REACTOME_GAB1_SIGNALOSOME Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.36[2] 0.00[3] -0.17[4] -0.19[5] 0.31[6] 0.04[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.39[9] 0.15[10] 0.15[11] -0.53[12] -0.74[13] -0.92[14]
3 CSK Tyrosine-protein kinase CSK [15] -0.43[16] -1.01[17] -0.75[18] -1.09[19] -1.63[20] -2.08[21]
4 PXN Paxillin [22] 0.20[23] -0.16[24] -0.24[25] 1.03[26] 0.87[27] -1.57[28]
5 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [29] -1.27[30] -1.23[31] -0.26[32] 0.98[33] 0.36[34] 1.78[35]
6 EGFR Epidermal growth factor receptor [36] -1.50[37] -1.95[38] 0.81[39] -0.65[40] -0.16[41] 1.43[42]
7 AREG Amphiregulin [43] -3.66[44] -6.98[45] -8.86[46] -10.78[47] -0.61[48] -11.53[49]
8 SRC Proto-oncogene tyrosine-protein kinase Src [50] 2.22[51] 2.13[52] 1.01[53] 1.32[54] 0.36[55] -2.07[56]
9 TGFA Protransforming growth factor alpha [57] 0.99[58] 1.97[59] -9.19[60] -2.04[61] -3.40[62] -1.61[63]
10 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.18[64] 0.38[65] 0.45[66] 0.05[67] 0.12[68] 0.70[69]
11 HBEGF Proheparin-binding EGF-like growth factor [70] -1.79[71] -2.68[72] -3.87[73] -0.78[74] -1.22[75] -3.65[76]
12 BTC Probetacellulin [77] -8.94[78] -9.41[79] -5.31[80] -3.96[81] -4.12[82] -4.14[83]
13 GAB1 GRB2-associated-binding protein 1 [84] 0.50[85] 1.51[86] 1.51[87] 0.85[88] 0.58[89] 1.66[90]
14 PAG1 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 -1.58[91] -2.50[92] 3.96[93] 1.79[94] 2.79[95] 3.55[96]
15 EREG Proepiregulin [97] 0.95[98] 0.80[99] -3.73[100] -2.65[101] 2.47[102] -2.69[103]
16 EGF Pro-epidermal growth factor [104] 1.17[105] 2.87[106] 6.37[107] 7.94[108] 5.23[109] 0.36[110]
17 EPGN Epigen [111] [112] [113] [114] [115] [116] [117]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte CSK
Mean 10.6
Standard deviation 1.8
Values 11 8.9 13 9 11
[16]
HepG2 CSK
Mean 30.4
Standard deviation 3.7
Values 33 28
[17]
HepG2.C3A CSK
Mean 19.1
Standard deviation 3
Values 21 17
[18]
HuH.7 CSK
Mean 23.7
Standard deviation 5.3
Values 27 18 26
[19]
SNU475 CSK
Mean 19.3
Standard deviation 0.29
Values 19 20
[20]
THLE CSK
Mean 16.3
Standard deviation 1.9
Values 15 18
[21]
liver CSK
Mean 8.27
Standard deviation 2.7
Values 7.6 6.5 6.7 12
[22]
ref_hepatocyte PXN
Mean 9.17
Standard deviation 8.7
Values 3.1 8.2 24 4 6.1
[23]
HepG2 PXN
Mean 40.5
Standard deviation 4
Values 43 38
[24]
HepG2.C3A PXN
Mean 29.7
Standard deviation 0.97
Values 30 29
[25]
HuH.7 PXN
Mean 29.2
Standard deviation 3.3
Values 33 27 27
[26]
SNU475 PXN
Mean 73
Standard deviation 6.8
Values 78 68
[27]
THLE PXN
Mean 79.6
Standard deviation 9.5
Values 73 86
[28]
liver PXN
Mean 10.2
Standard deviation 5.9
Values 16 3.9 14 6.6
[29]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[30]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[31]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[32]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[33]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[34]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[35]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[36]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[37]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[38]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[39]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[40]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[41]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[42]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[43]
ref_hepatocyte AREG
Mean 5.24
Standard deviation 9.3
Values 1.7 22 1.7 0.57 0.4
[44]
HepG2 AREG
Mean 1.59
Standard deviation 1.3
Values 2.5 0.67
[45]
HepG2.C3A AREG
Mean 0.15
Standard deviation 0.061
Values 0.11 0.19
[46]
HuH.7 AREG
Mean 0.0425
Standard deviation 0.021
Values 0.057 0.051 0.019
[47]
SNU475 AREG
Mean 0.0116
Standard deviation 0.016
Values 0.023 0
[48]
THLE AREG
Mean 16.4
Standard deviation 1.7
Values 15 18
[49]
liver AREG
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[50]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[51]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[52]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[53]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[54]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[55]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[56]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[57]
ref_hepatocyte TGFA
Mean 2
Standard deviation 1.3
Values 3.8 2.7 2.1 0.72 0.76
[58]
HepG2 TGFA
Mean 15.3
Standard deviation 2.1
Values 17 14
[59]
HepG2.C3A TGFA
Mean 28.4
Standard deviation 4.2
Values 25 31
[60]
HuH.7 TGFA
Mean 0.0129
Standard deviation 0.0035
Values 0.016 0.013 0.0094
[61]
SNU475 TGFA
Mean 1.88
Standard deviation 0.53
Values 1.5 2.3
[62]
THLE TGFA
Mean 0.903
Standard deviation 0.47
Values 1.2 0.57
[63]
liver TGFA
Mean 2.16
Standard deviation 0.15
Values 2.1 2.3 2.2 2
[64]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[65]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[66]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[67]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[68]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[69]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[70]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[71]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[72]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[73]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[74]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[75]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[76]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[77]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[78]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[79]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[80]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[82]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[83]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[84]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[85]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[86]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[87]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[88]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[89]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[90]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[91]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[92]
ref_hepatocyte PAG1
Mean 0.46
Standard deviation 0.27
Values 0.11 0.83 0.58 0.44 0.33
[93]
HepG2 PAG1
Mean 0.592
Standard deviation 0.44
Values 0.91 0.28
[94]
HepG2.C3A PAG1
Mean 0.295
Standard deviation 0.023
Values 0.31 0.28
[95]
HuH.7 PAG1
Mean 26.9
Standard deviation 22
Values 16 53 12
[96]
SNU475 PAG1
Mean 6.18
Standard deviation 1.6
Values 5 7.3
[97]
THLE PAG1
Mean 15.2
Standard deviation 0.93
Values 16 15
[98]
liver PAG1
Mean 17.8
Standard deviation 8.2
Values 10 22 12 27
[99]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[100]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[101]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[102]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[103]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[104]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[105]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[106]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[107]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[108]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[109]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[110]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[111]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[112]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[113]
ref_hepatocyte EPGN
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 EPGN
Mean 0.0544
Standard deviation 0.028
Values 0.074 0.034
[115]
HepG2.C3A EPGN
Mean 0.0501
Standard deviation 0.025
Values 0.068 0.032
[116]
HuH.7 EPGN
Mean 0.127
Standard deviation 0.084
Values 0.082 0.22 0.075
[117]
SNU475 EPGN
Mean 0.503
Standard deviation 0.27
Values 0.31 0.69
[118]
THLE EPGN
Mean 4.76
Standard deviation 1.2
Values 5.6 3.9
[119]
liver EPGN
Mean 0.161
Standard deviation 0.11
Values 0.12 0.17 0.051 0.3