acid receptor subunit rho-2 | [216] | -4.62[217] | -0.95[218] | 1.55[219] | 0.92[220] | -1.11[221] | 2.30[222] |
34 | KCNJ6 | G protein-activated inward rectifier potassium channel 2 | [223] | [224] | [225] | [226] | 0.45[227] | -5.63[228] | -2.18[229] |
35 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | [230] | -2.31[231] | [232] | [233] | 2.30[234] | 2.83[235] | 5.43[236] |
36 | GABBR1 | Gamma-aminobutyric acid type B receptor subunit 1 | [237] | 2.79[238] | 1.28[239] | 0.33[240] | 6.42[241] | 6.55[242] | 4.32[243] |
37 | KCNJ3 | G protein-activated inward rectifier potassium channel 1 | [244] | -1.98[245] | 0.93[246] | 4.74[247] | -0.80[248] | -2.33[249] | 5.01[250] |
38 | ADCY5 | Adenylate cyclase type 5 | [251] | 0.27[252] | 1.40[253] | 2.24[254] | 0.30[255] | 1.25[256] | 6.65[257] |
39 | KCNJ2 | Inward rectifier potassium channel 2 | [258] | -2.22[259] | [260] | [261] | 2.92[262] | 2.92[263] | 6.15[264] |
40 | KCNJ10 | ATP-sensitive inward rectifier potassium channel 10 | [265] | 8.30[266] | 1.55[267] | 0.36[268] | 2.08[269] | 0.38[270] | 4.91[271] |
41 | KCNJ16 | Inward rectifier potassium channel 16 | [272] | [273] | [274] | -1.55[275] | 2.51[276] | 0.37[277] | 5.98[278] |
42 | GABRA2 | Gamma-aminobutyric acid receptor subunit alpha-2 | [279] | 0.56[280] | 0.94[281] | 8.68[282] | 0.54[283] | -1.22[284] | 1.28[285] |
43 | GABBR2 | Gamma-aminobutyric acid type B receptor subunit 2 | [286] | 3.46[287] | 1.59[288] | 2.53[289] | 1.78[290] | 5.93[291] | 4.71[292] |
44 | ADCY4 | Adenylate cyclase type 4 | [293] | 0.21[294] | -0.73[295] | 1.72[296] | [297] | [298] | 8.64[299] |
45 | KCNJ12 | ATP-sensitive inward rectifier potassium channel 12 | [300] | [301] | [302] | -0.11[303] | 7.42[304] | 6.60[305] | 5.70[306] |
46 | GABRA3 | Gamma-aminobutyric acid receptor subunit alpha-3 | [307] | [308] | [309] | [310] | [311] | [312] | [313] |
47 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | [314] | [315] | [316] | [317] | [318] | [319] | [320] |
48 | GNAT3 | Guanine nucleotide-binding protein G(t) subunit alpha-3 | [321] | [322] | [323] | [324] | [325] | [326] | [327] |
49 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | [328] | [329] | [330] | [331] | [332] | [333] | [334] |
50 | GABRA6 | Gamma-aminobutyric acid receptor subunit alpha-6 | [335] | [336] | [337] | [338] | [339] | [340] | [341] |
51 | GABRQ | Gamma-aminobutyric acid receptor subunit theta | [342] | [343] | [344] | [345] | [346] | [347] | [348] |
52 | GABRR1 | Gamma-aminobutyric acid receptor subunit rho-1 | [349] | [350] | [351] | [352] | [353] | [354] | [355] |
53 | GABRG2 | Gamma-aminobutyric acid receptor subunit gamma-2 | [356] | [357] | [358] | [359] | [360] | [361] | [362] |
54 | GABRG3 | Gamma-aminobutyric acid receptor subunit gamma-3 | [363] | [364] | [365] | [366] | [367] | [368] | [369] |
55 | GNG8 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 | [370] | [371] | [372] | [373] | [374] | [375] | |
56 | GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 | [376] | [377] | [378] | [379] | [380] | [381] | [382] |
57 | KCNJ9 | G protein-activated inward rectifier potassium channel 3 | [383] | [384] | [385] | [386] | [387] | [388] | [389] |
58 | GNGT1 | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | [390] | [391] | [392] | [393] | [394] | [395] | [396] |
59 | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | [397] | [398] | [399] | [400] | [401] | [402] | |
60 | ADCY8 | Adenylate cyclase type 8 | [403] | [404] | [405] | [406] | [407] | [408] | [409] |