REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | YWHAE | 14-3-3 protein epsilon | [1] | -1.01[2] | -1.11[3] | -0.82[4] | -1.28[5] | -0.92[6] | -0.76[7] |
2 | YWHAZ | 14-3-3 protein zeta/delta | [8] | -0.35[9] | -0.71[10] | -0.45[11] | 0.48[12] | -0.62[13] | -0.84[14] |
3 | SUMO1 | Small ubiquitin-related modifier 1 | [15] | -1.37[16] | -1.42[17] | -1.85[18] | -1.89[19] | -1.62[20] | -0.74[21] |
4 | YWHAH | 14-3-3 protein eta | [22] | -1.14[23] | -1.76[24] | -1.85[25] | -1.61[26] | -1.70[27] | -1.16[28] |
5 | YWHAQ | 14-3-3 protein theta | [29] | 0.49[30] | 0.10[31] | -0.26[32] | 0.94[33] | 0.58[34] | 0.20[35] |
6 | SFN | 14-3-3 protein sigma | [36] | -2.14[37] | -2.70[38] | -2.37[39] | -8.25[40] | -8.86[41] | -9.29[42] |
7 | YWHAG | 14-3-3 protein gamma | [43] | 0.43[44] | -0.31[45] | -0.32[46] | 0.30[47] | -0.07[48] | -0.54[49] |
8 | YWHAB | 14-3-3 protein beta/alpha | [50] | 1.26[51] | 0.77[52] | -0.02[53] | 0.88[54] | 0.64[55] | 0.70[56] |
9 | BABAM1 | BRISC and BRCA1-A complex member 1 | [57] | -0.59[58] | -0.59[59] | 0.23[60] | -1.45[61] | -0.46[62] | -0.67[63] |
10 | RPA2 | Replication protein A 32 kDa subunit | [64] | -1.23[65] | -1.37[66] | -0.87[67] | -1.16[68] | -0.77[69] | -1.60[70] |
11 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [71] | 0.91[72] | 1.18[73] | -0.06[74] | -0.10[75] | 0.11[76] | 0.08[77] |
12 | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2 | [78] | -1.23[79] | -0.42[80] | -0.01[81] | -0.34[82] | -0.23[83] | 0.20[84] |
13 | RFC4 | Replication factor C subunit 4 | [85] | -0.75[86] | -0.32[87] | 0.19[88] | -1.39[89] | 0.26[90] | -1.95[91] |
14 | RFC2 | Replication factor C subunit 2 | [92] | -0.04[93] | -0.39[94] | -0.41[95] | -0.24[96] | 0.54[97] | 0.03[98] |
15 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [99] | 1.54[100] | 1.07[101] | 1.28[102] | 1.43[103] | 1.77[104] | 0.80[105] |
16 | RPA3 | Replication protein A 14 kDa subunit | [106] | -0.14[107] | 0.45[108] | 1.11[109] | -1.32[110] | -0.72[111] | 0.11[112] |
17 | CCNB1 | G2/mitotic-specific cyclin-B1 | [113] | 2.07[114] | 2.10[115] | 2.22[116] | 1.19[117] | 2.48[118] | -1.54[119] |
18 | RAD17 | Cell cycle checkpoint protein RAD17 | [120] | -0.62[121] | 0.26[122] | 0.24[123] | -0.76[124] | -0.09[125] | 0.37[126] |
19 | KAT5 | Histone acetyltransferase KAT5 | [127] | -0.55[128] | -0.35[129] | -1.44[130] | -1.26[131] | -1.02[132] | -0.27[133] |
20 | NBN | Nibrin | [134] | -0.19[135] | 0.78[136] | 0.47[137] | 1.08[138] | 0.52[139] | 2.07[140] |
21 | CDK1 | Cyclin-dependent kinase 1 | [141] | 1.48[142] | 3.33[143] | 2.00[144] | 1.85[145] | 2.99[146] | -1.67[147] |
22 | CHEK2 | Serine/threonine-protein kinase Chk2 | [148] | 0.33[149] | 0.56[150] | 0.90[151] | -0.67[152] | -0.72[153] | -2.48[154] |
23 | RFC5 | Replication factor C subunit 5 | [155] | 0.35[156] | 0.61[157] | 0.74[158] | -0.15[159] | 0.70[160] | -0.08[161] |
24 | TP53 | Cellular tumor antigen p53 | [162] | 1.86[163] | 1.22[164] | 1.91[165] | 0.87[166] | 0.85[167] | 0.76[168] |
25 | UIMC1 | BRCA1-A complex subunit RAP80 | [169] | 0.60[170] | 0.62[171] | 1.00[172] | -0.35[173] | 0.12[174] | 0.50[175] |
26 | BRCC3 | Lys-63-specific deubiquitinase BRCC36 | [176] | -0.24[177] | 0.49[178] | -0.28[179] | -0.65[180] | -0.16[181] | 1.24[182] |
27 | WEE1 | Wee1-like protein kinase | [183] | 0.53[184] | 0.74[185] | 1.41[186] | 0.31[187] | 0.15[188] | 0.26[189] |
28 | RAD50 | DNA repair protein RAD50 | [190] | 0.38[191] | 2.30[192] | 1.39[193] | 0.85[194] | 1.65[195] | 3.00[196] |
29 | RMI2 | RecQ-mediated genome instability protein 2 | [197] | 1.47[198] | 0.55[199] | 0.44[200] | -1.62[201] | -0.99[202] | -3.63[203] |
30 | RBBP8 | DNA endonuclease RBBP8 | [204] | 0.42[205] | 1.63[206] | 0.19[207] | 1.02[208] | 1.54[209] | 1.05[210] |
31 | PIAS4 | E3 SUMO-protein ligase PIAS4 | [211] | 0.47[212] | -0.22[213] | 0.46[214] | -0.95[215] | -0.52[216] | 0.39[217] |
32 | TOPBP1 | DNA topoisomerase 2-binding protein 1 | [218] | 1.25[219] | 2.07[220] | 2.17[221] | 1.71[222] | 2.44[223] | 1.68[224] |
33 | RNF8 | E3 ubiquitin-protein ligase RNF8 | [225] | 1.57[226] | 1.43[227] | 0.02[228] | 0.86[229] | 0.66[230] | 0.71[231] |
34 | RFC3 | Replication factor C subunit 3 | [232] | 1.40[233] | 2.06[234] | 2.13[235] | 0.83[236] | 1.75[237] | -0.07[238] |
35 | HUS1 | Checkpoint protein HUS1 | [239] | -0.49[240] | -0.42[241] | 0.05[242] | -0.53[243] | -0.41[244] | 2.17[245] |
36 | CHEK1 | Serine/threonine-protein kinase Chk1 | [246] | 1.76[247] | 1.92[248] | 1.42[249] | 1.73[250] | 2.28[251] | -1.23[252] |
37 | RNF168 | E3 ubiquitin-protein ligase RNF168 | [253] | 0.62[254] | 1.06[255] | 1.98[256] | -0.34[257] | 1.14[258] | 2.89[259] |
38 | MDC1 | Mediator of DNA damage checkpoint protein 1 | [260] | 2.71[261] | 2.91[262] | 3.18[263] | 2.47[264] | 2.72[265] | 2.25[266] |
39 | TOP3A | DNA topoisomerase 3-alpha | [267] | 2.19[268] | 1.66[269] | 1.89[270] | 1.43[271] | 2.14[272] | 2.60[273] |
40 | RAD1 | Cell cycle checkpoint protein RAD1 | [274] | 1.59[275] | 2.06[276] | 2.53[277] | 1.38[278] | 2.60[279] | 1.71[280] |
41 | RAD9A | Cell cycle checkpoint control protein RAD9A | [281] | 0.29[282] | 0.37[283] | 2.12[284] | 1.91[285] | 0.05[286] | 0.63[287] |
42 | BRCA1 | Breast cancer type 1 susceptibility protein | [288] | 1.89[289] | 2.94[290] | 3.26[291] | 1.73[292] | 2.57[293] | 2.47[294] |
43 | HERC2 | E3 ubiquitin-protein ligase HERC2 | [295] | 2.68[296] | 2.17[297] | 2.66[298] | 2.67[299] | 3.05[300] | 4.96[301] |
44 | ATRIP | ATR-interacting protein | [302] | 0.47[303] | 0.51[304] | 1.32[305] | -0.76[306] | 0.63[307] | 0.64[308] |
45 | ATR | Serine/threonine-protein kinase ATR | [309] | 1.32[310] | 2.11[311] | 2.13[312] | 2.11[313] | 2.39[314] | 4.35[315] |
46 | TP53BP1 | TP53-binding protein 1 | [316] | 2.81[317] | 2.11[318] | 3.01[319] | 3.52[320] | 3.29[321] | 3.08[322] |
47 | WRN | Werner syndrome ATP-dependent helicase | [323] | 0.83[324] | 2.09[325] | 3.96[326] | 1.28[327] | 1.41[328] | 2.77[329] |
48 | RMI1 | RecQ-mediated genome instability protein 1 | [330] | 0.81[331] | 1.84[332] | 2.22[333] | 1.66[334] | 2.82[335] | 1.78[336] |
49 | ATM | Serine-protein kinase ATM | [337] | 3.25[338] | 4.65[339] | 4.31[340] | 3.74[341] | 3.54[342] | 5.79[343] |
50 | CDC25C | M-phase inducer phosphatase 3 | [344] | 2.16[345] | 3.11[346] | 3.07[347] | 1.51[348] | 2.68[349] | -0.62[350] |
51 | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2 | [351] | 1.98[352] | 3.55[353] | 2.69[354] | 2.23[355] | 2.21[356] | 2.36[357] |
52 | EXO1 | Exonuclease 1 | [358] | 2.13[359] | 2.21[360] | 3.31[361] | 3.36[362] | 2.96[363] | -0.67[364] |
53 | BRIP1 | Fanconi anemia group J protein | [365] | 2.37[366] | 3.56[367] | 3.51[368] | 2.79[369] | 3.15[370] | 2.76[371] |
54 | BLM | Bloom syndrome protein | [372] | 1.77[373] | 2.92[374] | 3.66[375] | 2.48[376] | 2.87[377] | 0.42[378] |
55 | BARD1 | BRCA1-associated RING domain protein 1 | [379] | 1.54[380] | 2.32[381] | 2.28[382] | 2.28[383] | 2.68[384] | 2.67[385] |
56 | RAD9B | Cell cycle checkpoint control protein RAD9B | [386] | -3.11[387] | -0.11[388] | -0.87[389] | 0.01[390] | -0.33[391] | 0.01[392] |
57 | H4C6 | [393] | [394] | [395] | [396] | [397] | [398] | [399] | |
58 | H4C14 | [400] | [401] | [402] | [403] | [404] | [405] | [406] | |
59 | H2BC17 | [407] | [408] | [409] | [410] | [411] | [412] | [413] | |
60 | H2BC21 | [414] | [415] | [416] | [417] | [418] | [419] | [420] | |
61 | ABRAXAS | BRCA1-A complex subunit Abraxas 1 | [421] | [422] | [423] | [424] | [425] | [426] | [427] |
62 | NSD2 | Histone-lysine N-methyltransferase NSD2 | [428] | [429] | [430] | [431] | [432] | [433] | [434] |
63 | MRE11 | Double-strand break repair protein MRE11 | [435] | [436] | [437] | [438] | [439] | [440] | [441] |
64 | H2BC4 | [442] | [443] | [444] | [445] | [446] | [447] | [448] | |
65 | H2AX | [449] | [450] | [451] | [452] | [453] | [454] | [455] | |
66 | H2BC11 | [456] | [457] | [458] | [459] | [460] | [461] | [462] | |
67 | H2BC12 | [463] | [464] | [465] | [466] | [467] | [468] | [469] | |
68 | H4C2 | [470] | [471] | [472] | [473] | [474] | [475] | [476] | |
69 | H2BC13 | [477] | [478] | [479] | [480] | [481] | [482] | [483] | |
70 | H4C1 | [484] | [485] | [486] | [487] | [488] | [489] | [490] | |
71 | H4C15 | [491] | [492] | [493] | [494] | [495] | [496] | [497] | |
72 | H2BC8 | [498] | [499] | [500] | [501] | [502] | [503] | [504] | |
73 | H2BC14 | [505] | [506] | [507] | [508] | [509] | [510] | [511] | |
74 | H2BC5 | [512] | [513] | [514] | [515] | [516] | [517] | [518] | |
75 | H4C13 | [519] | [520] | [521] | [522] | [523] | [524] | [525] | |
76 | H2BC9 | [526] | [527] | [528] | [529] | [530] | [531] | [532] | |
77 | H2BC7 | [533] | [534] | [535] | [536] | [537] | [538] | [539] | |
78 | H4-16 | [540] | [541] | [542] | [543] | [544] | [545] | [546] | |
79 | H2BC3 | [547] | [548] | [549] | [550] | [551] | [552] | [553] | |
80 | BABAM2 | BRISC and BRCA1-A complex member 2 | [554] | [555] | [556] | [557] | [558] | [559] | [560] |
81 | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 | [561] | [562] | [563] | [564] | [565] | [566] | [567] |
82 | H4C3 | [568] | [569] | [570] | [571] | [572] | [573] | [574] | |
83 | H4C9 | [575] | [576] | [577] | [578] | [579] | [580] | [581] | |
84 | H2BS1 | [582] | [583] | [584] | [585] | [586] | [587] | [588] | |
85 | H4C12 | [589] | [590] | [591] | [592] | [593] | [594] | [595] | |
86 | H2BU1 | [596] | [597] | [598] | [599] | [600] | [601] | [602] | |
87 | H2BC10 | [603] | [604] | [605] | [606] | [607] | [608] | [609] | |
88 | H2BC6 | [610] | [611] | [612] | [613] | [614] | [615] | [616] | |
89 | H2BC1 | [617] | [618] | [619] | [620] | [621] | [622] | [623] | |
90 | H4C8 | [624] | [625] | [626] | [627] | [628] | [629] | [630] | |
91 | H4C5 | [631] | [632] | [633] | [634] | [635] | [636] | [637] | |
92 | H2BC15 | [638] | [639] | [640] | [641] | [642] | [643] | [644] | |
93 | H3-4 | [645] | [646] | [647] | [648] | [649] | [650] | [651] | |
94 | H4C4 | [652] | [653] | [654] | [655] | [656] | [657] | [658] | |
95 | H4C11 | [659] | [660] | [661] | [662] | [663] | [664] | [665] |