REACTOME_FRS_MEDIATED_FGFR4_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.31[2] -0.15[3] -0.65[4] 0.49[5] 0.97[6] 0.62[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.44[9] 0.00[10] -0.33[11] 0.16[12] -0.09[13] -0.34[14]
3 FGFR4 Fibroblast growth factor receptor 4 [15] 1.20[16] 1.27[17] 1.40[18] -4.63[19] -4.92[20] -0.15[21]
4 NRAS GTPase NRas [22] -0.13[23] 0.03[24] -0.01[25] 0.60[26] 0.01[27] -0.89[28]
5 HRAS GTPase HRas [29] -1.77[30] -2.74[31] -3.99[32] -1.35[33] -1.72[34] -3.30[35]
6 KLB Beta-klotho [36] -0.16[37] -0.60[38] 0.40[39] -6.36[40] -7.16[41] 0.91[42]
7 KRAS GTPase KRas [43] -1.27[44] -1.56[45] -0.42[46] 0.40[47] -0.09[48] 0.03[49]
8 SOS1 Son of sevenless homolog 1 [50] -0.86[51] 0.40[52] -0.54[53] 0.45[54] -0.48[55] -0.10[56]
9 FGF2 Fibroblast growth factor 2 [57] -7.44[58] -7.46[59] -3.76[60] 0.54[61] 1.96[62] -2.31[63]
10 FRS2 Fibroblast growth factor receptor substrate 2 [64] 0.53[65] 1.35[66] 1.40[67] 2.51[68] 1.98[69] 2.70[70]
11 FRS3 Fibroblast growth factor receptor substrate 3 [71] -0.13[72] -0.57[73] -2.04[74] -0.11[75] -0.61[76] -1.55[77]
12 FGF1 Fibroblast growth factor 1 [78] -3.52[79] -3.00[80] -7.92[81] 0.19[82] 1.61[83] -0.60[84]
13 FGF19 Fibroblast growth factor 19 [85] -2.82[86] -1.94[87] 4.35[88] 0.43[89] -3.19[90] [91]
14 FGF8 Fibroblast growth factor 8 [92] -4.09[93] -4.01[94] 0.03[95] -2.31[96] [97] 2.05[98]
15 FGF18 Fibroblast growth factor 18 [99] 1.02[100] -3.37[101] -1.65[102] 0.22[103] 0.66[104] -0.06[105]
16 FGF9 Fibroblast growth factor 9 [106] 1.50[107] -2.42[108] [109] 2.39[110] -2.89[111] -0.54[112]
17 FGF20 Fibroblast growth factor 20 [113] [114] [115] [116] [117] [118] [119]
18 FGF23 Fibroblast growth factor 23 [120] [121] [122] [123] [124] [125] [126]
19 FGF17 Fibroblast growth factor 17 [127] [128] [129] [130] [131] [132] [133]
20 FGF4 Fibroblast growth factor 4 [134] [135] [136] [137] [138] [139] [140]
21 FGF16 Fibroblast growth factor 16 [141] [142] [143] [144] [145] [146] [147]
22 FGF6 Fibroblast growth factor 6 [148] [149] [150] [151] [152] [153] [154]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte FGFR4
Mean 15.1
Standard deviation 12
Values 30 2.5 2.2 18 23
[16]
HepG2 FGFR4
Mean 129
Standard deviation 13
Values 1.2e+02 1.4e+02
[17]
HepG2.C3A FGFR4
Mean 146
Standard deviation 22
Values 1.6e+02 1.3e+02
[18]
HuH.7 FGFR4
Mean 209
Standard deviation 68
Values 2.4e+02 1.3e+02 2.5e+02
[19]
SNU475 FGFR4
Mean 1.47
Standard deviation 0.43
Values 1.2 1.8
[20]
THLE FGFR4
Mean 1.51
Standard deviation 0.45
Values 1.8 1.2
[21]
liver FGFR4
Mean 30.3
Standard deviation 10
Values 43 18 31 29
[22]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[23]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[24]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[25]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[26]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[27]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[28]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[29]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[30]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[31]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[32]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[33]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[34]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[35]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[36]
ref_hepatocyte KLB
Mean 9.92
Standard deviation 12
Values 30 1.9 0.71 6.7 9.9
[37]
HepG2 KLB
Mean 33.1
Standard deviation 23
Values 17 49
[38]
HepG2.C3A KLB
Mean 26.3
Standard deviation 0.12
Values 26 26
[39]
HuH.7 KLB
Mean 68.9
Standard deviation 30
Values 57 1e+02 46
[40]
SNU475 KLB
Mean 0.292
Standard deviation 0.04
Values 0.32 0.26
[41]
THLE KLB
Mean 0.21
Standard deviation 0.004
Values 0.21 0.21
[42]
liver KLB
Mean 41.2
Standard deviation 7.6
Values 52 37 40 36
[43]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[44]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[45]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[46]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[47]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[48]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[49]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[50]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[51]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[52]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[53]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[54]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[55]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[56]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[57]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[58]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[59]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[60]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[61]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[62]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[63]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[64]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[65]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[66]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[67]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[68]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[69]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[70]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[71]
ref_hepatocyte FRS3
Mean 0.88
Standard deviation 0.75
Values 2 0.11 0.65 0.39 1.3
[72]
HepG2 FRS3
Mean 3
Standard deviation 0.84
Values 3.6 2.4
[73]
HepG2.C3A FRS3
Mean 2.38
Standard deviation 0.57
Values 2.8 2
[74]
HuH.7 FRS3
Mean 1.13
Standard deviation 0.22
Values 1.1 0.94 1.4
[75]
SNU475 FRS3
Mean 1.98
Standard deviation 0.18
Values 2.1 1.9
[76]
THLE FRS3
Mean 1.75
Standard deviation 0.21
Values 1.9 1.6
[77]
liver FRS3
Mean 0.666
Standard deviation 0.45
Values 1.1 0.26 0.98 0.3
[78]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[79]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[80]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[81]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[82]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[83]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[84]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[85]
ref_hepatocyte FGF19
Mean 0.122
Standard deviation 0.27
Values 0 0 0.61 0 0
[86]
HepG2 FGF19
Mean 0.0644
Standard deviation 0.0062
Values 0.069 0.06
[87]
HepG2.C3A FGF19
Mean 0.128
Standard deviation 0.0016
Values 0.13 0.13
[88]
HuH.7 FGF19
Mean 13.1
Standard deviation 3.4
Values 11 17 12
[89]
SNU475 FGF19
Mean 0.397
Standard deviation 0.15
Values 0.51 0.29
[90]
THLE FGF19
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[91]
liver FGF19
Mean 0
Standard deviation 0
Values 0 0 0 0
[92]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[93]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[94]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[96]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[97]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[98]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[99]
ref_hepatocyte FGF18
Mean 0.0138
Standard deviation 0.031
Values 0 0 0 0.069 0
[100]
HepG2 FGF18
Mean 0.105
Standard deviation 0.039
Values 0.13 0.077
[101]
HepG2.C3A FGF18
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[102]
HuH.7 FGF18
Mean 0.0232
Standard deviation 0.02
Values 0 0.032 0.037
[103]
SNU475 FGF18
Mean 0.0388
Standard deviation 0.0024
Values 0.037 0.041
[104]
THLE FGF18
Mean 0.0657
Standard deviation 0.033
Values 0.089 0.043
[105]
liver FGF18
Mean 0.0294
Standard deviation 0.0072
Values 0.024 0.029 0.026 0.04
[106]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[107]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[108]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[109]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[111]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[112]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[113]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[115]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[118]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[119]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[120]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[124]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[126]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36
[127]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[129]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[130]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[131]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[132]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[133]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[134]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[139]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[140]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte FGF16
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 FGF16
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A FGF16
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 FGF16
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 FGF16
Mean 0
Standard deviation 0
Values 0 0
[146]
THLE FGF16
Mean 0
Standard deviation 0
Values 0 0
[147]
liver FGF16
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[148]
ref_hepatocyte FGF6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 FGF6
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[150]
HepG2.C3A FGF6
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 FGF6
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 FGF6
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE FGF6
Mean 0
Standard deviation 0
Values 0 0
[154]
liver FGF6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0