REACTOME_G1_S_DNA_DAMAGE_CHECKPOINTS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.18[2] | -1.25[3] | -1.05[4] | -1.38[5] | -1.10[6] | -0.45[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.74[16] | -0.50[17] | -0.68[18] | -0.53[19] | -0.72[20] | 0.00[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.51[23] | -2.09[24] | -1.65[25] | -1.24[26] | -1.95[27] | -0.95[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.33[30] | -1.71[31] | -1.74[32] | -1.03[33] | -1.48[34] | -0.58[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.63[37] | 0.76[38] | -0.50[39] | 0.60[40] | -0.01[41] | 0.45[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.18[44] | 0.31[45] | -0.69[46] | -0.65[47] | -0.05[48] | 0.28[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.31[51] | -1.07[52] | 0.03[53] | -0.67[54] | -0.95[55] | -0.01[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.06[58] | 0.13[59] | 0.33[60] | 0.76[61] | 0.59[62] | -0.34[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.01[65] | -0.97[66] | -0.77[67] | -1.02[68] | -0.74[69] | -0.78[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.39[72] | -0.01[73] | -0.01[74] | -0.29[75] | -0.17[76] | -0.30[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.52[79] | 0.27[80] | 0.27[81] | 0.24[82] | 0.09[83] | -0.22[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.41[86] | 0.28[87] | 0.15[88] | 0.54[89] | 0.21[90] | -0.30[91] |
14 | PSMC3 | 26S proteasome regulatory subunit 6A | [92] | -0.44[93] | -0.48[94] | 0.21[95] | -0.66[96] | -0.62[97] | 0.17[98] |
15 | PSMA3 | Proteasome subunit alpha type-3 | [99] | -1.03[100] | 0.00[101] | -0.60[102] | 0.08[103] | -0.52[104] | -0.05[105] |
16 | PSMB6 | Proteasome subunit beta type-6 | [106] | -0.48[107] | -0.30[108] | -0.09[109] | -0.46[110] | -0.89[111] | 0.10[112] |
17 | PSMA2 | Proteasome subunit alpha type-2 | [113] | -0.56[114] | 0.42[115] | 0.83[116] | 0.03[117] | 0.25[118] | 0.33[119] |
18 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [120] | -0.05[121] | 0.00[122] | 0.27[123] | 0.74[124] | 0.05[125] | 0.01[126] |
19 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [127] | -0.13[128] | 0.27[129] | 0.20[130] | -0.35[131] | -0.03[132] | -0.17[133] |
20 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [134] | 0.04[135] | 0.31[136] | 0.52[137] | -0.07[138] | 0.53[139] | -0.14[140] |
21 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [141] | 1.57[142] | 0.78[143] | 0.92[144] | 1.04[145] | 2.17[146] | 0.89[147] |
22 | PSMC1 | 26S proteasome regulatory subunit 4 | [148] | -0.11[149] | -0.01[150] | -0.59[151] | 1.22[152] | 0.59[153] | 0.05[154] |
23 | PSMA1 | Proteasome subunit alpha type-1 | [155] | 0.08[156] | 0.50[157] | 0.63[158] | 0.80[159] | 0.14[160] | 0.54[161] |
24 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [162] | 1.70[163] | 1.74[164] | 2.83[165] | 0.87[166] | 1.50[167] | 0.77[168] |
25 | PSMC5 | 26S proteasome regulatory subunit 8 | [169] | 0.39[170] | 0.32[171] | 0.47[172] | 0.20[173] | 0.46[174] | 0.31[175] |
26 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [176] | 0.79[177] | 0.31[178] | 0.98[179] | 0.74[180] | 0.80[181] | 0.02[182] |
27 | PSMB8 | Proteasome subunit beta type-8 | [183] | -1.61[184] | -2.17[185] | -9.31[186] | 0.71[187] | -0.75[188] | -0.67[189] |
28 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [190] | -0.03[191] | 0.61[192] | 0.93[193] | 0.60[194] | 0.48[195] | -0.12[196] |
29 | PSMC4 | 26S proteasome regulatory subunit 6B | [197] | 0.39[198] | 0.46[199] | 0.46[200] | 0.23[201] | 0.19[202] | 0.36[203] |
30 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [204] | -0.76[205] | -0.25[206] | -1.26[207] | -0.40[208] | 0.26[209] | -0.23[210] |
31 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [211] | 0.44[212] | 0.58[213] | 1.15[214] | 0.66[215] | 0.02[216] | -0.05[217] |
32 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [218] | 1.86[219] | 0.60[220] | -2.04[221] | -0.59[222] | 1.79[223] | -0.41[224] |
33 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [225] | -0.38[226] | -0.27[227] | -0.51[228] | 0.28[229] | 0.19[230] | -0.13[231] |
34 | PSMC6 | 26S proteasome regulatory subunit 10B | [232] | -0.09[233] | 1.52[234] | 0.41[235] | 0.64[236] | 0.42[237] | 0.53[238] |
35 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [239] | 0.80[240] | 0.44[241] | 1.10[242] | 1.05[243] | 1.05[244] | 1.35[245] |
36 | PSMC2 | 26S proteasome regulatory subunit 7 | [246] | 0.55[247] | 0.98[248] | 0.83[249] | 1.44[250] | 1.11[251] | 1.41[252] |
37 | PSME3 | Proteasome activator complex subunit 3 | [253] | 1.78[254] | 1.53[255] | 1.28[256] | 1.47[257] | 1.58[258] | 0.97[259] |
38 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [260] | 1.54[261] | 1.89[262] | 1.84[263] | 2.27[264] | 2.12[265] | 2.16[266] |
39 | PSMB10 | Proteasome subunit beta type-10 | [267] | -1.19[268] | -0.56[269] | -2.38[270] | 0.06[271] | -1.26[272] | 0.01[273] |
40 | PSMA5 | Proteasome subunit alpha type-5 | [274] | 1.87[275] | 2.32[276] | 1.96[277] | 2.32[278] | 1.73[279] | 2.00[280] |
41 | PSMF1 | Proteasome inhibitor PI31 subunit | [281] | 2.25[282] | 2.32[283] | 1.20[284] | 1.33[285] | 0.94[286] | 1.94[287] |
42 | PSMB2 | Proteasome subunit beta type-2 | [288] | 2.03[289] | 1.79[290] | 2.25[291] | 2.63[292] | 2.46[293] | 2.48[294] |
43 | PSMB9 | Proteasome subunit beta type-9 | [295] | -1.98[296] | -4.57[297] | -6.81[298] | 1.88[299] | -0.54[300] | -0.41[301] |
44 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [302] | 0.40[303] | 0.92[304] | 0.01[305] | 0.50[306] | 0.79[307] | 0.81[308] |
45 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [309] | 0.93[310] | 1.51[311] | 1.75[312] | 0.29[313] | 0.58[314] | 0.52[315] |
46 | CDK2 | Cyclin-dependent kinase 2 | [316] | 0.60[317] | 0.90[318] | 1.33[319] | 1.38[320] | 1.79[321] | -0.76[322] |
47 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [323] | 0.96[324] | 1.31[325] | 1.40[326] | 2.18[327] | 1.34[328] | 0.80[329] |
48 | PSME4 | Proteasome activator complex subunit 4 | [330] | 2.49[331] | 3.43[332] | 3.50[333] | 2.73[334] | 2.54[335] | 3.07[336] |
49 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [337] | 3.13[338] | 4.68[339] | 1.97[340] | 1.91[341] | 2.60[342] | 3.59[343] |
50 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [344] | 1.38[345] | 0.96[346] | 2.59[347] | 2.56[348] | 2.49[349] | 2.25[350] |
51 | CHEK2 | Serine/threonine-protein kinase Chk2 | [351] | 1.12[352] | 1.69[353] | 2.14[354] | 1.15[355] | 0.60[356] | -1.85[357] |
52 | TP53 | Cellular tumor antigen p53 | [358] | 2.65[359] | 2.35[360] | 3.16[361] | 2.69[362] | 2.18[363] | 1.38[364] |
53 | PCBP4 | Poly(rC)-binding protein 4 | [365] | 3.82[366] | 3.19[367] | 2.38[368] | 1.73[369] | 2.10[370] | 0.12[371] |
54 | CCNE1 | G1/S-specific cyclin-E1 | [372] | 2.25[373] | 2.50[374] | 0.73[375] | 1.00[376] | 1.41[377] | -3.20[378] |
55 | CCNA2 | Cyclin-A2 | [379] | 3.22[380] | 4.37[381] | 3.76[382] | 3.40[383] | 4.61[384] | 0.20[385] |
56 | CHEK1 | Serine/threonine-protein kinase Chk1 | [386] | 2.55[387] | 3.05[388] | 2.67[389] | 3.55[390] | 3.60[391] | -0.60[392] |
57 | CDC25A | M-phase inducer phosphatase 1 | [393] | 2.44[394] | 3.21[395] | 3.61[396] | 1.74[397] | 3.02[398] | -1.23[399] |
58 | PHF20 | PHD finger protein 20 | [400] | 3.15[401] | 3.07[402] | 3.67[403] | 4.61[404] | 3.45[405] | 3.18[406] |
59 | ATM | Serine-protein kinase ATM | [407] | 4.05[408] | 5.78[409] | 5.56[410] | 5.56[411] | 4.86[412] | 6.41[413] |
60 | MDM4 | Protein Mdm4 | [414] | 2.66[415] | 3.80[416] | 4.29[417] | 3.69[418] | 3.39[419] | 5.98[420] |
61 | CCNE2 | G1/S-specific cyclin-E2 | [421] | 1.44[422] | 1.97[423] | 1.55[424] | 4.44[425] | 4.16[426] | 1.07[427] |
62 | ZNF385A | Zinc finger protein 385A | [428] | 2.57[429] | -0.35[430] | 0.62[431] | 2.99[432] | 2.88[433] | 1.04[434] |
63 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [435] | 5.10[436] | 3.00[437] | 6.46[438] | 6.61[439] | 8.21[440] | -0.73[441] |
64 | CCNA1 | Cyclin-A1 | [442] | [443] | -2.24[444] | [445] | 0.61[446] | 7.84[447] | [448] |
65 | PSMB11 | Proteasome subunit beta type-11 | [449] | [450] | [451] | [452] | [453] | [454] | [455] |
66 | SEM1 | Putative protein SEM1, isoform 2 | [456] | [457] | [458] | [459] | [460] | [461] | [462] |
67 | COP1 | [463] | [464] | [465] | [466] | [467] | [468] | [469] | |
68 | PSMA8 | Proteasome subunit alpha type-7-like | [470] | [471] | [472] | [473] | [474] | [475] | [476] |